{"id":"https://openalex.org/W57636002","doi":null,"title":"Radioimmunoassay of human high molecular weight kininogen in normal and deficient plasmas.","display_name":"Radioimmunoassay of human high molecular weight kininogen in normal and deficient plasmas.","publication_year":1980,"publication_date":"1980-04-01","ids":{"openalex":"https://openalex.org/W57636002","mag":"57636002","pmid":"https://pubmed.ncbi.nlm.nih.gov/6153694"},"language":"en","primary_location":{"id":"pmid:6153694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6153694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103187210","display_name":"David Proud","orcid":"https://orcid.org/0000-0001-9629-6595","observed_orcids":["https://orcid.org/0000-0001-9629-6595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Proud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072017527","display_name":"Jack V. Pierce","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J V Pierce","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060033079","display_name":"John J. Pisano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Pisano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.3625,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.95366972,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"95","issue":"4","first_page":"563","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-molecular-weight-kininogen","display_name":"high molecular weight kininogen","score":0.9940000176429749},{"id":"https://openalex.org/keywords/kininogen-deficiency","display_name":"kininogen deficiency","score":0.7630000114440918},{"id":"https://openalex.org/keywords/radioimmunoassay","display_name":"radioimmunoassay","score":0.8180000185966492},{"id":"https://openalex.org/keywords/kallikrein-kinin-system","display_name":"kallikrein-kinin system","score":0.8849999904632568},{"id":"https://openalex.org/keywords/immunoaffinity-chromatography","display_name":"immunoaffinity chromatography","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"cross-reactivity","score":0.5929999947547913},{"id":"https://openalex.org/keywords/plasma-kallikrein","display_name":"plasma kallikrein","score":0.7910000085830688},{"id":"https://openalex.org/keywords/kinin-release","display_name":"kinin release","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2777902427","wikidata":"https://www.wikidata.org/wiki/Q6413860","display_name":"Kininogen","level":4,"score":0.9369300603866577},{"id":"https://openalex.org/C2781317560","wikidata":"https://www.wikidata.org/wiki/Q24721273","display_name":"High-molecular-weight kininogen","level":5,"score":0.798179566860199},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.7579278945922852},{"id":"https://openalex.org/C2776246183","wikidata":"https://www.wikidata.org/wiki/Q421924","display_name":"Kinin","level":4,"score":0.7036823034286499},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6709707379341125},{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.6637194156646729},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6627017855644226},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5583413243293762},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.5422608852386475},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.5119829773902893},{"id":"https://openalex.org/C152328610","wikidata":"https://www.wikidata.org/wiki/Q7240014","display_name":"Prekallikrein","level":4,"score":0.46683040261268616},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4385416805744171},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.390585720539093},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31901177763938904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18080821633338928},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17794349789619446},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17173445224761963},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07076296210289001}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007704","descriptor_name":"Kininogens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007704","descriptor_name":"Kininogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007705","descriptor_name":"Kinins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6153694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6153694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:57636002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6153694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2096144517","https://openalex.org/W2471504413","https://openalex.org/W1966671054","https://openalex.org/W2079212890","https://openalex.org/W298911325","https://openalex.org/W2980151640","https://openalex.org/W2020292347","https://openalex.org/W226553083","https://openalex.org/W1861020171","https://openalex.org/W2053295848"],"abstract_inverted_index":{"An":[0],"RIA":[1,166],"for":[2],"human":[3,53,68],"HMW":[4,18,62,83,106,134,177],"kininogen,":[5],"capable":[6],"of":[7,11,42,74,82,94,101,113,120,129,154,163,202,217],"detecting":[8],"150":[9],"pg":[10],"antigen,":[12],"has":[13],"been":[14],"developed.":[15],"Antibody":[16],"to":[17,30,66,86],"kininogen":[19,63,84,107,135],"was":[20,28,89,146,158],"purified":[21,123],"by":[22,122],"immunoaffinity":[23],"chromatography,":[24],"and":[25,33,52,60,71,78,183,194,200,223],"double-antibody":[26],"precipitation":[27],"used":[29],"separate":[31],"free":[32],"bound":[34],"antigen.":[35,69],"Of":[36],"the":[37,43,67,114,215,218],"LMW":[38],"kininogens":[39],"only":[40],"one":[41],"forms":[44],"tested":[45],"(B3.2)":[46],"showed":[47,57,64,187,197],"significant":[48,148,189],"cross-reaction":[49],"(2%).":[50],"Bradykinin":[51],"plasma":[54,124],"kallikrein":[55],"both":[56],"no":[58,188],"cross-reaction,":[59,190],"monkey":[61],"identity":[65],"Intraassay":[70],"interassay":[72],"coefficients":[73],"variation":[75],"were":[76,168],"2%":[77],"1.5%,":[79],"respectively.":[80,206],"Recovery":[81],"added":[85],"6":[87],"plasmas":[88,97,173,185,196],"97.7%":[90],"+/-":[91,103,109,131],"1.8%.":[92],"Assay":[93],"17":[95],"normal":[96,164,203],"gave":[98],"a":[99,127],"level":[100,128],"90.8":[102],"2.5":[104],"micrograms/ml":[105,133],"(mean":[108],"S.E.M.).":[110],"A":[111],"bioassay":[112],"samples,":[115],"based":[116],"on":[117,171,214],"specific":[118],"release":[119],"kinin":[121],"kallikrein,":[125],"yielded":[126],"90.2":[130],"2.8":[132],"(r":[136],"=":[137],"0.83,":[138],"p":[139],"less":[140],"than":[141],"0.001).":[142],"In":[143],"neither":[144],"assay":[145],"any":[147,155],"sex":[149],"difference":[150],"observed.":[151],"No":[152],"evidence":[153],"antigenic":[156,204],"fragments":[157],"seen":[159],"upon":[160],"gel":[161],"filtration":[162],"plasmas.":[165],"measurements":[167],"also":[169],"performed":[170],"seven":[172],"reportedly":[174],"deficient":[175],"in":[176,221],"kininogen.":[178],"Williams,":[179],"Dayton,":[180],"San":[181],"Francisco,":[182],"Flaujeac":[184],"all":[186],"whereas":[191],"Fitzgerald,":[192],"Reid":[193],"Detroit":[195],"1.0%,":[198],"2.5%,":[199],"3.5%":[201],"levels,":[205],"This":[207],"sensitive,":[208],"convenient":[209],"method":[210],"should":[211],"facilitate":[212],"studies":[213],"role":[216],"kallikrein-kinin":[219],"system":[220],"health":[222],"disease.":[224]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}