{"id":"https://openalex.org/W57981633","doi":"https://doi.org/10.1182/blood.v79.3.559.559","title":"Localization of a PlA1 epitope to the amino terminal 66 residues of platelet glycoprotein IIIa.","display_name":"Localization of a PlA1 epitope to the amino terminal 66 residues of platelet glycoprotein IIIa.","publication_year":1992,"publication_date":"1992-02-01","ids":{"openalex":"https://openalex.org/W57981633","doi":"https://doi.org/10.1182/blood.v79.3.559.559","mag":"57981633","pmid":"https://pubmed.ncbi.nlm.nih.gov/1370635"},"language":"en","primary_location":{"id":"pmid:1370635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1370635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110273810","display_name":"Ron D. Bowditch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R D Bowditch","raw_affiliation_strings":["Committee on Vascular Biology, Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Vascular Biology, Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014660411","display_name":"Patricia H. Tani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P H Tani","raw_affiliation_strings":["Committee on Vascular Biology, Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Vascular Biology, Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083952709","display_name":"Carol Halloran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C E Halloran","raw_affiliation_strings":["Committee on Vascular Biology, Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Vascular Biology, Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067192657","display_name":"Andrew L. Frelinger","orcid":"https://orcid.org/0000-0002-6871-7441","observed_orcids":["https://orcid.org/0000-0002-6871-7441"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A L Frelinger","raw_affiliation_strings":["Committee on Vascular Biology, Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Vascular Biology, Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110901531","display_name":"Robert McMillan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R McMillan","raw_affiliation_strings":["Committee on Vascular Biology, Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Vascular Biology, Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032907445","display_name":"Mark H. Ginsberg","orcid":"https://orcid.org/0000-0002-5685-5417","observed_orcids":["https://orcid.org/0000-0002-5685-5417"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M H Ginsberg","raw_affiliation_strings":["Committee on Vascular Biology, Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Vascular Biology, Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":null,"apc_paid":null,"fwci":2.4889,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.87803833,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"79","issue":"3","first_page":"559","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-glycoprotein-iiia","display_name":"platelet glycoprotein IIIa","score":0.9679999947547913},{"id":"https://openalex.org/keywords/alloantigen","display_name":"alloantigen","score":0.6850000023841858},{"id":"https://openalex.org/keywords/epitope-mapping","display_name":"epitope mapping","score":0.8009999990463257},{"id":"https://openalex.org/keywords/amino-terminal-region","display_name":"amino-terminal region","score":0.5400000214576721},{"id":"https://openalex.org/keywords/epitope-mimics","display_name":"epitope mimics","score":0.7239999771118164},{"id":"https://openalex.org/keywords/alloantibody-detection","display_name":"alloantibody detection","score":0.8799999952316284},{"id":"https://openalex.org/keywords/platelet-alloimmunization","display_name":"platelet alloimmunization","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.9277127981185913},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.7457578182220459},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6735979318618774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6152677536010742},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5788378715515137},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5464984774589539},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5464764833450317},{"id":"https://openalex.org/C2781241564","wikidata":"https://www.wikidata.org/wiki/Q1347450","display_name":"Epitope mapping","level":4,"score":0.522646427154541},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.5111537575721741},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39723238348960876},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16668769717216492},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14619234204292297}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1370635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1370635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"mag:57981633","doi":"https://doi.org/10.1182/blood.v79.3.559.559","is_oa":false,"landing_page_url":"http://www.bloodjournal.org/content/bloodjournal/79/3/559.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1294100001","display_name":null,"funder_award_id":"HL-28235","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1922325578","display_name":"FIBRONECTIN AND PLATELETS","funder_award_id":"5r01hl028235-12","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2439430869","display_name":null,"funder_award_id":"HL 37945","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3263340342","display_name":null,"funder_award_id":"AR 27214","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5029637385","display_name":"PATHOGENESIS OF THE IMMUNE THROMBOCYTOPENIAS","funder_award_id":"5r01hl037945-23","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W102598677","https://openalex.org/W285592170","https://openalex.org/W569951484","https://openalex.org/W1567129527","https://openalex.org/W1982177692","https://openalex.org/W2002029477","https://openalex.org/W2012847227","https://openalex.org/W2015623521","https://openalex.org/W2031842889","https://openalex.org/W2036931150","https://openalex.org/W2084884863","https://openalex.org/W2093916196","https://openalex.org/W2138270253","https://openalex.org/W2194734893","https://openalex.org/W2402463253","https://openalex.org/W2408164906","https://openalex.org/W2410007954","https://openalex.org/W2465578337"],"related_works":["https://openalex.org/W285592170","https://openalex.org/W92599696","https://openalex.org/W2426336133","https://openalex.org/W2292795303","https://openalex.org/W2002029477","https://openalex.org/W7100469213","https://openalex.org/W102598677","https://openalex.org/W2015623521","https://openalex.org/W37884768","https://openalex.org/W2462021133"],"abstract_inverted_index":{"A":[0],"platelet":[1],"glycoprotein":[2],"(GP)":[3],"IIIa":[4],"epitope":[5,96,125],"library":[6],"was":[7],"constructed":[8],"by":[9,43,69],"insertion":[10],"of":[11,58,62,77,104,122,133],"randomly":[12],"cleaved":[13],"GPIIIa":[14,105],"cDNA":[15],"fragments":[16],"in":[17,70,74],"the":[18,53,75,107,111],"prokaryotic":[19],"expression":[20],"vector":[21],"lambda":[22],"gt22":[23],"and":[24,41,129],"screened":[25],"with":[26,65,85],"purified":[27],"anti-PlA1":[28,48,78],"antibodies":[29],"for":[30,110,131],"clones":[31,38],"expressing":[32],"a":[33,66,93,100,123],"PlA1":[34,94,124],"epitope.":[35],"Five":[36],"independent":[37],"were":[39],"isolated":[40],"characterized":[42],"nucleotide":[44],"sequencing.":[45],"The":[46],"smallest":[47],"reactive":[49],"clone":[50,82],"obtained":[51],"encoded":[52],"amino":[54],"terminal":[55],"66":[56],"residues":[57],"mature":[59],"GPIIIa.":[60],"Substitution":[61],"leucine33":[63],"(PlA1)":[64],"proline33":[67],"(PlA2)":[68],"vitro":[71],"mutagenesis":[72],"resulted":[73],"loss":[76],"reactivity;":[79],"however,":[80],"this":[81],"still":[83],"reacted":[84],"anti-GPIIIa":[86],"polyclonal":[87],"antibodies.":[88],"These":[89],"data":[90],"indicate":[91],"that":[92,118],"alloantigenic":[95],"is":[97],"located":[98],"within":[99],"small,":[101],"unglycosylated":[102],"fragment":[103],"containing":[106],"polymorphism":[108],"responsible":[109],"PIA":[112],"phenotype.":[113],"Furthermore,":[114],"these":[115,134],"results":[116],"prove":[117],"small":[119],"recombinant":[120],"mimics":[121],"may":[126],"be":[127],"synthesized":[128],"used":[130],"detection":[132],"alloantibodies.":[135]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}