{"id":"https://openalex.org/W572598855","doi":null,"title":"Disseny, s\u00edntesi, avaluaci\u00f3 farmacol\u00f2gica i modelatge molecular de nous inhibidors de l\u2019acetilcolinesterasa de lloc d\u2019uni\u00f3 dual","display_name":"Disseny, s\u00edntesi, avaluaci\u00f3 farmacol\u00f2gica i modelatge molecular de nous inhibidors de l\u2019acetilcolinesterasa de lloc d\u2019uni\u00f3 dual","publication_year":2012,"publication_date":"2012-05-04","ids":{"openalex":"https://openalex.org/W572598855","mag":"572598855"},"language":"ca","primary_location":{"id":"pmh:oai:dnet:tdr_________::5518712a4f75d8f9d96e062f815bf7fd","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/81071","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2445/34845","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016337207","display_name":"Carlos Galdeano Cantador","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Carlos Galdeano Cantador","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016337207"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibitors","display_name":"acetylcholinesterase inhibitors","score":0.9079999923706055},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7749999761581421},{"id":"https://openalex.org/keywords/amyloid-beta-aggregation","display_name":"amyloid-beta aggregation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/catalytic-site","display_name":"catalytic site","score":0.8349999785423279},{"id":"https://openalex.org/keywords/butyrylcholinesterase","display_name":"butyrylcholinesterase","score":0.8600000143051147},{"id":"https://openalex.org/keywords/prion-peptide","display_name":"prion peptide","score":0.4650000035762787},{"id":"https://openalex.org/keywords/molecular-modeling","display_name":"molecular modeling","score":0.4230000078678131},{"id":"https://openalex.org/keywords/hybrid-inhibitors","display_name":"hybrid inhibitors","score":0.38600000739097595},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.5540000200271606},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5550000071525574},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.4359999895095825},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.5139999985694885},{"id":"https://openalex.org/keywords/molecular-dynamics-free-energy-calculation","display_name":"molecular dynamics free energy calculation","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.6980326175689697},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.5383027791976929},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.46439793705940247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34964486956596375},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3425552248954773},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28655359148979187},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dnet:tdr_________::5518712a4f75d8f9d96e062f815bf7fd","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/81071","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/81071","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/81071","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:diposit.ub.edu:2445/34845","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/81071","pdf_url":"http://hdl.handle.net/2445/34845","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tesis Doctorals - Departament - Farmacologia i Qu\u00edmica Terap\u00e8utica","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:572598855","doi":null,"is_oa":false,"landing_page_url":"http://diposit.ub.edu/dspace/bitstream/2445/34845/2/CGC_TESI.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:diposit.ub.edu:2445/34845","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/81071","pdf_url":"http://hdl.handle.net/2445/34845","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tesis Doctorals - Departament - Farmacologia i Qu\u00edmica Terap\u00e8utica","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G171757370","display_name":"Bio-Inspired Self-assembled Nano-Enabled Surfaces","funder_award_id":"214538","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1894583210","display_name":null,"funder_award_id":"PRIN2007","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G271131015","display_name":null,"funder_award_id":"SAF2009-10553","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G4182764015","display_name":null,"funder_award_id":"SAF 2006/01249","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G593685302","display_name":null,"funder_award_id":"CTQ2008-03768/PPQ","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G6446058743","display_name":null,"funder_award_id":"PI080400","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G8214109310","display_name":null,"funder_award_id":"2005-SGR00180","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320323553","display_name":"Universit\u00e0 di Bologna","ror":"https://ror.org/01111rn36"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W572598855.pdf","grobid_xml":"https://content.openalex.org/works/W572598855.