{"id":"https://openalex.org/W57650279","doi":null,"title":"Antiviral effect of ribavirin on Junin virus replication in vitro.","display_name":"Antiviral effect of ribavirin on Junin virus replication in vitro.","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W57650279","mag":"57650279","pmid":"https://pubmed.ncbi.nlm.nih.gov/2825242"},"language":"en","primary_location":{"id":"pmid:2825242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2825242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Argentina de microbiologia","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Rodr\u00edguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"M Rodr\u00edguez","raw_affiliation_strings":["C\u00e1tedra de Microbiolog\u00eda, Parasitolog\u00eda e Inmunolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C\u00e1tedra de Microbiolog\u00eda, Parasitolog\u00eda e Inmunolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050832426","display_name":"Joseph B. McCormick","orcid":"https://orcid.org/0000-0002-5844-8102","observed_orcids":["https://orcid.org/0000-0002-5844-8102"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"J B McCormick","raw_affiliation_strings":["Universidad de Buenos Aires"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Buenos Aires","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055488017","display_name":"Weissenbacher Mc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"M C Weissenbacher","raw_affiliation_strings":["Universidad de Buenos Aires"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Buenos Aires","institution_ids":["https://openalex.org/I24354313"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I24354313"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.00517933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"18","issue":"2","first_page":"69","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":1.0},{"id":"https://openalex.org/keywords/junin-virus","display_name":"Junin virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/argentine-hemorrhagic-fever","display_name":"Argentine hemorrhagic fever","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.7829999923706055},{"id":"https://openalex.org/keywords/vero-cells","display_name":"Vero cells","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cytopathic-effect","display_name":"cytopathic effect","score":0.9169999957084656},{"id":"https://openalex.org/keywords/plaque-formation","display_name":"plaque formation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/virus-yield","display_name":"virus yield","score":0.4790000021457672},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.9573720693588257},{"id":"https://openalex.org/C2775955205","wikidata":"https://www.wikidata.org/wiki/Q51929761","display_name":"Junin virus","level":5,"score":0.8828627467155457},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6950854063034058},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6576610207557678},{"id":"https://openalex.org/C2775996393","wikidata":"https://www.wikidata.org/wiki/Q1149147","display_name":"Cytopathic effect","level":3,"score":0.5655745267868042},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5548916459083557},{"id":"https://openalex.org/C2779574689","wikidata":"https://www.wikidata.org/wiki/Q2368907","display_name":"Arenavirus","level":5,"score":0.5058659911155701},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.48805439472198486},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.46691039204597473},{"id":"https://openalex.org/C2779756493","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral drug","level":3,"score":0.43620193004608154},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4261499345302582},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39273184537887573},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.344632089138031},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.12257632613182068},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0809718668460846},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.06512311100959778},{"id":"https://openalex.org/C2780190958","wikidata":"https://www.wikidata.org/wiki/Q1878776","display_name":"Lymphocytic choriomeningitis","level":4,"score":0.05638524889945984},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001116","descriptor_name":"Arenaviridae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006477","descriptor_name":"Arenaviruses, New World","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006477","descriptor_name":"Arenaviruses, New World","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2825242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2825242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Argentina de microbiologia","raw_type":"Journal Article"},{"id":"mag:57650279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2825242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1566698368","https://openalex.org/W1973497192","https://openalex.org/W2001653092","https://openalex.org/W2130394030","https://openalex.org/W1991681974","https://openalex.org/W7098402830","https://openalex.org/W2087610677","https://openalex.org/W2907253555","https://openalex.org/W2019455710","https://openalex.org/W2206845419"],"abstract_inverted_index":{"The":[0,75],"effect":[1,36,96],"of":[2,10,16,30,51,68,78,88],"Ribavirin":[3,69,82,106],"(1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide)":[4],"on":[5,42,98,114],"the":[6,13,31,34,46,55,85,89,94],"replication":[7],"in":[8,83,99],"vitro":[9],"Junin":[11,79],"virus,":[12],"causative":[14],"agent":[15,110],"Argentine":[17],"Hemorrhagic":[18],"Fever":[19],"(AHF),":[20],"was":[21],"examined.":[22],"A":[23],"concentration":[24,50,67],"as":[25,27],"low":[26,86],"3.12":[28],"micrograms/ml":[29,53],"drug":[32,90],"inhibited":[33],"cytopathic":[35],"observed":[37,97],"five":[38],"days":[39],"post-infection":[40],"(pi)":[41],"Vero":[43],"cells.":[44],"On":[45],"other":[47,103],"hand,":[48],"a":[49,107],"25":[52],"reduced":[54],"virus":[56,80],"yield":[57],"and":[58,93],"specific":[59],"antigen":[60],"formation":[61,72],"to":[62,81],"undetectable":[63],"levels.":[64],"This":[65],"same":[66],"prevented":[70],"plaque":[71],"under":[73],"methylcellulose.":[74],"high":[76],"sensitivity":[77],"vitro,":[84],"toxicity":[87],"for":[91],"mammals":[92],"therapeutic":[95],"vivo":[100],"infections":[101],"with":[102],"arenaviruses,":[104],"makes":[105],"promising":[108],"antiviral":[109],"that":[111],"deserves":[112],"testing":[113],"AHF":[115],"primate":[116],"models":[117],"before":[118],"clinical":[119],"trials":[120],"are":[121],"undertaken.":[122]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
