{"id":"https://openalex.org/W577202108","doi":"https://doi.org/10.5551/jat1973.15.1_287","title":"Regression of Atherosclerosis in Homozygous Familial Hypercholesterolemia by Plasma Exchange Therapy","display_name":"Regression of Atherosclerosis in Homozygous Familial Hypercholesterolemia by Plasma Exchange Therapy","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W577202108","doi":"https://doi.org/10.5551/jat1973.15.1_287","mag":"577202108"},"language":"en","primary_location":{"id":"doi:10.5551/jat1973.15.1_287","doi":"https://doi.org/10.5551/jat1973.15.1_287","is_oa":true,"landing_page_url":"https://doi.org/10.5551/jat1973.15.1_287","pdf_url":"https://www.jstage.jst.go.jp/article/jat1973/15/1/15_1_287/_pdf","source":{"id":"https://openalex.org/S4210238089","display_name":"The Journal of Japan Atherosclerosis Society","issn_l":"0386-2682","issn":["0386-2682","2185-8284"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313348","host_organization_name":"Japan Atherosclerosis Society","host_organization_lineage":["https://openalex.org/P4310313348"],"host_organization_lineage_names":["Japan Atherosclerosis Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Japan Atherosclerosis Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/jat1973/15/1/15_1_287/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110153218","display_name":"Bun-ichiro Kishino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117281","display_name":"Sumitomo Hospital","ror":"https://ror.org/02m9ewz37","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210117281"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Bun-ichiro KISHINO","raw_affiliation_strings":["Department of Internal Medicine, Sumitomo Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Sumitomo Hospital","institution_ids":["https://openalex.org/I4210117281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034922501","display_name":"Toshiro Kikkawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117281","display_name":"Sumitomo Hospital","ror":"https://ror.org/02m9ewz37","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210117281"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiro KIKKAWA","raw_affiliation_strings":["Department of Internal Medicine, Sumitomo Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Sumitomo Hospital","institution_ids":["https://openalex.org/I4210117281"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022444323","display_name":"Akira Yamamoto","orcid":"https://orcid.org/0000-0002-1058-4762","observed_orcids":["https://orcid.org/0000-0002-1058-4762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akira YAMAMOTO","raw_affiliation_strings":["Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.362,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.59367671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"1","first_page":"287","last_page":"292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homozygous-familial-hypercholesterolemia","display_name":"homozygous familial hypercholesterolemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/therapeutic-plasma-exchange","display_name":"plasma exchange","score":0.7490000128746033},{"id":"https://openalex.org/keywords/plasmapheresis","display_name":"plasmapheresis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/atherosclerosis-regression","display_name":"atherosclerosis regression","score":0.8460000157356262},{"id":"https://openalex.org/keywords/coronary-stenosis","display_name":"coronary artery stenosis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/probucol","display_name":"probucol","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cholestyramine","display_name":"cholestyramine","score":0.8920000195503235},{"id":"https://openalex.org/keywords/serum-cholesterol-lowering","display_name":"serum cholesterol lowering","score":0.7070000171661377},{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C2778842783","wikidata":"https://www.wikidata.org/wiki/Q603502","display_name":"Plasmapheresis","level":3,"score":0.8661975860595703},{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.8612358570098877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7157531976699829},{"id":"https://openalex.org/C2776167589","wikidata":"https://www.wikidata.org/wiki/Q10354103","display_name":"Probucol","level":3,"score":0.670712947845459},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5562006831169128},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5039727091789246},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.4875761866569519},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.4853633642196655},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.39719289541244507},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36137115955352783},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33256733417510986},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3230269253253937},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.06945371627807617},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5551/jat1973.15.1_287","doi":"https://doi.org/10.5551/jat1973.15.1_287","is_oa":true,"landing_page_url":"https://doi.org/10.5551/jat1973.15.1_287","pdf_url":"https://www.jstage.jst.go.jp/article/jat1973/15/1/15_1_287/_pdf","source":{"id":"https://openalex.org/S4210238089","display_name":"The