{"id":"https://openalex.org/W575845765","doi":null,"title":"REPAIR OF BIPYRIMIDINE PHOTOPRODUCTS AT TELOMERES OF ULTRAVIOLET LIGHT IRRADIATED MAMMALIAN CELLS","display_name":"REPAIR OF BIPYRIMIDINE PHOTOPRODUCTS AT TELOMERES OF ULTRAVIOLET LIGHT IRRADIATED MAMMALIAN CELLS","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W575845765","mag":"575845765"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:23645","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/23645/1/parikhDP_ETDPitt2014.pdf","pdf_url":"http://d-scholarship.pitt.edu/23645/1/parikhDP_ETDPitt2014.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"University of Pittsburgh ETD"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/23645/1/parikhDP_ETDPitt2014.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091621122","display_name":"Dhvani Parikh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dhvani Parikh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091621122"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01763931,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.03359999880194664,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomeres","display_name":"telomeres","score":0.9509999752044678},{"id":"https://openalex.org/keywords/uv-photoproducts","display_name":"UV photoproducts","score":0.7229999899864197},{"id":"https://openalex.org/keywords/cyclobutane-pyrimidine-dimers","display_name":"cyclobutane pyrimidine dimers","score":0.9750000238418579},{"id":"https://openalex.org/keywords/6-4-photoproducts","display_name":"6-4 photoproducts","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.9959999918937683},{"id":"https://openalex.org/keywords/shelterin-complex","display_name":"shelterin complex","score":0.6380000114440918},{"id":"https://openalex.org/keywords/uv-c-irradiation","display_name":"UV-C irradiation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.8640000224113464},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.6579999923706055},{"id":"https://openalex.org/keywords/telomere-maintenance","display_name":"telomere maintenance","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.7883951663970947},{"id":"https://openalex.org/C167975912","wikidata":"https://www.wikidata.org/wiki/Q1018722","display_name":"Pyrimidine dimer","level":4,"score":0.7123898863792419},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.7082326412200928},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.6627446413040161},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5932385921478271},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.545140266418457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.530457615852356},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5145799517631531},{"id":"https://openalex.org/C2778378917","wikidata":"https://www.wikidata.org/wiki/Q612693","display_name":"Xeroderma pigmentosum","level":4,"score":0.5069999694824219},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5022237300872803},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4919452369213104},{"id":"https://openalex.org/C2776879488","wikidata":"https://www.wikidata.org/wiki/Q3959366","display_name":"Shelterin","level":5,"score":0.4273183047771454},{"id":"https://openalex.org/C2987116853","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet light","level":2,"score":0.4179005026817322},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3614312410354614},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3283403515815735},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3020904064178467},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21305450797080994},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.17966404557228088},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0971708595752716},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:23645","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/23645/1/parikhDP_ETDPitt2014.pdf","pdf_url":"http://d-scholarship.pitt.edu/23645/1/parikhDP_ETDPitt2014.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"University of Pittsburgh ETD"},{"id":"mag:575845765","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/23645/1/parikhDP_ETDPitt2014.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:23645","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/23645/1/parikhDP_ETDPitt2014.pdf","pdf_url":"http://d-scholarship.pitt.edu/23645/1/parikhDP_ETDPitt2014.