{"id":"https://openalex.org/W583587535","doi":null,"title":"The Effects that Non-steroidal Anti-inflammatory Drugs (NSAID) have on Cancer Related Fatigue in a Mouse Model","display_name":"The Effects that Non-steroidal Anti-inflammatory Drugs (NSAID) have on Cancer Related Fatigue in a Mouse Model","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W583587535","mag":"583587535"},"language":"en","primary_location":{"id":"pmh:oai:kb.osu.edu:1811/48945","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1811/48945","pdf_url":"http://hdl.handle.net/1811/48945","source":{"id":"https://openalex.org/S4306402304","display_name":"The Knowledge Bank (The Ohio State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52357470","host_organization_name":"The Ohio State University","host_organization_lineage":["https://openalex.org/I52357470"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1811/48945","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024166616","display_name":"D Dan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"D Dan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5024166616"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.6528000235557556,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.6528000235557556,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.15080000460147858,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-related-fatigue","display_name":"cancer-related fatigue","score":0.9629999995231628},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.8920000195503235},{"id":"https://openalex.org/keywords/ibuprofen","display_name":"ibuprofen","score":1.0},{"id":"https://openalex.org/keywords/skeletal-muscle-atrophy","display_name":"skeletal muscle atrophy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lewis-lung-carcinoma","display_name":"Lewis lung carcinoma","score":0.8629999756813049},{"id":"https://openalex.org/keywords/muscle-mass","display_name":"muscle mass","score":0.9150000214576721},{"id":"https://openalex.org/keywords/muscle-protein-degradation","display_name":"muscle protein degradation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/spleen-size","display_name":"spleen size","score":0.9649999737739563},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tumor-bearing-mice","display_name":"tumor-bearing mice","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2778141389","wikidata":"https://www.wikidata.org/wiki/Q5031385","display_name":"Cancer-related fatigue","level":3,"score":0.7282265424728394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.653303861618042},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4993293285369873},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.426372230052948},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36273813247680664}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kb.osu.edu:1811/48945","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1811/48945","pdf_url":"http://hdl.handle.net/1811/48945","source":{"id":"https://openalex.org/S4306402304","display_name":"The Knowledge Bank (The Ohio State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52357470","host_organization_name":"The Ohio State University","host_organization_lineage":["https://openalex.org/I52357470"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:583587535","doi":null,"is_oa":false,"landing_page_url":"http://kb.osu.edu/dspace/handle/1811/48945","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:kb.osu.edu:1811/48945","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1811/48945","pdf_url":"http://hdl.handle.net/1811/48945","source":{"id":"https://openalex.org/S4306402304","display_name":"The Knowledge Bank (The Ohio State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52357470","host_organization_name":"The Ohio State University","host_organization_lineage":["https://openalex.org/I52357470"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W583587535.pdf","grobid_xml":"https://content.openalex.org/works/W583587535.