{"id":"https://openalex.org/W58321705","doi":null,"title":"Hypersensitivity to rapamycin of BJAB B lymphoblastoid cells.","display_name":"Hypersensitivity to rapamycin of BJAB B lymphoblastoid cells.","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W58321705","mag":"58321705","pmid":"https://pubmed.ncbi.nlm.nih.gov/8778023","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384106"},"language":"en","primary_location":{"id":"pmid:8778023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8778023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1384106/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110137595","display_name":"John E. Kay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J E Kay","raw_affiliation_strings":["School of Biological Sciences, University of Sussex, Brighton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Sussex, Brighton, UK","institution_ids":["https://openalex.org/I162608824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103531534","display_name":"Malcolm C. Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M C Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006411259","display_name":"Victoria Jane Frost","orcid":"https://orcid.org/0000-0003-4929-0873","observed_orcids":["https://orcid.org/0000-0003-4929-0873"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Frost","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012927662","display_name":"G Y Morgan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Y Morgan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3165,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.47128626,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"87","issue":"3","first_page":"390","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/bjab-cells","display_name":"BJAB cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/b-lymphoblastoid-cells","display_name":"B lymphoblastoid cells","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.6060000061988831},{"id":"https://openalex.org/keywords/fkbp12","display_name":"FKBP12","score":0.8500000238418579},{"id":"https://openalex.org/keywords/immunophilins","display_name":"immunophilins","score":0.6100000143051147},{"id":"https://openalex.org/keywords/fk506","display_name":"FK506","score":0.8159999847412109},{"id":"https://openalex.org/keywords/peptidyl-prolyl-cis-trans-isomerase","display_name":"peptidyl-prolyl isomerase","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6659901738166809},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.6418071985244751},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5563849806785583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5203320980072021},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5187421441078186},{"id":"https://openalex.org/C113842279","wikidata":"https://www.wikidata.org/wiki/Q1873857","display_name":"Lymphoblast","level":3,"score":0.504546046257019},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3526310324668884},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3248971104621887},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20493018627166748},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18966218829154968},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1347949206829071},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004306","descriptor_name":"Dose-Response Relationship, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011090","descriptor_name":"Polyenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8778023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8778023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1384106","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1384106/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"mag:58321705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8778023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1384106","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1384106/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W28981592","https://openalex.org/W1485463834","https://openalex.org/W1527374206","https://openalex.org/W1533596330","https://openalex.org/W1537196537","https://openalex.org/W1597228305","https://openalex.org/W1863217888","https://openalex.org/W1996206538","https://openalex.org/W2005873886","https://openalex.org/W2015174638","https://openalex.org/W2035509838","https://openalex.org/W2044301435","https://openalex.org/W2048373800","https://openalex.org/W2048794678","https://openalex.org/W2050145078","https://openalex.org/W2057106513","https://openalex.org/W2078577005","https://openalex.org/W2084977836","https://openalex.org/W2087136249","https://openalex.org/W2088857009","https://openalex.org/W2089389853","https://openalex.org/W2090308278","https://openalex.org/W2104943404","https://openalex.org/W2169523708","https://openalex.org/W2404137608","https://openalex.org/W2415546118","https://openalex.org/W2432836690"],"related_works":["https://openalex.org/W28981592","https://openalex.org/W1988050497","https://openalex.org/W2138588240","https://openalex.org/W2153592280","https://openalex.org/W2015277956","https://openalex.org/W2027328554","https://openalex.org/W1993730263","https://openalex.org/W1527374206","https://openalex.org/W2415186638","https://openalex.org/W2069105509"],"abstract_inverted_index":{"Proliferation":[0],"of":[1,16,101,105,121,158,180],"the":[2,17,48,53,65,75,108,130,136,147,170,178],"BJAB":[3,58,115,122,159],"B-lymphoblastoid":[4,44],"cell":[5,33,45,56,59],"line":[6,34,46,51],"was":[7,35,61],"rapidly":[8],"and":[9,81,103,139],"almost":[10],"completely":[11],"suppressed":[12],"by":[13,64,135,150],"picomolar":[14],"concentrations":[15],"immunosuppressive":[18,67],"macrolide":[19],"rapamycin":[20,40,80,106,120,181],"(50%":[21],"inhibitory":[22],"concentration":[23],"10-20":[24],"pM":[25],"for":[26,145,172,177],"cells":[27,123,160],"reactivated":[28,161],"from":[29,107,162],"stationary":[30,163],"phase).":[31],"This":[32],"considerably":[36],"more":[37],"sensitive":[38,175],"to":[39,74,119],"than":[41],"any":[42],"other":[43,186],"tested,":[47],"Jurkat":[49],"T-cell":[50],"or":[52,70,91,185],"HL60":[54],"promyelocytic":[55],"line.":[57],"proliferation":[60,157],"not":[62],"affected":[63],"related":[66],"macrolides":[68],"FK506":[69,90],"L-685,818,":[71],"which":[72],"bind":[73],"immunophilin":[76],"FKBP12":[77,102],"competitively":[78,95],"with":[79],"also":[82,112,166],"inhibit":[83],"its":[84],"peptidylprolyl":[85],"cis-trans":[86],"isomerase":[87],"activity.":[88],"Excess":[89],"L-685,818":[92],"added":[93],"simultaneously":[94],"antagonized":[96],"rapamycin's":[97],"anti-proliferative":[98],"action.":[99],"Levels":[100],"uptake":[104],"culture":[109,183],"medium":[110],"were":[111],"normal":[113],"in":[114,153,182],"cells.":[116],"The":[117,156],"hypersensitivity":[118],"thus":[124],"reflects":[125],"an":[126],"unusual":[127],"dependence":[128],"on":[129],"intracellular":[131],"signalling":[132],"system":[133,144],"targeted":[134],"rapamycin-FKBP12":[137],"complex,":[138],"may":[140],"provide":[141],"a":[142,173],"model":[143],"elucidating":[146],"role":[148],"played":[149],"this":[151],"pathway":[152],"lymphocyte":[154],"activation.":[155],"phase":[164],"can":[165],"be":[167],"used":[168],"as":[169],"basis":[171],"highly":[174],"bioassay":[176],"presence":[179],"media":[184],"biological":[187],"fluids.":[188]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}