{"id":"https://openalex.org/W577294467","doi":"https://doi.org/10.1038/srep11126","title":"Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71","display_name":"Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71","publication_year":2015,"publication_date":"2015-06-09","ids":{"openalex":"https://openalex.org/W577294467","doi":"https://doi.org/10.1038/srep11126","mag":"577294467","pmid":"https://pubmed.ncbi.nlm.nih.gov/26057209","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4460895"},"language":"en","primary_location":{"id":"doi:10.1038/srep11126","doi":"https://doi.org/10.1038/srep11126","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep11126","pdf_url":"https://www.nature.com/articles/srep11126.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep11126.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006845904","display_name":"Sibylle Mitschka","orcid":"https://orcid.org/0000-0003-2169-8957","observed_orcids":["https://orcid.org/0000-0003-2169-8957"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sibylle Mitschka","raw_affiliation_strings":["Molecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007372940","display_name":"Thomas Ulas","orcid":"https://orcid.org/0000-0002-9785-4197","observed_orcids":["https://orcid.org/0000-0002-9785-4197"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Ulas","raw_affiliation_strings":["Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011285485","display_name":"Tobias Goller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Goller","raw_affiliation_strings":["Molecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Karin Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karin Schneider","raw_affiliation_strings":["Molecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055357467","display_name":"Angela Egert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Angela Egert","raw_affiliation_strings":["Department of Developmental Pathology, Institute of Pathology, University of Bonn, Medical School, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Pathology, Institute of Pathology, University of Bonn, Medical School, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011670025","display_name":"J\u00e9r\u00f4me Mertens","orcid":"https://orcid.org/0000-0002-4291-4121","observed_orcids":["https://orcid.org/0000-0002-4291-4121"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00e9r\u00f4me Mertens","raw_affiliation_strings":["Institute for Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904651","display_name":"Oliver Br\u00fcstle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Br\u00fcstle","raw_affiliation_strings":["Institute for Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015796348","display_name":"Hubert Schorle","orcid":"https://orcid.org/0000-0001-8272-0076","observed_orcids":["https://orcid.org/0000-0001-8272-0076"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hubert Schorle","raw_affiliation_strings":["Department of Developmental Pathology, Institute of Pathology, University of Bonn, Medical School, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Pathology, Institute of Pathology, University of Bonn, Medical School, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019504046","display_name":"Marc Beyer","orcid":"https://orcid.org/0000-0001-9704-148X","observed_orcids":["https://orcid.org/0000-0001-9704-148X"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marc Beyer","raw_affiliation_strings":["Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008122286","display_name":"Kathrin Klee","orcid":"https://orcid.org/0000-0003-2408-1282","observed_orcids":["https://orcid.org/0000-0003-2408-1282"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kathrin Klee","raw_affiliation_strings":["Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jia Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jia Xue","raw_affiliation_strings":["Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000887206","display_name":"Patrick S. G\u00fcnther","orcid":"https://orcid.org/0000-0002-9135-7819","observed_orcids":["https://orcid.org/0000-0002-9135-7819","https://orcid.org/0000-0002-1532-7263"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Patrick G\u00fcnther","raw_affiliation_strings":["Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082416154","display_name":"Kevin E. Bassler","orcid":"https://orcid.org/0000-0002-4780-372X","observed_orcids":["https://orcid.org/0000-0002-4780-372X"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kevin Bassler","raw_affiliation_strings":["Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073445890","display_name":"Joachim Ludwig Schultze","orcid":"https://orcid.org/0000-0003-2812-9853","observed_orcids":["https://orcid.org/0000-0003-2812-9853"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim L. Schultze","raw_affiliation_strings":["Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012137496","display_name":"Waldemar Kolanus","orcid":"https://orcid.org/0000-0003-1325-9444","observed_orcids":["https://orcid.org/0000-0003-1325-9444"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Waldemar Kolanus","raw_affiliation_strings":["Molecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012137496"],"corresponding_institution_ids":["https://openalex.org/I135140700"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.4153,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.79859532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"11126","last_page":"11126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trim71","display_name":"TRIM71","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tripartite-motif-proteins","display_name":"tripartite motif proteins","score":0.8410000205039978},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.6359999775886536},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.8519999980926514},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.5360000133514404},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.8429999947547913},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.5770000219345093},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7037918567657471},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.6232357621192932},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6184631586074829},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5693167448043823},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.487942636013031},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.4377908706665039},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.4329184591770172},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.4135754704475403},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3641144633293152},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.312158465385437},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30629903078079224}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054258","descriptor_name":"Neural Plate","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/srep11126","doi":"https://doi.org/10.1038/srep11126","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep11126","pdf_url":"https://www.nature.com/articles/srep11126.