{"id":"https://openalex.org/W58340772","doi":null,"title":"TRPM2 in the Central Nervous System: Physiological Role and Critical Regulatory Pathways","display_name":"TRPM2 in the Central Nervous System: Physiological Role and Critical Regulatory Pathways","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W58340772","mag":"58340772"},"language":"en","primary_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-2237","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/1010","pdf_url":"https://ir.lib.uwo.ca/etd/1010","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.lib.uwo.ca/etd/1010","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049217541","display_name":"Jillian C. Belrose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jillian C. Belrose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5049217541"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0041841,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0778999999165535,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trpm2","display_name":"TRPM2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.9449999928474426},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.7559999823570251},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7250000238418579},{"id":"https://openalex.org/keywords/amyloid-beta-oligomers","display_name":"amyloid-beta oligomers","score":0.8629999756813049},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8610000014305115},{"id":"https://openalex.org/keywords/fyn-tyrosine-kinase","display_name":"Fyn tyrosine kinase","score":0.9190000295639038},{"id":"https://openalex.org/keywords/calcium-permeable-cation-channel","display_name":"calcium-permeable cation channel","score":0.7459999918937683},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.9599999785423279},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.753000020980835},{"id":"https://openalex.org/keywords/channel-regulation","display_name":"channel regulation","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5849363207817078},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5564652681350708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3614935278892517}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ir.lib.uwo.ca:etd-2237","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/1010","pdf_url":"https://ir.lib.uwo.ca/etd/1010","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},{"id":"pmh:oai:uwo.scholaris.ca:20.500.14721/37759","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14721/37759","pdf_url":null,"source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},{"id":"mag:58340772","doi":null,"is_oa":false,"landing_page_url":"https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=2237&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-2237","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/1010","pdf_url":"https://ir.lib.uwo.ca/etd/1010","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W58340772.pdf","grobid_xml":"https://content.openalex.org/works/W58340772.grobid-xml"},"referenced_works_count":275,"referenced_works":["https://openalex.org/W20569675","https://openalex.org/W88045577","https://openalex.org/W118386170","https://openalex.org/W139517887","https://openalex.org/W155152945","https://openalex.org/W183120660","https://openalex.org/W1261161723","https://openalex.org/W1494623690","https://openalex.org/W1496201154","https://openalex.org/W1496294957","https://openalex.org/W1500368251","https://openalex.org/W1515328725","https://openalex.org/W1537218374","https://openalex.org/W1547104500","https://openalex.org/W1562466147","https://openalex.org/W1566041406","https://openalex.org/W1577837690","https://openalex.org/W1577989916","https://openalex.org/W1595570385","https://openalex.org/W1600903666","https://openalex.org/W1607531254","https://openalex.org/W1616459298","https://openalex.org/W1639407471","https://openalex.org/W1869926743","https://openalex.org/W1884366104","https://openalex.org/W1893185987","https://openalex.org/W1934289385","https://openalex.org/W1962254068","https://openalex.org/W1964260585","https://openalex.org/W1964545403","https://openalex.org/W1965336618","https://openalex.org/W1965761291","https://openalex.org/W1966397085","https://openalex.org/W1967117930","https://openalex.org/W1967463041","https://openalex.org/W1968728549","https://openalex.org/W1968937229","https://openalex.org/W1969196466","https://openalex.org/W1969292775","https://openalex.org/W1970054043","https://openalex.org/W1972035895","https://openalex.org/W1972812522","https://openalex.org/W1972965665","https://openalex.org/W1973524650","https://openalex.org/W1974558436","https://openalex.org/W1974955556","https://openalex.org/W1976674321","https://openalex.org/W1977817124","https://openalex.org/W1978354565","https://openalex.org/W1978483995","https://openalex.org/W1979349684","https://openalex.org/W1979566060","https://openalex.org/W1979720174","https://openalex.org/W1979791785","https://openalex.org/W1980750700","https://openalex.org/W1981757532","https://openalex.org/W1982373527","https://openalex.org/W1983143611","https://openalex.org/W1983480912","