{"id":"https://openalex.org/W57299431","doi":null,"title":"Cellular and Biochemical Effects of Sparstolonin B on Endothelial Cells to Inhibit Angiogenesis","display_name":"Cellular and Biochemical Effects of Sparstolonin B on Endothelial Cells to Inhibit Angiogenesis","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W57299431","mag":"57299431"},"language":"en","primary_location":{"id":"pmh:oai:scholarcommons.sc.edu:etd-3581","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.sc.edu/etd/2654","pdf_url":"https://scholarcommons.sc.edu/etd/2654","source":{"id":"https://openalex.org/S4306401386","display_name":"Scholar Commons (University of South Carolina)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155781252","host_organization_name":"University of South Carolina","host_organization_lineage":["https://openalex.org/I155781252"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarcommons.sc.edu/etd/2654","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108822380","display_name":"Marwa Belhaj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marwa Belhaj","raw_affiliation_strings":["University of South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Carolina","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108822380"],"corresponding_institution_ids":["https://openalex.org/I155781252"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00217804,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.8379999995231628},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9169999957084656},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/sparganium-stoloniferum","display_name":"Sparganium stoloniferum","score":0.9570000171661377},{"id":"https://openalex.org/keywords/stress-fibers","display_name":"stress fibers","score":0.8519999980926514},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.7419999837875366},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.8920000195503235},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":1.0},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8652366399765015},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.557369589805603},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5414907932281494},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.42756664752960205},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4258747696876526},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.41934558749198914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.403866708278656},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3681938350200653},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3590651750564575},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23777100443840027},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22767269611358643},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15565600991249084}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarcommons.sc.edu:etd-3581","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.sc.edu/etd/2654","pdf_url":"https://scholarcommons.sc.edu/etd/2654","source":{"id":"https://openalex.org/S4306401386","display_name":"Scholar Commons (University of South Carolina)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155781252","host_organization_name":"University of South Carolina","host_organization_lineage":["https://openalex.org/I155781252"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},{"id":"mag:57299431","doi":null,"is_oa":false,"landing_page_url":"https://scholarcommons.sc.edu/cgi/viewcontent.cgi?article=3581&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarcommons.sc.edu:etd-3581","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.sc.edu/etd/2654","pdf_url":"https://scholarcommons.sc.edu/etd/2654","source":{"id":"https://openalex.org/S4306401386","display_name":"Scholar Commons (University of South Carolina)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155781252","host_organization_name":"University of South Carolina","host_organization_lineage":["https://openalex.org/I155781252"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W57299431.pdf","grobid_xml":"https://content.openalex.org/works/W57299431.