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"University of Pittsburgh ETD"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320314997","display_name":"Strong","ror":"https://ror.org/041vyzr56"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W575845765.pdf","grobid_xml":"https://content.openalex.org/works/W575845765.grobid-xml"},"referenced_works_count":163,"referenced_works":["https://openalex.org/W166238300","https://openalex.org/W630352753","https://openalex.org/W1215835221","https://openalex.org/W1491876634","https://openalex.org/W1493767608","https://openalex.org/W1531823089","https://openalex.org/W1539294572","https://openalex.org/W1541838847","https://openalex.org/W1556435247","https://openalex.org/W1560193685","https://openalex.org/W1582232835","https://openalex.org/W1588385434","https://openalex.org/W1676646253","https://openalex.org/W1790962026","https://openalex.org/W1809626339","https://openalex.org/W1889725400","https://openalex.org/W1966730729","https://openalex.org/W1970891016","https://openalex.org/W1972973476","https://openalex.org/W1973268287","https://openalex.org/W1974691766","https://openalex.org/W1976385056","https://openalex.org/W1977437036","https://openalex.org/W1977449047","https://openalex.org/W1978916795","https://openalex.org/W1979417055","https://openalex.org/W1979756343","https://openalex.org/W1980614967","https://openalex.org/W1981775109","https://openalex.org/W1982199027","https://openalex.org/W1982232706","https://openalex.org/W1982602899","https://openalex.org/W1984353960","https://openalex.org/W1985877547","https://openalex.org/W1986433324","https://openalex.org/W1988204678","https://openalex.org/W1989208996","https://openalex.org/W1989829234","https://openalex.org/W1990294201","https://openalex.org/W1990423201","https://openalex.org/W1992406114","https://openalex.org/W1997617471","https://openalex.org/W1998000773","https://openalex.org/W1999334180","https://openalex.org/W2000605935","https://openalex.org/W2002957935","https://openalex.org/W2003667713","https://openalex.org/W2003745942","https://openalex.org/W2005289526","https://openalex.org/W2007771316","https://openalex.org/W2012798916","https://openalex.org/W2014013625","https://openalex.org/W2014175835","https://openalex.org/W2014903992","https://openalex.org/W2015725762","https://openalex.org/W2015853472","https://openalex.org/W2015966719","https://openalex.org/W2015967593","https://openalex.org/W2019034413","https://openalex.org/W2019595755","https://openalex.org/W2020449338","https://openalex.org/W2021982887","https://openalex.org/W2024939172","https://openalex.org/W2026506163","https://openalex.org/W2027960166","https://openalex.org/W2030761487","https://openalex.org/W2032407757","https://openalex.org/W2035272991","https://openalex.org/W2037936898","https://openalex.org/W2038060623","https://openalex.org/W2038135691","https://openalex.org/W2038531677","https://openalex.org/W2039543972","https://openalex.org/W2043021712","https://openalex.org/W2044143247","https://openalex.org/W2044427470","https://openalex.org/W2045549538","https://openalex.org/W2045702252","https://openalex.org/W2046082575","https://openalex.org/W2046466087","https://openalex.org/W2050302428","https://openalex.org/W2050783603","https://openalex.org/W2055614863","https://openalex.org/W2055792599","https://openalex.org/W2055955746","https://openalex.org/W2056089116","https://openalex.org/W2057363282","https://openalex.org/W2057953406","https://openalex.org/W2058151233","https://openalex.org/W2058881274","https://openalex.org/W2058981467","https://openalex.org/W2059709996","https://openalex.org/W2060955969","https://openalex.org/W2062150992","https://openalex.org/W2065304067","https://openalex.org/W2070821144","https://openalex.org/W2070918875","https://openalex.org/W2071245356","https://openalex.org/W2072744580","https://openalex.org/W2072908461","https://openalex.org/W2073204556","https://openalex.org/W2073502125","https://openalex.org/W2075168304","https://openalex.org/W2076095338","https://openalex.org/W2077725124","https://openalex.org/W2078390005","https://openalex.org/W2078485114","https://openalex.org/W2078518665","https://openalex.org/W2080726979","https://openalex.org/W2081145376","https://openalex.org/W2082139407","https://openalex.org/W2084369408","https://openalex.org/W2087406053","https://openalex.org/W2089362593","https://openalex.org/W2090566390","https://openalex.org/W2092535084","https://openalex.org/W2095301528","https://openalex.org/W2097657243","https://openalex.org/W2098312065","https://openalex.org/W2105669930","https://openalex.org/W2108482850","https://openalex.org/W2108931268","https://openalex.org/W2109816131","https://openalex.org/W2109961065","https://openalex.org/W2113716833","https://openalex.org/W2115655831","https://openalex.org/W2117692326","https://openalex.org/W2119438437","https://openalex.org/W2122020045","https://openalex.org/W2124139300","https://openalex.org/W2126493139","https://openalex.org/W2126525177","https://openalex.org/W2130218225","https://openalex.org/W2133038385","https://openalex.org/W2133150611","https://openalex.org/W2134390575","https://openalex.org/W2140356389","https://openalex.org/W2141436536","https://openalex.org/W2143989418","https://openalex.org/W2144222655","https