{"id":"https://openalex.org/W574635990","doi":null,"title":"Cellular and Viral Factors that Control Human Papillomavirus Type 16 Late Gene Expression","display_name":"Cellular and Viral Factors that Control Human Papillomavirus Type 16 Late Gene Expression","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W574635990","mag":"574635990"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-150706","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150706","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150706","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074206605","display_name":"Monika Somberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Monika Somberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5074206605"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hpv-16","display_name":"HPV16","score":0.9890000224113464},{"id":"https://openalex.org/keywords/late-gene-expression","display_name":"late gene expression","score":0.9760000109672546},{"id":"https://openalex.org/keywords/ptb","display_name":"PTB","score":0.44200000166893005},{"id":"https://openalex.org/keywords/asf-sf2","display_name":"ASF/SF2","score":0.9210000038146973},{"id":"https://openalex.org/keywords/splicing","display_name":"splicing","score":0.527999997138977},{"id":"https://openalex.org/keywords/mrna-splicing","display_name":"mRNA splicing","score":0.6449999809265137},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.777999997138977},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.7429999709129333},{"id":"https://openalex.org/keywords/viral-persistence","display_name":"viral persistence","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cellular-factors","display_name":"cellular factors","score":0.3100000023841858},{"id":"https://openalex.org/keywords/viral-factors","display_name":"viral factors","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.6745945811271667},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6024997234344482},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5997676849365234},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5753282308578491},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5545632839202881},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.5432433485984802},{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.4535263180732727},{"id":"https://openalex.org/C2776270601","wikidata":"https://www.wikidata.org/wiki/Q9055203","display_name":"Papillomaviridae","level":4,"score":0.44877445697784424},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42809727787971497},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39827343821525574},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3781210780143738},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23594549298286438},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15082919597625732},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-150706","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150706","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:574635990","doi":null,"is_oa":false,"landing_page_url":"http://uu.diva-portal.org/smash/get/diva2:410043/FULLTEXT02","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-150706","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150706","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":149,"referenced_works":["https://openalex.org/W155823813","https://openalex.org/W198328352","https://openalex.org/W205169601","https://openalex.org/W1043076208","https://openalex.org/W1493333110","https://openalex.org/W1497009420","https://openalex.org/W1497290886","https://openalex.org/W1533778931","https://openalex.org/W1539426772","https://openalex.org/W1553081734","https://openalex.org/W1573394606","https://openalex.org/W1581360649","https://openalex.org/W1583082810","https://openalex.org/W1589532501","https://openalex.org/W1594645405","https://openalex.org/W1607774948","https://openalex.org/W1744584399","https://openalex.org/W1767781328","https://openalex.org/W1771001171","https://openalex.org/W1790543114","https://openalex.org/W1860866234","https://openalex.org/W1964533726","https://openalex.org/W1965681041","https://openalex.org/W1967618732","https://openalex.org/W1968890221","https://openalex.org/W1969660104","https://openalex.org/W1970108031","https://openalex.org/W1973158635","https://openalex.org/W1973916539","https://openalex.org/W1976335773","https://openalex.org/W1982895273","https://openalex.org/W1984277953","https://openalex.org/W1989050882","https://openalex.org/W1989770493","https://openalex.org/W1990301074","https://openalex.org/W1991948865","https://openalex.org/W1992274603","https://openalex.org/W1994467484","https://openalex.org/W2000596495","https://openalex.org/W2001509514","https://openalex.org/W2001913935","https://openalex.org/W2007401297","https://openalex.org/W2008540641","https://openalex.org/W2010852376","https://openalex.org/W2013043484","https://openalex.org/W2016775797","https://openalex.org/W2018305417","https://openalex.org/W2020797020","https://openalex.org/W2022234493","https://openalex.org/W2023018590","https://openalex.org/W2023814357","https://openalex.org/W2025823298","https://openalex.org/W2026008221","https://openalex.org/W2026923004","https://openalex.org/W2027465253","https://openalex.org/W2029242514","https://openalex.org/W2030849945","https://openalex.org/W2031061513","https://openalex.org/W2032928525","https://openalex.org/W2035637932","https://openalex.org/W2038424676","https://openalex.org/W2038500217","https://openalex.org/W2038739727","https://openalex.org/W2041569598","https://openalex.org/W2043276968","https://openalex.org/W2045300068","https://openalex.org/W2045324963","https://openalex.org/W2046002852","https://openalex.org/W2049128875","https://openalex.org/W2052931181","https://openalex.org/W2056172118","https://openalex.org/W2057479447","https://openalex.org/W2061845887","