{"id":"https://openalex.org/W582182564","doi":"https://doi.org/10.1371/journal.pone.0130624","title":"NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes","display_name":"NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes","publication_year":2015,"publication_date":"2015-06-19","ids":{"openalex":"https://openalex.org/W582182564","doi":"https://doi.org/10.1371/journal.pone.0130624","mag":"582182564","pmid":"https://pubmed.ncbi.nlm.nih.gov/26091541","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4474809"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0130624","doi":"https://doi.org/10.1371/journal.pone.0130624","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0130624","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0130624&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0130624&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011118327","display_name":"Audrey Gustin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Audrey Gustin","raw_affiliation_strings":["Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024518374","display_name":"M\u00e9lanie Kirchmeyer","orcid":"https://orcid.org/0009-0007-6588-3261","observed_orcids":["https://orcid.org/0009-0007-6588-3261"]},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"M\u00e9lanie Kirchmeyer","raw_affiliation_strings":["Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082487959","display_name":"Eric Koncina","orcid":"https://orcid.org/0000-0003-4764-1510","observed_orcids":["https://orcid.org/0000-0003-4764-1510"]},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Eric Koncina","raw_affiliation_strings":["Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079307857","display_name":"Paul Felten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Paul Felten","raw_affiliation_strings":["Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074363260","display_name":"Sophie Losciuto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Sophie Losciuto","raw_affiliation_strings":["Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046350634","display_name":"Tony Heurtaux","orcid":"https://orcid.org/0000-0002-1709-5312","observed_orcids":["https://orcid.org/0000-0002-1709-5312"]},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Tony Heurtaux","raw_affiliation_strings":["Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049298032","display_name":"Aubry Tardivel","orcid":"https://orcid.org/0009-0008-9997-8151","observed_orcids":["https://orcid.org/0009-0008-9997-8151"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Aubry Tardivel","raw_affiliation_strings":["Biochemistry Institute, University of Lausanne, Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Institute, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026119795","display_name":"Paul Heuschling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Paul Heuschling","raw_affiliation_strings":["Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091491867","display_name":"Catherine Dostert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":true,"raw_author_name":"Catherine Dostert","raw_affiliation_strings":["Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Research Unit, Faculty of Science, Technology and Communication, University of Luxembourg, Luxembourg, Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091491867"],"corresponding_institution_ids":["https://openalex.org/I186903577"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":10.1527,"has_fulltext":true,"cited_by_count":378,"citation_normalized_percentile":{"value":0.98981542,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"10","issue":"6","first_page":"e0130624","last_page":"e0130624"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":1.0},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/il-1beta-secretion","display_name":"IL-1\u03b2 secretion","score":0.9390000104904175},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.8700000047683716},{"id":"https://openalex.org/keywords/il-1alpha","display_name":"IL-1\u03b1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.8309999704360962},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8989999890327454},{"id":"https://openalex.org/keywords/p2x7-receptor","display_name":"P2X7 receptor","score":0.9729999899864197},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.9493006467819214},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.9122213125228882},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.7627719640731812},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.58797287940979},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5127185583114624},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.4635991156101227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43756625056266785},{"id":"https://openalex.org/C187831198","wikidata":"https://www.wikidata.org/wiki/Q18034187","display_name":"AIM2","level":4,"score":0.4283660352230072},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.41869089007377625},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39608436822891235},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3907879889011383},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3469063639640808},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3146355450153351},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.15615877509117126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09630972146987915}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020170","descriptor_name":"Caspase 1","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020170","descriptor_name":"Caspase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020170","descriptor_name":"Caspase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053582","descriptor_name":"Interleukin-1alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0130624","doi":"https://doi.org/10.1371/journal.pone.0130624","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0130624","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0130624&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4474809","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4474809","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:26091541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26091541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unil.ch:iris/96566","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/96566","pdf_url":"https://iris.unil.ch/bitstreams/a5a32373-fea5-468b-9da6-82cf055e25b0/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:orbilu.uni.lu:10993/26403","doi":null,"is_oa":true,"landing_page_url":"https://orbilu.uni.lu/handle/10993/26403","pdf_url":"https://orbilu.uni.lu/bitstream/10993/26403/1/2015%20-%20PLOS%20One%20%28Gustin%29.pdf","source":{"id":"https://openalex.org/S4306401815","display_name":"Open Repository and Bibliography (University of Luxembourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186903577","host_organization_name":"University of Luxembourg","host_organization_lineage":["https://openalex.org/I186903577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 10 (6) (2015-06-19)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.818.3535","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.818.3535","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/2a/95/pone.0130624.PMC4474809.