://openalex.org/W2147292419","https://openalex.org/W2147765162","https://openalex.org/W2147870309","https://openalex.org/W2150490516","https://openalex.org/W2151075563","https://openalex.org/W2151888603","https://openalex.org/W2158045853","https://openalex.org/W2160306258","https://openalex.org/W2161232591","https://openalex.org/W2161339106","https://openalex.org/W2164011916","https://openalex.org/W2164389045","https://openalex.org/W2164580633","https://openalex.org/W2164903782","https://openalex.org/W2167068573","https://openalex.org/W2167459214","https://openalex.org/W2168184899","https://openalex.org/W2169703790","https://openalex.org/W2170298709","https://openalex.org/W2336047139","https://openalex.org/W2418504295","https://openalex.org/W3148616860","https://openalex.org/W7095856360"],"related_works":["https://openalex.org/W2270952161","https://openalex.org/W7162644013","https://openalex.org/W2946038769","https://openalex.org/W7099689785","https://openalex.org/W2020449338","https://openalex.org/W2415961118","https://openalex.org/W2291222301","https://openalex.org/W2035272991","https://openalex.org/W4206888154","https://openalex.org/W3034084670"],"abstract_inverted_index":{"Telomeres":[0],"at":[1,145,267,278],"chromosome":[2,50,57,146],"ends":[3,147],"promote":[4],"genome":[5],"stability,":[6],"survival,":[7],"and":[8,12,16,26,56,82,95,100,134,148,164,175,183,189,210,240,259,269,284,295,319],"proliferation":[9],"in":[10,18,238,290,297,312],"cells,":[11],"prevent":[13],"degenerative":[14],"diseases":[15,294],"cancer":[17,296],"humans.":[19,298],"Human":[20],"telomeres":[21,44,268,279],"are":[22,62,121,151],"10-15":[23],"kilobases":[24],"long":[25],"consist":[27],"of":[28,74,193,245,261,273,303,315],"about":[29],"1500":[30],"tandem":[31],"TTAGGG":[32],"repeats.":[33],"Six":[34],"telomeric":[35,184,204,211,222,236],"proteins":[36],"form":[37,144],"a":[38,49,124,262],"shelterin":[39],"complex":[40],"that":[41,105,131,227,241],"protects":[42],"the":[43,191,257],"from":[45,186],"being":[46],"recognized":[47],"as":[48],"break,":[51],"thereby":[52],"preventing":[53],"inappropriate":[54],"repair":[55,128,221,265],"fusions.":[58],"Telomeric":[59],"DNA":[60,93,185,237,264],"sequences":[61],"vulnerable":[63],"to":[64,168,235,308],"ultraviolet":[65],"light":[66],"(UV)-induced":[67],"damage.":[68],"UV":[69],"creates":[70],"primarily":[71],"two":[72,214],"types":[73],"photoproducts":[75,84,88,133,142,229],"within":[76],"DNA:":[77],"cyclobutane":[78],"pyrimidine":[79],"dimers":[80],"(CPDs)":[81],"6-4":[83,176,205,223],"(6-4":[85],"PPs).":[86],"Unrepaired":[87],"can":[89,102,110],"stall":[90],"or":[91,97],"block":[92],"replication":[94],"transcription,":[96],"if":[98,141,149],"tolerated":[99],"bypassed,":[101],"introduce":[103],"mutations":[104],"cause":[106],"genomic":[107,114,182],"instability":[108],"which":[109,172],"drive":[111],"carcinogenesis.":[112],"In":[113],"DNA,":[115],"these":[116,187],"potentially":[117],"harmful":[118],"cellular":[119,242],"effects":[120],"avoided":[122],"through":[123],"specialized":[125],"nucleotide":[126],"excision":[127],"(NER)":[129],"pathway":[130,266],"removes":[132],"restores":[135],"normal":[136],"DNA.":[137],"This":[138],"dissertation":[139],"investigated":[140],"also":[143],"they":[150],"repaired":[152,201],"over":[153],"time":[154],"by":[155,207,213],"NER.":[156],"We":[157,179,225],"exposed":[158],"skin":[159],"fibroblasts":[160,188],"BJ-hTERT":[161,199],"(NER":[162,166],"proficient)":[163],"XP-A":[165,217],"deficient)":[167],"10":[169],"J/m2":[170],"UVC":[171,197,243],"induces":[173],"CPD":[174],"PP":[177],"lesions.":[178],"then":[180],"extracted":[181],"measured":[190],"rate":[192],"lesion":[194],"disappearance.":[195],"Post":[196],"exposure,":[198],"cells":[200,218,248],"all":[202],"detectable":[203],"PPs":[206],"six":[208],"hours":[209],"CPDs":[212],"days.":[215],"However,":[216],"did":[219],"not":[220],"PPs.":[224],"observed":[226],"unrepaired":[228,275],"inhibit":[230],"telomere":[231,250,282],"TRF1":[232],"protein":[233],"binding":[234],"vitro,":[239],"irradiation":[244],"NER":[246],"deficient":[247],"causes":[249],"aberrations.":[251],"Our":[252],"novel":[253],"findings":[254],"have":[255],"uncovered":[256],"presence":[258],"importance":[260],"major":[263],"increase":[270],"our":[271,304],"understanding":[272],"how":[274],"bulky":[276],"adducts":[277],"may":[280],"impact":[281],"structure":[283],"function.":[285],"Telomere":[286],"maintenance":[287],"is":[288],"essential":[289],"protection":[291],"against":[292],"age-related":[293],"The":[299],"public":[300],"health":[301],"relevance":[302],"study":[305],"thus,":[306],"relates":[307],"its":[309],"potential":[310],"usefulness":[311],"developing":[313],"biomarkers":[314],"toxicology":[316],"for":[317],"aging":[318],"cancer.":[320]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}