{"id":"https://openalex.org/W58632028","doi":null,"title":"Synaptic plasticity in Hippocampus. Long-term depression and its relation to long-term potentiation","display_name":"Synaptic plasticity in Hippocampus. Long-term depression and its relation to long-term potentiation","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W58632028","mag":"58632028"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/15040","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2077/15040","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091069854","display_name":"Min\u2010Yi Xiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Min\u2010Yi Xiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091069854"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9169999957084656},{"id":"https://openalex.org/keywords/long-term-depression","display_name":"long-term depression","score":0.8389999866485596},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9480000138282776},{"id":"https://openalex.org/keywords/homosynaptic-plasticity","display_name":"homosynaptic plasticity","score":0.8830000162124634},{"id":"https://openalex.org/keywords/ampa-receptors","display_name":"AMPA receptors","score":0.8510000109672546},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.6389999985694885},{"id":"https://openalex.org/keywords/n6-cyclohexyladenosine","display_name":"N6-cyclohexyladenosine","score":0.9649999737739563},{"id":"https://openalex.org/keywords/presynaptic-inhibition","display_name":"presynaptic inhibition","score":0.6050000190734863},{"id":"https://openalex.org/keywords/paired-pulse-facilitation","display_name":"paired-pulse facilitation","score":0.871999979019165},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.9490000009536743}],"concepts":[{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.787112832069397},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6910711526870728},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.6675372123718262},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5956487655639648},{"id":"https://openalex.org/C73009533","wikidata":"https://www.wikidata.org/wiki/Q1517140","display_name":"Long-term depression","level":5,"score":0.5471023321151733},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.5181942582130432},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.4541485011577606},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4393446743488312},{"id":"https://openalex.org/C194973443","wikidata":"https://www.wikidata.org/wiki/Q1420291","display_name":"Metaplasticity","level":4,"score":0.43383529782295227},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39958328008651733},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17583486437797546},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14407452940940857},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12134447693824768},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.08757346868515015},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/15040","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2077/15040","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:58632028","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/handle/2077/15040","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1962539779","https://openalex.org/W4248005208","https://openalex.org/W184331644","https://openalex.org/W30611063","https://openalex.org/W2171336978","https://openalex.org/W1982937689","https://openalex.org/W3080465713","https://openalex.org/W2059010387","https://openalex.org/W6889594271","https://openalex.org/W2014148866"],"abstract_inverted_index":{"Synaptic":[0],"plasticity":[1,20],"has":[2,40],"long":[3],"been":[4,41],"considered":[5],"as":[6,100,209,299],"a":[7,112,189,199,278,300],"cellular":[8],"basis":[9],"for":[10,71],"learning":[11],"and":[12,27,91,111,121,135,152,205,212,221,235,272,303,318],"memory.":[13],"The":[14,34,76,267],"most":[15],"prominent":[16],"forms":[17],"of":[18,36,46,53,89,106,119,133,143,148,161,201,265,289,313,320],"such":[19,208,333],"are":[21],"the":[22,32,37,44,47,51,80,96,108,130,141,146,149,159,176,256,262],"homosynaptic":[23,81],"long-term":[24,28],"potentiation":[25],"(LTP)":[26],"depression":[29,211],"(LTD)":[30],"in":[31,50,187,191,283],"hippocampus.":[33],"aim":[35],"present":[38],"study":[39],"to":[42,158,225,232],"advance":[43],"understanding":[45],"mechanisms":[48],"involved":[49],"expression":[52],"hippocampal":[54,60],"LTP/LTD.":[55],"Experiments":[56],"were":[57,74,223],"performed":[58],"on":[59,95,145],"slices":[61],"from":[62],"12-18":[63],"day":[64],"old":[65],"Sprague-Dawley":[66],"rats.":[67],"Standard":[68],"electrophysiological":[69],"techniques":[70],"extracellular":[72],"recording":[73],"used.":[75],"results":[77,268],"showed":[78],"that":[79,219,242,270,293],"LTD":[82,144,204,220,271],"was":[83,155,197,216,239],"associated":[84,115],"with":[85,116,230],"equal":[86,117],"relative":[87],"changes":[88,207],"AMPA":[90,109,120,134,153,234],"NMDA":[92,122,136,151,179,236],"responses.":[93,123,237],"LTP,":[94],"other":[97],"hand,":[98],"occurred":[99],"an":[101],"early":[102,263],"(<30-60":[103],"min)":[104],"change":[105,132],"predominantly":[107],"response,":[110],"later":[113],"one":[114],"increases":[118],"An":[124],"adenosine":[125],"agonist":[126],"N6-cyclohexyladenosine":[127],"(CHA)":[128],"mimicked":[129],"parallel":[131],"responses":[137,154],"during":[138,194],"LTD.":[139,195],"Furthermore,":[140],"effect":[142],"waveforms":[147],"isolated":[150],"found":[156,218],"compatible":[157],"action":[160],"several":[162],"drugs":[163],"attenuating":[164],"synaptic":[165,280],"transmission":[166],"by":[167,247,259,311,327],"presynaptic,":[168],"but":[169,254],"not":[170,243],"postsynaptic,":[171],"mechanisms.":[172],"However,":[173],"experiments":[174],"using":[175],"activity":[177],"dependent":[178],"channel":[180],"blocker":[181],"(+)-MK-801":[182],"hydrogen":[183],"maleate":[184],"(MK-801)":[185],"failed":[186],"demonstrating":[188],"decrease":[190],"transmitter":[192],"release":[193],"There":[196],"also":[198,217,255],"lack":[200],"interaction":[202],"between":[203],"presynaptic":[206],"CHA-induced":[210],"paired-pulse":[213],"facilitation.":[214],"It":[215,238],"LTP":[222,253,276],"able":[224],"repeatedly":[226],"reverse":[227,252],"each":[228],"other,":[229],"respect":[231],"both":[233],"further":[240],"demonstrated":[241],"only":[244],"LTD,":[245],"induced":[246],"special":[248],"induction":[249],"paradigms,":[250],"could":[251,309,323],"test":[257],"stimulation":[258],"itself":[260],"facilitated":[261],"decay":[264],"LTP.":[266],"suggest":[269],"(later":[273],"part":[274],"of)":[275],"involve":[277],"common":[279,295],"modification,":[281],"although":[282],"different":[284],"directions.":[285],"A":[286],"possible":[287],"explanation":[288],"our":[290],"data":[291],"is":[292],"this":[294,308],"modification":[296],"takes":[297],"place":[298],"co-ordinated":[301],"pre-":[302],"postsynaptic":[304],"change.":[305],"In":[306],"principle,":[307],"occur":[310],"alterations":[312],"existing":[314],"synapses.":[315],"Alternatively,":[316],"elimination":[317],"formation":[319],"(functional)":[321],"synapses":[322,330,334],"be":[324],"involved,":[325],"perhaps":[326],"functionally":[328],"silencing":[329],"or":[331],"bringing":[332],"into":[335],"play.":[336]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
