{"id":"https://openalex.org/W57002359","doi":null,"title":"The Gordon Wilson Lecture. Growth hormone replacement in adults and other uses.","display_name":"The Gordon Wilson Lecture. Growth hormone replacement in adults and other uses.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W57002359","mag":"57002359","pmid":"https://pubmed.ncbi.nlm.nih.gov/9601130","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2194327"},"language":"en","primary_location":{"id":"pmid:9601130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9601130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transactions of the American Clinical and Climatological Association","raw_type":"Lecture"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2194327/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114128911","display_name":"M L Vance","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M L Vance","raw_affiliation_strings":["University of Virginia Medical Center, Charlottesville, VA 22908, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia Medical Center, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I4210134211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5114128911"],"corresponding_institution_ids":["https://openalex.org/I4210134211"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"109","issue":null,"first_page":"87","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-replacement-therapy","display_name":"growth hormone replacement therapy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/growth-hormone-releasing-hormone","display_name":"growth hormone-releasing hormone","score":0.8830000162124634},{"id":"https://openalex.org/keywords/growth-hormone-secretion-regulation","display_name":"growth hormone secretion regulation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/hypothalamic-disease","display_name":"hypothalamic disease","score":0.640999972820282},{"id":"https://openalex.org/keywords/pituitary-disorders","display_name":"pituitary disorders","score":0.996999979019165},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.9700000286102295},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.9070000052452087},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":1.0},{"id":"https://openalex.org/keywords/muscle-strength","display_name":"muscle strength","score":0.9470000267028809},{"id":"https://openalex.org/keywords/exercise-endurance","display_name":"exercise endurance","score":0.9580000042915344},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8360000252723694},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.996999979019165},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9589999914169312},{"id":"https://openalex.org/keywords/muscle-disorders","display_name":"muscle disorders","score":0.9010000228881836}],"concepts":[{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6167306900024414},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5970011353492737},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5850446224212646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5543981194496155},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.5537558197975159},{"id":"https://openalex.org/C2780159708","wikidata":"https://www.wikidata.org/wiki/Q17003363","display_name":"Hormone replacement therapy (female-to-male)","level":3,"score":0.5131471753120422},{"id":"https://openalex.org/C2779952775","wikidata":"https://www.wikidata.org/wiki/Q369262","display_name":"Growth hormone deficiency","level":4,"score":0.46511343121528625},{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.4543551206588745},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4484529197216034},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.37200334668159485},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.16792064905166626}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007027","descriptor_name":"Hypothalamic Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010900","descriptor_name":"Pituitary Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:9601130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9601130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transactions of the American Clinical and Climatological Association","raw_type":"Lecture"},{"id":"pmh:oai:pubmedcentral.nih.gov:2194327","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2194327/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trans Am Clin Climatol Assoc","raw_type":"Text"},{"id":"mag:57002359","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9601130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2194327","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2194327/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trans Am Clin Climatol Assoc","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1908144174","https://openalex.org/W1935313559","https://openalex.org/W1966180464","https://openalex.org/W1972356965","https://openalex.org/W1984487014","https://openalex.org/W1993192586","https://openalex.org/W1995707695","https://openalex.org/W1999759703","https://openalex.org/W2016733772","https://openalex.org/W2017901669","https://openalex.org/W2022601698","https://openalex.org/W2029599650","https://openalex.org/W2045250642","https://openalex.org/W2050386090","https://openalex.org/W2063587143","https://openalex.org/W2065004245","https://openalex.org/W2066102305","https://openalex.org/W2070283543","https://openalex.org/W2080185465","https://openalex.org/W2084056819","https://openalex.org/W2098999072","https://openalex.org/W2100488282","https://openalex.org/W2105251665","https://openalex.org/W2111528719","https://openalex.org/W2120108803","https://openalex.org/W2126705498","https://openalex.org/W2158139052","https://openalex.org/W2158214742","https://openalex.org/W2165675667","https://openalex.org/W2181043099","https://openalex.org/W2315987042","https://openalex.org/W2336653813"],"related_works":["https://openalex.org/W2137848721","https://openalex.org/W2163029986","https://openalex.org/W195729059","https://openalex.org/W2787612994","https://openalex.org/W2102147970","https://openalex.org/W2155793376","https://openalex.org/W1971899894","https://openalex.org/W1989926192","https://openalex.org/W2431750974","https://openalex.org/W1968751000"],"abstract_inverted_index":{"The":[0,67,148],"modern":[1],"era":[2],"of":[3,15,19,29,45,48,52,60,69,118,150],"growth":[4,24,64,70,151],"hormone":[5,25,65,71,152],"research":[6],"began":[7],"in":[8,34,40,75,80,112,122,153],"1981":[9],"with":[10,124],"the":[11,16,42,46,108],"characterization":[12],"and":[13,22,32,37,62,102,114,146,163,170,172],"synthesis":[14,21],"primary":[17],"stimulator":[18],"GH":[20,49,76,119,138],"secretion,":[23],"releasing":[26],"hormone.":[27],"Discovery":[28,51],"this":[30],"peptide":[31],"studies":[33,86,106],"human":[35],"adults":[36,78,123],"children":[38],"resulted":[39,111],"unraveling":[41],"complex":[43],"nature":[44],"regulation":[47],"secretion.":[50],"regulatory":[53],"mechanisms":[54],"has":[55],"permitted":[56],"a":[57,88],"greater":[58],"understanding":[59],"normal":[61],"abnormal":[63],"physiology.":[66],"use":[68,149],"therapeutically":[72],"as":[73,157],"replacement":[74,121,139],"deficient":[77],"is":[79,166],"its":[81],"medical":[82],"infancy,":[83],"but":[84],"preliminary":[85],"indicate":[87],"beneficial":[89,142],"effect":[90],"on":[91,144],"body":[92],"composition,":[93],"serum":[94],"lipid":[95],"concentrations,":[96],"bone":[97],"mineral":[98],"density,":[99],"muscle":[100],"strength,":[101],"exercise":[103],"endurance.":[104],"These":[105],"over":[107],"past":[109],"decade":[110],"Food":[113],"Drug":[115],"Administration":[116],"approval":[117],"for":[120],"hypothalamic":[125],"or":[126,135],"pituitary":[127],"disease.":[128],"It":[129],"remains":[130],"to":[131,175],"be":[132,176],"determined":[133],"whether":[134],"not":[136],"chronic":[137],"will":[140],"have":[141],"effects":[143],"morbidity":[145],"mortality.":[147],"other":[154],"areas":[155],"such":[156],"aging,":[158],"catabolic":[159],"illness,":[160],"obesity,":[161],"diabetes,":[162],"muscular":[164],"disorders":[165],"under":[167],"active":[168],"investigation":[169],"risks":[171],"benefits":[173],"remain":[174],"determined.":[177]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}