{"id":"https://openalex.org/W58385246","doi":"https://doi.org/10.1007/978-1-4419-7358-0_19","title":"Optimising the Development of Antibodies as Treatment for Cancer","display_name":"Optimising the Development of Antibodies as Treatment for Cancer","publication_year":2010,"publication_date":"2010-11-18","ids":{"openalex":"https://openalex.org/W58385246","doi":"https://doi.org/10.1007/978-1-4419-7358-0_19","mag":"58385246"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4419-7358-0_19","doi":"https://doi.org/10.1007/978-1-4419-7358-0_19","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4419-7358-0_19","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Principles of Anticancer Drug Development","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2490299627","display_name":"Principles of Anticancer Drug Development"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110966878","display_name":"Craig P. Carden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Craig P. Carden","raw_affiliation_strings":["Section of Medicine and Drug Development Unit, Institute of Cancer Research, Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Medicine and Drug Development Unit, Institute of Cancer Research, Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012989377","display_name":"Hendrik\u2010Tobias Arkenau","orcid":"https://orcid.org/0000-0002-2015-1549","observed_orcids":["https://orcid.org/0000-0002-2015-1549","https://orcid.org/0000-0003-0372-0540"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hendrik-Tobias Arkenau","raw_affiliation_strings":["Section of Medicine and Drug Development Unit, Institute of Cancer Research, Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Medicine and Drug Development Unit, Institute of Cancer Research, Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I4210121186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072378199","display_name":"Johann Sebastian De Bono","orcid":"https://orcid.org/0000-0002-2034-595X","observed_orcids":["https://orcid.org/0000-0002-2034-595X"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Johann S. de Bono","raw_affiliation_strings":["Section of Medicine and Drug Development Unit, Institute of Cancer Research, Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Medicine and Drug Development Unit, Institute of Cancer Research, Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I4210121186"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072378199"],"corresponding_institution_ids":["https://openalex.org/I142947616","https://openalex.org/I4210121186"],"apc_list":null,"apc_paid":null,"fwci":1.4742,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.80905287,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"535","last_page":"567"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8830000162124634},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7789999842643738},{"id":"https://openalex.org/keywords/antibody-development","display_name":"antibody development","score":0.7390000224113464},{"id":"https://openalex.org/keywords/antibody-production","display_name":"antibody production","score":0.699999988079071},{"id":"https://openalex.org/keywords/clinical-drug-development","display_name":"clinical development","score":0.7049999833106995},{"id":"https://openalex.org/keywords/antibody-repertoire","display_name":"antibody repertoire","score":0.4819999933242798},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6882026791572571},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6821330189704895},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.4618574380874634},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.4428706169128418},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.42938685417175293},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4284104108810425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37785449624061584},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35739976167678833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3328912854194641},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3086697459220886},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.21061882376670837},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17952746152877808},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09134110808372498}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4419-7358-0_19","doi":"https://doi.org/10.1007/978-1-4419-7358-0_19","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4419-7358-0_19","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Principles of Anticancer Drug