{"id":"https://openalex.org/W584288153","doi":null,"title":"SIV Escape from Immune Recognition Due to Selection Pressure of Immunodominant CD8+ Epitope GAG-CM9 and TRIM5 Restriction Sites","display_name":"SIV Escape from Immune Recognition Due to Selection Pressure of Immunodominant CD8+ Epitope GAG-CM9 and TRIM5 Restriction Sites","publication_year":2013,"publication_date":"2013-06-27","ids":{"openalex":"https://openalex.org/W584288153","mag":"584288153"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:18507","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/18507/1/Griffin_Kimberly_thesis_2013.pdf","pdf_url":"https://d-scholarship.pitt.edu/18507/1/Griffin_Kimberly_thesis_2013.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050963421","display_name":"K.R. Griffin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"K.R. Griffin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5050963421"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simian-immunodeficiency-virus","display_name":"simian immunodeficiency virus","score":0.7269999980926514},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.75},{"id":"https://openalex.org/keywords/viral-immune-evasion","display_name":"viral immune evasion","score":0.6449999809265137},{"id":"https://openalex.org/keywords/trim5alpha","display_name":"TRIM5\u03b1","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cd8-t-cell-responses","display_name":"CD8+ T cell responses","score":0.6370000243186951},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.8149999976158142},{"id":"https://openalex.org/keywords/mamu-a-01","display_name":"Mamu-A*01","score":0.796999990940094},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.5740000009536743},{"id":"https://openalex.org/keywords/immunodominant-epitopes","display_name":"immunodominant epitopes","score":0.7689999938011169},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.6650000214576721},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"viral evolution","score":0.3140000104904175},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C2777995582","wikidata":"https://www.wikidata.org/wiki/Q1890246","display_name":"Simian immunodeficiency virus","level":3,"score":0.7301948070526123},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6624679565429688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6617577075958252},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.64185631275177},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6404021978378296},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.562716543674469},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.518907368183136},{"id":"https://openalex.org/C2779175743","wikidata":"https://www.wikidata.org/wiki/Q156606","display_name":"Rhesus macaque","level":2,"score":0.4664302170276642},{"id":"https://openalex.org/C6881719","wikidata":"https://www.wikidata.org/wiki/Q5611048","display_name":"Group-specific antigen","level":3,"score":0.4613916873931885},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45554155111312866},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4320261776447296},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.4146101772785187},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4126482605934143},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.39303120970726013},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.3700862228870392},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10719400644302368}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:18507","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/18507/1/Griffin_Kimberly_thesis_2013.pdf","pdf_url":"https://d-scholarship.pitt.edu/18507/1/Griffin_Kimberly_thesis_2013.