{"id":"https://openalex.org/W58519422","doi":null,"title":"Neuroprotection against iron-induced cell death by perineuronal nets - an in vivo analysis of oxidative stress.","display_name":"Neuroprotection against iron-induced cell death by perineuronal nets - an in vivo analysis of oxidative stress.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W58519422","mag":"58519422","pmid":"https://pubmed.ncbi.nlm.nih.gov/23383386","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3560462"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2564831","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3560462","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3560462","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060319828","display_name":"Anne Suttkus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne Suttkus","raw_affiliation_strings":["University of Leipzig, Department for Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute for Brain Research Jahnallee 59, 04109 Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leipzig, Department for Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute for Brain Research Jahnallee 59, 04109 Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023470145","display_name":"Susanne Rohn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susanne Rohn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Carsten J\u00e4ger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carsten J\u00e4ger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003366066","display_name":"Thomas Arendt","orcid":"https://orcid.org/0000-0003-4553-1625","observed_orcids":["https://orcid.org/0000-0003-4553-1625"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Arendt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043070566","display_name":"Markus Morawski","orcid":"https://orcid.org/0000-0002-3817-5186","observed_orcids":["https://orcid.org/0000-0002-3817-5186"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Markus Morawski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9233,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.83803673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"1","issue":"2","first_page":"122","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perineuronal-nets","display_name":"perineuronal nets","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8690000176429749},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.996999979019165},{"id":"https://openalex.org/keywords/chondroitin-sulfate-proteoglycans","display_name":"chondroitin sulfate proteoglycans","score":0.890999972820282},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tenascin-r","display_name":"tenascin-R","score":0.8309999704360962},{"id":"https://openalex.org/keywords/ion-homeostasis","display_name":"ion homeostasis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8410000205039978},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7009999752044678},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8640000224113464},{"id":"https://openalex.org/keywords/barrel-cortex","display_name":"barrel cortex","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7931499481201172},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7655904293060303},{"id":"https://openalex.org/C129987498","wikidata":"https://www.wikidata.org/wiki/Q7168586","display_name":"Perineuronal net","level":3,"score":0.7555587887763977},{"id":"https://openalex.org/C2779553658","wikidata":"https://www.wikidata.org/wiki/Q408014","display_name":"Chondroitin sulfate","level":3,"score":0.5837758183479309},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5476008653640747},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.524291455745697},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4640822410583496},{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.4578371047973633},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.3224830627441406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31231430172920227},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.2905806303024292},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.27452096343040466},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17373377084732056},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14227551221847534},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:2564831","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3560462","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3560462","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3560462","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Neurodegener Dis","raw_type":"Text"},{"id":"pmid:23383386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23383386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of neurodegenerative disease","raw_type":"Journal Article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/248138","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/248138","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"mag:58519422","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23383386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2564831","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3560462","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W127053426","https://openalex.org/W1500029814","https://openalex.org/W1543143540","https://openalex.org/W1968455009","https://openalex.org/W1981777487","https://openalex.org/W1985604909","https://openalex.org/W1993916224","https://openalex.org/W2022728601","https://openalex.org/W2027751507","https://openalex.org/W2030249003","https://openalex.org/W2033004840","https://openalex.org/W2033614083","https://openalex.org/W2035362565","https://openalex.org/W2039314393","https://openalex.org/W2039933828","https://openalex.org/W2045316454","https://openalex.org/W2046113429","https://openalex.org/W2059626103","https://openalex.org/W2062065994","https://openalex.org/W2063629979","https://openalex.org/W2077729437","https://openalex.org/W2080077761","https://openalex.org/W2091187766","https://openalex.org/W2092620953","https://openalex.org/W2098974321","https://openalex.org/W2099040370","https://openalex.org/W2112587738","https://openalex.org/W2146369085"],"related_works":["https://openalex.org/W2092620953","https://openalex.org/W2022932966","https://openalex.org/W2126787661","https://openalex.org/W6995678124","https://openalex.org/W2000829985","https://openalex.org/W4210383425","https://openalex.org/W4230688573","https://openalex.org/W7002350075","https://openalex.org/W7037341902","https://openalex.org/W3021557235"],"abstract_inverted_index":{"Perineuronal":[0],"nets":[1],"(PNs)":[2],"are":[3,58,78],"a":[4,88,135,190,207],"specialized":[5],"form":[6],"of":[7,13,18,96,119,127,134,138,152,161,175,195,214],"extracellular":[8],"matrix,":[9],"surrounding":[10],"different":[11],"types":[12],"neurons":[14,77,197,201],"and":[15,29,46,62,66,94,101,163],"mainly":[16],"consist":[17],"chondroitin":[19,43],"sulfate":[20,44],"proteoglycans":[21],"connected":[22],"to":[23,34,60,107,109,200],"hyaluronan,":[24],"stabilized":[25],"by":[26,39,115,179],"link":[27],"protein":[28],"cross-linked":[30],"via":[31],"tenascin-R.":[32],"Due":[33],"their":[35],"polyanionic":[36],"character,":[37],"caused":[38],"the":[40,69,92,117,141,145,212],"highly":[41],"charged":[42],"glycosaminoglycan":[45],"hyaluronan":[47],"components,":[48],"PNs":[49,176,215],"might":[50],"be":[51],"involved":[52],"in":[53,91,112,198],"local":[54,70],"ion":[55],"homeostasis.":[56],"They":[57],"able":[59],"scavenge":[61],"bind":[63],"redox-active":[64],"ions":[65],"thus":[67],"reduce":[68],"oxidative":[71,83,110],"potential.":[72],"We":[73],"investigated":[74],"whether":[75],"netenwrapped":[76],"less":[79],"vulnerable":[80],"against":[81,216],"iron-induced":[82,217],"processes.":[84],"Oxidative":[85],"stress":[86,111],"is":[87,105],"key":[89],"factor":[90],"development":[93],"progression":[95],"neurodegenerative":[97],"diseases":[98],"like":[99],"Alzheimer's":[100],"Parkinson's":[102],"disease.":[103],"Iron":[104],"believed":[106],"contribute":[108],"Alzheimer":[113],"brains":[114],"catalyzing":[116],"generation":[118],"free":[120],"radicals.":[121],"For":[122],"examining":[123],"potential":[124],"neuroprotective":[125,208],"effects":[126],"PNs,":[128],"mice":[129],"were":[130,156],"microinjected":[131],"with":[132,211],"0.2\u03bcl":[133],"20mM":[136],"solution":[137],"FeCl3":[139],"into":[140],"barrel":[142],"field":[143],"while":[144],"control":[146],"group":[147],"received":[148],"an":[149],"equal":[150],"volume":[151],"0.9%":[153],"NaCl.":[154],"Brains":[155],"analyzed":[157],"after":[158],"time":[159],"intervals":[160],"24h":[162],"72h.":[164],"Neuronal":[165],"degeneration":[166,193],"was":[167,177],"visualized":[168],"using":[169],"Fluoro-Jade":[170],"B":[171],"staining.":[172],"The":[173,187,204],"presence":[174,213],"assessed":[178],"Wisteria":[180],"floribunda":[181],"agglutinin":[182],"histochemistry":[183],"or":[184],"aggrecan":[185],"immunocytochemistry.":[186],"analysis":[188],"showed":[189],"significant":[191],"lower":[192],"rate":[194],"net-ensheathed":[196],"comparison":[199],"without":[202],"PNs.":[203],"results":[205],"suggest":[206],"mechanism":[209],"associated":[210],"cell":[218],"death.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}