{"id":"https://openalex.org/W57755157","doi":"https://doi.org/10.1007/bf00405905","title":"Autonomous cortisol secretion by a metastatic Leydig cell carcinoma associated with Klinefelter's syndrome","display_name":"Autonomous cortisol secretion by a metastatic Leydig cell carcinoma associated with Klinefelter's syndrome","publication_year":1981,"publication_date":"1981-04-01","ids":{"openalex":"https://openalex.org/W57755157","doi":"https://doi.org/10.1007/bf00405905","mag":"57755157","pmid":"https://pubmed.ncbi.nlm.nih.gov/7016888","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12253784"},"language":"en","primary_location":{"id":"doi:10.1007/bf00405905","doi":"https://doi.org/10.1007/bf00405905","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00405905","pdf_url":null,"source":{"id":"https://openalex.org/S10075937","display_name":"Journal of Cancer Research and Clinical Oncology","issn_l":"0084-5353","issn":["0084-5353","0171-5216","0301-1585","1432-1335"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12253784/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050880946","display_name":"Klaus Knyrim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270573","display_name":"Stiftung Universit\u00e4tsmedizin Essen","ror":"https://ror.org/00ykp8811","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4405270573"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Knyrim","raw_affiliation_strings":["Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Hufelandstr. 55, D-4300, Essen 1, Federal Republic of Germany","Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Essen 1, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Hufelandstr. 55, D-4300, Essen 1, Federal Republic of Germany","institution_ids":["https://openalex.org/I4405270573"]},{"raw_affiliation_string":"Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Essen 1, Federal Republic of Germany","institution_ids":["https://openalex.org/I4405270573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050509096","display_name":"Markus Higi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270573","display_name":"Stiftung Universit\u00e4tsmedizin Essen","ror":"https://ror.org/00ykp8811","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4405270573"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Higi","raw_affiliation_strings":["Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Hufelandstr. 55, D-4300, Essen 1, Federal Republic of Germany","Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Essen 1, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Hufelandstr. 55, D-4300, Essen 1, Federal Republic of Germany","institution_ids":["https://openalex.org/I4405270573"]},{"raw_affiliation_string":"Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Essen 1, Federal Republic of Germany","institution_ids":["https://openalex.org/I4405270573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108459600","display_name":"D. K. Hossfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270573","display_name":"Stiftung Universit\u00e4tsmedizin Essen","ror":"https://ror.org/00ykp8811","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4405270573"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. K. Hossfeld","raw_affiliation_strings":["Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Hufelandstr. 55, D-4300, Essen 1, Federal Republic of Germany","Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Essen 1, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Hufelandstr. 55, D-4300, Essen 1, Federal Republic of Germany","institution_ids":["https://openalex.org/I4405270573"]},{"raw_affiliation_string":"Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Essen 1, Federal Republic of Germany","institution_ids":["https://openalex.org/I4405270573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111640624","display_name":"S. Seeber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270573","display_name":"Stiftung Universit\u00e4tsmedizin Essen","ror":"https://ror.org/00ykp8811","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4405270573"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Seeber","raw_affiliation_strings":["Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Hufelandstr. 55, D-4300, Essen 1, Federal Republic of Germany","Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Essen 1, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Hufelandstr. 55, D-4300, Essen 1, Federal Republic of Germany","institution_ids":["https://openalex.org/I4405270573"]},{"raw_affiliation_string":"Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Essen 1, Federal Republic of Germany","institution_ids":["https://openalex.org/I4405270573"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042282312","display_name":"C. G. Schmidt","orcid":"https://orcid.org/0000-0002-9021-8227","observed_orcids":["https://orcid.org/0000-0002-9021-8227"]},"institutions":[{"id":"https://openalex.org/I4405270573","display_name":"Stiftung Universit\u00e4tsmedizin Essen","ror":"https://ror.org/00ykp8811","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4405270573"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. G. Schmidt","raw_affiliation_strings":["Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Hufelandstr. 55, D-4300, Essen 1, Federal Republic of Germany","Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Essen 1, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Hufelandstr. 