{"id":"https://openalex.org/W58179997","doi":null,"title":"X-ray and UV mutagenesis in two L5178Y cell strains differing in tumorigenicity, radiosensitivity, and DNA repair.","display_name":"X-ray and UV mutagenesis in two L5178Y cell strains differing in tumorigenicity, radiosensitivity, and DNA repair.","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W58179997","mag":"58179997","pmid":"https://pubmed.ncbi.nlm.nih.gov/6582899","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149131"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1522202","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149131","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149131","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007258208","display_name":"Janusz Z. Beer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Z Beer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078694487","display_name":"Elizabeth D. Jacobson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E D Jacobson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111830441","display_name":"Helen H. Evans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H H Evans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111674215","display_name":"I. Szumiel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Szumiel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3038,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.48133182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"6","issue":null,"first_page":"107","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.1145000010728836,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.034699998795986176,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l5178y-mouse-lymphoma-cells","display_name":"L5178Y cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/x-ray-mutagenesis","display_name":"X-ray mutagenesis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/uv-mutagenesis","display_name":"UV mutagenesis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.6209999918937683},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cross-sensitivity","display_name":"cross-sensitivity","score":0.5640000104904175},{"id":"https://openalex.org/keywords/hgprt-locus","display_name":"HGPRT locus","score":0.7160000205039978},{"id":"https://openalex.org/keywords/6-thioguanine-resistance","display_name":"6-thioguanine resistance","score":0.9679999947547913},{"id":"https://openalex.org/keywords/spontaneous-mutation-frequency","display_name":"spontaneous mutation frequency","score":0.7400000095367432},{"id":"https://openalex.org/keywords/tumorigenicity","display_name":"tumorigenicity","score":0.7710000276565552},{"id":"https://openalex.org/keywords/radiation-lethality","display_name":"radiation lethality","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.779630184173584},{"id":"https://openalex.org/C78179603","wikidata":"https://www.wikidata.org/wiki/Q14864606","display_name":"Hypoxanthine-guanine phosphoribosyltransferase","level":4,"score":0.6920232176780701},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6907322406768799},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6185826659202576},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.5863223075866699},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5509114861488342},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.528602123260498},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4820455014705658},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.47501620650291443},{"id":"https://openalex.org/C2781116151","wikidata":"https://www.wikidata.org/wiki/Q410305","display_name":"Hypoxanthine","level":3,"score":0.44531917572021484},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4420018196105957},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.44122716784477234},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4389662742614746},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4352077543735504},{"id":"https://openalex.org/C102306862","wikidata":"https://www.wikidata.org/wiki/Q6943735","display_name":"Mutation frequency","level":4,"score":0.42351996898651123},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.3551696538925171},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33426105976104736},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1414964199066162},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12851101160049438},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0714339017868042},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007940","descriptor_name":"Leukemia L5178","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007940","descriptor_name":"Leukemia L5178","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007942","descriptor_name":"Leukemia, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1522202","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149131","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2149131","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149131","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer Suppl","raw_type":"Text"},{"id":"pmid:6582899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6582899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of cancer. Supplement","raw_type":"Comparative Study"},{"id":"mag:58179997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6582899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1522202","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149131","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2017480816","https://openalex.org/W2079198418","https://openalex.org/W2089855581","https://openalex.org/W2134712717"],"related_works":["https://openalex.org/W1964993984","https://openalex.org/W2087285993","https://openalex.org/W1969276818","https://openalex.org/W2011002646","https://openalex.org/W2319049823","https://openalex.org/W1975323729","https://openalex.org/W2162277598","https://openalex.org/W2028463952","https://openalex.org/W2016548019","https://openalex.org/W2015489907"],"abstract_inverted_index":{"L5178Y-R":[0],"(LY-R)":[1],"and":[2,12,20,26,32,39,45,119,129,136,149],"L5178Y-S":[3],"(LY-S)":[4],"cells":[5,71,82,95,158,191],"are":[6,159],"inversely":[7],"cross":[8],"sensitive":[9],"to":[10,100,178,201],"X-rays":[11,114],"UV":[13,131],"(254":[14],"nm)":[15],"radiation":[16],"(Dox":[17],"=":[18,24,30,37],"0.94":[19],"0.69":[21],"Gy,":[22],"Dqx":[23],"0.32":[25],"0.010":[27],"Gy;":[28],"Douv":[29],"0.07":[31],"5.5":[33],"J":[34,41,142],"m-2,":[35,42],"Dquv":[36],"3.8":[38],"1.6":[40],"for":[43,93,113,130,147,181],"LY-R":[44,94,148,182],"LY-S":[46,70,81,150,157,190],"cells,":[47,151],"respectively).":[48],"Mutagenicity":[49],"of":[50,80,88,164,169,189,196],"the":[51,56,76,162,186,194],"two":[52,86],"cell":[53],"strains":[54],"at":[55,84],"hypoxanthine-guanine":[57],"phosphoribosyl":[58],"transferase":[59],"(HGPRT)":[60],"locus":[61],"was":[62,83],"examined":[63],"using":[64],"6-thioguanine":[65],"resistance":[66],"as":[67],"a":[68],"marker.":[69],"showed":[72],"remarkably":[73],"low":[74,187],"mutability;":[75],"spontaneous":[77],"mutation":[78,111],"frequency":[79],"least":[85],"orders":[87],"magnitude":[89],"lower":[90],"than":[91,97],"that":[92,156,193],"(less":[96],"or":[98],"equal":[99],"0.005":[101],"vs.":[102],"approximately":[103],"2.5":[104],"mutants":[105,123,140],"per":[106,124,126,141,144],"10(5)":[107,127,145],"survivors).":[108],"The":[109,153,175],"induced":[110],"rates":[112],"were":[115],"0.95":[116],"+/-":[117,121,134,138],"0.14":[118],"0.35":[120],"0.09":[122],"Gy":[125],"survivors,":[128,146],"radiation,":[132],"21.5":[133],"8.2":[135],"0.04":[137],"0.02":[139],"m-2":[143],"respectively.":[152],"results":[154],"suggest":[155],"efficient":[160],"in":[161,203],"repair":[163],"UV-induced":[165],"damage":[166],"but":[167],"not":[168],"lesions":[170,198],"produced":[171],"by":[172],"ionizing":[173],"radiation.":[174],"reverse":[176],"appears":[177],"be":[179],"true":[180],"cells.":[183],"In":[184],"addition,":[185],"mutability":[188],"suggests":[192],"processing":[195],"pre-mutational":[197],"may":[199],"lead":[200],"lethality":[202],"this":[204],"strain.":[205]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
