{"id":"https://openalex.org/W579107115","doi":null,"title":"B\u00fasqueda de Biomarcadores Asociados con la Respuesta al Tratamiento con Interfer\u00f3n-beta en Pacientes con Esclerosis M\u00faltiple Remitente-Recurrente","display_name":"B\u00fasqueda de Biomarcadores Asociados con la Respuesta al Tratamiento con Interfer\u00f3n-beta en Pacientes con Esclerosis M\u00faltiple Remitente-Recurrente","publication_year":2013,"publication_date":"2013-12-18","ids":{"openalex":"https://openalex.org/W579107115","mag":"579107115"},"language":"es","primary_location":{"id":"mag:579107115","doi":null,"is_oa":false,"landing_page_url":"https://ddd.uab.cat/pub/tesis/2013/hdl_10803_129151/mcl1de1.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091751427","display_name":"Manuel Comabella","orcid":"https://orcid.org/0000-0002-2373-6657","observed_orcids":["https://orcid.org/0000-0002-2373-6657"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Manuel Comabella L\u00f3pez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091751427"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.875},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.9010000228881836},{"id":"https://openalex.org/keywords/peripheral-blood-cells","display_name":"peripheral blood cells","score":0.7260000109672546},{"id":"https://openalex.org/keywords/monocytic-cells","display_name":"monocytic cells","score":0.6909999847412109},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.7260000109672546},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8619999885559082},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.5770000219345093},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.5619999766349792},{"id":"https://openalex.org/keywords/genomics","display_name":"genomics","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8123829960823059},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.6046397089958191},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.47858643531799316},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.15799498558044434}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:579107115","doi":null,"is_oa":false,"landing_page_url":"https://ddd.uab.cat/pub/tesis/2013/hdl_10803_129151/mcl1de1.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1500818454","https://openalex.org/W1565999785","https://openalex.org/W1639967516","https://openalex.org/W1651987642","https://openalex.org/W1967544492","https://openalex.org/W1968558564","https://openalex.org/W1972673753","https://openalex.org/W1975519799","https://openalex.org/W1986279897","https://openalex.org/W1991107765","https://openalex.org/W2002276824","https://openalex.org/W2009297045","https://openalex.org/W2021271171","https://openalex.org/W2021338588","https://openalex.org/W2021719585","https://openalex.org/W2034275921","https://openalex.org/W2040007196","https://openalex.org/W2042312470","https://openalex.org/W2043683714","https://openalex.org/W2046413321","https://openalex.org/W2062793260","https://openalex.org/W2075413744","https://openalex.org/W2076220518","https://openalex.org/W2077917257","https://openalex.org/W2078442450","https://openalex.org/W2082363371","https://openalex.org/W2083156858","https://openalex.org/W2083665192","https://openalex.org/W2084284866","https://openalex.org/W2086779744","https://openalex.org/W2095008935","https://openalex.org/W2095402874","https://openalex.org/W2099447582","https://openalex.org/W2100382163","https://openalex.org/W2106980391","https://openalex.org/W2107100842","https://openalex.org/W2107277218","https://openalex.org/W2108295257","https://openalex.org/W2110065044","https://openalex.org/W2111048324","https://openalex.org/W2111810014","https://openalex.org/W2112787962","https://openalex.org/W2115475836","https://openalex.org/W2118330057","https://openalex.org/W2123257865","https://openalex.org/W2136811387","https://openalex.org/W2139367012","https://openalex.org/W2142793548","https://openalex.org/W2148595669","https://openalex.org/W2149014007","https://openalex.org/W2150495005","https://openalex.org/W2155991561","https://openalex.org/W2160063406","https://openalex.org/W2164238938","https://openalex.org/W2164739461","https://openalex.org/W2169098250","https://openalex.org/W2170073367","https://openalex.org/W2170989872","https://openalex.org/W2171467864","https://openalex.org/W2303778066"],"related_works":["https://openalex.org/W6980249560","https://openalex.org/W2516673961","https://openalex.org/W2284845035","https://openalex.org/W2978895193","https://openalex.org/W4389412025","https://openalex.org/W2074533826","https://openalex.org/W7038119617","https://openalex.org/W2111264374","https://openalex.org/W1553247595","https://openalex.org/W2768716006"],"abstract_inverted_index":{"El":[0],"interferon-beta":[1],"(IFN?)":[2],"es":[3,40,90],"un":[4,120,126,260],"tratamiento":[5,43,99,155,187,276],"parcialmente":[6],"efectivo":[7],"en":[8,102,244,267,279],"pacientes":[9,55,103,148,215,252],"con":[10,75,100,104,149,156,188,216,253,264,277,282],"esclerosis":[11],"multiple":[12],"remitente-recurrente":[13],"(EMRR).":[14],"Disminuye":[15],"el":[16,36,42,83,280],"numero":[17],"de":[18,27,54,66,72,86,93,96,109,122,136,144,147,163,169,177,196,203,206,225,235,238,246,251,262],"brotes":[19],"y":[20,24,115,218,258],"reduce":[21],"la":[22,28,62,76,91,107,201,226,233,268,273],"actividad":[23],"carga":[25],"lesional":[26],"enfermedad":[29],"medidas":[30],"por":[31,133,160,167,174],"resonancia":[32],"magnetica.":[33],"Sin":[34],"embargo,":[35],"coste":[37],"del":[38,186],"IFN?":[39,101,157,278],"elevado,":[41],"tiene":[44],"efectos":[45],"secundarios":[46],"y,":[47],"sobretodo,":[48],"existe":[49],"una":[50,161],"proporcion":[51],"relativamente":[52],"importante":[53],"que":[56,68,124,151,180,193,198,211,232],"no":[57,64,152],"responden":[58,153],"al":[59,78,98,154,221,256,275],"mismo.":[60],"En":[61,80],"actualidad,":[63],"disponemos":[65],"biomarcadores":[67,94,123,263],"se":[69,117,158,182,191,241],"puedan":[70],"asociar":[71],"forma":[73],"fiable":[74],"respuesta":[77,97,255,274],"IFN?.":[79,189,222],"este":[81],"contexto,":[82],"objetivo":[84],"principal":[85],"esta":[87,140],"tesis":[88,228],"doctoral":[89,229],"identificacion":[92],"moleculares":[95],"EMRR.":[105],"Mediante":[106],"aplicacion":[108],"tecnologias":[110],"denominadas":[111],"\u201comicas\u201d,":[112],"principalmente":[113],"genomica":[114],"transcriptomica,":[116],"ha":[118],"identificado":[119],"grupo":[121],"presentan":[125],"denominador":[127],"funcional":[128],"comun,":[129],"su":[130],"induccion":[131,170],"predominante":[132,171],"los":[134,175,204,210,236],"IFNs":[135,176,205,237],"tipo":[137,178,207,239],"1.":[138],"De":[139],"forma,":[141],"las":[142],"celulas":[143,245],"sangre":[145,247],"periferica":[146],"EMRR":[150],"caracterizan":[159],"huella":[162],"expresion":[164],"genica":[165],"formada":[166],"genes":[168,197],"o":[172],"selectiva":[173],"1,":[179],"ya":[181],"encuentra":[183,242],"presente":[184,227],"antes":[185],"Tambien":[190],"observo":[192],"algunos":[194],"polimorfismos":[195],"pertenecen":[199],"a":[200],"via":[202,234],"1":[208,240],"fueron":[209],"mejor":[212],"discriminaron":[213],"entre":[214],"buena":[217],"mala":[219,254],"respuestal":[220],"Los":[223],"resultados":[224],"permiten":[230],"concluir":[231],"alterada":[243],"periferica,":[248],"posiblemente":[249],"monocitos,":[250],"IFN?,":[257],"propone":[259],"conjunto":[261],"potencial":[265],"uso":[266],"practica":[269],"clinica":[270],"para":[271],"predecir":[272],"paciente":[281],"EM.":[283]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
