{"id":"https://openalex.org/W58086106","doi":"https://doi.org/10.1023/a:1006961919775","title":"Adaptation of the ubiquitin-proteasome proteolytic pathway in cancer cachexia","display_name":"Adaptation of the ubiquitin-proteasome proteolytic pathway in cancer cachexia","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W58086106","doi":"https://doi.org/10.1023/a:1006961919775","mag":"58086106","pmid":"https://pubmed.ncbi.nlm.nih.gov/10363651"},"language":"en","primary_location":{"id":"doi:10.1023/a:1006961919775","doi":"https://doi.org/10.1023/a:1006961919775","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1006961919775","pdf_url":null,"source":{"id":"https://openalex.org/S197962172","display_name":"Molecular Biology Reports","issn_l":"0301-4851","issn":["0301-4851","1573-4978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042111402","display_name":"Didier Attaix","orcid":"https://orcid.org/0000-0002-0429-9957","observed_orcids":["https://orcid.org/0000-0002-0429-9957"]},"institutions":[{"id":"https://openalex.org/I4210137075","display_name":"Centre de Recherche en Nutrition Humaine d'Auvergne","ror":"https://ror.org/03rzyjb72","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210088668","https://openalex.org/I4210128870","https://openalex.org/I4210137075"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Didier Attaix","raw_affiliation_strings":["Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Institut National de la Recherche Agronomique, Unit\u00e9 d'Etude du M\u00e9tabolisme Azot\u00e9, Ceyrat, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Institut National de la Recherche Agronomique, Unit\u00e9 d'Etude du M\u00e9tabolisme Azot\u00e9, Ceyrat, France","institution_ids":["https://openalex.org/I4210137075","https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081409044","display_name":"Lydie Combaret","orcid":"https://orcid.org/0000-0001-6550-8700","observed_orcids":["https://orcid.org/0000-0001-6550-8700"]},"institutions":[{"id":"https://openalex.org/I4210137075","display_name":"Centre de Recherche en Nutrition Humaine d'Auvergne","ror":"https://ror.org/03rzyjb72","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210088668","https://openalex.org/I4210128870","https://openalex.org/I4210137075"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lydie Combaret","raw_affiliation_strings":["Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Institut National de la Recherche Agronomique, Unit\u00e9 d'Etude du M\u00e9tabolisme Azot\u00e9, 63122, Ceyrat, France","Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Institut National de la Recherche Agronomique, Unit\u00e9 d'Etude du M\u00e9tabolisme Azot\u00e9, Ceyrat, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Institut National de la Recherche Agronomique, Unit\u00e9 d'Etude du M\u00e9tabolisme Azot\u00e9, 63122, Ceyrat, France","institution_ids":["https://openalex.org/I4210137075","https://openalex.org/I4387154544"]},{"raw_affiliation_string":"Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Institut National de la Recherche Agronomique, Unit\u00e9 d'Etude du M\u00e9tabolisme Azot\u00e9, Ceyrat, France","institution_ids":["https://openalex.org/I4210137075","https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106425156","display_name":"T. Tilignac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137075","display_name":"Centre de Recherche en Nutrition Humaine d'Auvergne","ror":"https://ror.org/03rzyjb72","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210088668","https://openalex.org/I4210128870","https://openalex.org/I4210137075"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thomas Tilignac","raw_affiliation_strings":["Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Institut National de la Recherche Agronomique, Unit\u00e9 d'Etude du M\u00e9tabolisme Azot\u00e9, 63122, Ceyrat, France","Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Institut National de la Recherche Agronomique, Unit\u00e9 d'Etude du M\u00e9tabolisme Azot\u00e9, Ceyrat, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Institut National de la Recherche Agronomique, Unit\u00e9 d'Etude du M\u00e9tabolisme Azot\u00e9, 63122, Ceyrat, France","institution_ids":["https://openalex.org/I4210137075","https://openalex.org/I4387154544"]},{"raw_affiliation_string":"Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Institut National de la Recherche Agronomique, Unit\u00e9 d'Etude du M\u00e9tabolisme Azot\u00e9, Ceyrat, France","institution_ids":["https://openalex.org/I4210137075","https://openalex.org/I4387154544"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107594333","display_name":"Daniel Taillandier","orcid":"https://orcid.org/0000-0003-4520-0551","observed_orcids":["https://orcid.org/0000-0003-4520-0551"]},"institutions":[{"id":"https://openalex.org/I4210137075","display_name":"Centre de Recherche en Nutrition Humaine d'Auvergne","ror":"https://ror.org/03rzyjb72","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210088668","https://openalex.org/I4210128870","https://openalex.org/I4210137075"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Taillandier","raw_affiliation_strings":["Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Institut National de la Recherche Agronomique, Unit\u00e9 d'Etude du M\u00e9tabolisme Azot\u00e9, 63122, Ceyrat, France","Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Institut National de la Recherche Agronomique, Unit\u00e9 d'Etude du M\u00e9tabolisme Azot\u00e9, Ceyrat, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Institut National de la Recherche Agronomique, Unit\u00e9 d'Etude du M\u00e9tabolisme Azot\u00e9, 63122, Ceyrat, France","institution_ids":["https://openalex.org/I4210137075","https://openalex.org/I4387154544"]},{"raw_affiliation_string":"Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Institut National de la Recherche Agronomique, Unit\u00e9 d'Etude du M\u00e9tabolisme