{"id":"https://openalex.org/W573580590","doi":null,"title":"Cloning and characterization of an Eph receptor and its ligand ephrin in the developing primary olfactory pathway of the moth Manduca sexta","display_name":"Cloning and characterization of an Eph receptor and its ligand ephrin in the developing primary olfactory pathway of the moth Manduca sexta","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W573580590","mag":"573580590"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/280361","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/280361","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation-Reproduction (electronic)"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058096548","display_name":"Megumi Kaneko","orcid":"https://orcid.org/0000-0002-6389-5839","observed_orcids":["https://orcid.org/0000-0002-6389-5839"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Megumi Kaneko","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6389-5839","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058096548"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eph-receptors","display_name":"Eph receptors","score":0.8330000042915344},{"id":"https://openalex.org/keywords/ephrins","display_name":"ephrins","score":0.9319999814033508},{"id":"https://openalex.org/keywords/eph-ephrin-signaling","display_name":"Eph/ephrin signaling","score":0.8640000224113464},{"id":"https://openalex.org/keywords/olfactory-receptor-neurons","display_name":"olfactory sensory neurons","score":0.7350000143051147},{"id":"https://openalex.org/keywords/axon-guidance","display_name":"axon guidance","score":0.7319999933242798},{"id":"https://openalex.org/keywords/axon-sorting","display_name":"axon sorting","score":0.7910000085830688},{"id":"https://openalex.org/keywords/antennal-lobe","display_name":"antennal lobe","score":0.8730000257492065},{"id":"https://openalex.org/keywords/glomerulus","display_name":"glomeruli","score":0.7570000290870667},{"id":"https://openalex.org/keywords/fasciclin-ii","display_name":"Fasciclin II","score":0.9649999737739563},{"id":"https://openalex.org/keywords/neurite-outgrowth-inhibition","display_name":"neurite outgrowth inhibition","score":0.753000020980835},{"id":"https://openalex.org/keywords/manduca-sexta","display_name":"Manduca sexta","score":0.8579999804496765},{"id":"https://openalex.org/keywords/insect-olfaction","display_name":"insect olfaction","score":0.6890000104904175},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-signaling","display_name":"receptor tyrosine kinase signaling","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2780312687","wikidata":"https://www.wikidata.org/wiki/Q1366539","display_name":"Manduca sexta","level":3,"score":0.8588017821311951},{"id":"https://openalex.org/C19331615","wikidata":"https://www.wikidata.org/wiki/Q423602","display_name":"Erythropoietin-producing hepatocellular (Eph) receptor","level":4,"score":0.6183630228042603},{"id":"https://openalex.org/C121050878","wikidata":"https://www.wikidata.org/wiki/Q5135020","display_name":"Cloning (programming)","level":2,"score":0.5161624550819397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4919879138469696},{"id":"https://openalex.org/C2779980732","wikidata":"https://www.wikidata.org/wiki/Q24774756","display_name":"Olfactory receptor","level":3,"score":0.4352509081363678},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38291069865226746},{"id":"https://openalex.org/C201792869","wikidata":"https://www.wikidata.org/wiki/Q1054094","display_name":"Olfactory system","level":2,"score":0.3670407235622406},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3388039767742157},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33777928352355957},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2995358109474182},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.180658221244812},{"id":"https://openalex.org/C2777612826","wikidata":"https://www.wikidata.org/wiki/Q1390","display_name":"Insect","level":2,"score":0.17034244537353516},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07385659217834473},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/280361","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/280361","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation-Reproduction (electronic)"},{"id":"mag:573580590","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/handle/10150/280361","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":257,"referenced_works":["https://openalex.org/W7846284","https://openalex.org/W1172571241","https://openalex.org/W1500005691","https://openalex.org/W1516209325","https://openalex.org/W1524612873","https://openalex.org/W1550298976","https://openalex.org/W1557599121","https://openalex.org/W1559752086","https://openalex.org/W1563223888","https://openalex.org/W1564577788","https://openalex.org/W1572738986","https://openalex.org/W1575310353","https://openalex.org/W1585228727","https://openalex.org/W1585587409","https://openalex.org/W1594867935","https://openalex.org/W1605009719","https://openalex.org/W1622452015","https://openalex.org/W1673346837","https://openalex.org/W1674744817","https://openalex.org/W1740677000","https://openalex.org/W1819949295","https://openalex.org/W1839617277","https://openalex.org/W1850700774","https://openalex.org/W1875292783","https://openalex.org/W1878215242","https://openalex.org/W1890363957","https://openalex.org/W1913092726","https://openalex.org/W1946674388","https://openalex.org/W1964963678","https://openalex.org/W1965537228","https://openalex.org/W1965680643","https://openalex.org/W1965943283","https://openalex.org/W1966529319","https://openalex.org/W1967372779","https://openalex.org/W1967949471","https://openalex.org/W1968824667","https://openalex.org/W1970256374","https://openalex.org/W1970602904","https://openalex.org/W1970684598","https://openalex.org/W1971783543","https://openalex.org/W1972201383","https://openalex.org/W1973629131","https://openalex.org/W1974326501","https://openalex.org/W1974539788","https://openalex.org/W1974905424","https://openalex.org/W1976053867","https://openalex.org/W1976488367","https://openalex.org/W1977413405","https://openalex.org/W1977455576","https://openalex.org/W1977922844","https://openalex.org/W1978936588","https://openalex.org/W1979365412","https://openalex.org/W1980094138","https://openalex.org/W1980131619","https://openalex.org/W1981090500","https://openalex.org/W1982024326","https://openalex.org/W1982326391","https://openalex.org/W1982368729","https://openalex.org/W1983075472","https://openalex.org/W1983134628","https://openalex.org/W1984121486","https://openalex.org/W1985698109","https://openalex.org/W1986297593","https://openalex.org/W1986778708","https://openalex.org/W1987452519","https://openalex.org/W1988594478","https://openalex.org/W1991344540","https://openalex.org/W1992709523","https://openalex.org/W1992994620","https://openalex.org/W1993822264","https://openalex.org/W1994472142","https://openalex.org/W1995691453","https://openalex.org/W1996439275","https://openalex.org/W1996617320","https://openalex.org/W1997946018","https://openalex.org/W1998311697","https://openalex.org/W1998312044","https://openalex.org/W1999966549","https://openalex.org/W2000814069","https://openalex.org/W2001994631","https://openalex.org/W2004026630","https://openalex.org/W2004766332","https://openalex.org/W2004827507","https://openalex.org/W2004997535","https://openalex.org/W2005791282","https://openalex.org/W2007209883","https://openalex.org/W2007320153","https://openalex.org/W2008118471","https://openalex.org/W2008506955","https://openalex.org/W2009278618","https://openalex.org/W2010605441","https://openalex.org/W2012468813","https://openalex.org/W2013969835","https://openalex.org/W2014260701","https://openalex.org/W2014699405","https://openalex.org/W2014705520","https://openalex.org/W2016256500","https://openalex.org/W2016366860","https://openalex.org/W2016550440","https://openalex.org/W2017519742","https://openalex.org/W2017923612","https://openalex.org/W2017973929","https://openalex.org/W2018345068","https://openalex.org/W2021025315","https://openalex.org/W2021182179","https://openalex.org/W2022790467","https://openalex.org/W2023400159","https://openalex.org/W2023479786","https://openalex.org/W2024525681","https://openalex.org/W2024796527","https://openalex.org/W2025444657","https://openalex.org/W2028163567","https://openalex.org/W2028587304","https://openalex.org/W2028920013","https://openalex.org/W2029441863","https://openalex.org/W2030696262","https://openalex.org/W2032082827","https://openalex.org/W2032085080","https://openalex.org/W2033430552","https://openalex.org/W2033508386","https://openalex.org/W2034064964","https://openalex.org/W2034911186","https://openalex.