{"id":"https://openalex.org/W58618526","doi":null,"title":"\u03b2-adrenergic receptor cAMP and PI3K signaling in primary cultures of brown adipocytes.","display_name":"\u03b2-adrenergic receptor cAMP and PI3K signaling in primary cultures of brown adipocytes.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W58618526","mag":"58618526"},"language":"en","primary_location":{"id":"mag:58618526","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:196837","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058282928","display_name":"Daniel L. Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel L. Yamamoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029279424","display_name":"Ekaterina Chernogubova","orcid":"https://orcid.org/0000-0002-3051-653X","observed_orcids":["https://orcid.org/0000-0002-3051-653X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ekaterina Chernogubova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023365025","display_name":"Dana S. Hutchinson","orcid":"https://orcid.org/0000-0001-9947-0106","observed_orcids":["https://orcid.org/0000-0001-9947-0106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dana S. Hutchinson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9947-0106","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060907492","display_name":"Julia Nevzorova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia Nevzorova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044821695","display_name":"Tore Bengtsson","orcid":"https://orcid.org/0000-0002-5396-030X","observed_orcids":["https://orcid.org/0000-0002-5396-030X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tore Bengtsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.11940000206232071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.9079999923706055},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8619999885559082},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.9900000095367432},{"id":"https://openalex.org/keywords/brown-adipocytes","display_name":"brown adipocytes","score":0.996999979019165},{"id":"https://openalex.org/keywords/skeletal-muscle-cells","display_name":"skeletal muscle cells","score":0.6949999928474426},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.7639999985694885},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.6169999837875366},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/dpi","display_name":"DPI","score":0.5370000004768372},{"id":"https://openalex.org/keywords/mitochondrial-complex-i","display_name":"mitochondrial complex I","score":0.6880000233650208},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.5139999985694885},{"id":"https://openalex.org/keywords/myod","display_name":"MyoD","score":0.8069999814033508},{"id":"https://openalex.org/keywords/myotube-fusion","display_name":"myotube fusion","score":0.640999972820282},{"id":"https://openalex.org/keywords/skeletal-muscle-differentiation","display_name":"skeletal muscle differentiation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6789282560348511},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6542251706123352},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6451838612556458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.500098705291748},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48575595021247864},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.4808245897293091},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4582776725292206},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.45822960138320923},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45118221640586853},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3986985981464386},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.3924689292907715},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.37650784850120544},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37546002864837646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23673245310783386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:58618526","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:196837","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W192775457","https://openalex.org/W67050714","https://openalex.org/W186078087","https://openalex.org/W2132695367","https://openalex.org/W2981165097","https://openalex.org/W130300178","https://openalex.org/W17342854","https://openalex.org/W2070238866","https://openalex.org/W7058553612","https://openalex.org/W179640083"],"abstract_inverted_index":{"Glucose":[0],"metabolism":[1],"in":[2,20,106,136,166,206],"insulin-sensitive":[3],"tissues":[4,22],"such":[5],"as":[6,59],"skeletal":[7,42,103,163,172],"muscle":[8,43,104,164,173],"and":[9,96,128,186,223],"adipose":[10],"tissue":[11],"is":[12,65,93,181],"tightly":[13],"regulated":[14],"by":[15,38],"external":[16],"stimuli.":[17],"Metabolic":[18],"changes":[19,32],"these":[21],"have":[23,46,109,154,192,200],"direct":[24],"effects":[25],"on":[26,72],"whole":[27],"body":[28],"metabolism.":[29],"Such":[30],"metabolic":[31,224],"can":[33,175,199],"be":[34,176,216],"induced":[35],"or":[36],"influenced":[37],"adrenergic":[39],"stimulation.In":[40],"L6":[41],"cells,":[44],"we":[45,108,153],"seen":[47,193],"that":[48,79,92,111,194],"the":[49,56,82,137,195,204,210],"\u03b22-adrenergic":[50],"receptor":[51],"increases":[52,117],"glycogen":[53],"synthesis":[54],"to":[55],"same":[57,211],"extent":[58],"insulin.":[60],"The":[61],"\u03b22-adrenergically":[62],"mediated":[63],"effect":[64,91],"independent":[66,124],"of":[67,86,125,150,162,203],"cyclic":[68,89],"AMP":[69,90],"but":[70],"dependent":[71],"PI3K.In":[73,102],"brown":[74],"adipocytes,":[75],"our":[76],"data":[77],"suggest":[78],"signaling":[80,122,222],"from":[81],"\u03b2-adrenergic":[83],"receptors":[84],"consists":[85],"an":[87,148],"acute":[88],"rapidly":[94],"desensitized":[95],"then":[97],"a":[98,121,156],"prolonged":[99],"signal":[100],"involving":[101],"cells":[105,165,174],"culture,":[107],"shown":[110],"DPI":[112,131],"(a":[113],"NADPH":[114,126],"oxidase":[115,127],"inhibitor)":[116],"glucose":[118,151],"uptake":[119],"through":[120],"pathway":[123],"insulin":[129],"signaling.":[130],"instead":[132],"inhibits":[133],"complex":[134],"1":[135],"mitochondrial":[138],"respiratory":[139],"chain,":[140],"which":[141],"lowers":[142],"ATP":[143],"levels.":[144],"This":[145,179,213],"activates":[146],"AMPK,":[147],"activator":[149],"uptake.Furthermore,":[152],"developed":[155],"model":[157],"system":[158,180,214],"for":[159,183,189,220],"ordered":[160],"fusion":[161],"culture.":[167],"In":[168],"this":[169],"system,":[170],"differentiating":[171],"studied":[177],"separately.":[178],"optimal":[182],"microscopy":[184],"techniques":[185],"easily":[187],"adaptable":[188],"micromanipulations.":[190],"We":[191],"myogenic":[196],"factor":[197],"MyoD":[198],"different":[201,207],"expression":[202],"protein":[205],"nuclei":[208],"within":[209],"myotube.":[212],"could":[215],"used":[217],"with":[218],"advantage":[219],"intracellular":[221],"studies.":[225]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
