{"id":"https://openalex.org/W585907176","doi":null,"title":"Functional analysis of Ipf1/Pdx1, MFng and Id during pancreatic growth and differentiation","display_name":"Functional analysis of Ipf1/Pdx1, MFng and Id during pancreatic growth and differentiation","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W585907176","mag":"585907176"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-1671","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1671","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1671","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Per Svensson","orcid":"https://orcid.org/0000-0003-0372-6272","observed_orcids":["https://orcid.org/0000-0003-0372-6272"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Per Svensson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0372-6272","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreas-development","display_name":"pancreatic development","score":0.7139999866485596},{"id":"https://openalex.org/keywords/id-proteins","display_name":"Id proteins","score":0.42899999022483826},{"id":"https://openalex.org/keywords/pancreatic-progenitor-cells","display_name":"pancreatic progenitor cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.8149999976158142},{"id":"https://openalex.org/keywords/ngn3","display_name":"Ngn3","score":0.8420000076293945},{"id":"https://openalex.org/keywords/pancreatic-agenesis","display_name":"pancreatic agenesis","score":0.6060000061988831},{"id":"https://openalex.org/keywords/islet-development","display_name":"islet development","score":0.4230000078678131},{"id":"https://openalex.org/keywords/acinar-cells","display_name":"acinar cells","score":0.6980000138282776},{"id":"https://openalex.org/keywords/her3","display_name":"HER3","score":0.9430000185966492},{"id":"https://openalex.org/keywords/pax6","display_name":"Pax6","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C2779050171","wikidata":"https://www.wikidata.org/wiki/Q18027973","display_name":"PDX1","level":4,"score":0.5955063104629517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3777713179588318},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3258799910545349},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15073490142822266},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0927196741104126}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-1671","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1671","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:585907176","doi":null,"is_oa":false,"landing_page_url":"http://umu.diva-portal.org/smash/get/diva2:141782/FULLTEXT01","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-1671","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1671","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":186,"referenced_works":["https://openalex.org/W61239125","https://openalex.org/W189021323","https://openalex.org/W1488156534","https://openalex.org/W1491063745","https://openalex.org/W1520149501","https://openalex.org/W1535245497","https://openalex.org/W1560488482","https://openalex.org/W1568038787","https://openalex.org/W1569944510","https://openalex.org/W1573536022","https://openalex.org/W1593837562","https://openalex.org/W1603199091","https://openalex.org/W1721336579","https://openalex.org/W1830287761","https://openalex.org/W1844743435","https://openalex.org/W1849335746","https://openalex.org/W1873165927","https://openalex.org/W1883901605","https://openalex.org/W1918701699","https://openalex.org/W1919210158","https://openalex.org/W1961434948","https://openalex.org/W1964633462","https://openalex.org/W1966589379","https://openalex.org/W1967115518","https://openalex.org/W1971135307","https://openalex.org/W1972676659","https://openalex.org/W1975295123","https://openalex.org/W1976724245","https://openalex.org/W1977253322","https://openalex.org/W1977962361","https://openalex.org/W1978310574","https://openalex.org/W1979504970","https://openalex.org/W1979505297","https://openalex.org/W1980797966","https://openalex.org/W1981053128","https://openalex.org/W1981115584","https://openalex.org/W1981792027","https://openalex.org/W1982186905","https://openalex.org/W1982749387","https://openalex.org/W1983712244","https://openalex.org/W1986058398","https://openalex.org/W1986164542","https://openalex.org/W1989167529","https://openalex.org/W1990185237","https://openalex.org/W1990803574","https://openalex.org/W1990826732","https://openalex.org/W1990891647","https://openalex.org/W1993055783","https://openalex.org/W1995420824","https://openalex.org/W1995615216","https://openalex.org/W1995717845","https://openalex.org/W1998146679","https://openalex.org/W1998706040","https://openalex.org/W1999112733","https://openalex.org/W2001990792","https://openalex.org/W2003377692","https://openalex.org/W2003702370","https://openalex.org/W2005331344","https://openalex.org/W2005688198","https://openalex.org/W2006676089","https://openalex.org