{"id":"https://openalex.org/W58170104","doi":null,"title":"HIV type 1 integrase inhibitors: from basic research to clinical implications.","display_name":"HIV type 1 integrase inhibitors: from basic research to clinical implications.","publication_year":2008,"publication_date":"2008-07-01","ids":{"openalex":"https://openalex.org/W58170104","mag":"58170104","pmid":"https://pubmed.ncbi.nlm.nih.gov/18820719"},"language":"en","primary_location":{"id":"pmid:18820719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18820719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS reviews","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043880049","display_name":"Oyebisi Jegede","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149910238","display_name":"Kent State University","ror":"https://ror.org/049pfb863","country_code":"US","type":"education","lineage":["https://openalex.org/I149910238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oyebisi Jegede","raw_affiliation_strings":["Department of Cellular and Molecular Biology, Kent State University, Kent, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Biology, Kent State University, Kent, Ohio, USA","institution_ids":["https://openalex.org/I149910238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012688052","display_name":"John Babu","orcid":"https://orcid.org/0000-0001-6157-2211","observed_orcids":["https://orcid.org/0000-0001-6157-2211","https://orcid.org/0009-0009-4699-0349"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Babu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045870972","display_name":"Roberto Di Santo","orcid":"https://orcid.org/0000-0002-4279-7666","observed_orcids":["https://orcid.org/0000-0002-4279-7666"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberto Di Santo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111719543","display_name":"Damian J. McColl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Damian J McColl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068488252","display_name":"Jan Weber","orcid":"https://orcid.org/0000-0002-2799-7352","observed_orcids":["https://orcid.org/0000-0002-2799-7352","https://orcid.org/0009-0003-6771-354X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Weber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016448752","display_name":"Miguel E. Qui\u00f1ones\u2010Mateu","orcid":"https://orcid.org/0000-0001-9170-5601","observed_orcids":["https://orcid.org/0000-0001-9170-5601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel Qui\u00f1ones-Mateu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5517,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.922005,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"3","first_page":"172","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-integrase-inhibitors","display_name":"HIV-1 integrase inhibitors","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hiv-1-integration","display_name":"HIV-1 integration","score":0.9470000267028809},{"id":"https://openalex.org/keywords/antiretroviral-drugs","display_name":"antiretroviral drugs","score":0.8659999966621399},{"id":"https://openalex.org/keywords/integrase-inhibitor-resistance","display_name":"integrase inhibitor resistance","score":0.6819999814033508},{"id":"https://openalex.org/keywords/hiv-1-replication","display_name":"HIV-1 replication","score":0.8209999799728394},{"id":"https://openalex.org/keywords/reverse-transcriptase-inhibitors","display_name":"reverse transcriptase inhibitors","score":0.6859999895095825},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.8989999890327454},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C14430832","wikidata":"https://www.wikidata.org/wiki/Q412550","display_name":"Integrase","level":3,"score":0.9286295175552368},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.8468625545501709},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.769047737121582},{"id":"https://openalex.org/C2777302000","wikidata":"https://www.wikidata.org/wiki/Q412251","display_name":"Integrase inhibitor","level":5,"score":0.7682232856750488},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.7211270332336426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6386522054672241},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.5409932732582092},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.4652230441570282},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.4518458843231201},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.43201541900634766},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3599013686180115},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.32874178886413574},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.27278876304626465},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.24387416243553162},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23422306776046753},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.20977255702018738},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19269448518753052},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12174192070960999},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0936756432056427},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019428","descriptor_name":"HIV Integrase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019428","descriptor_name":"HIV