{"id":"https://openalex.org/W585008689","doi":null,"title":"PERIPHERAL MEDIATORS OF COLORECTAL NOCICEPTION AND SENSITIZATION","display_name":"PERIPHERAL MEDIATORS OF COLORECTAL NOCICEPTION AND SENSITIZATION","publication_year":2012,"publication_date":"2012-12-17","ids":{"openalex":"https://openalex.org/W585008689","mag":"585008689"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:16878","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/16878/1/kiyatkin_etd_2012.pdf","pdf_url":"http://d-scholarship.pitt.edu/16878/1/kiyatkin_etd_2012.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/16878/1/kiyatkin_etd_2012.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051916309","display_name":"Michael E. Kiyatkin","orcid":"https://orcid.org/0000-0002-4458-7152","observed_orcids":["https://orcid.org/0000-0002-4458-7152"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael E. Kiyatkin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4458-7152","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5051916309"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.35569998621940613,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.35569998621940613,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.3353999853134155,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.2937000095844269,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.921999990940094},{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/p2x3-receptor","display_name":"P2X3 receptor","score":0.984000027179718},{"id":"https://openalex.org/keywords/colorectal-distension","display_name":"colorectal distension","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mechanosensing","display_name":"mechanosensing","score":0.828000009059906},{"id":"https://openalex.org/keywords/visceral-hypersensitivity","display_name":"visceral hypersensitivity","score":0.7139999866485596},{"id":"https://openalex.org/keywords/tnp-atp","display_name":"TNP-ATP","score":0.9980000257492065},{"id":"https://openalex.org/keywords/zymosan","display_name":"zymosan","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.6666116714477539},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.6282541751861572},{"id":"https://openalex.org/C25194021","wikidata":"https://www.wikidata.org/wiki/Q17157162","display_name":"Mechanosensation","level":4,"score":0.6011088490486145},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.5863040685653687},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.5623210668563843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5341137051582336},{"id":"https://openalex.org/C2776512019","wikidata":"https://www.wikidata.org/wiki/Q1816418","display_name":"Efferent","level":3,"score":0.4741727113723755},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.470813125371933},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4655996263027191},{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.4579353332519531},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.4038696885108948},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38725823163986206},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3734912872314453},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36094868183135986},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34937965869903564},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3110601305961609},{"id":"https://openalex.org/C2779263132","wikidata":"https://www.wikidata.org/wiki/Q2215671","display_name":"Afferent","level":2,"score":0.21481961011886597},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20340973138809204},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1616377830505371},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.14797458052635193}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:16878","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/16878/1/kiyatkin_etd_2012.pdf","pdf_url":"http://d-scholarship.pitt.edu/16878/1/kiyatkin_etd_2012.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:585008689","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/16878/1/kiyatkin_etd_2012.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:16878","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/16878/1/kiyatkin_etd_2012.pdf","pdf_url":"http://d-scholarship.pitt.edu/16878/1/kiyatkin_etd_2012.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W585008689.pdf","grobid_xml":"https://content.openalex.org/works/W585008689.