org/W2035815744","https://openalex.org/W2036950925","https://openalex.org/W2037301662","https://openalex.org/W2037367102","https://openalex.org/W2037641677","https://openalex.org/W2038786943","https://openalex.org/W2038894508","https://openalex.org/W2039569931","https://openalex.org/W2042482088","https://openalex.org/W2042495612","https://openalex.org/W2042524484","https://openalex.org/W2043007476","https://openalex.org/W2043562994","https://openalex.org/W2043672666","https://openalex.org/W2044751105","https://openalex.org/W2048189081","https://openalex.org/W2048228486","https://openalex.org/W2051392943","https://openalex.org/W2051949367","https://openalex.org/W2052065200","https://openalex.org/W2055729953","https://openalex.org/W2056689831","https://openalex.org/W2057258868","https://openalex.org/W2059132747","https://openalex.org/W2060063624","https://openalex.org/W2060943078","https://openalex.org/W2061647766","https://openalex.org/W2061824022","https://openalex.org/W2062758517","https://openalex.org/W2063468575","https://openalex.org/W2063759377","https://openalex.org/W2064215369","https://openalex.org/W2064963621","https://openalex.org/W2066422154","https://openalex.org/W2067495948","https://openalex.org/W2069186336","https://openalex.org/W2069853795","https://openalex.org/W2070462593","https://openalex.org/W2070493820","https://openalex.org/W2072877773","https://openalex.org/W2073428493","https://openalex.org/W2074345277","https://openalex.org/W2074349002","https://openalex.org/W2074523510","https://openalex.org/W2075269673","https://openalex.org/W2076202639","https://openalex.org/W2076450755","https://openalex.org/W2077525498","https://openalex.org/W2079262407","https://openalex.org/W2079346946","https://openalex.org/W2079898410","https://openalex.org/W2081656219","https://openalex.org/W2082144494","https://openalex.org/W2082494746","https://openalex.org/W2082581761","https://openalex.org/W2085532366","https://openalex.org/W2088023367","https://openalex.org/W2089598622","https://openalex.org/W2090505541","https://openalex.org/W2091334133","https://openalex.org/W2091869845","https://openalex.org/W2092845948","https://openalex.org/W2093264945","https://openalex.org/W2093436655","https://openalex.org/W2093467487","https://openalex.org/W2093982711","https://openalex.org/W2094001496","https://openalex.org/W2096791952","https://openalex.org/W2097186487","https://openalex.org/W2099879944","https://openalex.org/W2100403768","https://openalex.org/W2100852823","https://openalex.org/W2101168877","https://openalex.org/W2101846435","https://openalex.org/W2102270872","https://openalex.org/W2105006060","https://openalex.org/W2106264684","https://openalex.org/W2106882534","https://openalex.org/W2107356967","https://openalex.org/W2107358115","https://openalex.org/W2107447583","https://openalex.org/W2108613636","https://openalex.org/W2109191553","https://openalex.org/W2115654943","https://openalex.org/W2116564217","https://openalex.org/W2116908394","https://openalex.org/W2120558693","https://openalex.org/W2120613121","https://openalex.org/W2121952955","https://openalex.org/W2122121550","https://openalex.org/W2122587655","https://openalex.org/W2124248841","https://openalex.org/W2125156606","https://openalex.org/W2126402843","https://openalex.org/W2130039540","https://openalex.org/W2130652863","https://openalex.org/W2133125799","https://openalex.org/W2133889652","https://openalex.org/W2138505246","https://openalex.org/W2141652419","https://openalex.org/W2142190178","https://openalex.org/W2143727542","https://openalex.org/W2143730384","https://openalex.org/W2144997267","https://openalex.org/W2146597600","https://openalex.org/W2148013477","https://openalex.org/W2151582772","https://openalex.org/W2155008209","https://openalex.org/W2155048209","https://openalex.org/W2155207257","https://openalex.org/W2155742892","https://openalex.org/W2156800219","https://openalex.org/W2157313061","https://openalex.org/W2157726561","https://openalex.org/W2159792869","https://openalex.org/W2160089953","https://openalex.org/W2163181687","https://openalex.org/W2163197205","https://openalex.org/W2166699767","https://openalex.org/W2167768159","https://openalex.org/W2168344733","https://openalex.org/W2169499901","https://openalex.org/W2170145245","https://openalex.org/W2170467038","https://openalex.org/W2170562570","https://openalex.org/W2171263596","