{"id":"https://openalex.org/W585192099","doi":"https://doi.org/10.1212/wnl.84.14_supplement.i11-1b","title":"ALS monocytes exhibit a pro-inflammatory gene expression (I11-1B)","display_name":"ALS monocytes exhibit a pro-inflammatory gene expression (I11-1B)","publication_year":2015,"publication_date":"2015-04-06","ids":{"openalex":"https://openalex.org/W585192099","doi":"https://doi.org/10.1212/wnl.84.14_supplement.i11-1b","mag":"585192099"},"language":"nl","primary_location":{"id":"doi:10.1212/wnl.84.14_supplement.i11-1b","doi":"https://doi.org/10.1212/wnl.84.14_supplement.i11-1b","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.84.14_supplement.i11-1b","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100694249","display_name":"Weihua Zhao","orcid":"https://orcid.org/0000-0002-5672-7132","observed_orcids":["https://orcid.org/0000-0002-5672-7132"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weihua Zhao","raw_affiliation_strings":["Houston Methodist Neurological Institute, Houston Methodist Hospital Houston TX United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Neurological Institute, Houston Methodist Hospital Houston TX United States","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048445973","display_name":"David R. Beers","orcid":"https://orcid.org/0000-0002-8757-3500","observed_orcids":["https://orcid.org/0000-0002-8757-3500"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Beers","raw_affiliation_strings":["Houston Methodist Neurological Institute, Houston Methodist Hospital Houston TX United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Neurological Institute, Houston Methodist Hospital Houston TX United States","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068186230","display_name":"Hooten Christopher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hooten Christopher","raw_affiliation_strings":["Department of Neurosurgery University of Florida Gainesville FL United States","Houston Methodist Neurological Institute Houston TX United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery University of Florida Gainesville FL United States","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"Houston Methodist Neurological Institute Houston TX United States","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015630437","display_name":"Stanley H. Appel","orcid":"https://orcid.org/0000-0003-2747-6298","observed_orcids":["https://orcid.org/0000-0003-2747-6298"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley Appel","raw_affiliation_strings":["Houston Methodist Neurological Institute, Houston, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Neurological Institute, Houston, TX, United States","institution_ids":["https://openalex.org/I1295876152"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00782046,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"14_supplement","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8299999833106995},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8960000276565552},{"id":"https://openalex.org/keywords/proinflammatory-gene-expression","display_name":"pro-inflammatory gene expression","score":0.9390000104904175},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7630000114440918},{"id":"https://openalex.org/keywords/mip-2","display_name":"CXCL2","score":0.7239999771118164},{"id":"https://openalex.org/keywords/tim-3","display_name":"TIM-3","score":0.7129999995231628},{"id":"https://openalex.org/keywords/classical-monocytes","display_name":"classical monocytes","score":0.6549999713897705},{"id":"https://openalex.org/keywords/nonclassical-monocytes","display_name":"non-classical monocytes","score":0.8379999995231628},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8970000147819519},{"id":"https://openalex.org/keywords/nlrp3","display_name":"NLRP3","score":0.859000027179718},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cxcl1","display_name":"CXCL1","score":0.8889999985694885},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4945978820323944},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4880332052707672},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48189908266067505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42748960852622986},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3892522156238556},