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3433804","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4460895","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4460895","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4460895","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:26057209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26057209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/srep11126","doi":"https://doi.org/10.1038/srep11126","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep11126","pdf_url":"https://www.nature.com/articles/srep11126.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1485794032","display_name":null,"funder_award_id":"TP-A02","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1767776421","display_name":null,"funder_award_id":"SFB 704","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2034871011","display_name":null,"funder_award_id":"SFB 832","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G264648268","display_name":null,"funder_award_id":"SFB 645","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W577294467.pdf","grobid_xml":"https://content.openalex.org/works/W577294467.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W1502327375","https://openalex.org/W1505372769","https://openalex.org/W1965428318","https://openalex.org/W1968931043","https://openalex.org/W1969065113","https://openalex.org/W1971645224","https://openalex.org/W1974595624","https://openalex.org/W1975200987","https://openalex.org/W1975464080","https://openalex.org/W1978842800","https://openalex.org/W1980217666","https://openalex.org/W1983301971","https://openalex.org/W1988294855","https://openalex.org/W1995547197","https://openalex.org/W2000290477","https://openalex.org/W2003207389","https://openalex.org/W2011182193","https://openalex.org/W2015396326","https://openalex.org/W2017840637","https://openalex.org/W2020131259","https://openalex.org/W2021894549","https://openalex.org/W2023710119","https://openalex.org/W2024234501","https://openalex.org/W2025075195","https://openalex.org/W2030362521","https://openalex.org/W2031285837","https://openalex.org/W2038934023","https://openalex.org/W2044222229","https://openalex.org/W2050594481","https://openalex.org/W2053441740","https://openalex.org/W2058521801","https://openalex.org/W2061425021","https://openalex.org/W2068780842","https://openalex.org/W2077327925","https://openalex.org/W2079130661","https://openalex.org/W2082931608","https://openalex.org/W2084332810","https://openalex.org/W2084521437","https://openalex.org/W2087981068","https://openalex.org/W2088412871","https://openalex.org/W2094947748","https://openalex.org/W2097948046","https://openalex.org/W2104893769","https://openalex.org/W2106033637","https://openalex.org/W2107575419","https://openalex.org/W2108234281","https://openalex.org/W2110015307","https://openalex.org/W2115476694","https://openalex.org/W2115948084","https://openalex.org/W2116365634","https://openalex.org/W2117131162","https://openalex.org/W2120491421","https://openalex.org/W2122864540","https://openalex.org/W2123883826","https://openalex.org/W2124486107","https://openalex.org/W2124989632","https://openalex.org/W2125987139","https://openalex.org/W2126795909","https://openalex.org/W2132380965","https://openalex.org/W2134482986","https://openalex.org/W2135668873","https://openalex.org/W2137065828","https://openalex.org/W2137531873","https://openalex.org/W2138487969","https://openalex.org/W2139657402","https://openalex.org/W2139958362","https://openalex.org/W2141413663","https://openalex.org/W2141602707","https://openalex.org/W2146606376","https://openalex.org/W2147231609","https://openalex.org/W2149930662","https://openalex.org/W2150014868","https://openalex.org/W2150098952","https://openalex.org/W2153424791","https://openalex.org/W2154833122","https://openalex.org/W2155227864","https://openalex.org/W2155382831","https://openalex.org/W2156354373","https://openalex.org/W2157932359","https://openalex.org/W2158610627","https://openalex.org/W2161224111","https://openalex.org/W2162716784","https://openalex.org/W2163132655","https://openalex.org/W2163636666","https://openalex.org/W2168247876","https://openalex.org/W2171030481","https://openalex.org/W2179438025","https://openalex.org/W4232123484"],"related_works":["https://openalex.org/W3214746934","https://openalex.org/W7131208074","https://openalex.org/W2109106721","https://openalex.org/W7006584916","https://openalex.org/W3132018777","https://openalex.org/W4200074785","https://openalex.org/W2786698717","https://openalex.org/W2135341744","https://openalex.org/W2627819133","https://openalex.org/W2766513470"],"abstract_inverted_index":{"Regulatory":[0],"networks":[1,29,125],"for":[2,86,150],"differentiation":[3,47,68,182],"and":[4,34,45,67,78,140],"pluripotency":[5,44,91,127,193],"in":[6,112,123,135,183,195],"embryonic":[7],"stem":[8,55],"(ES)":[9],"cells":[10,56,137,144],"have":[11],"long":[12],"been":[13],"suggested":[14],"to":[15,36,58,92],"be":[16,50,83],"mutually":[17],"exclusive.":[18],"However,":[19],"with":[20,107,169],"the":[21,40,101,156,192],"identification":[22],"of":[23,27,43,62,65,97,100,126,133,142,181,191],"many":[24,147],"new":[25],"components":[26],"these":[28,143],"ranging":[30],"from":[31,90],"epigenetic,":[32],"transcriptional,":[33],"translational":[35],"even":[37],"post-translational":[38],"mechanisms,":[39],"cellular":[41],"states":[42],"early":[46],"might":[48,82],"not":[49,121,187],"strictly":[51],"bi-modal,":[52],"but":[53,128,146],"differentiating":[54],"appear":[57],"go":[59],"through":[60],"phases":[61],"simultaneous":[63],"expression":[64,166],"stemness":[66,139],"genes.":[69],"Translational":[70],"regulators":[71],"such":[72],"as":[73],"RNA":[74,108],"binding":[75,109],"proteins":[76],"(RBPs)":[77],"micro":[79],"RNAs":[80],"(miRNAs)":[81],"prime":[84],"candidates":[85],"guiding":[87],"a":[88,189],"cell":[89],"differentiation.":[93,131],"Using":[94],"Trim71,":[95],"one":[96],"two":[98],"members":[99],"Tripartite":[102],"motif":[103],"(Trim)":[104],"protein":[105],"family":[106],"activity":[110],"expressed":[111],"murine":[113],"ES":[114,196],"cells,":[115],"we":[116],"demonstrate":[117],"that":[118,176],"Trim71":[119,134,177],"is":[120],"involved":[122],"regulatory":[124],"regulates":[129],"neural":[130,151,164],"Loss":[132],"mES":[136,161],"leaves":[138],"self-maintenance":[141],"intact,":[145],"genes":[148],"required":[149],"development":[152],"are":[153],"up-regulated":[154],"at":[155],"same":[157],"time.":[158],"Concordantly,":[159],"Trim71(-/-)":[160],"show":[162],"increased":[163],"marker":[165],"following":[167],"treatment":[168],"retinoic":[170],"acid.":[171],"Our":[172],"findings":[173],"strongly":[174],"suggest":[175],"keeps":[178],"priming":[179],"steps":[180],"check,":[184],"which":[185],"do":[186],"pre-require":[188],"loss":[190],"network":[194],"cells.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