https://openalex.org/W2180005201","https://openalex.org/W2183259168","https://openalex.org/W2184257663","https://openalex.org/W2185351394","https://openalex.org/W2238664430","https://openalex.org/W2336005198","https://openalex.org/W2395259830","https://openalex.org/W2414774643","https://openalex.org/W2416726847"],"related_works":["https://openalex.org/W2150221516","https://openalex.org/W7095267807","https://openalex.org/W2131937304","https://openalex.org/W2084041227","https://openalex.org/W2079346946","https://openalex.org/W2148116878","https://openalex.org/W7005683163","https://openalex.org/W2155742892","https://openalex.org/W2163197205","https://openalex.org/W2039375647"],"abstract_inverted_index":{"This":[0],"dissertation":[1],"investigates":[2],"possible":[3],"roles":[4],"of":[5,30,76,138,144,172,254,266,316,324],"the":[6,17,23,31,73,99,103,154,173,185,201,207,220,322],"Eph":[7,32,45,83,107,163,295],"family":[8],"receptor":[9,33,91,122],"tyrosine":[10],"kinases":[11],"and":[12,35,46,49,78,85,109,128,178,243,270,297,303,326],"their":[13,96],"ligand":[14,37,57,126],"ephrins":[15,86,110,166],"in":[16,22,66,169,184,195,223,241,244,284,313],"developing":[18],"primary":[19,100],"olfactory":[20,90,191],"pathway":[21],"moth":[24],"Manduca":[25,28],"sexta.":[26],"The":[27],"homologs":[29],"(MsEph)":[34],"ephrin":[36],"(MsEphrin)":[38],"are":[39,87,111,167,282],"most":[40],"closely":[41],"related":[42],"to":[43,72,98],"Drosophila":[44],"ephrin,":[47],"respectively,":[48],"biochemical":[50],"assays":[51],"establishes":[52],"MsEphrin":[53,79,179,210,228],"as":[54,231],"a":[55,132,273,285,309],"functional":[56],"for":[58,235,268],"MsEph.":[59],"In":[60,160,175],"situ":[61,242],"labeling":[62,265],"with":[63,120,212,289,300],"Fc-fusion":[64],"probes":[65],"which":[67,314],"IgG":[68],"Fc":[69],"was":[70],"linked":[71],"extracellular":[74],"domain":[75],"MsEph":[77,177],"reveals":[80,278],"that":[81,118,227,249,279],"both":[82],"receptors":[84,108,164,296],"expressed":[88],"on":[89,136,200,239],"cell":[92,275],"(ORC)":[93],"axons":[94,140,152,256,259,318],"during":[95],"ingrowth":[97],"brain":[101],"center,":[102],"antennal":[104],"lobe":[105],"(AL).":[106],"differentially":[112],"distributed":[113,283],"among":[114],"identifiable":[115],"glomeruli":[116,119,281],"such":[117],"high":[121],"staining":[123,127],"show":[124],"little":[125],"vice":[129],"versa,":[130],"indicating":[131],"complementary":[133],"Eph/ephrin":[134,269],"expression":[135,147],"subsets":[137],"ORC":[139,151,236,317],"innervating":[141],"particular":[142],"set":[143],"glomeruli.":[145,293],"Their":[146],"appears":[148],"upregulated":[149],"once":[150],"reach":[153],"region":[155],"where":[156],"axon":[157],"sorting":[158,315],"occurs.":[159],"contrast,":[161],"neither":[162],"nor":[165],"detectable":[168],"intrinsic":[170],"components":[171],"AL.":[174],"vitro,":[176],"proteins,":[180,211],"when":[181],"present":[182],"homogeneously":[183],"substratum,":[186],"inhibit":[187],"neurite":[188],"outgrowth":[189],"from":[190,257],"epithelial":[192],"explants.":[193],"Moreover,":[194],"patterned":[196],"substrata,":[197],"neurites":[198],"growing":[199],"standard":[202],"substratum":[203,208],"avoid":[204],"extending":[205],"onto":[206],"containing":[209],"behaviors":[213],"characterized":[214],"by":[215,321],"turning":[216],"or":[217,291],"stopping":[218],"at":[219],"border.":[221],"These":[222],"vitro":[224,245],"observations":[225],"indicate":[226],"can":[229],"act":[230],"an":[232],"inhibitory/repulsive":[233],"cue":[234],"axons.":[237],"Based":[238],"these":[240],"results,":[246],"I":[247],"hypothesize":[248],"Eph-ephrin":[250],"signaling":[251],"mediates":[252],"segregation":[253],"Eph-positive":[255],"ephrin-positive":[258,292],"through":[260],"repulsive":[261,327],"inter-axonal":[262],"interactions.":[263],"Simultaneous":[264],"ALs":[267],"fasciclin":[271,301],"II,":[272],"homophilic":[274],"adhesion":[276],"molecule,":[277],"fasciclin-positive":[280],"partially":[286],"overlapping":[287],"pattern":[288],"Eph-":[290],"Thus,":[294],"ephrins,":[298],"together":[299],"II":[302],"other":[304],"adhesive/repulsive":[305],"cues,":[306],"might":[307],"constitute":[308],"combinatorial":[310],"molecular":[311],"system":[312],"is":[319],"determined":[320],"balance":[323],"adhesive":[325],"forces.":[328]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}