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:584288153","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/18507/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1974422884","https://openalex.org/W1975240882","https://openalex.org/W1979762554","https://openalex.org/W1987970975","https://openalex.org/W2002292720","https://openalex.org/W2011837112","https://openalex.org/W2027458871","https://openalex.org/W2030154869","https://openalex.org/W2043892428","https://openalex.org/W2044831502","https://openalex.org/W2057040546","https://openalex.org/W2073077999","https://openalex.org/W2082314789","https://openalex.org/W2083512827","https://openalex.org/W2088005137","https://openalex.org/W2106266657","https://openalex.org/W2149166876","https://openalex.org/W2159225279","https://openalex.org/W2160215815","https://openalex.org/W4313342455"],"related_works":["https://openalex.org/W2988849323","https://openalex.org/W7098235828","https://openalex.org/W2081450236","https://openalex.org/W2526863567","https://openalex.org/W7125572809","https://openalex.org/W1990624998","https://openalex.org/W2030088058","https://openalex.org/W2066803746","https://openalex.org/W2135255228","https://openalex.org/W1492241828"],"abstract_inverted_index":{"HIV/AIDS":[0],"has":[1],"been":[2],"a":[3,38,122,153],"major":[4],"public":[5],"health":[6],"focus":[7],"for":[8,78,115,262],"more":[9,24],"than":[10,31],"40":[11],"years.":[12],"By":[13],"using":[14],"the":[15,48,64,69,75,81,89,95,112,166,188,215,231,238,245,248,257,274,299,307,314,321,327],"rhesus":[16,128],"macaque/SIV":[17],"model,":[18],"we":[19],"are":[20,86],"able":[21],"to":[22,62,110,230,266,284,288,306,320],"learn":[23],"about":[25],"immune":[26,311,331],"response":[27,312],"and":[28,43,74,99,136,146,157,161,175,199,209,220,291],"host":[29,42,82],"genetics":[30],"through":[32],"human":[33],"study":[34,60],"alone.":[35],"There":[36],"is":[37,61],"complex":[39],"interplay":[40],"between":[41,196],"viral":[44,116,133,322],"factors":[45],"that":[46,85,256],"determine":[47,111],"course":[49],"of":[50,57,67,94,124,217,250,329],"an":[51,104,225,263,285],"HIV/SIV":[52],"infection.":[53],"The":[54],"overall":[55,310],"goal":[56],"this":[58],"retrospective":[59],"analyze":[63],"dual":[65],"evolution":[66],"both":[68,218],"immunodominant":[70],"CD8+":[71],"GAG-CM9":[72,275],"epitope":[73],"binding":[76],"sites":[77],"restriction":[79],"by":[80,132],"protein":[83],"TRIM5\u03b1":[84,318],"located":[87],"on":[88],"highly":[90],"conserved":[91],"GAG":[92],"region":[93],"SIV":[96,105],"genome.":[97],"Early":[98,234],"late":[100,221],"time":[101,222,235,253],"points":[102,223,236,254],"in":[103,187,301,309],"infection":[106],"will":[107],"be":[108,194,304],"analyzed":[109],"favored":[113],"drivers":[114],"escape.":[117],"In":[118,211],"Specific":[119,212],"Aim":[120,213],"1,":[121],"cohort":[123],"15":[125],"Mamu":[126],"A*01":[127],"macaques":[129],"was":[130,185,204,260],"characterized":[131],"load":[134],"profile":[135],"TRIM5":[137,296,302],"haplotype.":[138,297],"Six":[139,163],"animals":[140,144,151,159,164,170,177,198],"were":[141,171,178,228],"\u201cControllers,\u201d":[142],"5":[143],"maintained":[145,152],"\u201cIntermediate":[147],"Viral":[148,155],"Load,\u201d":[149,156],"3":[150],"\u201cHigh":[154],"2":[158,176],"\u201cCrashed":[160],"Burned.\u201d":[162],"had":[165],"TRIM5TFP/TFP":[167],"haplotype,":[168],"7":[169],"classified":[172,179],"as":[173,180,313],"TRIM5TFP/Q,":[174],"TRIM5Q/Q.":[181],"No":[182,190,269],"TRIM5CypA":[183],"allele":[184],"found":[186],"cohort.":[189],"statistical":[191],"significance":[192,205],"could":[193],"shown":[195],"TFP/TFP":[197,208],"TFP/Q":[200],"animals,":[201],"but":[202],"there":[203],"when":[206],"comparing":[207],"Q/Q.":[210],"2,":[214],"sequence":[216],"early":[219],"from":[224,237],"immunotherapeutic":[226],"trial":[227,239],"compared":[229],"original":[232],"inoculum.":[233],"showed":[240,255,292],"near":[241],"complete":[242],"homology":[243],"with":[244,295,316,326],"inoculum":[246],"at":[247,273,278],"residues":[249,280],"interest.":[251],"Late":[252],"R98S":[258],"mutation":[259,271],"important":[261],"animal\u2019s":[264,286],"ability":[265,287],"control":[267,289],"virus.":[268],"significant":[270],"occurred":[272],"epitope.":[276],"Mutations":[277],"anchor":[279],"did":[281],"not":[282],"contribute":[283],"virus":[290],"no":[293],"correlation":[294,325],"However,":[298],"polymorphisms":[300],"may":[303],"contributing":[305],"variation":[308],"avidity":[315],"which":[317],"binds":[319],"capsid":[323],"shows":[324],"strength":[328],"innate":[330],"signaling.":[332]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