/W2009673030","https://openalex.org/W2012449451","https://openalex.org/W2014423461","https://openalex.org/W2015325225","https://openalex.org/W2015761261","https://openalex.org/W2015974087","https://openalex.org/W2016633058","https://openalex.org/W2018042402","https://openalex.org/W2019007505","https://openalex.org/W2019384565","https://openalex.org/W2019938563","https://openalex.org/W2020099375","https://openalex.org/W2020713821","https://openalex.org/W2021803232","https://openalex.org/W2022131947","https://openalex.org/W2023445515","https://openalex.org/W2023830997","https://openalex.org/W2026503236","https://openalex.org/W2027477192","https://openalex.org/W2029225725","https://openalex.org/W2029669820","https://openalex.org/W2031204411","https://openalex.org/W2031531828","https://openalex.org/W2033045615","https://openalex.org/W2033801528","https://openalex.org/W2035621553","https://openalex.org/W2035885377","https://openalex.org/W2036264366","https://openalex.org/W2036334886","https://openalex.org/W2037108680","https://openalex.org/W2037132744","https://openalex.org/W2039140546","https://openalex.org/W2040362901","https://openalex.org/W2042102537","https://openalex.org/W2042167294","https://openalex.org/W2042537754","https://openalex.org/W2043279623","https://openalex.org/W2045042058","https://openalex.org/W2045390772","https://openalex.org/W2046051277","https://openalex.org/W2046281270","https://openalex.org/W2047094334","https://openalex.org/W2047563941","https://openalex.org/W2048056915","https://openalex.org/W2049690785","https://openalex.org/W2053178092","https://openalex.org/W2055598818","https://openalex.org/W2057216898","https://openalex.org/W2061159816","https://openalex.org/W2062602107","https://openalex.org/W2064574277","https://openalex.org/W2064756027","https://openalex.org/W2069288695","https://openalex.org/W2069852343","https://openalex.org/W2071894403","https://openalex.org/W2073020869","https://openalex.org/W2082802107","https://openalex.org/W2083184185","https://openalex.org/W2084707443","https://openalex.org/W2089509534","https://openalex.org/W2090467664","https://openalex.org/W2093346922","https://openalex.org/W2093873743","https://openalex.org/W2094074434","https://openalex.org/W2094686345","https://openalex.org/W2095380487","https://openalex.org/W2096181900","https://openalex.org/W2097330469","https://openalex.org/W2097352432","https://openalex.org/W2098503611","https://openalex.org/W2100200642","https://openalex.org/W2101321402","https://openalex.org/W2106004510","https://openalex.org/W2107427447","https://openalex.org/W2110287546","https://openalex.org/W2111341494","https://openalex.org/W2113421261","https://openalex.org/W2114688668","https://openalex.org/W2115482726","https://openalex.org/W2116010045","https://openalex.org/W2116100337","https://openalex.org/W2121209202","https://openalex.org/W2124769526","https://openalex.org/W2125164793","https://openalex.org/W2126705032","https://openalex.org/W2128007109","https://openalex.org/W2129415908","https://openalex.org/W2132408316","https://openalex.org/W2134349499","https://openalex.org/W2136667046","https://openalex.org/W2137424064","https://openalex.org/W2137987484","https://openalex.org/W2138224451","https://openalex.org/W2138957442","https://openalex.org/W2139943786","https://openalex.org/W2140923392","https://openalex.org/W2142486892","https://openalex.org/W2143760153","https://openalex.org/W2144107141","https://openalex.org/W2146127531","https://openalex.org/W2146129198","https://openalex.org/W2146466993","https://openalex.org/W2148986068","https://openalex.org/W2150932464","https://openalex.org/W2151672008","https://openalex.org/W2155006762","https://openalex.org/W2155066685","https://openalex.org/W2155553788","https://openalex.org/W2156219329","https://openalex.org/W2156314428","https://openalex.org/W2159418321","https://openalex.org/W2159887702","https://openalex.org/W2160105055","https://openalex.org/W2160362993","https://openalex.org/W2162097271","https://openalex.org/W2163592665","https://openalex.org/W2168583421","https://openalex.org/W2169056321","https://openalex.org/W2171019508","https://openalex.org/W2172326429","https://openalex.org/W2187818572","https://openalex.org/W2223979714","https://openalex.org/W2318718797","https://openalex.org/W2789682581","https://openalex.org/W6989597371","https://openalex.org/W7096759447"],"related_works":["https://openalex.org/W283738260","https://openalex.org/W628017832","https://openalex.org/W1998706040","https://openalex.org/W2005688198","https://openalex.org/W189021323","https://openalex.org/W2161350305","https://openalex.org/W7095150071","https://openalex.org/W1918701699","https://openalex.org/W2044935342","https://openalex.org/W251271246"],"abstract_inverted_index":{"The":[0,13,39,226,244,257,299,318],"pancreas":[1,44,75,110,143,255,405,469],"is":[2,140,163,288,303,344,442],"an":[3,412],"endodermally":[4],