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1973058915","https://openalex.org/W1973341557","https://openalex.org/W2024304423","https://openalex.org/W2024483586","https://openalex.org/W2036673023","https://openalex.org/W2058167160","https://openalex.org/W2073114469","https://openalex.org/W2089391522","https://openalex.org/W2103690577","https://openalex.org/W2107251975","https://openalex.org/W2121063540","https://openalex.org/W2122248675","https://openalex.org/W2155289323"],"related_works":["https://openalex.org/W7099055784","https://openalex.org/W999333924","https://openalex.org/W1045073016","https://openalex.org/W136578636","https://openalex.org/W2000515779","https://openalex.org/W2765336561","https://openalex.org/W2070199743","https://openalex.org/W2463614068","https://openalex.org/W2138320433","https://openalex.org/W2910090256"],"abstract_inverted_index":{"Purpose:":[0],"Fatigue":[1],"is":[2,10,16,29,52,56,75,104,124,298,310],"a":[3,17,46,107,117,168,185,253,270],"debilitating":[4],"symptom":[5,53],"in":[6,49,67,94,109,320],"cancer":[7,21,50],"patients.":[8],"It":[9],"believed":[11],"that":[12,59,294],"skeletal":[13,295],"muscle":[14,65,86,91,230,243,248,266,280,288,296,303,318],"wasting":[15,66,297,304,319],"main":[18],"cause":[19],"of":[20,26,33,41,72,80,90,147,162,179,182,218,247,262,279],"related":[22,299],"fatigue":[23,103],"(CRF).":[24],"As":[25],"now,":[27],"there":[28],"no":[30,196,199,238],"effective":[31,314],"treatment":[32],"CRF.":[34],"According":[35],"to":[36,76,116,135,171,300,306,312,316],"the":[37,42,78,97,136,148,177,228],"2009-2013":[38],"Research":[39],"Agenda":[40],"Oncology":[43],"Nursing":[44],"Society,":[45],"high":[47],"priority":[48],"research":[51,309],"management.":[54],"There":[55,251],"some":[57],"evidence":[58],"nonsteriodal":[60],"anti-inflammatory":[61],"drugs":[62],"(NSAIDs)":[63],"reduce":[64,317],"tumor-bearing":[68],"mice.":[69,130],"The":[70,122,131,188],"purpose":[71],"this":[73],"study":[74],"determine":[77],"effects":[79],"ibuprofen,":[81],"an":[82,260],"NSAID,":[83],"on":[84,211,224,241],"fatigue,":[85],"mass,":[87,244],"and":[88,120,138,155,206,216,227,233,265,269,277,284,287,302],"biomarkers":[89,246,278],"protein":[92,249,281],"breakdown":[93],"mice":[95,132,149],"bearing":[96],"Lewis":[98],"lung":[99],"carcinoma.":[100],"In":[101],"mice,":[102],"measured":[105,210],"as":[106,158],"decrease":[108],"voluntary":[110],"wheel":[111],"running":[112],"activity":[113],"(VMRA)":[114],"relative":[115],"baseline.":[118],"Sample":[119],"methods:":[121],"sample":[123],"24":[125],"adult,":[126],"age-matched":[127],"female":[128],"C57BI/6":[129],"were":[133,150,165,209,222],"acclimated":[134],"cages":[137],"wheels":[139],"for":[140],"7":[141],"days.":[142],"On":[143],"day":[144,225],"one,":[145],"half":[146,156],"inoculated":[151],"with":[152,167,322],"tumor":[153,219],"cells":[154],"served":[157],"healthy":[159],"controls.":[160],"Half":[161],"each":[163],"group":[164],"implanted":[166],"pellet":[169],"designed":[170],"release":[172],"5":[173],"mg/kg/day":[174],"Ibuprofen":[175,236],"over":[176],"course":[178],"21":[180],"days":[181,212],"tumor-growth":[183],"or":[184,245],"placebo":[186],"pellet.":[187,201],"4":[189],"groups":[190],"are":[191],"tumor/placebo":[192,197],"pellet,":[193,195,198],"tumor/ibuprofen":[194,200],"VWRA,":[202,242],"body":[203],"weight,":[204],"food":[205],"water":[207],"intake":[208],"0,":[213],"7,":[214],"14,":[215],"19":[217],"growth.":[220],"Mice":[221],"euthanized":[223],"20":[226],"gastrocnemius":[229],"was":[231,252],"removed":[232],"weighed.":[234],"Results:":[235],"had":[237],"significant":[239,254,271],"effect":[240],"degradation.":[250],"negative":[255],"relationship":[256,273],"between":[257,274,285],"spleen":[258,275],"size,":[259],"indicator":[261],"systemic":[263],"inflammation,":[264,301],"mass":[267,289],"(-.53),":[268],"positive":[272],"size":[276],"degradation":[282],"(.6),":[283],"VWRA":[286],"(.4).":[290],"These":[291],"data":[292],"confirm":[293],"contributes":[305],"fatigue.":[307,324],"More":[308],"needed":[311],"develop":[313],"interventions":[315],"patients":[321],"cancer-related":[323]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}