{"id":"https://openalex.org/W575718767","doi":null,"title":"Structural Determinants of T Wave Alternans in Patients with Cardiomyopathy","display_name":"Structural Determinants of T Wave Alternans in Patients with Cardiomyopathy","publication_year":2012,"publication_date":"2012-03-26","ids":{"openalex":"https://openalex.org/W575718767","mag":"575718767"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/32288","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/32288","pdf_url":"https://utoronto.scholaris.ca/bitstreams/be839f6e-2a22-41d0-8638-5a7c8263cd77/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/be839f6e-2a22-41d0-8638-5a7c8263cd77/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047179300","display_name":"Adrian M. Suszko","orcid":"https://orcid.org/0000-0001-8185-1998","observed_orcids":["https://orcid.org/0000-0001-8185-1998"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Adrian M. Suszko","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8185-1998","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5047179300"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-wave-alternans","display_name":"T-wave alternans","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.9449999928474426},{"id":"https://openalex.org/keywords/myocardial-scar","display_name":"myocardial scar","score":0.6520000100135803},{"id":"https://openalex.org/keywords/late-gadolinium-enhancement","display_name":"late gadolinium enhancement","score":0.847000002861023},{"id":"https://openalex.org/keywords/grey-zone","display_name":"gray zone","score":0.6959999799728394},{"id":"https://openalex.org/keywords/action-potential-duration-alternans","display_name":"action potential duration alternans","score":0.7929999828338623},{"id":"https://openalex.org/keywords/ventricular-arrhythmia-risk","display_name":"ventricular arrhythmia risk","score":0.7559999823570251},{"id":"https://openalex.org/keywords/slow-conduction","display_name":"slow conduction","score":0.6830000281333923},{"id":"https://openalex.org/keywords/structural-factors","display_name":"structural factors","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7313320636749268},{"id":"https://openalex.org/C2777325121","wikidata":"https://www.wikidata.org/wiki/Q3613169","display_name":"T wave alternans","level":3,"score":0.7238100171089172},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.7215508818626404},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6816806197166443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6305875778198242},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.4775329828262329},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4132891297340393},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.2938274145126343},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.26701754331588745},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.15081137418746948},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.058202654123306274},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/32288","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/32288","pdf_url":"https://utoronto.scholaris.ca/bitstreams/be839f6e-2a22-41d0-8638-5a7c8263cd77/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/32288","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/32288","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:575718767","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/handle/1807/32288","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/32288","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/32288","pdf_url":"https://utoronto.scholaris.ca/bitstreams/be839f6e-2a22-41d0-8638-5a7c8263cd77/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W575718767.pdf","grobid_xml":"https://content.openalex.org/works/W575718767.grobid-xml"},"referenced_works_count":147,"referenced_works":["https://openalex.org/W84927980","https://openalex.org/W100085122","https://openalex.org/W121250741","https://openalex.org/W125273241","https://openalex.org/W173843559","https://openalex.org/W1260141814","https://openalex.org/W1496355709","https://openalex.org/W1497394495","https://openalex.org/W1503470162","https://openalex.org/W1518428823","https://openalex.org/W1522893165","https://openalex.org/W1539399265","https://openalex.org/W1540934127","https://openalex.org/W1581740802","https://openalex.org/W1747748421","https://openalex.org/W1940548743","https://openalex.org/W1966190213","https://openalex.org/W1967201090","https://openalex.org/W1972327900","https://openalex.org/W1973228369","https://openalex.org/W1974396072","https://openalex.org/W1974691466","https://openalex.org/W1975369649","https://openalex.org/W1975869151","https://openalex.org/W1977653128","https://openalex.org/W1982332647","https://openalex.org/W1982883262","https://openalex.org/W1983374780","https://openalex.org/W1984313043","https://openalex.org/W1985940938","https://openalex.org/W1986565058","https://openalex.org/W1988280325","https://openalex.org/W1993060122","https://openalex.org/W1995033447","https://openalex.org/W1995191313","https://openalex.org/W1996033332","https://openalex.org/W1998474130","https://openalex.org/W1998609175","https://openalex.org/W2000403548","https://openalex.org/W2001256011","https://openalex.org/W2002708087","https://openalex.org/W2003783126","https://openalex.org/W2004659005","https://openalex.org/W2009775227","https://openalex.org/W2015967782","https://openalex.org/W2019723167","https://openalex.org/W2020137045","https://openalex.org/W2020476315","https://openalex.org