"derived":[5],"organ":[6],"consisting":[7],"of":[8,20,42,47,71,82,91,148,232,260,301,320,352,357,367,385,418,423,428,466,473],"three":[9],"major":[10,40],"cell":[11,249,316,393,399],"lineages.":[12],"endocrine":[14],"cells,":[15],"organised":[16],"into":[17,36],"the":[18,37,43,64,83,89,92,108,146,157,198,217,272,282,330,347,353,386,398,403,416,424,432,446,467],"Islets":[19],"Langerhans,":[21],"regulate":[22,267],"blood":[23],"glucose":[24],"homeostasis":[25],"by":[26,115,224,270,305,374,395],"producing":[27],"and":[28,34,79,94,104,122,161,184,228,252,277,297,333,350,407,421,454,464],"secreting":[29],"hormones":[30],"such":[31,118],"as":[32,119,132,236,365],"glucagon":[33],"insulin":[35],"bloodstream.":[38],"part":[41],"consists":[45],"however":[46,460],"acinar":[48],"cells":[49,294],"that":[50,54,342,461],"produce":[51],"digestive":[52],"enzymes":[53],"are":[55,362,409,470],"transported":[56],"via":[57,111],"a":[58,77,112,194,237,310,321,369,429],"highly":[59],"branched":[60],"ductal":[61],"system":[62],"to":[63,106,221,266],"duodenum":[65],"where":[66],"they":[67,371],"function":[68,351,457,465],"in":[69,74,88,153,166,186,203,216,291,314,324,329,334,411,445],"breakdown":[70],"food.":[72],"Early":[73],"development":[76],"dorsal":[78,93],"ventral":[80,95],"evagination":[81,147],"foregut":[84],"epithelium":[85,332],"appear,":[86],"resulting":[87,165],"formation":[90],"pancreatic":[96,99,149,168,187,199,241,292,322,331,425],"bud.":[97],"These":[98],"buds":[100,150],"subsequently":[101],"grow,":[102],"branch":[103],"differentiate":[105],"form":[107],"mature":[109],"process":[113],"controlled":[114],"intrinsic":[116],"factors,":[117,121],"transcription":[120],"extracellular":[123],"signals.":[124],"Insulin":[125],"promoter":[126],"factor":[127],"1":[128],"(Ipf1),":[129],"also":[130,391,443],"known":[131,364],"Pdx1":[133],"(for":[134],"Pancreatic":[135],"duodenal":[136],"homeobox":[137],"gene":[138],"1),":[139],"required":[141],"for":[142,197,239,312,346,431],"development.":[144,256],"Although":[145],"still":[151],"occurs":[152],"Ipf1/Pdx1":[154,176,204],"mutant":[155,337],"mice,":[156,338],"subsequent":[158],"proliferation,":[159],"branching":[160],"differentiation":[162,253,349,463],"impaired,":[164],"complete":[167],"agenesis.":[169],"Gene":[170],"array":[171],"profiling":[172],"identified":[173,220],"several":[174],"candidate":[175],"target":[177],"genes,":[178],"including":[179],"FgfR2IIIb,":[180],"ErbB3,":[181],"Ptf1a/p48,":[182],"Pax6":[183],"Nkx6.1,":[185],"progenitor":[188,242],"cells.":[189,243],"Together":[190],"these":[191,436],"genes":[192],"provide":[193,340],"mechanistic":[195],"explanation":[196],"growth":[200],"arrest":[201],"observed":[202],"deficient":[205],"mice.":[206],"In":[207,402,438],"addition,":[208,439],"Spondin1,":[209],"which":[210,307],"has":[211],"not":[212],"previously":[213,263],"been":[214,264],"described":[215],"pancreas,":[218,448],"was":[219],"be":[222],"regulated":[223,304],"Ipf1/Pdx1.":[225],"spatial":[227],"temporal":[229],"expression":[230,300,441],"pattern":[231],"Spondin1":[233,235],"defines":[234],"marker":[238],"early":[240],"Notch":[245,268,275],"signalling":[246,269],"pathway":[247],"controls":[248],"type":[250],"specification":[251],"during":[254,415,435],"Fringe":[258,286],"family":[259],"proteins":[261,361,390,434],"have":[262],"shown":[265],"altering":[271],"interaction":[273],"between":[274,295],"receptors":[276],"their":[278],"ligands,":[279],"hence":[280],"affecting":[281],"cellular":[283],"response.":[284],"Manic":[285],"(MFng)":[287],"transiently":[289],"expressed":[290],"pro-endocrine":[293,315],"E9.5":[296],"E14.5.":[298],"MFng":[302,313,328,335,343],"Ngn3,":[306],"may":[308],"suggest":[309,459],"role":[311,430],"maturation.":[317],"lack":[319],"phenotype":[323],"transgenic":[325],"mice":[326],"overexpressing":[327],"null":[336],"however,":[339],"evidence":[341],"dispensable":[345],"specification,":[348,462],"adult":[354,468],"pancreas.":[355],"Inhibitors":[356],"DNA":[358],"binding":[359],"(Id)":[360],"generally":[363],"inhibitors":[366],"differentiation,":[368],"feature":[370],"mainly":[372],"perform":[373],"forming":[375],"non-functional":[376],"heterodimers":[377],"with":[378,397],"bHLH":[379,387],"proteins,":[380],"thereby":[381],"inhibiting":[382],"downstream":[383],"targets":[384],"proteins.":[388],"Id":[389,433,474],"promote":[392],"proliferation":[394,420],"interacting":[396],"cycle":[400],"machinery.":[401],"developing":[404],"Id2":[406],"Id3":[408],"co-expressed":[410],"overlapping":[413],"manner":[414],"period":[417],"massive":[419],"expansion":[422],"epithelium,":[426],"suggestive":[427],"processes.":[437],"Id4":[440],"detected":[444],"embryonic":[447],"albeit":[449],"at":[450],"lower":[451],"levels.":[452],"Gain-":[453],"loss-":[455],"of-":[456],"analyses":[458],"largely":[471],"independent":[472],"function.":[475]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}