{"id":"https://openalex.org/W584897690","doi":null,"title":"Metabolic fate of [14C] quercetin in the ACI rat.","display_name":"Metabolic fate of [14C] quercetin in the ACI rat.","publication_year":1983,"publication_date":"1983-02-01","ids":{"openalex":"https://openalex.org/W584897690","mag":"584897690","pmid":"https://pubmed.ncbi.nlm.nih.gov/6876476"},"language":"en","primary_location":{"id":"pmid:6876476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6876476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Japanese journal of experimental medicine","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004628440","display_name":"Ichiro Ueno","orcid":"https://orcid.org/0000-0003-1616-3683","observed_orcids":["https://orcid.org/0000-0003-1616-3683"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Ueno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"N Nakano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Nakano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035810762","display_name":"Iwao Hirono","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Hirono","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8785,"has_fulltext":false,"cited_by_count":128,"citation_normalized_percentile":{"value":0.66975881,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"53","issue":"1","first_page":"41","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.1152999997138977,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.0737999975681305,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9150000214576721},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.699999988079071},{"id":"https://openalex.org/keywords/glucuronidation","display_name":"glucuronidation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/sulfation","display_name":"sulfation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/3-o-methylquercetin","display_name":"3-O-methylquercetin","score":0.7990000247955322},{"id":"https://openalex.org/keywords/biliary-excretion","display_name":"biliary excretion","score":0.7020000219345093},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.9020000100135803},{"id":"https://openalex.org/keywords/carcinogenicity","display_name":"carcinogenicity","score":0.6480000019073486},{"id":"https://openalex.org/keywords/aci-rats","display_name":"ACI rats","score":0.5860000252723694},{"id":"https://openalex.org/keywords/microbial-degradation","display_name":"microbial degradation","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.9735144376754761},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.7492343187332153},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7347171902656555},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6632843613624573},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.6285400986671448},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.59965980052948},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.5156975388526917},{"id":"https://openalex.org/C2779186261","wikidata":"https://www.wikidata.org/wiki/Q137786","display_name":"Glucuronide","level":3,"score":0.4762442409992218},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.4550051689147949},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4436684548854828},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.4216853082180023},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36673659086227417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18616268038749695},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0863337516784668},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.056962549686431885}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011912","descriptor_name":"Rats, Inbred ACI","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6876476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6876476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Japanese journal of experimental medicine","raw_type":"Comparative Study"},{"id":"mag:584897690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6876476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2011965157","https://openalex.org/W2491665532","https://openalex.org/W2079984779","https://openalex.org/W2088721678","https://openalex.org/W1990510082","https://openalex.org/W7002040894","https://openalex.org/W2119627765","https://openalex.org/W1990224633","https://openalex.org/W1188851105","https://openalex.org/W2270263877"],"abstract_inverted_index":{"To":[0,79],"explain":[1],"why":[2],"quercetin,":[3],"a":[4],"mutagenic":[5],"flavonoid":[6],"distributed":[7],"widely":[8],"in":[9,15,70,86,135,176,194],"edible":[10],"plants,":[11],"showed":[12],"no":[13],"carcinogenicity":[14,173],"experimental":[16],"animals,":[17],"overall":[18],"metabolic":[19],"fate":[20],"of":[21,51,83,111,158,172,174,201,207,210],"the":[22,87,95,112,118,136,145,153,170,177,187,195,208],"drug":[23],"was":[24,30,57,101,106,115,124,132,141],"pursued":[25],"using":[26],"radiolabeled":[27,84],"compound.":[28],"[4-(14)C]Quercetin":[29],"administered":[31,59,107,113],"orally":[32,63],"or":[33,62],"intraperitoneally":[34,61],"to":[35,64,126,181],"male":[36],"ACI":[37],"rats":[38,67,96],"and":[39,43,53,68,75,89,129,147,155,162,199],"its":[40,183,191],"distribution,":[41],"metabolism":[42,198],"excretion":[44],"were":[45,77],"studied":[46],"by":[47],"autoradiography":[48],"and/or":[49],"quantitation":[50],"radioactivity,":[52],"chemical":[54,81],"analysis.":[55],"[14C]Quercetin":[56],"also":[58],"intravenously,":[60],"bile":[65,88,146],"duct-cannulated":[66],"radioactivities":[69],"CO2":[71],"expired,":[72],"bile,":[73],"urine":[74,148],"feces":[76],"measured.":[78],"elucidate":[80],"structure":[82],"flavonoids":[85,92],"urine,":[90],"urinary":[91],"derived":[93],"from":[94,117,186],"given":[97],"non-labeled":[98],"quercetin":[99,175,202],"diet":[100],"analyzed":[102],"chemically.":[103],"When":[104],"[14C]-quercetin":[105],"orally,":[108],"around":[109,130],"20%":[110],"[14C]quercetin":[114,140,161],"absorbed":[116,139],"digestive":[119,188],"tract,":[120],"more":[121],"than":[122],"30%":[123,131],"decomposed":[125],"yield":[127],"14CO2":[128],"excreted":[133,143],"unchanged":[134],"feces.":[137],"The":[138,165],"rapidly":[142],"into":[144],"within":[149],"48":[150],"hours":[151],"as":[152],"glucuronide":[154],"sulfate":[156],"conjugates":[157],"[14C]quercetin,":[159],"3'-O-monomethyl":[160],"4'-O-monomethyl":[163],"[14C]quercetin.":[164],"present":[166],"data":[167],"indicate":[168],"that":[169],"lack":[171,209],"rat":[178],"is":[179],"attributable":[180],"neither":[182],"poor":[184],"absorption":[185],"tract":[189],"nor":[190],"microbial":[192],"degradation":[193],"tract.":[196],"Efficient":[197],"elimination":[200],"may":[203],"be":[204],"one":[205],"reason":[206],"carcinogenicity.":[211]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}