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a651de33a360456c83b6f5c5120ba84f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a651de33a360456c83b6f5c5120ba84f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 6, p e0130624 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1455212","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_NLRP3_Inflammasome_Is_Expressed_and_Functional_in_Mouse_Brain_Microglia_but_Not_in_Astrocytes_/1455212","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:serval.unil.ch:BIB_1ACEC6ADC676","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_1ACEC6ADC676","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plos One, vol. 10, no. 6, pp. e0130624","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0130624","doi":"https://doi.org/10.1371/journal.pone.0130624","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0130624","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0130624&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310700","display_name":"Universit\u00e9 du Luxembourg","ror":"https://ror.org/036x5ad56"},{"id":"https://openalex.org/F4320321038","display_name":"Fonds National de la Recherche Luxembourg","ror":"https://ror.org/039z13y21"},{"id":"https://openalex.org/F4320323831","display_name":"Universit\u00e9 de Lausanne","ror":"https://ror.org/019whta54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W582182564.pdf","grobid_xml":"https://content.openalex.org/works/W582182564.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1502842924","https://openalex.org/W1529674879","https://openalex.org/W1811472601","https://openalex.org/W1825604636","https://openalex.org/W1877235802","https://openalex.org/W1965942744","https://openalex.org/W1966634013","https://openalex.org/W1967535998","https://openalex.org/W1969993314","https://openalex.org/W1971915082","https://openalex.org/W1972941961","https://openalex.org/W1976129489","https://openalex.org/W1978525572","https://openalex.org/W1979776162","https://openalex.org/W1981649246","https://openalex.org/W1986285940","https://openalex.org/W1986611577","https://openalex.org/W1990872391","https://openalex.org/W1993780955","https://openalex.org/W1993976394","https://openalex.org/W2000249621","https://openalex.org/W2004973724","https://openalex.org/W2009800174","https://openalex.org/W2015283405","https://openalex.org/W2029991969","https://openalex.org/W2034678408","https://openalex.org/W2034946303","https://openalex.org/W2035824519","https://openalex.org/W2056490358","https://openalex.org/W2056768275","https://openalex.org/W2058834884","https://openalex.org/W2062269430","https://openalex.org/W2065403797","https://openalex.org/W2074472141","https://openalex.org/W2074661552","https://openalex.org/W2076063079","https://openalex.org/W2078378216","https://openalex.org/W2079320514","https://openalex.org/W2082400315","https://openalex.org/W2090859543","https://openalex.org/W2093176960","https://openalex.org/W2119098586","https://openalex.org/W2120003285","https://openalex.org/W2120302366","https://openalex.org/W2124836944","https://openalex.org/W2130300200","https://openalex.org/W2137127784","https://openalex.org/W2140882296","https://openalex.org/W2144479616","https://openalex.org/W2144651868","https://openalex.org/W2147546596","https://openalex.org/W2150149802","https://openalex.org/W2162341392","https://openalex.org/W2171487873","https://openalex.org/W6659328827"],"related_works":["https://openalex.org/W7100297404","https://openalex.org/W2310099388","https://openalex.org/W2975117257","https://openalex.org/W1502842924","https://openalex.org/W2979373607","https://openalex.org/W1591352894","https://openalex.org/W2020008646","https://openalex.org/W2588228682","https://openalex.org/W2605685784","https://openalex.org/W2092817697"],"abstract_inverted_index":{"Neuroinflammation":[0],"is":[1,94],"the":[2,6,36,62,82,97,101,164,182,206],"local":[3],"reaction":[4],"of":[5,30,38,42,59,92,166],"brain":[7,17,63,207],"to":[8,23,84,96,108,125,130,180],"infection,":[9],"trauma,":[10],"toxic":[11],"molecules":[12],"or":[13,139],"protein":[14],"aggregates.":[15],"The":[16],"resident":[18],"macrophages,":[19],"microglia,":[20,170],"are":[21,64],"able":[22,107,124,179],"trigger":[24],"an":[25,48,202],"appropriate":[26],"response":[27,129],"involving":[28],"secretion":[29,91,111,189],"cytokines":[31],"and":[32,40,57,68,90,145,187,208],"chemokines,":[33],"resulting":[34],"in":[35,51,61,72,100,128,163,185,191,205,210],"activation":[37,199],"astrocytes":[39],"recruitment":[41],"peripheral":[43],"immune":[44],"cells.":[45],"IL-1\u03b2":[46,93,110,127,168,188],"plays":[47],"important":[49,203],"role":[50,204],"this":[52],"response;":[53],"yet":[54],"its":[55,69],"production":[56],"mode":[58],"action":[60],"not":[65,106,161],"fully":[66],"understood":[67],"precise":[70],"implication":[71],"neurodegenerative":[73,157],"diseases":[74],"needs":[75],"further":[76],"characterization.":[77],"Our":[78],"results":[79],"indicate":[80],"that":[81],"capacity":[83],"form":[85],"a":[86,156,172,192],"functional":[87],"NLRP3":[88,119,183],"inflammasome":[89,120,133,184,198],"limited":[95],"microglial":[98],"compartment":[99],"mouse":[102],"brain.":[103],"We":[104],"were":[105,123,178],"observe":[109],"from":[112],"astrocytes,":[113],"nor":[114],"do":[115],"they":[116],"express":[117],"all":[118],"components.":[121],"Microglia":[122],"produce":[126],"different":[131],"classical":[132],"activators,":[134],"such":[135],"as":[136],"ATP,":[137],"Nigericin":[138],"Alum.":[140],"Similarly,":[141],"microglia":[142,186],"secreted":[143],"IL-18":[144],"IL-1\u03b1,":[146],"two":[147],"other":[148],"inflammasome-linked":[149],"pro-inflammatory":[150,174],"factors.":[151],"Cell":[152],"stimulation":[153],"with":[154],"\u03b1-synuclein,":[155],"disease-related":[158],"peptide,":[159],"did":[160],"result":[162],"release":[165],"active":[167],"by":[169],"despite":[171],"weak":[173],"effect.":[175],"Amyloid-\u03b2":[176],"peptides":[177],"activate":[181],"occurred":[190],"P2X7":[193],"receptor-independent":[194],"manner.":[195],"Thus":[196],"microglia-dependent":[197],"can":[200],"play":[201],"especially":[209],"neuroinflammatory":[211],"conditions.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":32},{"year":2024,"cited_by_count":34},{"year":2023,"cited_by_count":38},{"year":2022,"cited_by_count":34},{"year":2021,"cited_by_count":45},{"year":2020,"cited_by_count":58},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":30},{"year":2017,"cited_by_count":38},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}