{"id":"https://openalex.org/W58720712","doi":null,"title":"The modulatory role of melatonin on immune responsiveness.","display_name":"The modulatory role of melatonin on immune responsiveness.","publication_year":2006,"publication_date":"2006-05-01","ids":{"openalex":"https://openalex.org/W58720712","mag":"58720712","pmid":"https://pubmed.ncbi.nlm.nih.gov/16729718"},"language":"en","primary_location":{"id":"pmid:16729718","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16729718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in investigational drugs (London, England : 2000)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061059602","display_name":"Antonio Carrillo\u2010Vico","orcid":"https://orcid.org/0000-0002-8516-0999","observed_orcids":["https://orcid.org/0000-0002-8516-0999"]},"institutions":[{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonio Carrillo-Vico","raw_affiliation_strings":["Department of Medical Biochemistry and Molecular Biology, The University of Seville Medical School, Avda Sanchez Pizjuan 4, 41009 Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Molecular Biology, The University of Seville Medical School, Avda Sanchez Pizjuan 4, 41009 Seville, Spain","institution_ids":["https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063159500","display_name":"Russel Joseph Reiter","orcid":"https://orcid.org/0000-0001-6763-4225","observed_orcids":["https://orcid.org/0000-0001-6763-4225"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Russel J Reiter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053551673","display_name":"Patricia Judith Lardone","orcid":"https://orcid.org/0000-0003-1793-3985","observed_orcids":["https://orcid.org/0000-0003-1793-3985"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia J Lardone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Juan Luis Herrera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Luis Herrera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045530122","display_name":"Rafael Fern\u00e1ndez-Montesinos","orcid":"https://orcid.org/0000-0002-5062-4239","observed_orcids":["https://orcid.org/0000-0002-5062-4239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rafael Fern\u00e1ndez-Montesinos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017730925","display_name":"Juan Miguel Guerrero","orcid":"https://orcid.org/0000-0001-7553-0119","observed_orcids":["https://orcid.org/0000-0001-7553-0119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Miguel Guerrero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067897234","display_name":"David Pozo","orcid":"https://orcid.org/0000-0002-3732-4960","observed_orcids":["https://orcid.org/0000-0002-3732-4960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Pozo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.1565,"has_fulltext":false,"cited_by_count":217,"citation_normalized_percentile":{"value":0.96337079,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"7","issue":"5","first_page":"423","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":1.0},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/pineal-gland","display_name":"pineal gland","score":0.972000002861023},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.703000009059906},{"id":"https://openalex.org/keywords/intracrine-signaling","display_name":"intracrine signaling","score":0.6299999952316284},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.8360000252723694},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.9860000014305115},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.6610000133514404},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":1.0},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.9580000042915344},{"id":"https://openalex.org/keywords/immune-cells","display_name":"immune cells","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.9402446746826172},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.7701880931854248},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7617168426513672},{"id":"https://openalex.org/C63263939","wikidata":"https://www.wikidata.org/wiki/Q3153691","display_name":"Intracrine","level":4,"score":0.7003769278526306},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.6484674215316772},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.643302321434021},{"id":"https://openalex.org/C2780059843","wikidata":"https://www.wikidata.org/wiki/Q198654","display_name":"Pineal gland","level":3,"score":0.5973119735717773},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.55436772108078},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4981217384338379},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3326357305049896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3099071681499481},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28929638862609863},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.28819549083709717},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15833988785743713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.054693400859832764}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010870","descriptor_name":"Pineal Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D044094","descriptor_name":"Receptors, Melatonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16729718","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16729718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in