Azot\u00e9, Ceyrat, France","institution_ids":["https://openalex.org/I4210137075","https://openalex.org/I4387154544"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":null,"fwci":0.3342,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.32637923,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"26","issue":"1-2","first_page":"77","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.6557999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.6557999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.24580000340938568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-cachexia","display_name":"cancer cachexia","score":0.9490000009536743},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9520000219345093},{"id":"https://openalex.org/keywords/skeletal-muscle-proteolysis","display_name":"skeletal muscle proteolysis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/polyubiquitination","display_name":"polyubiquitination","score":0.8370000123977661},{"id":"https://openalex.org/keywords/26s-proteasome","display_name":"26S proteasome","score":0.9620000123977661},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.6079999804496765},{"id":"https://openalex.org/keywords/anorexia","display_name":"anorexia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8360000252723694},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hormones","display_name":"hormones","score":0.7200000286102295},{"id":"https://openalex.org/keywords/proteolysis-inducing-factor","display_name":"proteolysis-inducing factor","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cachexia-prevention","display_name":"cachexia prevention","score":0.9390000104904175}],"concepts":[{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.8216553926467896},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.8053568005561829},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7393316030502319},{"id":"https://openalex.org/C2777704314","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cachexia","level":3,"score":0.6670256853103638},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.5326240658760071},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5163175463676453},{"id":"https://openalex.org/C2779764123","wikidata":"https://www.wikidata.org/wiki/Q7972881","display_name":"Wasting","level":2,"score":0.49046680331230164},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48721402883529663},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4762815833091736},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.4333884119987488},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3342251777648926},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1936424970626831},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13644257187843323},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08921843767166138},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002100","descriptor_name":"Cachexia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002100","descriptor_name":"Cachexia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002100","descriptor_name":"Cachexia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1023/a:1006961919775","doi":"https://doi.org/10.1023/a:1006961919775","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1006961919775","pdf_url":null,"source":{"id":"https://openalex.org/S197962172","display_name":"Molecular Biology Reports","issn_l":"0301-4851","issn":["0301-4851","1573-4978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology Reports","raw_type":"journal-article"},{"id":"pmid:10363651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10363651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology reports","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02695730v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-02695730","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Biology Reports, 1999, 26, pp.77-82","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323038","display_name":"Conseil R\u00e9gional d'Auvergne","ror":"https://ror.org/03b7vrw33"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W39454084","https://openalex.org/W185143481","https://openalex.org/W317702181","https://openalex.org/W1491990921","https://openalex.org/W1508909871","https://openalex.org/W1513460209","https://openalex.org/W1559546643","https://openalex.org/W1569573362","https://openalex.org/W1573278669","https://openalex.org/W1772198037","https://openalex.org/W1904980709","https://openalex.org/W1910033896","https://openalex.org/W1968862012","https://openalex.org/W1983882253","https://openalex.org/W1984111867","https://openalex.org/W1992718316","https://openalex.org/W1993725521","https://openalex.org/W2000979284","https://openalex.org/W2002139436","https://openalex.org/W2003900067","https://openalex.org/W2010856745","https://openalex.org/W2021957090","https://openalex.org/W2041138100","https://openalex.org/W2042914613","https://openalex.org/W2046662379","https://openalex.org/W2063266560","https://openalex.org/W2063443397","https://openalex.org/W2065681494","https://openalex.org/W2065918344","https://openalex.org/W2066446604","https://openalex.org/W2074496192","https://openalex.org/W2084046750","https://openalex.org/W2086687462","https://openalex.org/W2102615617","https://openalex.org/W2123852931","https://openalex.org/W2131721418","https://openalex.org/W2156523912","https://openalex.org/W2169878803","https://openalex.org/W2178503716","https://openalex.org/W2341277428","https://openalex.org/W2412052819","https://openalex.org/W4245058170"],"related_works":["https://openalex.org/W2347256837","https://openalex.org/W317702181","https://openalex.org/W76987000","https://openalex.org/W2113617434","https://openalex.org/W1976138701","https://openalex.org/W2340067062","https://openalex.org/W2004830125","https://openalex.org/W2089658859","https://openalex.org/W1567171932","https://openalex.org/W275794664"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}