{"id":"https://openalex.org/W58058435","doi":null,"title":"Reslizumab, a humanized anti-IL-5 mAb for the treatment of eosinophil-mediated inflammatory conditions.","display_name":"Reslizumab, a humanized anti-IL-5 mAb for the treatment of eosinophil-mediated inflammatory conditions.","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W58058435","mag":"58058435","pmid":"https://pubmed.ncbi.nlm.nih.gov/19479666"},"language":"en","primary_location":{"id":"pmid:19479666","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19479666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in molecular therapeutics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024936437","display_name":"Garry M. Walsh","orcid":"https://orcid.org/0000-0002-7138-4078","observed_orcids":["https://orcid.org/0000-0002-7138-4078"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Garry M Walsh","raw_affiliation_strings":["University of Aberdeen, School of Medicine, Institute of Medical Sciences, Aberdeen, UK. g.m.walsh@abdn.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Aberdeen, School of Medicine, Institute of Medical Sciences, Aberdeen, UK. g.m.walsh@abdn.ac.uk","institution_ids":["https://openalex.org/I195460627"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024936437"],"corresponding_institution_ids":["https://openalex.org/I195460627"],"apc_list":null,"apc_paid":null,"fwci":5.6216,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.95961062,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"3","first_page":"329","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12538","display_name":"Eosinophilic Esophagitis","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reslizumab","display_name":"reslizumab","score":1.0},{"id":"https://openalex.org/keywords/anti-il-5-monoclonal-antibody","display_name":"anti-IL-5 monoclonal antibody","score":0.921999990940094},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9200000166893005},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.9229999780654907},{"id":"https://openalex.org/keywords/eosinophilic-esophagitis","display_name":"eosinophilic esophagitis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/eosinophilic-gastroenteritis","display_name":"eosinophilic gastroenteritis","score":0.890999972820282},{"id":"https://openalex.org/keywords/hypereosinophilic-syndrome","display_name":"hypereosinophilic syndrome","score":0.9900000095367432},{"id":"https://openalex.org/keywords/nasal-polyps","display_name":"nasal polyps","score":0.9210000038146973},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/eosinophilia","display_name":"eosinophilia","score":0.7670000195503235},{"id":"https://openalex.org/keywords/allergic-diseases","display_name":"allergic diseases","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7969173192977905},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.781485915184021},{"id":"https://openalex.org/C2781065132","wikidata":"https://www.wikidata.org/wiki/Q2057356","display_name":"Eosinophilic esophagitis","level":3,"score":0.775099515914917},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.759966254234314},{"id":"https://openalex.org/C2777832160","wikidata":"https://www.wikidata.org/wiki/Q3306175","display_name":"Mepolizumab","level":4,"score":0.6883196830749512},{"id":"https://openalex.org/C2779185760","wikidata":"https://www.wikidata.org/wiki/Q3638304","display_name":"Benralizumab","level":5,"score":0.647208571434021},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6057562232017517},{"id":"https://openalex.org/C2780769369","wikidata":"https://www.wikidata.org/wiki/Q4375","display_name":"Bronchoconstriction","level":3,"score":0.5629826188087463},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.49668627977371216},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.46414533257484436},{"id":"https://openalex.org/C181901479","wikidata":"https://www.wikidata.org/wiki/Q14877650","display_name":"Interleukin 5","level":4,"score":0.4559295177459717},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3899900019168854},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3264542818069458},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27206873893737793},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.1393587291240692},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.1332632601261139}],"mesh":[{"descriptor_ui":"D000075202","descriptor_name":"Contraindications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010330","descriptor_name":"Patents as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015848","descriptor_name":"Interleukin-5","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19479666","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19479666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in molecular therapeutics","raw_type":"Journal Article"},{"id":"mag:58058435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19479666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2739450515","https://openalex.org/W4298086400","https://openalex.org/W2117615503","https://openalex.org/W1786965289","https://openalex.org/W7024399199","https://openalex.org/W2339552918","https://openalex.org/W2607242956","https://openalex.org/W7164323705","https://openalex.org/W2344865876","https://openalex.org/W2796394543"],"abstract_inverted_index":{"Eosinophils":[0],"are":[1,179],"pro-inflammatory":[2],"cells":[3],"that":[4],"make":[5],"a":[6,53,85,151,163],"major":[7],"contribution":[8],"to":[9,25,35,126,181],"allergic":[10],"diseases":[11],"affecting":[12],"the":[13,31,36,45,132,183,190,201],"upper":[14],"and":[15,19,28,34,40,72,97,138,150,166,173,198],"lower":[16],"airways,":[17],"skin":[18],"gastrointestinal":[20],"tract.":[21],"IL-5":[22],"is":[23,52,162],"central":[24],"eosinophil":[26,98],"maturation":[27],"release":[29],"from":[30,48],"bone":[32],"marrow,":[33],"subsequent":[37],"accumulation,":[38],"activation":[39],"persistence":[41],"of":[42,88,124,134,186,192,203],"eosinophils":[43],"in":[44,64,69,84,105,115,144,157],"tissues.":[46],"Reslizumab":[47,161],"Ception":[49],"Therapeutics":[50],"Inc":[51],"humanized":[54],"mAb":[55],"with":[56,90,117,146,159],"potent":[57],"IL-5-neutralizing":[58],"effects.":[59],"The":[60],"agent":[61],"inhibited":[62],"eosinophilia":[63],"several":[65],"animal":[66],"models;":[67],"reductions":[68],"airway":[70],"hyperactivity":[71],"bronchoconstriction":[73],"were":[74,111,142],"also":[75],"observed.":[76],"Clinical":[77],"trials":[78,141,178,205],"for":[79,169],"reslizumab":[80],"have":[81],"been":[82],"completed":[83],"small":[86],"number":[87],"patients":[89,116,121,145,158],"asthma,":[91],"nasal":[92],"polyposis,":[93,175],"hypereosinophilic":[94],"syndrome":[95],"(HES)":[96],"gastroenteritis":[99],"(EG).":[100],"Eosinophil":[101],"depletion":[102],"was":[103,155],"observed":[104],"all":[106],"trials,":[107],"but":[108],"clinical":[109],"responses":[110],"often":[112],"limited,":[113],"particularly":[114],"asthma;":[118],"furthermore,":[119],"some":[120],"exhibited":[122],"rebound":[123],"disease":[125,187],"levels":[127],"greater":[128],"than":[129],"baseline.":[130],"At":[131],"time":[133],"publication,":[135],"phase":[136,139,152],"II/III":[137],"III":[140],"ongoing":[143,156],"eosinophilic":[147,174],"esophagitis":[148],"(EE),":[149],"II":[153],"trial":[154],"asthma.":[160],"potentially":[164],"efficacious":[165],"well-tolerated":[167],"treatment":[168],"EG,":[170],"EE,":[171],"HES":[172],"although":[176],"more":[177],"required":[180],"understand":[182],"underlying":[184],"mechanism":[185],"rebound.":[188],"However,":[189],"rarity":[191],"conditions":[193],"such":[194,204],"as":[195],"HES,":[196],"EE":[197],"EG":[199],"makes":[200],"conduct":[202],"difficult.":[206]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}