investigational drugs (London, England : 2000)","raw_type":"Journal Article"},{"id":"mag:58720712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16729718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W71494981","https://openalex.org/W192466990","https://openalex.org/W265456471","https://openalex.org/W1563943938","https://openalex.org/W1572881837","https://openalex.org/W1581035845","https://openalex.org/W1581691059","https://openalex.org/W1594539812","https://openalex.org/W1854794930","https://openalex.org/W1969934878","https://openalex.org/W1970627910","https://openalex.org/W1972302398","https://openalex.org/W1973675862","https://openalex.org/W1974986610","https://openalex.org/W1976540106","https://openalex.org/W1981065568","https://openalex.org/W1981129901","https://openalex.org/W1986615746","https://openalex.org/W1988148616","https://openalex.org/W1991117658","https://openalex.org/W1991332240","https://openalex.org/W1992507060","https://openalex.org/W1995972463","https://openalex.org/W1998713395","https://openalex.org/W1999548924","https://openalex.org/W2002853842","https://openalex.org/W2006761570","https://openalex.org/W2009745241","https://openalex.org/W2012204755","https://openalex.org/W2013551886","https://openalex.org/W2015542694","https://openalex.org/W2018981915","https://openalex.org/W2019102246","https://openalex.org/W2021399303","https://openalex.org/W2023069349","https://openalex.org/W2023183146","https://openalex.org/W2027098689","https://openalex.org/W2029317094","https://openalex.org/W2029479550","https://openalex.org/W2033147224","https://openalex.org/W2034348289","https://openalex.org/W2043569138","https://openalex.org/W2043891664","https://openalex.org/W2047196174","https://openalex.org/W2051047016","https://openalex.org/W2051121914","https://openalex.org/W2053561175","https://openalex.org/W2064481302","https://openalex.org/W2067299095","https://openalex.org/W2067503520","https://openalex.org/W2074658037","https://openalex.org/W2077176956","https://openalex.org/W2077198366","https://openalex.org/W2079716400","https://openalex.org/W2081393756","https://openalex.org/W2086328444","https://openalex.org/W2087647563","https://openalex.org/W2088662013","https://openalex.org/W2091661826","https://openalex.org/W2092237408","https://openalex.org/W2092549653","https://openalex.org/W2103486570","https://openalex.org/W2106139754","https://openalex.org/W2112916976","https://openalex.org/W2126012445","https://openalex.org/W2127228129","https://openalex.org/W2131847829","https://openalex.org/W2136791868","https://openalex.org/W2140649712","https://openalex.org/W2143817769","https://openalex.org/W2148379844","https://openalex.org/W2152858413","https://openalex.org/W2155679235","https://openalex.org/W2162568193","https://openalex.org/W2164058704","https://openalex.org/W2166174226","https://openalex.org/W2167587119","https://openalex.org/W2339708504","https://openalex.org/W2415663550","https://openalex.org/W2419158472","https://openalex.org/W2436255953","https://openalex.org/W2466594397"],"related_works":["https://openalex.org/W2992503005","https://openalex.org/W1965356571","https://openalex.org/W2033147224","https://openalex.org/W2011370804","https://openalex.org/W7096869015","https://openalex.org/W21182095","https://openalex.org/W21787028","https://openalex.org/W2766432857","https://openalex.org/W4400768876","https://openalex.org/W1035910884"],"abstract_inverted_index":{"Afterhe":[0],"successful":[1],"discovery":[2],"of":[3,31,41,57,107,132],"the":[4,20,29,32,45,51,70,86,94,120,127,130],"melatonin":[5,18,61,91],"molecule":[6,65],"by":[7,143],"Aaron":[8],"B":[9],"Lerner":[10],"et":[11],"al":[12],"at":[13,28],"Yale":[14],"University":[15],"in":[16,39,123],"1958,":[17],"and":[19,47,100,114,119,139],"pineal":[21],"gland,":[22],"a":[23,54,63],"tiny":[24],"endocrine":[25,46],"gland":[26],"situated":[27],"center":[30],"human":[33],"brain,":[34],"have":[35,85],"primarily":[36],"been":[37],"considered":[38,78],"terms":[40],"their":[42],"effects":[43,68],"on":[44,69],"reproductive":[48],"systems.":[49],"During":[50],"last":[52],"decade,":[53],"substantial":[55],"body":[56],"research":[58],"has":[59],"defined":[60],"as":[62,79],"remarkable":[64],"with":[66,109],"pleiotropic":[67],"immune":[71,134],"system.":[72],"Moreover,":[73],"its":[74],"synthesis":[75],"cannot":[76],"be":[77,137],"exclusively":[80],"endocrine;":[81],"key":[82],"immunocompetent":[83],"cells":[84],"functional":[87],"enzymatic":[88],"machinery":[89],"for":[90],"synthesis,":[92],"paving":[93],"wayfo":[95],"r":[96],"complex":[97],"intracrine,":[98],"autocrine":[99],"paracrine":[101],"regulatory":[102],"loops.":[103],"The":[104],"immunomodulatory":[105],"role":[106],"melatonin,":[108],"regard":[110],"to":[111],"infection,":[112],"inflammation":[113],"autoimmunity,":[115],"is":[116],"outlined":[117],"here,":[118],"evidence":[121],"discussed":[122],"this":[124],"review":[125],"strengthens":[126],"notion":[128],"that":[129],"nature":[131],"an":[133],"response":[135],"may":[136],"modified,":[138],"therefore":[140],"therapeutically":[141],"manipulated,":[142],"circadian":[144],"effector":[145],"signals.":[146]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":16}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