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33153092861175537},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3114960193634033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3038867115974426},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22083747386932373}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.84.14_supplement.i11-1b","doi":"https://doi.org/10.1212/wnl.84.14_supplement.i11-1b","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.84.14_supplement.i11-1b","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389409496","https://openalex.org/W2612761397","https://openalex.org/W2607829140","https://openalex.org/W3007381143","https://openalex.org/W2013640472","https://openalex.org/W3185005025","https://openalex.org/W2565173958","https://openalex.org/W3194624704","https://openalex.org/W2314812422","https://openalex.org/W2119656827"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"whether":[3],"circulating":[4],"monocytes/macrophages":[5],"in":[6,29,48,169,193,199,242,253,268,287],"patients":[7,91,149,180,211,227,272],"with":[8,44,173,244],"amyotrophic":[9],"lateral":[10],"sclerosis":[11],"(ALS)":[12],"have":[13,34],"a":[14,103,237],"unique":[15,76],"inflammatory":[16],"gene":[17,77,121],"expression.":[18],"BACKGROUND:":[19],"Increasing":[20],"evidence":[21],"supports":[22],"the":[23,26,51,134,137,147,174,194,200,259,264],"role":[24],"of":[25,88,105,136,141,158,220],"immune":[27],"system":[28],"ALS":[30,90,148,170,179,210,226,232,271],"disease":[31,46,279],"progression.":[32],"We":[33],"previously":[35],"reported":[36],"that":[37,156,207],"decreased":[38,265],"regulatory":[39,248],"T":[40,247],"lymphocytes":[41],"are":[42,234,241],"associated":[43],"rapid":[45,195],"progression":[47],"ALS,":[49],"but":[50,197,217],"monocyte/macrophage":[52],"population":[53,60],"has":[54],"not":[55,198],"been":[56],"carefully":[57],"studied.":[58],"This":[59],"can":[61],"be":[62],"divided":[63,182],"into":[64,183],"classical":[65],"(CD14+/CD16-),":[66],"non-classical":[67,214],"(CD16+/CD14low),":[68],"and":[69,92,96,113,150,165,185,228,240,263,281],"intermediate":[70],"(CD16+/CD14+)":[71],"subpopulations,":[72],"each":[73],"having":[74],"their":[75,251],"expression":[78,122,157],"signatures.":[79],"DESIGN/METHODS:":[80],"Human":[81],"monocytes":[82,127,171,233,262,267],"were":[83,128,152,167,181],"obtained":[84],"from":[85],"peripheral":[86],"blood":[87],"45":[89],"24":[93],"healthy":[94,175,229],"volunteers,":[95],"subsequently":[97],"purified":[98,107,126],"by":[99,130],"negative":[100],"selection.":[101],"From":[102],"portion":[104],"these":[106],"cells,":[108,249],"total":[109],"RNA":[110],"was":[111,191],"extracted":[112],"subjected":[114],"to":[115,119,285],"quantitative":[116],"RT-PCR":[117],"(qRT-PCR)":[118],"measure":[120],"levels.":[123],"The":[124,144,255],"remaining":[125],"analyzed":[129],"flow":[131],"cytometry":[132],"for":[133,278,282],"levels":[135],"three":[138],"different":[139],"subpopulations":[140],"monocytes/macrophages.":[142],"RESULTS:":[143],"demographics":[145],"between":[146],"volunteers":[151],"similar.":[153],"qRT-PCR":[154],"revealed":[155],"inflammation-related":[159],"genes,":[160],"IL-1\u03b2,":[161],"NLRP3,":[162],"IL-8,":[163],"CXCL1,":[164],"CXCL2":[166,189,257],"increased":[168,192,256,260],"compared":[172],"control":[176],"monocytes.":[177],"When":[178],"slowly":[184,224],"rapidly":[186,208,269],"progressing":[187,209,225,270],"groups,":[188],"mRNA":[190],"group,":[196],"slow":[201],"group.":[202],"Flow":[203],"cytometric":[204],"analysis":[205],"determined":[206],"had":[212],"less":[213],"(CD16+/CD14low)":[215],"monocytes,":[216,222],"enhanced":[218],"numbers":[219],"TIM3+":[221,261],"than":[223],"controls.":[230],"CONCLUSIONS:":[231],"skewed":[235],"towards":[236],"pro-inflammatory":[238],"state,":[239],"accord":[243],"reduced":[245],"anti-inflammatory":[246],"suggesting":[250],"participation":[252],"inflammation.":[254],"expression,":[258],"CD16+/CD14low":[266],"could":[273],"possibly":[274],"serve":[275],"as":[276],"biomarkers":[277],"progression,":[280],"monitoring":[283],"response":[284],"treatment":[286],"clinical":[288],"trials.":[289],"Study":[290],"Supported":[291],"by:":[292],"Glaxosmithkline,":[293],"NIH,":[294],"Muscular":[295],"Dystrophy":[296],"Association":[297]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}