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W36000590","https://openalex.org/W1508246267","https://openalex.org/W1535151445","https://openalex.org/W1861708461","https://openalex.org/W1967151184","https://openalex.org/W1968903249","https://openalex.org/W1979733618","https://openalex.org/W1985569332","https://openalex.org/W1994360534","https://openalex.org/W1994936239","https://openalex.org/W1995827857","https://openalex.org/W1996016298","https://openalex.org/W2000292756","https://openalex.org/W2005093123","https://openalex.org/W2007035508","https://openalex.org/W2017763556","https://openalex.org/W2019219781","https://openalex.org/W2028046357","https://openalex.org/W2030816211","https://openalex.org/W2043630178","https://openalex.org/W2054114044","https://openalex.org/W2055599116","https://openalex.org/W2058037557","https://openalex.org/W2065470651","https://openalex.org/W2068576343","https://openalex.org/W2069795464","https://openalex.org/W2078683567","https://openalex.org/W2086329688","https://openalex.org/W2090376073","https://openalex.org/W2093855538","https://openalex.org/W2094330253","https://openalex.org/W2096487429","https://openalex.org/W2108244474","https://openalex.org/W2110401218","https://openalex.org/W2112430693","https://openalex.org/W2112911107","https://openalex.org/W2116999983","https://openalex.org/W2117413404","https://openalex.org/W2121822802","https://openalex.org/W2133858220","https://openalex.org/W2137825287","https://openalex.org/W2143516276","https://openalex.org/W2150465569","https://openalex.org/W2151492748","https://openalex.org/W2163902815","https://openalex.org/W2165913277","https://openalex.org/W2322523258"],"related_works":["https://openalex.org/W572914991","https://openalex.org/W2019219781","https://openalex.org/W1980727947","https://openalex.org/W2031789504","https://openalex.org/W183372158","https://openalex.org/W2615491366","https://openalex.org/W3127970995","https://openalex.org/W2010237215","https://openalex.org/W2134354061","https://openalex.org/W2125792588"],"abstract_inverted_index":{"Angiogenesis":[0,33],"is":[1,55],"the":[2,20,44,72,82,94,109,147,176,212],"process":[3],"of":[4,22,46,84,97,111,135,187,196,202],"new":[5],"blood":[6],"vessel":[7],"development":[8],"by":[9,216],"endothelial":[10,115,123,197],"cells":[11,116],"from":[12,61],"pre-existing":[13],"vasculature;":[14],"however,":[15],"abnormal":[16],"angiogenesis":[17],"contributes":[18,37],"to":[19,38,166,185],"pathogenesis":[21],"many":[23],"disorders":[24],"such":[25],"as":[26,77],"cardiovascular":[27],"diseases,":[28],"cancer,":[29],"and":[30,41,49,132,179,200],"chronic":[31],"inflammation.":[32],"in":[34,71,99,108,141,145,164,183,211],"atherosclerotic":[35],"plaques":[36],"their":[39],"instability":[40],"therefore":[42],"increases":[43],"risk":[45],"plaque":[47],"rupture":[48],"thrombus":[50],"formation.":[51],"Sparstolonin":[52],"B":[53],"(SsnB)":[54],"a":[56,142,209],"novel":[57],"bioactive":[58],"compound":[59],"isolated":[60],"Sparganium":[62],"stoloniferum,":[63],"an":[64,78],"herb":[65],"that":[66,173,194],"has":[67],"been":[68],"used":[69],"historically":[70],"Chinese":[73],"herbal":[74,79],"medicine":[75],"\"SanLeng\"":[76],"remedy":[80],"for":[81],"treatment":[83],"several":[85],"inflammatory":[86],"diseases.":[87],"In":[88,101,154],"this":[89],"study,":[90],"we":[91,156],"have":[92,157],"explored":[93],"anti-angiogenic":[95,213],"properties":[96],"SsnB":[98,104,121,174],"vitro.":[100],"cell":[102,124,129,198],"culture,":[103],"induced":[105,122,215],"rapid":[106],"changes":[107],"morphology":[110,199],"human":[112],"umbilical":[113],"vein":[114],"(HUVECs).":[117],"After":[118],"6":[119],"hours,":[120],"actin":[125],"stress":[126],"fibers,":[127],"increased":[128],"perimeter/area":[130],"ratio,":[131],"enhanced":[133],"formation":[134],"focal":[136],"adhesions.":[137],"These":[138,191],"effects":[139,214],"occurred":[140,182],"dose-dependent":[143],"manner":[144],"which":[146,181],"maximum":[148],"effect":[149],"was":[150],"at":[151],"100\uf06dM":[152],"SsnB.":[153,169,217],"addition,":[155],"also":[158],"analyzed":[159],"early":[160,203],"response":[161,165,184,204],"gene":[162],"expression":[163],"100":[167],"\uf06dM":[168],"Our":[170],"data":[171],"show":[172],"blocked":[175],"up-regulation":[177],"c-Myc":[178],"c-Fos,":[180],"addition":[186],"vehicle":[188],"control":[189],"(DMSO).":[190],"results":[192],"imply":[193],"alteration":[195],"change":[201],"genes":[205],"regulation":[206],"may":[207],"play":[208],"role":[210]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}