https://openalex.org/W1983913371","https://openalex.org/W1985241009","https://openalex.org/W1986120363","https://openalex.org/W1986295281","https://openalex.org/W1987199749","https://openalex.org/W1987842796","https://openalex.org/W1989918632","https://openalex.org/W1990378255","https://openalex.org/W1990653561","https://openalex.org/W1991449336","https://openalex.org/W1995317658","https://openalex.org/W1995639654","https://openalex.org/W1996462430","https://openalex.org/W1997281208","https://openalex.org/W1997727568","https://openalex.org/W1999242709","https://openalex.org/W1999294311","https://openalex.org/W1999357946","https://openalex.org/W1999968276","https://openalex.org/W2002181764","https://openalex.org/W2003148573","https://openalex.org/W2005354224","https://openalex.org/W2005390388","https://openalex.org/W2005493046","https://openalex.org/W2006471221","https://openalex.org/W2007005858","https://openalex.org/W2007487855","https://openalex.org/W2007627173","https://openalex.org/W2009062700","https://openalex.org/W2010312001","https://openalex.org/W2013859768","https://openalex.org/W2014593683","https://openalex.org/W2015852310","https://openalex.org/W2016323146","https://openalex.org/W2016978148","https://openalex.org/W2017122609","https://openalex.org/W2020578899","https://openalex.org/W2020881671","https://openalex.org/W2021235911","https://openalex.org/W2021280501","https://openalex.org/W2021424485","https://openalex.org/W2022260179","https://openalex.org/W2022367435","https://openalex.org/W2022532556","https://openalex.org/W2023465483","https://openalex.org/W2023860307","https://openalex.org/W2024431713","https://openalex.org/W2024473428","https://openalex.org/W2025221670","https://openalex.org/W2025801062","https://openalex.org/W2026508968","https://openalex.org/W2027873424","https://openalex.org/W2028541149","https://openalex.org/W2028594041","https://openalex.org/W2028638764","https://openalex.org/W2028857539","https://openalex.org/W2028950501","https://openalex.org/W2030756376","https://openalex.org/W2031484072","https://openalex.org/W2031624140","https://openalex.org/W2032609739","https://openalex.org/W2033274989","https://openalex.org/W2033549832","https://openalex.org/W2034614910","https://openalex.org/W2034762925","https://openalex.org/W2035082265","https://openalex.org/W2035460326","https://openalex.org/W2036626166","https://openalex.org/W2036650593","https://openalex.org/W2037477146","https://openalex.org/W2040483531","https://openalex.org/W2042270905","https://openalex.org/W2045892248","https://openalex.org/W2046388858","https://openalex.org/W2046491231","https://openalex.org/W2046933839","https://openalex.org/W2047686125","https://openalex.org/W2048570076","https://openalex.org/W2049225057","https://openalex.org/W2049801826","https://openalex.org/W2050066016","https://openalex.org/W2051023125","https://openalex.org/W2053318380","https://openalex.org/W2053665966","https://openalex.org/W2053846841","https://openalex.org/W2054209007","https://openalex.org/W2055518236","https://openalex.org/W2057415995","https://openalex.org/W2057990190","https://openalex.org/W2058148599","https://openalex.org/W2058245542","https://openalex.org/W2058459224","https://openalex.org/W2061405268","https://openalex.org/W2061900670","https://openalex.org/W2064227979","https://openalex.org/W2065169750","https://openalex.org/W2065685531","https://openalex.org/W2066346206","https://openalex.org/W2066358338","https://openalex.org/W2067565438","https://openalex.org/W2067775666","https://openalex.org/W2067929856","https://openalex.org/W2068337326","https://openalex.org/W2069594598","https://openalex.org/W2070519260","https://openalex.org/W2071531069","https://openalex.org/W2072625029","https://openalex.org/W2072662467","https://openalex.org/W2073293904","https://openalex.org/W2073598808","https://openalex.org/W2074396059","https://openalex.org/W2075451080","https://openalex.org/W2076442408","https://openalex.org/W2077567337","https://openalex.org/W2078089860","https://openalex.org/W2078518903","https://openalex.org/W2078745766","https://openalex.org/W2079721032","https://openalex.org/W2081070804","https://openalex.org/W2081413793","https://openalex.org/W2082119586","https://openalex.org/W2084400475","https://openalex.org/W2084971502","https://openalex.org/W2084973310","https://openalex.org/W2085222910","https://openalex.org/W2086346644","https://openalex.org/W2086369374","https://openalex.org/W2086392211","https://openalex.org/W2088494482","https://openalex.org/W2090501101","https://openalex.org/W2091097006","https://openalex.org/W2091602584","https://openalex.org/W2093767043","https://openalex.org/W2094691641","https://openalex.org/W2094851021","https://openalex.org/W2095484045","https://openalex.org/W2096410114","https://openalex.org/W2096545929","https://openalex.org/W2096701787","https://openalex.org/W2097095684","https://openalex.org/W2097828163","https://openalex.org/W2099207242","https://openalex.org/W2101257013","https://openalex.org/W2101371013","https://openalex.org/W2102732075","https://openalex.org/W2103031848","https://openalex.org/W2103127225","https://openalex.org/W2105746545","https://openalex.org/W2109392358","https://openalex.org/W2109807917","https://openalex.org/W2110534885","https://openalex.org/W2110827218","https://openalex.org/W2110831253","https://openalex.org/W2111017303","https://openalex.org/W2111191371","https://openalex.org/W2113333476","https://openalex.org/W2114610934","https://openalex.org/W2114911095","https://openalex.org/W2116498178","https://openalex.org/W2117801156","https://openalex.org/W2119589189","https://openalex.org/W2120853484","https://openalex.org/W2120905810","https://openalex.org/W2121067105","https://openalex.org/W2122532139","https://openalex.org/W2125269304","https://openalex.org/W2125984333","https://openalex.org/W2129412868","https://openalex.org/W2129761500","https://openalex.org/W2131399935","https://openalex.org/W2131438817","https://openalex.org/W2132486552","https://openalex.org/W2133083344","https://openalex.org/W2133631618","https://openalex.org/W2139955764","https://openalex.org/W2142493853","https://openalex.org/W2142943752","https://openalex.org/W2144047489","https://openalex.org/W2144625840","https://openalex.org/W2145301870","https://openalex.org/W2148994398","https://openalex.org/W2151425581","https://openalex.org/W2153690605","https://openalex.org/W2155634762","https://openalex.org/W2156263771","https://openalex.org/W2156746537","https://openalex.org/W2157145196","https://openalex.org/W2157174760","https://openalex.org/W2158847036","https://openalex.org/W2159391283","https://openalex.org/W2159838014","https://openalex.org/W2161162275","https://openalex.org/W2161977058","https://openalex.org/W2162092568","https://openalex.org/W2163643313","https://openalex.org/W2163756947","https://openalex.org/W2164558765","https://openalex.org/W2165021720","https://openalex.org/W2165743783","https://openalex.org/W2166977877","https://openalex.org/W2167284177","https://openalex.org/W2167318614","https://openalex.org/W2167611139","https://openalex.org/W2168709353","https://openalex.org/W2168838919","https://openalex.org/W2169079203","https://openalex.org/W2169878907","https://openalex.org/W2171349254","https://openalex.org/W2172073905","https://openalex.org/W2181575857","https://openalex.org/W2337001455","https://openalex.org/W2337569019","https://openalex.org/W2397369936","https://openalex.org/W2407564086","https://openalex.org/W2413546591","https://openalex.org/W4238215801"],"related_works":["https://openalex.org/W2802671986","https://openalex.org/W7099605321","https://openalex.org/W2164558765","https://openalex.org/W2223781517","https://openalex.org/W4226053954","https://openalex.org/W88045577","https://openalex.org/W4211064399","https://openalex.org/W2884315900","https://openalex.org/W2296402508","https://openalex.org/W1972085322"],"abstract_inverted_index":{"TRPM2":[0,22,34,46,74,91,106,113,136,170,194,200],"is":[1,7,13,47,153],"a":[2,120,140,173,191],"non-selective":[3],"cation":[4],"channel":[5,35,107],"which":[6],"permeable":[8],"to":[9,123,189],"calcium.":[10],"Although":[11],"expression":[12,58],"highest":[14],"in":[15,23,56,73,87,101,131,144,180,195,201],"the":[16,18,31,69,102,125,166,187],"brain,":[17],"physiological":[19],"role":[20,192],"for":[21,49,193],"neurons":[24],"was":[25,61],"unknown.":[26],"Furthermore,":[27],"our":[28],"understanding":[29],"of":[30,66,71,104,127,135,155,163],"pathways":[32],"regulating":[33],"function":[36,60],"required":[37,48],"further":[38],"investigation.":[39],"In":[40],"this":[41],"thesis,":[42],"we":[43],"identified":[44],"that":[45,95,112,151],"NMDAR-dependent":[50],"long-term":[51],"depression":[52],"(LTD).":[53],"No":[54],"change":[55],"NMDAR":[57],"or":[59],"observed":[62,130],"following":[63],"genetic":[64],"deletion":[65],"TRPM2.":[67,160],"Instead,":[68],"loss":[70,103],"NMDAR-LTD":[72],"knockout":[75],"mice":[76],"results":[77,100,185],"from":[78],"diminished":[79,96],"GSK-3\u03b2":[80],"activation.":[81],"We":[82,93,109,149],"next":[83],"examined":[84],"whether":[85],"age":[86,99],"vitro":[88],"could":[89],"facilitate":[90],"currents.":[92],"demonstrate":[94,111,150],"glutathione":[97],"with":[98,157],"basal":[105],"inhibition.":[108],"subsequently":[110],"currents":[114,179],"are":[115,186],"enhanced":[116],"by":[117],"oligomeric":[118],"A\u03b2,":[119],"peptide":[121,176],"proposed":[122],"initiate":[124],"majority":[126],"toxic":[128],"effects":[129],"Alzheimer\u2019s":[132,206],"disease.":[133,207],"Potentiation":[134],"may":[137],"involve":[138],"Fyn,":[139],"tyrosine":[141],"kinase":[142],"implicated":[143],"oxidative":[145],"stress":[146],"and":[147,158,172,197],"neurotoxicity.":[148],"Fyn":[152,164],"capable":[154],"interacting":[156],"phosphorylating":[159],"Acute":[161],"application":[162],"through":[165],"patch":[167],"pipette":[168],"potentiates":[169],"currents,":[171],"Fyn(39-57)":[174],"mimetic":[175],"significantly":[177],"attenuates":[178],"cultured":[181],"hippocampal":[182],"neurons.":[183],"These":[184],"first":[188],"establish":[190],"neurons,":[196],"also":[198],"implicate":[199],"neurodegenerative":[202],"disorders":[203],"such":[204],"as":[205]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