/W2020827376","https://openalex.org/W2024411973","https://openalex.org/W2024752964","https://openalex.org/W2026037820","https://openalex.org/W2031053544","https://openalex.org/W2033989169","https://openalex.org/W2034786923","https://openalex.org/W2035221711","https://openalex.org/W2035766144","https://openalex.org/W2036469356","https://openalex.org/W2037462241","https://openalex.org/W2038127109","https://openalex.org/W2043261886","https://openalex.org/W2047273318","https://openalex.org/W2047970481","https://openalex.org/W2050824263","https://openalex.org/W2054421446","https://openalex.org/W2058749448","https://openalex.org/W2060551608","https://openalex.org/W2061424979","https://openalex.org/W2062024423","https://openalex.org/W2064826554","https://openalex.org/W2065246793","https://openalex.org/W2065782742","https://openalex.org/W2068799518","https://openalex.org/W2069502665","https://openalex.org/W2070779934","https://openalex.org/W2072142813","https://openalex.org/W2076796644","https://openalex.org/W2076922908","https://openalex.org/W2078083480","https://openalex.org/W2078321501","https://openalex.org/W2088602930","https://openalex.org/W2094886506","https://openalex.org/W2101482473","https://openalex.org/W2101578104","https://openalex.org/W2101634799","https://openalex.org/W2101742222","https://openalex.org/W2102074106","https://openalex.org/W2103502580","https://openalex.org/W2104483699","https://openalex.org/W2111156400","https://openalex.org/W2111174244","https://openalex.org/W2112279366","https://openalex.org/W2112737414","https://openalex.org/W2115156315","https://openalex.org/W2115928923","https://openalex.org/W2116351152","https://openalex.org/W2118251481","https://openalex.org/W2118333950","https://openalex.org/W2120123802","https://openalex.org/W2121450671","https://openalex.org/W2123181530","https://openalex.org/W2125009440","https://openalex.org/W2127854713","https://openalex.org/W2128788602","https://openalex.org/W2131719250","https://openalex.org/W2132453249","https://openalex.org/W2132603512","https://openalex.org/W2135225379","https://openalex.org/W2135236486","https://openalex.org/W2135287006","https://openalex.org/W2136635869","https://openalex.org/W2138879085","https://openalex.org/W2144941539","https://openalex.org/W2145264435","https://openalex.org/W2145470297","https://openalex.org/W2148734617","https://openalex.org/W2150962221","https://openalex.org/W2153563375","https://openalex.org/W2153760572","https://openalex.org/W2156393131","https://openalex.org/W2157449099","https://openalex.org/W2157858793","https://openalex.org/W2158084840","https://openalex.org/W2159267254","https://openalex.org/W2159453909","https://openalex.org/W2161260778","https://openalex.org/W2162273778","https://openalex.org/W2162718501","https://openalex.org/W2162826334","https://openalex.org/W2165669217","https://openalex.org/W2167648211","https://openalex.org/W2167744805","https://openalex.org/W2170785868","https://openalex.org/W2171065134","https://openalex.org/W2171700197","https://openalex.org/W2181139178","https://openalex.org/W2313547185","https://openalex.org/W2325990028","https://openalex.org/W2334859129","https://openalex.org/W2395425468","https://openalex.org/W2404504455","https://openalex.org/W2412136784","https://openalex.org/W2412186912","https://openalex.org/W2425662256","https://openalex.org/W2442822067","https://openalex.org/W2468481754","https://openalex.org/W2474141771"],"related_works":["https://openalex.org/W71636448","https://openalex.org/W2065782742","https://openalex.org/W2121282100","https://openalex.org/W2326710401","https://openalex.org/W7099759403","https://openalex.org/W2938810654","https://openalex.org/W1974824397","https://openalex.org/W2129310800","https://openalex.org/W2329009688","https://openalex.org/W1973387802"],"abstract_inverted_index":{"Structural":[0],"barriers":[1],"can":[2],"promote":[3,36,130],"discordant":[4],"action":[5],"potential":[6],"(AP)":[7],"duration":[8],"alternans,":[9],"T":[10],"wave":[11],"alternans":[12],"(TWA)":[13],"and":[14,19,29,45,52,69,87,100,118],"tachyarrhythmia":[15],"in":[16,38,57,92,122,132,137],"animal":[17],"hearts":[18],"simulation":[20],"studies.":[21],"We":[22],"hypothesized":[23],"that":[24,129],"heterogeneous":[25],"scar":[26,32,112],"(gray":[27],"zone)":[28],"dense":[30],"midwall":[31,88],"(midwall":[33],"core)":[34],"would":[35],"TWA":[37,78,98,121,131],"patients":[39,60,134],"with":[40,97],"cardiomyopathy":[41,59,133],"by":[42],"slowing":[43],"conduction":[44],"uncoupling":[46],"transmural":[47],"APs,":[48],"respectively.":[49],"Scar":[50],"core":[51,86,89],"gray":[53,83],"zone":[54],"were":[55,90],"quantified":[56],"40":[58],"using":[61],"late":[62],"gadolinium":[63],"enhanced":[64],"cardiac":[65],"magnetic":[66],"resonance":[67],"imaging":[68],"related":[70,101],"to":[71,102,115],"the":[72,93,116,127],"results":[73],"of":[74,82,120,126,142],"a":[75,103],"clinically":[76],"validated":[77],"test.":[79],"The":[80],"percentages":[81],"zone,":[84],"epicardial":[85],"greater":[91],"+TWA":[94],"group,":[95],"correlated":[96],"magnitude":[99],"lower":[104],"heart":[105],"rate":[106],"onset":[107],"for":[108],"TWA.":[109],"These":[110],"specific":[111],"patterns":[113],"contribute":[114],"genesis":[117],"severity":[119],"cardiomyopathy.":[123],"Greater":[124],"knowledge":[125],"substrates":[128],"is":[135],"valuable":[136],"determining":[138],"those":[139],"at":[140],"risk":[141],"lethal":[143],"ventricular":[144],"arrhythmias.":[145]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
