{"id":"https://openalex.org/W577598487","doi":"https://doi.org/10.1007/978-4-431-68231-8_63","title":"Amelioration of Septal Cholinergic Neuronal Degeneration After Nerve Growth Factor Deprivation by Cytokine-Activated Astrocytes","display_name":"Amelioration of Septal Cholinergic Neuronal Degeneration After Nerve Growth Factor Deprivation by Cytokine-Activated Astrocytes","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W577598487","doi":"https://doi.org/10.1007/978-4-431-68231-8_63","mag":"577598487"},"language":"en","primary_location":{"id":"doi:10.1007/978-4-431-68231-8_63","doi":"https://doi.org/10.1007/978-4-431-68231-8_63","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-4-431-68231-8_63","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent Advances in Neurotraumatology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W569798267","display_name":"Recent Advances in Neurotraumatology"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017102129","display_name":"Kazunari Yoshida","orcid":"https://orcid.org/0000-0001-5776-2741","observed_orcids":["https://orcid.org/0000-0001-5776-2741"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunari Yoshida","raw_affiliation_strings":["Department of Neurosurgery, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068501642","display_name":"Masachika Sagoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masachika Sagoh","raw_affiliation_strings":["Department of Neurosurgery, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086467236","display_name":"Hirooki Wakamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirooki Wakamoto","raw_affiliation_strings":["Department of Neurosurgery, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088916498","display_name":"Takahito Yazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahito Yazaki","raw_affiliation_strings":["Department of Neurosurgery, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109112581","display_name":"Mitsuhiro Otani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuhiro Otani","raw_affiliation_strings":["Department of Neurosurgery, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111389555","display_name":"Shigeo Toya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeo Toya","raw_affiliation_strings":["Department of Neurosurgery, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072968010","display_name":"Fred H. Gage","orcid":"https://orcid.org/0000-0002-0938-4106","observed_orcids":["https://orcid.org/0000-0002-0938-4106"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred H. Gage","raw_affiliation_strings":["Department of Neurosciences, University of California, 92093, San Diego, La\u2019Jolla, California, USA","Department of Neurosciences, University of California-San Diego, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, 92093, San Diego, La\u2019Jolla, California, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Neurosciences, University of California-San Diego, La Jolla, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16624685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"279","last_page":"282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9729999899864197},{"id":"https://openalex.org/keywords/septal-cholinergic-neurons","display_name":"septal cholinergic neurons","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8289999961853027},{"id":"https://openalex.org/keywords/ngf-deprivation","display_name":"NGF deprivation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9980000257492065},{"id":"https://openalex.org/keywords/choline-acetyltransferase","display_name":"choline acetyltransferase","score":0.9160000085830688},{"id":"https://openalex.org/keywords/astrocyte-neuron-co-culture","display_name":"astrocyte-neuron co-culture","score":0.8410000205039978},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.8192462921142578},{"id":"https://openalex.org/C104966671","wikidata":"https://www.wikidata.org/wiki/Q12167532","display_name":"Cholinergic neuron","level":3,"score":0.7861731648445129},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.6535292863845825},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6506769061088562},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6500176191329956},{"id":"https://openalex.org/C198399640","wikidata":"https://www.wikidata.org/wiki/Q14863671","display_name":"Choline acetyltransferase","level":3,"score":0.585905909538269},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.580793023109436},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.522045373916626},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4464433491230011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42251184582710266},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3418586254119873},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3313808739185333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27562201023101807},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2054905891418457},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05723881721496582}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-4-431-68231-8_63","doi":"https://doi.org/10.1007/978-4-431-68231-8_63","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-4-431-68231-8_63","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent Advances in Neurotraumatology","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W240091683","https://openalex.org/W1609471181","https://openalex.org/W1983465575","https://openalex.org/W1988925814","https://openalex.org/W2011784314","https://openalex.org/W2027724538","https://openalex.org/W2033494272","https://openalex.org/W2040256853","https://openalex.org/W2045776001","https://openalex.org/W2050119939","https://openalex.org/W2071490280","https://openalex.org/W2094084246","https://openalex.org/W2095873344","https://openalex.org/W4242634578","https://openalex.org/W6603639717"],"related_works":["https://openalex.org/W2039379167","https://openalex.org/W2033494272","https://openalex.org/W2062841992","https://openalex.org/W2038201520","https://openalex.org/W1997349127","https://openalex.org/W53117511","https://openalex.org/W2320073138","https://openalex.org/W2034417232","https://openalex.org/W2000958534","https://openalex.org/W2072959295"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}