{"id":"https://openalex.org/W570597774","doi":"https://doi.org/10.1371/journal.pone.0130692","title":"EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia","display_name":"EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia","publication_year":2015,"publication_date":"2015-06-17","ids":{"openalex":"https://openalex.org/W570597774","doi":"https://doi.org/10.1371/journal.pone.0130692","mag":"570597774","pmid":"https://pubmed.ncbi.nlm.nih.gov/26083390","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4470658"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0130692","doi":"https://doi.org/10.1371/journal.pone.0130692","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0130692","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0130692&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0130692&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048542303","display_name":"Sara Charmsaz","orcid":"https://orcid.org/0000-0002-6003-702X","observed_orcids":["https://orcid.org/0000-0002-6003-702X"]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Sara Charmsaz","raw_affiliation_strings":["QIMR Berghofer Medical Research Institute, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QIMR Berghofer Medical Research Institute, Brisbane, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070725639","display_name":"Kirrilee J. Beckett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kirrilee Beckett","raw_affiliation_strings":["QIMR Berghofer Medical Research Institute, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QIMR Berghofer Medical Research Institute, Brisbane, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fiona M. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Fiona M. Smith","raw_affiliation_strings":["QIMR Berghofer Medical Research Institute, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QIMR Berghofer Medical Research Institute, Brisbane, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004396257","display_name":"Claudia Bruedigam","orcid":"https://orcid.org/0000-0002-9580-1446","observed_orcids":["https://orcid.org/0000-0002-9580-1446"]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Claudia Bruedigam","raw_affiliation_strings":["QIMR Berghofer Medical Research Institute, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QIMR Berghofer Medical Research Institute, Brisbane, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035808651","display_name":"Andrew S. Moore","orcid":"https://orcid.org/0000-0001-8062-1779","observed_orcids":["https://orcid.org/0000-0001-8062-1779"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4210167058","display_name":"Children's Health Queensland Hospital and Health Service","ror":"https://ror.org/02t3p7e85","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131","https://openalex.org/I4210167058"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrew S. Moore","raw_affiliation_strings":["The University of Queensland, Brisbane, Australia; Children's Health Queensland Hospital and Health Service, Brisbane, Australia","Children's Health Queensland Hospital and Health Service, Brisbane, Australia","The University of Queensland, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Queensland, Brisbane, Australia; Children's Health Queensland Hospital and Health Service, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4210167058"]},{"raw_affiliation_string":"Children's Health Queensland Hospital and Health Service, Brisbane, Australia","institution_ids":["https://openalex.org/I4210167058"]},{"raw_affiliation_string":"The University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036264210","display_name":"Fares Al\u2010Ejeh","orcid":"https://orcid.org/0000-0002-1553-0077","observed_orcids":["https://orcid.org/0000-0002-1553-0077"]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Fares Al-Ejeh","raw_affiliation_strings":["QIMR Berghofer Medical Research Institute, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QIMR Berghofer Medical Research Institute, Brisbane, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084825146","display_name":"Steven Lane","orcid":"https://orcid.org/0000-0002-8050-6209","observed_orcids":["https://orcid.org/0000-0002-8050-6209"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Steven W. Lane","raw_affiliation_strings":["QIMR Berghofer Medical Research Institute, Brisbane, Australia; The University of Queensland, Brisbane, Australia","QIMR Berghofer Medical Research Institute, Brisbane, Australia","The University of Queensland, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QIMR Berghofer Medical Research Institute, Brisbane, Australia; The University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I217937681"]},{"raw_affiliation_string":"QIMR