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W1561647671","https://openalex.org/W1568306639","https://openalex.org/W1961850939","https://openalex.org/W1969451266","https://openalex.org/W1969897630","https://openalex.org/W1971048984","https://openalex.org/W1973851363","https://openalex.org/W1976042714","https://openalex.org/W1976161355","https://openalex.org/W1976499671","https://openalex.org/W1980314143","https://openalex.org/W1981775239","https://openalex.org/W1987170637","https://openalex.org/W1987334111","https://openalex.org/W1988562891","https://openalex.org/W1991889711","https://openalex.org/W1993672505","https://openalex.org/W1997687318","https://openalex.org/W2000279187","https://openalex.org/W2003633347","https://openalex.org/W2004863803","https://openalex.org/W2006102445","https://openalex.org/W2006489170","https://openalex.org/W2008320401","https://openalex.org/W2009221410","https://openalex.org/W2009277432","https://openalex.org/W2010426046","https://openalex.org/W2011779746","https://openalex.org/W2012089886","https://openalex.org/W2013761166","https://openalex.org/W2018279778","https://openalex.org/W2018352404","https://openalex.org/W2022175253","https://openalex.org/W2025022665","https://openalex.org/W2025644108","https://openalex.org/W2026976753","https://openalex.org/W2029954340","https://openalex.org/W2031391963","https://openalex.org/W2032817710","https://openalex.org/W2035043090","https://openalex.org/W2041269990","https://openalex.org/W2046252479","https://openalex.org/W2047244077","https://openalex.org/W2050456292","https://openalex.org/W2063268875","https://openalex.org/W2063384935","https://openalex.org/W2063463571","https://openalex.org/W2065054824","https://openalex.org/W2065100984","https://openalex.org/W2069721803","https://openalex.org/W2070234396","https://openalex.org/W2075369230","https://openalex.org/W2075480632","https://openalex.org/W2077973224","https://openalex.org/W2081580623","https://openalex.org/W2082641306","https://openalex.org/W2085958374","https://openalex.org/W2087538505","https://openalex.org/W2088093305","https://openalex.org/W2089112315","https://openalex.org/W2094181196","https://openalex.org/W2099348521","https://openalex.org/W2105259065","https://openalex.org/W2107857520","https://openalex.org/W2111297587","https://openalex.org/W2112918122","https://openalex.org/W2126681168","https://openalex.org/W2142178921","https://openalex.org/W2143410390","https://openalex.org/W2144135498","https://openalex.org/W2146910635","https://openalex.org/W2158603760","https://openalex.org/W2178327831","https://openalex.org/W2318777851","https://openalex.org/W2468957886","https://openalex.org/W2808236469","https://openalex.org/W2953341487"],"related_works":["https://openalex.org/W9095722","https://openalex.org/W7120507009","https://openalex.org/W7052970689","https://openalex.org/W7037606632","https://openalex.org/W2318279343","https://openalex.org/W7120677196","https://openalex.org/W7009494609","https://openalex.org/W2047244077","https://openalex.org/W2047400607","https://openalex.org/W2530033787"],"abstract_inverted_index":{"El":[0,84,134],"principal":[1],"factor":[2],"desencadenant":[3],"del":[4,117,214],"proc\u00e9s":[5],"de":[6,38,58,67,76,79,81,137,145,155,163,167,175,197,229],"neurodegeneraci\u00f3":[7,80],"que":[8,41,71,89,92,120,150,186],"caracteritza":[9],"la":[10,25,68,77,82,109,168,206,211],"Malaltia":[11],"d\u2019Alzheimer":[12],"(MA)":[13],"\u00e9s":[14,141],"el":[15,65,95,131,172,190,194,235],"p\u00e8ptid":[16,23,105,132,215],"beta-amiloide":[17],"(BA).":[18],"La":[19],"formaci\u00f3":[20],"incrementada":[21],"d\u2019aquest":[22],"i":[24,31,48,193,203],"seva":[26,110,207],"agregaci\u00f3":[27],"en":[28,64,178],"forma":[29],"d\u2019olig\u00f2mers":[30],"fibrilles":[32],"estan":[33],"a":[34,74,121,153],"l\u2019origen":[35],"d\u2019una":[36],"cascada":[37,78],"processos":[39],"neurot\u00f2xics":[40],"culminen":[42],"amb":[43,94,189],"una":[44,54,147,156],"disfunci\u00f3":[45],"neuronal":[46],"generalitzada":[47],"mort":[49],"neuronal.":[50],"Recentment":[51],"s\u2019ha":[52],"descrit":[53],"funci\u00f3":[55],"no":[56,113],"colin\u00e8rgica":[57],"l\u2018enzim":[59],"acetilcolinesterasa":[60],"(AChE)":[61],"d\u2019import\u00e0ncia":[62],"fonamental":[63],"context":[66],"MA,":[69],"ja":[70],"col\u2022loca":[72],"l\u2019enzim":[73,90,198],"l\u2019inici":[75],"malaltia.":[83],"Prof.":[85],"Inestrosa":[86],"va":[87],"demostrar":[88],"AChE,":[91],"coexisteix":[93],"BA":[96,118,216],"\uf020en":[97],"les":[98],"plaques":[99],"senils,":[100],"es":[101,151,170],"pot":[102,129],"unir":[103],"al":[104,165],"accelerant":[106],"in":[107],"vitro":[108],"agregaci\u00f3.":[111],"L\u2019AChE":[112],"nom\u00e9s":[114],"promou":[115,123],"l\u2019agregaci\u00f3":[116,124,213,218],"\uf020sin\u00f3":[119],"m\u00e9s":[122],"d\u2019altres":[125],"p\u00e8ptids":[126,140,220],"amiloidog\u00e8nics,":[127],"com":[128],"ser":[130],"pri\u00f2nic.\\n\\n\\t\\t\\t\\t":[133],"lloc":[135,143,195],"d\u2019uni\u00f3":[136,149,238],"l\u2019AChE":[138],"d\u2019aquests":[139,219,240],"l\u2019anomenat":[142],"perif\u00e8ric":[144,196],"l\u2019enzim,":[146],"zona":[148],"troba":[152,171],"l\u2019entrada":[154],"cavitat":[157],"o":[158],"gorja":[159],"d\u2019uns":[160],"20":[161],"\u00c5":[162],"longitud,":[164],"fons":[166],"qual":[169],"centre":[173,191],"catal\u00edtic":[174,192],"l\u2019enzim.":[176],"Aix\u00ed,":[177],"aquesta":[179],"Tesi":[180],"Doctoral":[181],"quatre":[182],"noves":[183],"fam\u00edlies":[184],"d\u2019h\u00edbrids":[185],"interaccionen":[187],"simult\u00e0niament":[188],"han":[199,233],"estat":[200],"dissenyades,":[201],"sintetizades":[202],"avaluades":[204],"per":[205,223],"habilitat":[208],"d\u2019inhibir":[209],"l\u2019AChE,":[210],"butirilcolinesterasa,":[212],"\uf020i":[217],"amiloidog\u00e8nics":[221],"indu\u00efda":[222],"AChE.":[224],"A":[225],"m\u00e9s,":[226],"els":[227],"estudis":[228],"modelatge":[230],"molecular":[231],"realitzats":[232],"demostrat":[234],"car\u00e0cter":[236],"d\u2019inhibidors":[237],"dual":[239],"nous":[241],"h\u00edbrids.":[242]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}