Journal of Japan Atherosclerosis Society","issn_l":"0386-2682","issn":["0386-2682","2185-8284"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313348","host_organization_name":"Japan Atherosclerosis Society","host_organization_lineage":["https://openalex.org/P4310313348"],"host_organization_lineage_names":["Japan Atherosclerosis Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Japan Atherosclerosis Society","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5551/jat1973.15.1_287","doi":"https://doi.org/10.5551/jat1973.15.1_287","is_oa":true,"landing_page_url":"https://doi.org/10.5551/jat1973.15.1_287","pdf_url":"https://www.jstage.jst.go.jp/article/jat1973/15/1/15_1_287/_pdf","source":{"id":"https://openalex.org/S4210238089","display_name":"The Journal of Japan Atherosclerosis Society","issn_l":"0386-2682","issn":["0386-2682","2185-8284"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313348","host_organization_name":"Japan Atherosclerosis Society","host_organization_lineage":["https://openalex.org/P4310313348"],"host_organization_lineage_names":["Japan Atherosclerosis Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Japan Atherosclerosis Society","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W577202108.pdf","grobid_xml":"https://content.openalex.org/works/W577202108.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2015337748","https://openalex.org/W2023089750","https://openalex.org/W2163746841"],"related_works":["https://openalex.org/W2037195523","https://openalex.org/W616343998","https://openalex.org/W2023089750","https://openalex.org/W2607367691","https://openalex.org/W2036878806","https://openalex.org/W2068745409","https://openalex.org/W2398309840","https://openalex.org/W1985733199","https://openalex.org/W2606986393","https://openalex.org/W2213201963"],"abstract_inverted_index":{"Three":[0],"patients":[1,47],"in":[2,45,80,192,239,271],"members":[3],"of":[4,35,67,101,125,150,159,168,178,211,226,242,260,262,268],"the":[5,76,88,106,156,160,165,169,193,201,240,243,248,258],"same":[6],"family":[7],"(patient":[8],"1,":[9,183],"38yrs.":[10],"male;":[11],"patient":[12,16,81,96,120,140,154,182],"2,":[13,141],"41yrs.":[14],"female;":[15],"3,":[17,155],"44yrs.":[18],"female)":[19],"with":[20],"homozygous":[21,39],"familial":[22,40],"hypercholesterolemia":[23,41],"were":[24,54,145],"treated":[25],"by":[26],"repeated":[27],"plasma":[28,70,102,126,179,213],"exchange":[29,71,84,92,103,111,116,127,214],"for":[30,38],"several":[31],"years.":[32],"The":[33],"effectiveness":[34],"long-term":[36],"plasmapheresis":[37,151,227,254],"has":[42],"been":[43],"evaluated":[44],"three":[46],"receiving":[48],"hypolipidemic":[49],"dugs.Their":[50],"serum":[51,78,108],"cholesterol":[52,79,109],"levels":[53],"596\u00b140.0":[55],"(3),":[56],"719\u00b139.5":[57],"(3)":[58],"and":[59,69,87,104,114,128,134,164,200,215,232,247,255,265],"661\u00b125.7":[60],"(3)mg/dl":[61],"(MSD),":[62],"respectively.":[63],"After":[64,208],"5":[65],"years":[66,100,124,149,177,225],"probucol":[68,256],"at":[72],"2":[73,97],"weekly":[74],"intervals,":[75],"mean":[77,89,107],"1":[82],"before":[83,110],"was":[85,93,112,117,132,137,162,173,218,235],"427\u00b124mg/dl":[86],"value":[90,131,136],"after":[91,98,115,122,223],"137\u00b118mg/dl.":[94],"In":[95,119,139,153,181],"6":[99,123],"probucol,":[105,129,233],"533\u00b121mg/dl":[113],"143\u00b116mg/dl.":[118],"3":[121,148,176],"pre-exchange":[130],"409\u00b115mg/dl":[133],"postexchange":[135],"162\u00b111mg/dl.":[138],"aortocoronary":[142],"angiographic":[143],"appearances":[144],"unchanged":[146,174],"during":[147,175],"therapy.":[152],"irregular":[157,166],"appearance":[158,167],"aorta":[161],"improved":[163],"right":[170],"coronary":[171,186,269],"artery":[172],"exchange.":[180],"an":[184],"initial":[185],"angiogram":[187],"showed":[188],"a":[189,236],"50%":[190],"stenosis":[191,217,241],"left":[194,202,244,249],"anterior":[195,245],"descending":[196,246],"(LAD,":[197],"seg.":[198,205],"8)":[199],"circumflex":[203,250],"(CX,":[204],"13)":[206],"artery.":[207],"one":[209],"year":[210],"2L":[212],"cholestyramine,":[216],"much":[219],"more":[220],"severe.":[221],"However,":[222],"4":[224],"using":[228],"double":[229],"filtration":[230],"method":[231],"there":[234],"marked":[237],"improvement":[238],"artery.We":[251],"conclude":[252],"that":[253],"retards":[257],"rate":[259],"progression":[261],"atherosclerotic":[263],"changes":[264],"induces":[266],"regression":[267],"atherosclerosis":[270],"homozygotes.":[272]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