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W97582216","https://openalex.org/W1507605176","https://openalex.org/W1542859323","https://openalex.org/W1550485358","https://openalex.org/W1967307095","https://openalex.org/W1972345032","https://openalex.org/W1980588138","https://openalex.org/W1985243765","https://openalex.org/W1987550061","https://openalex.org/W1987729953","https://openalex.org/W1990352343","https://openalex.org/W1994266757","https://openalex.org/W2004832404","https://openalex.org/W2011114886","https://openalex.org/W2011491345","https://openalex.org/W2015395924","https://openalex.org/W2020588358","https://openalex.org/W2028010667","https://openalex.org/W2032310526","https://openalex.org/W2034234618","https://openalex.org/W2044044822","https://openalex.org/W2045099397","https://openalex.org/W2046403343","https://openalex.org/W2046687620","https://openalex.org/W2049740316","https://openalex.org/W2052370691","https://openalex.org/W2057002272","https://openalex.org/W2066106589","https://openalex.org/W2072763377","https://openalex.org/W2074640318","https://openalex.org/W2078537805","https://openalex.org/W2079854296","https://openalex.org/W2079968924","https://openalex.org/W2090227348","https://openalex.org/W2090813510","https://openalex.org/W2091216527","https://openalex.org/W2091711679","https://openalex.org/W2107988902","https://openalex.org/W2111569821","https://openalex.org/W2113768972","https://openalex.org/W2131712556","https://openalex.org/W2138322683","https://openalex.org/W2138981830","https://openalex.org/W2139406295","https://openalex.org/W2147288001","https://openalex.org/W2150934660","https://openalex.org/W2154881563","https://openalex.org/W2160876060","https://openalex.org/W2164818769","https://openalex.org/W2165979101","https://openalex.org/W2171717653","https://openalex.org/W2171747856","https://openalex.org/W2283581970","https://openalex.org/W2921267068"],"related_works":["https://openalex.org/W2155672992","https://openalex.org/W4392739328","https://openalex.org/W4382517144","https://openalex.org/W2107988902","https://openalex.org/W4312130035","https://openalex.org/W1550485358","https://openalex.org/W7011268450","https://openalex.org/W2031586330","https://openalex.org/W4224279731","https://openalex.org/W1972345032"],"abstract_inverted_index":{"Several":[0],"ion":[1],"channels":[2,30,213,235],"are":[3],"thought":[4],"to":[5,13,37,61,65,73,78,99,123,135,178,200,237],"facilitate":[6],"colorectal":[7,39,66,74,203],"afferent":[8,70,104,173,176],"neuron":[9],"sensitization,":[10],"which":[11],"contributes":[12],"abdominal":[14],"pain":[15,40],"in":[16,83,95,112,140,168,202,240,249],"irritable":[17],"bowel":[18],"syndrome":[19],"(IBS).":[20],"In":[21,155,185],"the":[22,158,186,243],"present":[23],"work,":[24],"I":[25,46],"hypothesized":[26],"that":[27],"two":[28],"such":[29],"\u2013":[31,35],"TRPV1":[32,159,196],"and":[33,41,53,56,69,106,119,152,162,167,197,206,215],"P2X3":[34,163,198],"cooperate":[36],"mediate":[38],"hypersensitivity.":[42],"To":[43],"test":[44],"this,":[45],"employed":[47],"TRPV1-P2X3":[48],"double":[49],"knockout":[50],"(TPDKO)":[51],"mice":[52,142],"pharmacological":[54,156,218],"antagonists":[55],"evaluated":[57],"combined":[58,180,217],"channel":[59],"contributions":[60],"whole-":[62],"organism":[63],"responses":[64,72,77,116,128,177],"distension":[67],"(CRD)":[68],"fiber":[71],"stretch.":[75],"Baseline":[76],"CRD":[79,91],"were":[80,109,126,137],"unexpectedly":[81],"greater":[82,183],"TPDKO":[84,96,113,141],"compared":[85],"with":[86],"control":[87,100],"mice,":[88,101],"but":[89],"zymosan-produced":[90],"hypersensitivity":[92],"was":[93,144],"absent":[94],"mice.":[97,114],"Relative":[98],"proportions":[102],"of":[103,117,129,149,195,211,224,233,246],"mechano-sensitive":[105],"-insensitive":[107],"classes":[108],"not":[110,132],"different":[111],"Whereas":[115],"mucosal":[118],"serosal":[120],"class":[121],"afferents":[122,134],"mechanical":[124],"probing":[125],"unaffected,":[127],"muscular":[130,151],"(but":[131],"muscular/mucosal)":[133],"stretch":[136],"significantly":[138],"attenuated":[139,175],"as":[143],"sensitization":[145],"by":[146],"inflammatory":[147],"soup":[148],"both":[150],"muscular/mucosal":[153],"afferents.":[154],"studies,":[157],"antagonist":[160,164],"A889425":[161],"TNP-ATP,":[165],"alone":[166],"combination,":[169],"applied":[170],"onto":[171],"stretch-sensitive":[172],"endings":[174],"stretch;":[179],"antagonism":[181,219],"produced":[182],"attenuation.":[184],"aggregate,":[187],"these":[188,234],"observations":[189],"suggest":[190],"that:":[191],"(1)":[192],"genetic":[193],"manipulation":[194],"leads":[199],"reduction":[201],"mechanosensation":[204,225],"peripherally":[205,226],"compensatory":[207],"changes":[208],"and/or":[209],"disinhibition":[210],"other":[212],"centrally":[214],"(2)":[216],"produces":[220],"more":[221],"robust":[222],"attenuation":[223],"than":[227],"single":[228],"antagonism.":[229],"The":[230],"relative":[231],"importance":[232],"appears":[236],"be":[238],"enhanced":[239],"hypersensitivity,":[241],"highlighting":[242],"potential":[244],"utility":[245],"multi-target":[247],"pharmacotherapy":[248],"IBS.":[250]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}