Berghofer Medical Research Institute, Brisbane, Australia","institution_ids":["https://openalex.org/I217937681"]},{"raw_affiliation_string":"The University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090491025","display_name":"Andy Boyd","orcid":"https://orcid.org/0000-0002-8614-3728","observed_orcids":["https://orcid.org/0000-0002-8614-3728"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrew W. Boyd","raw_affiliation_strings":["QIMR Berghofer Medical Research Institute, Brisbane, Australia; The University of Queensland, Brisbane, Australia","QIMR Berghofer Medical Research Institute, Brisbane, Australia","The University of Queensland, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QIMR Berghofer Medical Research Institute, Brisbane, Australia; The University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I217937681"]},{"raw_affiliation_string":"QIMR Berghofer Medical Research Institute, Brisbane, Australia","institution_ids":["https://openalex.org/I217937681"]},{"raw_affiliation_string":"The University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048542303"],"corresponding_institution_ids":["https://openalex.org/I217937681"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.3931,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.76645986,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"6","first_page":"e0130692","last_page":"e0130692"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.04320000112056732,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epha2","display_name":"EphA2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/eph-ephrin-signaling","display_name":"Eph/ephrin signaling","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mll-af9-leukemia","display_name":"MLL-AF9 leukemia","score":0.9599999785423279},{"id":"https://openalex.org/keywords/mll-translocation","display_name":"MLL translocation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/radioimmunotherapy","display_name":"radioimmunotherapy","score":0.7310000061988831},{"id":"https://openalex.org/keywords/therapy-targets","display_name":"therapy targets","score":0.5870000123977661},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C150582083","wikidata":"https://www.wikidata.org/wiki/Q18250395","display_name":"EPH receptor A2","level":4,"score":0.8039573431015015},{"id":"https://openalex.org/C19331615","wikidata":"https://www.wikidata.org/wiki/Q423602","display_name":"Erythropoietin-producing hepatocellular (Eph) receptor","level":4,"score":0.796144425868988},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6812920570373535},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6170295476913452},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5641657710075378},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5616644620895386},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.4663374125957489},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.45856818556785583},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3847527503967285},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3586708903312683},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.258236825466156},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11757209897041321}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015321","descriptor_name":"Gene Rearrangement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016499","descriptor_name":"Radioimmunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036104","descriptor_name":"Receptor, EphA2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D036104","descriptor_name":"Receptor, EphA2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051788","descriptor_name":"Myeloid-Lymphoid Leukemia Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0130692","doi":"https://doi.org/10.1371/journal.pone.0130692","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0130692","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0130692&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3443477","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4470658","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4470658","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4470658","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:26083390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26083390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b184908ece954ea6b70d7f54b79e0353","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b184908ece954ea6b70d7f54b79e0353","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 6, p e0130692 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0130692","doi":"https://doi.org/10.1371/journal.pone.0130692","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0130692","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0130692&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306239","display_name":"Conquer Cancer Foundation","ror":"https://ror.org/027327e78"},{"id":"https://openalex.org/F4320314063","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W570597774.pdf","grobid_xml":"https://content.openalex.org/works/W570597774.