{"id":"https://openalex.org/W576038994","doi":null,"title":"Renal ischemia/reperfusion injury in diabetes : experimental studies in the rat.","display_name":"Renal ischemia/reperfusion injury in diabetes : experimental studies in the rat.","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W576038994","mag":"576038994"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-1931","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1931","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1931","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072488171","display_name":"Jan Melin","orcid":"https://orcid.org/0000-0003-3405-3154","observed_orcids":["https://orcid.org/0000-0003-3405-3154"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jan Melin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3405-3154","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072488171"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.040699999779462814,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-ischemia-reperfusion-injury","display_name":"renal ischemia-reperfusion injury","score":0.9340000152587891},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.8980000019073486},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.4350000023841858},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cobalt-protoporphyrin","display_name":"cobalt protoporphyrin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tubulointerstitial-fibrosis","display_name":"tubulointerstitial fibrosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/renal-medulla","display_name":"renal medulla","score":0.7639999985694885},{"id":"https://openalex.org/keywords/candesartan","display_name":"candesartan","score":0.8880000114440918},{"id":"https://openalex.org/keywords/paf-antagonists","display_name":"PAF antagonists","score":0.7139999866485596},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":0.9700000286102295},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7449237108230591},{"id":"https://openalex.org/C2780721119","wikidata":"https://www.wikidata.org/wiki/Q7312492","display_name":"Renal ischemia","level":4,"score":0.5853254795074463},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.559928834438324},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5562856197357178},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5302944779396057},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5151978135108948},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4815376400947571},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4445817470550537},{"id":"https://openalex.org/C2780229479","wikidata":"https://www.wikidata.org/wiki/Q7312498","display_name":"Renal papillary necrosis","level":3,"score":0.4432026743888855},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.26235416531562805}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-1931","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1931","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:576038994","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/8131","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-1931","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1931","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":185,"referenced_works":["https://openalex.org/W23360501","https://openalex.org/W43539042","https://openalex.org/W63098812","https://openalex.org/W138102452","https://openalex.org/W182212959","https://openalex.org/W192011864","https://openalex.org/W316286216","https://openalex.org/W1561751955","https://openalex.org/W1594856996","https://openalex.org/W1932854388","https://openalex.org/W1968162805","https://openalex.org/W1970924247","https://openalex.org/W1971123920","https://openalex.org/W1971714938","https://openalex.org/W1972866381","https://openalex.org/W1973631125","https://openalex.org/W1974075521","https://openalex.org/W1975834822","https://openalex.org/W1976330342","https://openalex.org/W1976910340","https://openalex.org/W1977216789","https://openalex.org/W1978581565","https://openalex.org/W1981951271","https://openalex.org/W1982628508","https://openalex.org/W1986347387","https://openalex.org/W1989059321","https://openalex.org/W1991237280","https://openalex.org/W1991301758","https://openalex.org/W1991645916","https://openalex.org/W1993242384","https://openalex.org/W1996197861","https://openalex.org/W1996352187","https://openalex.org/W1998996095","https://openalex.org/W2000318625","https://openalex.org/W2001477429","https://openalex.org/W2002072388","https://openalex.org/W2003670762