https://openalex.org/W2062155770","https://openalex.org/W2063225252","https://openalex.org/W2063318299","https://openalex.org/W2063894948","https://openalex.org/W2064128877","https://openalex.org/W2065010457","https://openalex.org/W2065156784","https://openalex.org/W2065200151","https://openalex.org/W2065845640","https://openalex.org/W2068164803","https://openalex.org/W2070877870","https://openalex.org/W2073013784","https://openalex.org/W2073417582","https://openalex.org/W2075128563","https://openalex.org/W2075440912","https://openalex.org/W2075873712","https://openalex.org/W2076212147","https://openalex.org/W2076849957","https://openalex.org/W2076926089","https://openalex.org/W2077689651","https://openalex.org/W2080469626","https://openalex.org/W2082491111","https://openalex.org/W2086141003","https://openalex.org/W2086480947","https://openalex.org/W2087646866","https://openalex.org/W2090332314","https://openalex.org/W2092129813","https://openalex.org/W2092512684","https://openalex.org/W2096179259","https://openalex.org/W2096519399","https://openalex.org/W2098765233","https://openalex.org/W2100013052","https://openalex.org/W2100448174","https://openalex.org/W2101636442","https://openalex.org/W2101679570","https://openalex.org/W2102838147","https://openalex.org/W2103402872","https://openalex.org/W2103479918","https://openalex.org/W2107541219","https://openalex.org/W2107944906","https://openalex.org/W2108491241","https://openalex.org/W2108978314","https://openalex.org/W2109892705","https://openalex.org/W2111465790","https://openalex.org/W2112859230","https://openalex.org/W2113112766","https://openalex.org/W2114168715","https://openalex.org/W2114423503","https://openalex.org/W2116117084","https://openalex.org/W2116529873","https://openalex.org/W2117869477","https://openalex.org/W2117976997","https://openalex.org/W2120491114","https://openalex.org/W2121966590","https://openalex.org/W2123853921","https://openalex.org/W2125304732","https://openalex.org/W2127262509","https://openalex.org/W2127352755","https://openalex.org/W2128377619","https://openalex.org/W2131604495","https://openalex.org/W2132733539","https://openalex.org/W2135466312","https://openalex.org/W2136856855","https://openalex.org/W2138004014","https://openalex.org/W2138027990","https://openalex.org/W2138647063","https://openalex.org/W2144333644","https://openalex.org/W2150710841","https://openalex.org/W2153558905","https://openalex.org/W2154700546","https://openalex.org/W2155001271","https://openalex.org/W2158433767","https://openalex.org/W2159308373","https://openalex.org/W2170935295","https://openalex.org/W2170939558","https://openalex.org/W2413732202"],"related_works":["https://openalex.org/W616425446","https://openalex.org/W6741731","https://openalex.org/W1795687754","https://openalex.org/W1992164722","https://openalex.org/W1996071594","https://openalex.org/W576873450","https://openalex.org/W2019574419","https://openalex.org/W98403301","https://openalex.org/W2759861127","https://openalex.org/W2975615859"],"abstract_inverted_index":{"Human":[0],"papillomavirus":[1,59],"type":[2],"16":[3],"(HPV-16)":[4],"is":[5,21,34,65,93,119,276],"the":[6,37,40,47,75,78,136,141,147,194,217,226,246,251,270],"major":[7],"cause":[8],"of":[9,16,26,49,67,77,108,124,149,151,196,203,211,239,268,272],"cervical":[10,31,61],"cancer.":[11,32,171],"We":[12,172],"speculate":[13],"that":[14,39,134,167,186],"inhibition":[15],"HPV-16":[17,73,89,197,247,257,273],"late":[18,41,90,116,142,198,213,274],"gene":[19,91,117,199,258],"expression":[20,92,118,271],"a":[22,265],"prerequisite":[23],"for":[24],"establishment":[25],"persistence":[27],"and":[28,53,82,131,144,179,181,223,229,241,253],"progression":[29],"to":[30,70,112,128,138,145,158,170,264],"This":[33,154],"based":[35],"on":[36,140],"findings":[38,261],"proteins":[42,80,235],"are":[43,54],"found":[44,173],"only":[45],"in":[46,57,84,187,193,256],"nuclei":[48],"terminally":[50],"differentiated":[51],"epithelium,":[52],"never":[55],"detected":[56],"human":[58],"infected":[60,86],"cancer":[62,87],"cells.":[63],"It":[64],"therefore":[66],"great":[68],"importance":[69],"understand":[71,113,159],"how":[72,114,269],"controls":[74],"onset":[76],"immunogenic":[79],"L1":[81,228],"L2":[83],"an":[85],"cell.":[88],"tightly":[94],"regulated":[95],"by":[96,102],"differentiation-dependent":[97],"transcription":[98],"as":[99,101],"well":[100],"post-transcriptional":[103],"mechanisms.":[104],"The":[105,121,233],"long-term":[106],"goal":[107],"these":[109,152],"studies":[110],"was":[111,127],"HPV":[115,163],"regulated.":[120],"specific":[122],"aim":[123],"this":[125],"thesis":[126],"identify":[129],"cellular":[130,175],"viral":[132,183],"factors":[133],"force":[135],"virus":[137],"switch":[139],"genes,":[143],"determine":[146],"mechanism":[148],"action":[150,240],"factors.":[153],"will":[155],"help":[156],"us":[157],"under":[160],"which":[161,249],"circumstances":[162],"establish":[164],"persistent":[165],"infections":[166],"could":[168],"progress":[169],"three":[174,234],"factors;":[176],"PTB,":[177,204],"ASF/SF2":[178],"SRp30c,":[180],"one":[182],"factor;":[184],"AdE4orf4,":[185],"four":[188],"distinctive":[189],"ways":[190],"were":[191],"involved":[192],"regulation":[195],"expression.":[200],"Interestingly,":[201],"over-expression":[202],"AdE4orf4":[205,222],"or":[206],"SRp30c":[207,224],"produced":[208],"different":[209,237,242],"types":[210],"spliced":[212,227],"mRNAs.":[214],"PTB":[215],"induced":[216,225],"unspliced":[218],"L2/L1":[219],"mRNA,":[220,231],"while":[221],"L1i":[230],"respectively.":[232],"had":[236],"mechanisms":[238],"target":[243],"sites":[244],"within":[245],"genome,":[248],"revealed":[250],"many":[252],"complex":[254],"pathways":[255],"regulation.":[259],"These":[260],"have":[262],"contributed":[263],"broader":[266],"understanding":[267],"genes":[275],"controlled.":[277]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