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1556791620","https://openalex.org/W1576139194","https://openalex.org/W1853698148","https://openalex.org/W1874275835","https://openalex.org/W1947523625","https://openalex.org/W1973766530","https://openalex.org/W1982926397","https://openalex.org/W1992187858","https://openalex.org/W1997184614","https://openalex.org/W2014862318","https://openalex.org/W2029838406","https://openalex.org/W2038385234","https://openalex.org/W2038894508","https://openalex.org/W2040574920","https://openalex.org/W2042727692","https://openalex.org/W2049380625","https://openalex.org/W2051912646","https://openalex.org/W2082798625","https://openalex.org/W2083158374","https://openalex.org/W2092311035","https://openalex.org/W2093842873","https://openalex.org/W2102249975","https://openalex.org/W2114625470","https://openalex.org/W2118838302","https://openalex.org/W2134210826","https://openalex.org/W2134893174","https://openalex.org/W2135890002","https://openalex.org/W2139044676","https://openalex.org/W2153707709","https://openalex.org/W2170617671","https://openalex.org/W2572075110"],"related_works":["https://openalex.org/W7095076926","https://openalex.org/W798349665","https://openalex.org/W2055093995","https://openalex.org/W2500812307","https://openalex.org/W2118838302","https://openalex.org/W2528591865","https://openalex.org/W2557964173","https://openalex.org/W2559150302","https://openalex.org/W2125253164","https://openalex.org/W4385577605"],"abstract_inverted_index":{"Members":[0],"of":[1,5,45,80,87,96,102,112,185,191,211,230,236],"the":[2,57,100,110,181,186,231,248],"Eph":[3,46],"family":[4],"receptor":[6],"tyrosine":[7],"kinases":[8],"and":[9,26,35,48,62,73,106,120,128,135,140,228],"their":[10],"membrane":[11],"bound":[12],"ephrin":[13],"ligands":[14],"have":[15,29,52,153],"been":[16,30],"shown":[17],"to":[18],"play":[19],"critical":[20],"roles":[21],"in":[22,32,38,60,83,98,104,114,157,180,193,208,261],"many":[23,84],"developmental":[24],"processes":[25,37],"more":[27],"recently":[28],"implicated":[31],"both":[33],"normal":[34,158],"pathological":[36],"post-embryonic":[39],"tissues.":[40],"In":[41,64],"particular,":[42,65],"expression":[43,82,190],"studies":[44,51,147,161],"receptors":[47],"limited":[49],"functional":[50,176],"demonstrated":[53],"a":[54,94,204,243,257],"role":[55,101,111,156,177],"for":[56,178],"Eph/ephrin":[58],"system":[59],"hematopoiesis":[61,105,115],"leukemogenesis.":[63,107],"EphA2":[66,81,103,113,121,150,179,192,218,237,239,255],"was":[67,144,173],"reported":[68],"on":[69,226],"hematopoietic":[70,129],"stem":[71,130],"cells":[72,131],"stromal":[74],"cells.":[75],"There":[76],"are":[77],"also":[78],"reports":[79],"different":[85],"types":[86],"malignancies":[88],"including":[89],"leukemia,":[90],"however":[91],"there":[92,172],"is":[93],"lack":[95],"knowledge":[97],"understanding":[99],"We":[108,213],"explored":[109],"by":[116,196],"analyzing":[117],"wild":[118],"type":[119,210],"knockout":[122,134],"mice.":[123],"Mature,":[124],"differentiated":[125],"cells,":[126],"progenitors":[127],"derived":[132,166],"from":[133,167],"control":[136],"mice":[137],"were":[138],"analyzed":[139],"no":[141,174,224],"significant":[142],"abnormality":[143],"detected.":[145],"These":[146],"showed":[148,170,214],"that":[149,171,199,215],"does":[151],"not":[152],"an":[154],"obligatory":[155],"hematopoiesis.":[159],"Comparative":[160],"using":[162,238],"EphA2-negative":[163],"MLL-AF9":[164,197,232],"leukemias":[165,194,262],"EphA2-knockout":[168],"animals":[169],"detectable":[175],"initiation":[182],"or":[183],"progression":[184],"leukemic":[187,249],"process.":[188,250],"However,":[189],"initiated":[195],"suggested":[198],"this":[200,209],"protein":[201],"might":[202],"be":[203],"possible":[205],"therapy":[206],"target":[207,260],"leukemia.":[212],"treatment":[216],"with":[217,242,263],"monoclonal":[219,240],"antibody":[220,241],"IF7":[221],"alone":[222],"had":[223],"effect":[225],"tumorigenicity":[227],"latency":[229],"leukemias,":[233],"while":[234],"targeting":[235],"radioactive":[244],"payload":[245],"significantly":[246],"impaired":[247],"Altogether,":[251],"these":[252],"results":[253],"identify":[254],"as":[256],"potential":[258],"radio-therapeutic":[259],"MLL":[264],"translocation.":[265]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