","https://openalex.org/W2003700045","https://openalex.org/W2003847438","https://openalex.org/W2005922044","https://openalex.org/W2007234183","https://openalex.org/W2008486735","https://openalex.org/W2009326258","https://openalex.org/W2011409573","https://openalex.org/W2013177380","https://openalex.org/W2013664235","https://openalex.org/W2014169720","https://openalex.org/W2018145341","https://openalex.org/W2018920030","https://openalex.org/W2019275192","https://openalex.org/W2021752936","https://openalex.org/W2022593397","https://openalex.org/W2023285707","https://openalex.org/W2025619770","https://openalex.org/W2026135330","https://openalex.org/W2027255980","https://openalex.org/W2027750117","https://openalex.org/W2027917795","https://openalex.org/W2030127399","https://openalex.org/W2032836445","https://openalex.org/W2033095396","https://openalex.org/W2036884952","https://openalex.org/W2037528365","https://openalex.org/W2038453644","https://openalex.org/W2040961193","https://openalex.org/W2044102243","https://openalex.org/W2044773944","https://openalex.org/W2046463777","https://openalex.org/W2049899538","https://openalex.org/W2050916570","https://openalex.org/W2050971607","https://openalex.org/W2051354793","https://openalex.org/W2053609044","https://openalex.org/W2053802748","https://openalex.org/W2054000735","https://openalex.org/W2054425738","https://openalex.org/W2056017497","https://openalex.org/W2056964884","https://openalex.org/W2056976690","https://openalex.org/W2058160164","https://openalex.org/W2058903095","https://openalex.org/W2060423078","https://openalex.org/W2060654110","https://openalex.org/W2061394036","https://openalex.org/W2061685638","https://openalex.org/W2063595239","https://openalex.org/W2064737060","https://openalex.org/W2069728361","https://openalex.org/W2071167287","https://openalex.org/W2071422081","https://openalex.org/W2072990621","https://openalex.org/W2073567888","https://openalex.org/W2073640832","https://openalex.org/W2073713671","https://openalex.org/W2076095874","https://openalex.org/W2077053778","https://openalex.org/W2077357748","https://openalex.org/W2078663145","https://openalex.org/W2080028790","https://openalex.org/W2081308848","https://openalex.org/W2081322366","https://openalex.org/W2081742266","https://openalex.org/W2082645650","https://openalex.org/W2085889262","https://openalex.org/W2086254494","https://openalex.org/W2087098960","https://openalex.org/W2089430217","https://openalex.org/W2090262709","https://openalex.org/W2090969480","https://openalex.org/W2091262290","https://openalex.org/W2091321868","https://openalex.org/W2092169341","https://openalex.org/W2092281480","https://openalex.org/W2092711749","https://openalex.org/W2094100703","https://openalex.org/W2094139788","https://openalex.org/W2096352923","https://openalex.org/W2097349490","https://openalex.org/W2099462319","https://openalex.org/W2099725443","https://openalex.org/W2106240866","https://openalex.org/W2107404296","https://openalex.org/W2107545715","https://openalex.org/W2108530688","https://openalex.org/W2108935165","https://openalex.org/W2115418965","https://openalex.org/W2119514827","https://openalex.org/W2120279023","https://openalex.org/W2121036290","https://openalex.org/W2124098523","https://openalex.org/W2125571970","https://openalex.org/W2126112553","https://openalex.org/W2130383031","https://openalex.org/W2131230367","https://openalex.org/W2131761461","https://openalex.org/W2132729501","https://openalex.org/W2132758701","https://openalex.org/W2132889264","https://openalex.org/W2134360290","https://openalex.org/W2135667919","https://openalex.org/W2136898798","https://openalex.org/W2137406451","https://openalex.org/W2138302361","https://openalex.org/W2138928713","https://openalex.org/W2139723538","https://openalex.org/W2142267556","https://openalex.org/W2143683619","https://openalex.org/W2145082345","https://openalex.org/W2149482537","https://openalex.org/W2152223470","https://openalex.org/W2154977856","https://openalex.org/W2156647135","https://openalex.org/W2157631070","https://openalex.org/W2160908214","https://openalex.org/W2163957982","https://openalex.org/W2164553737","https://openalex.org/W2166803343","https://openalex.org/W2169061609","https://openalex.org/W2187075787","https://openalex.org/W2189331937","https://openalex.org/W2230956746","https://openalex.org/W2269957890","https://openalex.org/W2274413769","https://openalex.org/W2281369529","https://openalex.org/W2288242060","https://openalex.org/W2295785528","https://openalex.org/W2324409724","https://openalex.org/W2328554661","https://openalex.org/W2340025308","https://openalex.org/W2395776195","https://openalex.org/W2409138033","https://openalex.org/W2412097103","https://openalex.org/W2417207181","https://openalex.org/W2424005247","https://openalex.org/W2462492076","https://openalex.org/W2467826850","https://openalex.org/W2468153680","https://openalex.org/W2470359562","https://openalex.org/W2470877023","https://openalex.org/W2608707648","https://openalex.org/W2885639847","https://openalex.org/W2913618975","https://openalex.org/W4243550784","https://openalex.org/W4313310025","https://openalex.org/W4406056503"],"related_works":["https://openalex.org/W1987370895","https://openalex.org/W3021640874","https://openalex.org/W2969971721","https://openalex.org/W2005644048","https://openalex.org/W4400729396","https://openalex.org/W2555090249","https://openalex.org/W2993541300","https://openalex.org/W2964571431","https://openalex.org/W4200580614","https://openalex.org/W2052623915"],"abstract_inverted_index":{"Diabetes":[0],"mellitus":[1],"(DM)":[2],"is":[3],"one":[4],"of":[5,9,62,68,83,99,109,121,130,155,229,237,248,268,319,327],"the":[6,45,69,80,84,89,95,100,107,119,153,159,169,175,199,204,212,215,227,230,266,307],"leading":[7],"causes":[8],"end":[10],"stage":[11],"renal":[12,18,27,54,92,160,164,193,231,288,308,331],"failure.":[13],"An":[14],"increased":[15],"susceptibility":[16],"to":[17,36,244,291,323],"ischemia/reperfusion":[19],"(I/R)-injury":[20],"was":[21,50,57,94,103,136,274],"found":[22,78],"in":[23,41,47,79,88,140,158,234,242,253,260,277,296,310,334],"DM":[24,42,141,261,297,311],"rats.":[25,312],"Unilateral":[26],"ischemia":[28],"for":[29],"as":[30,32],"short":[31],"20":[33],"minutes":[34],"led":[35],"an":[37,246],"irreversible":[38],"progressive":[39,294],"injury":[40,46,56,176,233,295,309,333],"kidneys,":[43],"whereas":[44],"non-DM":[48],"kidneys":[49,262],"almost":[51],"reversible.":[52],"The":[53,91],"I/R":[55,116,139,190,232,289,332],"characterized":[58],"by":[59,106,118,270,282],"anuria,":[60],"infiltration":[61],"inflammatory":[63],"cells,":[64],"tubular":[65],"atrophy,":[66],"dilation":[67],"remaining":[70],"tubuli":[71],"and":[72,87,112,117,132,162,166,219],"tubulointerstitial":[73],"fibrosis.":[74],"Necrotic":[75],"areas":[76],"were":[77],"inner":[81],"parts":[82],"outer":[85],"medulla":[86,93,161],"papilla.":[90],"most":[96],"vulnerable":[97],"part":[98],"kidney.":[101],"This":[102],"seen":[104,137],"both":[105],"extent":[108],"fibrosis":[110],"four":[111],"eight":[113],"weeks":[114],"after":[115,126,138,168,174,263],"presence":[120],"TUNEL-positive":[122],"(apoptotic)":[123],"cells":[124,157],"6h":[125],"ischemia.":[127],"Increased":[128],"accumulation":[129],"HA":[131],"enhanced":[133],"CD44":[134],"expression":[135],"kidneys.":[142,298],"Treatment":[143,202],"with":[144,203],"long":[145],"acting":[146,184],"insulin":[147,172,185],"7-14":[148],"days":[149],"before":[150,189,301],"I/R,":[151],"decreased":[152],"number":[154],"apoptotic":[156],"protected":[163,192],"function":[165,194,259],"morphology":[167],"insult,":[170],"while":[171],"treatment":[173,300],"did":[177,196,224],"not":[178,197,225,275,304],"have":[179],"any":[180],"protective":[181],"effect.":[182],"Short":[183],"given":[186],"2-6":[187],"hours":[188],"partially":[191],"but":[195,303],"improve":[198,226],"morphological":[200],"picture.":[201],"angiotensin":[205],"II":[206],"receptor":[207],"type":[208],"1":[209],"blocker":[210],"candesartan,":[211],"PAF-antagonist":[213],"UR-12670,":[214],"immunosuppressive":[216],"agents":[217],"tacrolimus":[218],"cyclosporin":[220],"A,":[221],"or":[222],"prednisolone":[223],"outcome":[228],"DM.":[235,335],"Injection":[236],"cobalt":[238],"protoporphyrin":[239],"(CoPP)":[240],"intraperitoneally":[241],"order":[243],"induce":[245],"over-expression":[247],"heme":[249],"oxygenase-1":[250],"(HO-1)":[251],"resulted":[252],"a":[254,257,292,315],"trend":[255],"towards":[256],"better":[258],"I/R.":[264],"However,":[265],"induction":[267,326],"HO-1":[269,328],"intraperitoneal":[271],"CoPP":[272,320],"injection":[273],"achieved":[276],"all":[278],"rats,":[279],"when":[280],"examined":[281],"western":[283],"blot.":[284],"In":[285],"conclusion,":[286],"unilateral":[287],"leads":[290],"severe":[293],"Insulin":[299],"ischemia,":[302],"after,":[305],"reduces":[306],"Studies":[313],"using":[314],"more":[316],"reliable":[317],"administration":[318],"are":[321],"required":[322],"decide":[324],"if":[325],"protects":[329],"against":[330]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}