55, D-4300, Essen 1, Federal Republic of Germany","institution_ids":["https://openalex.org/I4405270573"]},{"raw_affiliation_string":"Dept. of Internal Medicine and Polyclinic (Tumor Research), University of Essen Medical School, West German Tumor Center, Essen 1, Federal Republic of Germany","institution_ids":["https://openalex.org/I4405270573"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405270573"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.00594137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"100","issue":"1","first_page":"85","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.3440000116825104,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.3440000116825104,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.19789999723434448,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.061500001698732376,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klinefelter-syndrome","display_name":"Klinefelter syndrome","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cushing-s-syndrome","display_name":"Cushing's syndrome","score":0.8199999928474426},{"id":"https://openalex.org/keywords/metastatic-testicular-tumor","display_name":"metastatic testicular tumor","score":0.656000018119812},{"id":"https://openalex.org/keywords/mitotane","display_name":"mitotane","score":0.8309999704360962},{"id":"https://openalex.org/keywords/androgen-receptor-antagonists","display_name":"androgen receptor antagonists","score":0.32499998807907104},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.7509999871253967},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.6729999780654907},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.8809999823570251},{"id":"https://openalex.org/keywords/estrone","display_name":"estrone","score":0.7689999938011169},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.4129999876022339},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6619246006011963},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.636268138885498},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.633771538734436},{"id":"https://openalex.org/C2777736315","wikidata":"https://www.wikidata.org/wiki/Q636846","display_name":"Leydig cell","level":4,"score":0.5846818089485168},{"id":"https://openalex.org/C2776314099","wikidata":"https://www.wikidata.org/wiki/Q207133","display_name":"Klinefelter syndrome","level":2,"score":0.5667726993560791},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5391471982002258},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5087743401527405},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.401891827583313},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3579109013080597},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.23692205548286438},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.07413572072982788}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007713","descriptor_name":"Klinefelter Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007984","descriptor_name":"Leydig Cell Tumor","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007984","descriptor_name":"Leydig Cell Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007984","descriptor_name":"Leydig Cell Tumor","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008939","descriptor_name":"Mitotane","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/bf00405905","doi":"https://doi.org/10.1007/bf00405905","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00405905","pdf_url":null,"source":{"id":"https://openalex.org/S10075937","display_name":"Journal of Cancer Research and Clinical Oncology","issn_l":"0084-5353","issn":["0084-5353","0171-5216","0301-1585","1432-1335"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:7016888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7016888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cancer research and clinical oncology","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:12253784","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12253784/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cancer Res Clin Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:12253784","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12253784/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cancer Res Clin Oncol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1966143200","https://openalex.org/W1990223599","https://openalex.org/W2000503613","https://openalex.org/W2007775559","https://openalex.org/W2016648193","https://openalex.org/W2017996228","https://openalex.org/W2020815302","https://openalex.org/W2021791265","https://openalex.org/W2039151248","https://openalex.org/W2044990411","https://openalex.org/W2045436764","https://openalex.org/W2058715321","https://openalex.org/W2074025532","https://openalex.org/W2082133483","https://openalex.org/W2088722617","https://openalex.org/W2093206986","https://openalex.org/W2107293418","https://openalex.org/W2150688618","https://openalex.org/W2162078230","https://openalex.org/W2342461018","https://openalex.org/W2404822463","https://openalex.org/W2407247858","https://openalex.org/W2407699807","https://openalex.org/W2471867012","https://openalex.org/W3023527264"],"related_works":["https://openalex.org/W2036311179","https://openalex.org/W2089010313","https://openalex.org/W2440484337","https://openalex.org/W2036755607","https://openalex.org/W2156075212","https://openalex.org/W2052429698","https://openalex.org/W2034667620","https://openalex.org/W2017996228","https://openalex.org/W2073307871","https://openalex.org/W4387095739"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}