Integrase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019428","descriptor_name":"HIV Integrase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:18820719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18820719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS reviews","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/46577","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000259857600005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:58170104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18820719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W52435932","https://openalex.org/W86894734","https://openalex.org/W154868291","https://openalex.org/W180725227","https://openalex.org/W641674561","https://openalex.org/W1488279264","https://openalex.org/W1497870368","https://openalex.org/W1540658340","https://openalex.org/W1602825981","https://openalex.org/W1738249403","https://openalex.org/W1975940894","https://openalex.org/W1977252302","https://openalex.org/W1977698783","https://openalex.org/W1978909186","https://openalex.org/W1980725180","https://openalex.org/W1982826681","https://openalex.org/W1983837630","https://openalex.org/W1986118467","https://openalex.org/W2000258383","https://openalex.org/W2005285871","https://openalex.org/W2007831756","https://openalex.org/W2014265802","https://openalex.org/W2015735338","https://openalex.org/W2020555083","https://openalex.org/W2025444624","https://openalex.org/W2032195660","https://openalex.org/W2032891258","https://openalex.org/W2038070445","https://openalex.org/W2040882764","https://openalex.org/W2041126567","https://openalex.org/W2050310420","https://openalex.org/W2050569727","https://openalex.org/W2053125329","https://openalex.org/W2055995901","https://openalex.org/W2062774485","https://openalex.org/W2064584173","https://openalex.org/W2065208435","https://openalex.org/W2067663373","https://openalex.org/W2068761442","https://openalex.org/W2073761857","https://openalex.org/W2075107877","https://openalex.org/W2084278833","https://openalex.org/W2085992210","https://openalex.org/W2086783015","https://openalex.org/W2087400133","https://openalex.org/W2088335428","https://openalex.org/W2090699693","https://openalex.org/W2096451161","https://openalex.org/W2107777256","https://openalex.org/W2107965709","https://openalex.org/W2109360985","https://openalex.org/W2117785982","https://openalex.org/W2117959947","https://openalex.org/W2124750119","https://openalex.org/W2127484412","https://openalex.org/W2129670212","https://openalex.org/W2132762790","https://openalex.org/W2133140574","https://openalex.org/W2134663557","https://openalex.org/W2137646827","https://openalex.org/W2149566197","https://openalex.org/W2150504993","https://openalex.org/W2151389386","https://openalex.org/W2155439940","https://openalex.org/W2157746949","https://openalex.org/W2157763155","https://openalex.org/W2160982073","https://openalex.org/W2167278859","https://openalex.org/W2171711893","https://openalex.org/W2292638872","https://openalex.org/W2400315967","https://openalex.org/W2413608660","https://openalex.org/W2621219747"],"related_works":["https://openalex.org/W2038196376","https://openalex.org/W2011081089","https://openalex.org/W2054025309","https://openalex.org/W2008041994","https://openalex.org/W2891697914","https://openalex.org/W7098730203","https://openalex.org/W36321477","https://openalex.org/W50335808","https://openalex.org/W4300789682","https://openalex.org/W1981989716"],"abstract_inverted_index":{"Similar":[0],"to":[1,94,112,132],"other":[2],"retroviruses,":[3],"productive":[4],"infection":[5],"with":[6],"HIV-1":[7,114,122],"requires":[8],"three":[9,68],"key":[10],"steps":[11],"in":[12],"the":[13,27,41,53,101,119,124,136,140],"viral":[14,20,24,28,34,42,50,54,58,69,102],"replication:":[15],"(i)":[16],"reverse":[17,29,81],"transcription":[18],"of":[19,33,47,121,126,130,150],"genomic":[21],"RNA":[22],"into":[23,36,56],"cDNA":[25,35],"by":[26,52],"transcriptase;":[30],"(ii)":[31],"integration":[32],"host":[37],"cell":[38],"genome":[39],"using":[40],"integrase;":[43],"and":[44,83,128,135],"(iii)":[45],"cleavage":[46],"newly":[48],"synthesized":[49],"polypeptide":[51],"protease":[55,84],"individual":[57],"proteins":[59],"during":[60],"new":[61],"virion":[62],"assembly.":[63],"Following":[64],"their":[65],"discovery,":[66],"all":[67],"enzymes":[70],"were":[71],"considered":[72],"as":[73,106],"targets":[74],"for":[75,89],"antiretroviral":[76,151],"drugs.":[77,152],"However,":[78],"while":[79],"multiple":[80],"transcriptase":[82],"inhibitors":[85],"have":[86],"been":[87],"used":[88],"more":[90],"than":[91],"12":[92],"years":[93],"treat":[95],"HIV-infected":[96],"individuals,":[97],"only":[98],"recently":[99],"has":[100],"integrase":[103,133],"enzyme":[104],"emerged":[105],"an":[107],"alternative,":[108],"clinically":[109],"validated":[110],"target":[111],"block":[113],"replication.":[115],"Here":[116],"we":[117],"review":[118],"biology":[120],"integration,":[123],"mechanisms":[125],"action":[127],"development":[129],"resistance":[131],"inhibitors,":[134],"latest":[137],"data":[138],"on":[139],"most":[141],"recent":[142],"clinical":[143],"trials":[144],"involving":[145],"this":[146],"promising,":[147],"novel":[148],"class":[149]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