Development","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":146,"referenced_works":["https://openalex.org/W35609119","https://openalex.org/W60759546","https://openalex.org/W105230889","https://openalex.org/W152902854","https://openalex.org/W192515921","https://openalex.org/W203608680","https://openalex.org/W410744402","https://openalex.org/W1484629663","https://openalex.org/W1529067860","https://openalex.org/W1539571840","https://openalex.org/W1549144603","https://openalex.org/W1705666194","https://openalex.org/W1782669727","https://openalex.org/W1831034898","https://openalex.org/W1845536886","https://openalex.org/W1900061753","https://openalex.org/W1939364580","https://openalex.org/W1957932316","https://openalex.org/W1964165239","https://openalex.org/W1964304371","https://openalex.org/W1965744027","https://openalex.org/W1965962344","https://openalex.org/W1968894514","https://openalex.org/W1969328947","https://openalex.org/W1969345980","https://openalex.org/W1973746851","https://openalex.org/W1974897855","https://openalex.org/W1976079919","https://openalex.org/W1982637165","https://openalex.org/W1987182889","https://openalex.org/W1988795495","https://openalex.org/W1988849896","https://openalex.org/W1991154912","https://openalex.org/W1993575340","https://openalex.org/W1996710470","https://openalex.org/W1997430285","https://openalex.org/W2003303180","https://openalex.org/W2006128988","https://openalex.org/W2010537388","https://openalex.org/W2013457791","https://openalex.org/W2014276741","https://openalex.org/W2014649183","https://openalex.org/W2016973656","https://openalex.org/W2023482225","https://openalex.org/W2027542837","https://openalex.org/W2030177226","https://openalex.org/W2030320989","https://openalex.org/W2030522563","https://openalex.org/W2034924732","https://openalex.org/W2037044333","https://openalex.org/W2039144093","https://openalex.org/W2043507805","https://openalex.org/W2043911652","https://openalex.org/W2044360617","https://openalex.org/W2047805567","https://openalex.org/W2048313558","https://openalex.org/W2054383673","https://openalex.org/W2056576838","https://openalex.org/W2056757647","https://openalex.org/W2061872647","https://openalex.org/W2062826169","https://openalex.org/W2063830050","https://openalex.org/W2064283997","https://openalex.org/W2064876070","https://openalex.org/W2065406906","https://openalex.org/W2066095112","https://openalex.org/W2066865216","https://openalex.org/W2068635250","https://openalex.org/W2069057600","https://openalex.org/W2071843728","https://openalex.org/W2074470232","https://openalex.org/W2075305667","https://openalex.org/W2078293125","https://openalex.org/W2082717401","https://openalex.org/W2083483697","https://openalex.org/W2085234074","https://openalex.org/W2087924085","https://openalex.org/W2088197737","https://openalex.org/W2090323470","https://openalex.org/W2091873290","https://openalex.org/W2094381069","https://openalex.org/W2094565468","https://openalex.org/W2098131693","https://openalex.org/W2099998343","https://openalex.org/W2100501926","https://openalex.org/W2104505549","https://openalex.org/W2104926542","https://openalex.org/W2110710051","https://openalex.org/W2113101064","https://openalex.org/W2115571948","https://openalex.org/W2120490763","https://openalex.org/W2122618533","https://openalex.org/W2122725450","https://openalex.org/W2125202200","https://openalex.org/W2125589864","https://openalex.org/W2127376103","https://openalex.org/W2129658913","https://openalex.org/W2129774558","https://openalex.org/W2130930654","https://openalex.org/W2131418340","https://openalex.org/W2133105825","https://openalex.org/W2135668465","https://openalex.org/W2136044635","https://openalex.org/W2137231887","https://openalex.org/W2137819350","https://openalex.org/W2139311073","https://openalex.org/W2140512094","https://openalex.org/W2141989396","https://openalex.org/W2142564546","https://openalex.org/W2143738177","https://openalex.org/W2144341535","https://openalex.org/W2146887062","https://openalex.org/W2149908785","https://openalex.org/W2150818243","https://openalex.org/W2153534791","https://openalex.org/W2155384808","https://openalex.org/W2160264356","https://openalex.org/W2160798258","https://openalex.org/W2164532418","https://openalex.org/W2166573361","https://openalex.org/W2167331614","https://openalex.org/W2168479321","https://openalex.org/W2170517479","https://openalex.org/W2171368669","https://openalex.org/W2171492233","https://openalex.org/W2240495935","https://openalex.org/W2242521660","https://openalex.org/W2246578212","https://openalex.org/W2318605753","https://openalex.org/W2326775643","https://openalex.org/W2328176730","https://openalex.org/W2337805480","https://openalex.org/W2347071246","https://openalex.org/W2395525054","https://openalex.org/W2398749866","https://openalex.org/W2406020918","https://openalex.org/W2421395535","https://openalex.org/W2479171025","https://openalex.org/W2528032056","https://openalex.org/W2589823065","https://openalex.org/W3009911602","https://openalex.org/W4244515316","https://openalex.org/W4244529233","https://openalex.org/W4255148547","https://openalex.org/W4298217633","https://openalex.org/W6606213128"],"related_works":["https://openalex.org/W3162714447","https://openalex.org/W2043228552","https://openalex.org/W2033619005","https://openalex.org/W7096269314","https://openalex.org/W4386559375","https://openalex.org/W2782220244","https://openalex.org/W2141387194","https://openalex.org/W1843298900","https://openalex.org/W41005441","https://openalex.org/W4211100110"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}