{"id":"https://openalex.org/W5719959","doi":"https://doi.org/10.1034/j.1600-065x.2000.00610.x","title":"An unsolved problem of the clonal selection theory and the model of an oligomeric B\u2010cell antigen receptor","display_name":"An unsolved problem of the clonal selection theory and the model of an oligomeric B\u2010cell antigen receptor","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W5719959","doi":"https://doi.org/10.1034/j.1600-065x.2000.00610.x","mag":"5719959","pmid":"https://pubmed.ncbi.nlm.nih.gov/11043764"},"language":"en","primary_location":{"id":"doi:10.1034/j.1600-065x.2000.00610.x","doi":"https://doi.org/10.1034/j.1600-065x.2000.00610.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-065x.2000.00610.x","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013470603","display_name":"Michael G. Reth","orcid":"https://orcid.org/0000-0002-1025-7198","observed_orcids":["https://orcid.org/0000-0002-1025-7198"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I4210164321","display_name":"Max Planck Institute of Immunobiology and Epigenetics","ror":"https://ror.org/058xzat49","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210164321"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Reth","raw_affiliation_strings":["Department of Molecular Immunology, Biology III, University of Freiburg and Max-Planck-Institute for Immunobiology, Germany. reth@immunbio.mpg.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Immunology, Biology III, University of Freiburg and Max-Planck-Institute for Immunobiology, Germany. reth@immunbio.mpg.de","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I4210164321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023211409","display_name":"J\u00fcrgen Wienands","orcid":"https://orcid.org/0000-0001-8278-7668","observed_orcids":["https://orcid.org/0000-0001-8278-7668"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Wienands","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033597781","display_name":"Wolfgang W A Schamel","orcid":"https://orcid.org/0000-0003-4496-3100","observed_orcids":["https://orcid.org/0000-0003-4496-3100"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W W Schamel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.7781,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.83617255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"176","issue":"1","first_page":"10","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-receptor","display_name":"B cell receptor","score":0.925000011920929},{"id":"https://openalex.org/keywords/clonal-selection-theory","display_name":"clonal selection theory","score":0.925000011920929},{"id":"https://openalex.org/keywords/burnet","display_name":"Burnet","score":0.5619999766349792},{"id":"https://openalex.org/keywords/pre-b-cell-receptor","display_name":"pre-B cell receptor","score":0.7509999871253967},{"id":"https://openalex.org/keywords/allelic-exclusion","display_name":"allelic exclusion","score":0.824999988079071},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.8429999947547913},{"id":"https://openalex.org/keywords/negative-selection","display_name":"negative selection","score":0.9990000128746033},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/receptor-conformational-change","display_name":"receptor conformational change","score":0.6840000152587891},{"id":"https://openalex.org/keywords/antigen-binding","display_name":"antigen binding","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2776954793","wikidata":"https://www.wikidata.org/wiki/Q1150780","display_name":"Clonal selection","level":2,"score":0.6459934115409851},{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.6019882559776306},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5513295531272888},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4316824674606323},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4079054296016693},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39278802275657654},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3531111776828766},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22216325998306274},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2211425006389618},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.20931336283683777}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017637","descriptor_name":"Clonal Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1034/j.1600-065x.2000.00610.x","doi":"https://doi.org/10.1034/j.1600-065x.2000.00610.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-065x.2000.00610.x","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},{"id":"pmid:11043764","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11043764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320334763","display_name":"Leibniz-Gemeinschaft","ror":"https://ror.org/01n6r0e97"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2132161238","https://openalex.org/W2039073711","https://openalex.org/W4406406986","https://openalex.org/W1982008474","https://openalex.org/W140255454","https://openalex.org/W1776652835","https://openalex.org/W2088364573","https://openalex.org/W2078146013","https://openalex.org/W2169990475","https://openalex.org/W4391488857"],"abstract_inverted_index":{"The":[0],"B":[1,17,47,58,139,153,182],"cell":[2,140],"antigen":[3,160],"receptor":[4],"(BCR)":[5],"plays":[6],"a":[7,120,133,163],"central":[8],"role":[9],"in":[10,162],"the":[11,20,30,36,40,52,69,75,81,92,124,129,138,166,171],"development,":[12],"survival":[13,53,151],"and":[14,29,42,54,83,96,111,150,178],"activation":[15,55,179],"of":[16,26,32,45,56,62,104,152,165,176,180],"lymphocytes.":[18],"As":[19,35],"pre-BCR,":[21],"it":[22,38,67,145],"controls":[23,39],"allelic":[24],"exclusion":[25],"heavy":[27],"chains":[28],"expansion":[31],"pre-B":[33],"cells.":[34,59,154,183],"BCR,":[37,125],"positive":[41,148],"negative":[43,174],"selection":[44,107,149,175],"immature":[46,177],"cells":[48],"as":[49,51,100,132],"well":[50],"mature":[57,181],"Recent":[60],"studies":[61,115],"receptors":[63],"have":[64],"shown":[65],"that":[66,71,169],"is":[68,94],"ligand":[70],"brings":[72],"them":[73],"into":[74],"conformation":[76],"necessary":[77],"for":[78,91,123,173],"signaling.":[79],"How":[80],"multiple":[82],"structurally":[84],"diverse":[85],"antigens":[86],"could":[87],"fulfill":[88],"this":[89,99,143],"task":[90],"BCR":[93,130],"unknown,":[95],"we":[97],"regard":[98],"an":[101],"unsolved":[102],"problem":[103],"Burnet's":[105],"clonal":[106],"theory":[108],"This":[109],"question":[110],"our":[112],"recent":[113],"biochemical":[114],"lead":[116],"us":[117],"to":[118,127,156],"propose":[119],"new":[121],"model":[122],"according":[126],"which":[128],"exists":[131],"precise":[134],"oligomeric":[135,167],"complex":[136,168],"on":[137],"surface.":[141],"In":[142],"form,":[144],"can":[146],"signal":[147,172],"Binding":[155],"self-":[157],"or":[158],"foreign":[159],"results":[161],"distortion":[164],"gives":[170]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}