{"id":"https://openalex.org/W569723067","doi":"https://doi.org/10.1002/9780470035009","title":"Signalling Pathways in Acute Oxygen Sensing","display_name":"Signalling Pathways in Acute Oxygen Sensing","publication_year":2006,"publication_date":"2006-01-13","ids":{"openalex":"https://openalex.org/W569723067","doi":"https://doi.org/10.1002/9780470035009","mag":"569723067"},"language":"en","primary_location":{"id":"doi:10.1002/9780470035009","doi":"https://doi.org/10.1002/9780470035009","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470035009","pdf_url":null,"source":{"id":"https://openalex.org/S9764341","display_name":"Novartis Foundation symposium","issn_l":"1528-2511","issn":["1528-2511","1935-4657"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Novartis Foundation Symposia","raw_type":"edited-book"},"volume":null,"type":"book","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012389732","display_name":"Derek J. Chadwick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chadwick, Derek J. 1948-","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5012389732"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.25,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.79166667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0723000019788742,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11968","display_name":"High Altitude and Hypoxia","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxygen-sensing","display_name":"oxygen sensing","score":0.7829999923706055},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7839999794960022},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor","display_name":"hypoxia-inducible factor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/prolyl-hydroxylase","display_name":"prolyl hydroxylase","score":0.972000002861023},{"id":"https://openalex.org/keywords/carotid-body","display_name":"carotid body","score":0.8450000286102295},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8920000195503235},{"id":"https://openalex.org/keywords/bk-channels","display_name":"BK channels","score":0.8410000205039978},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.8090000152587891},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.6380000114440918},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8230000138282776},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/hypoxic-pulmonary-vasoconstriction","display_name":"hypoxic pulmonary vasoconstriction","score":0.8930000066757202},{"id":"https://openalex.org/keywords/chromaffin-cells","display_name":"chromaffin cells","score":0.6970000267028809},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.4816128611564636},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.4742414355278015},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.44333773851394653},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36336952447891235},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27357324957847595},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2440212070941925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2362881600856781},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18328320980072021},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/9780470035009","doi":"https://doi.org/10.1002/9780470035009","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470035009","pdf_url":null,"source":{"id":"https://openalex.org/S9764341","display_name":"Novartis Foundation symposium","issn_l":"1528-2511","issn":["1528-2511","1935-4657"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Novartis Foundation Symposia","raw_type":"edited-book"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-014683132","doi":null,"is_oa":false,"landing_page_url":"http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014683132&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2610155116","https://openalex.org/W4409681284","https://openalex.org/W2889160185","https://openalex.org/W2123162584","https://openalex.org/W2740188901","https://openalex.org/W2015873509","https://openalex.org/W2151398015","https://openalex.org/W4205114283","https://openalex.org/W2028086254","https://openalex.org/W2981691519"],"abstract_inverted_index":{"Symposium":[0],"on":[1,29],"Signalling":[2],"pathways":[3],"in":[4,105,130,133,170,202,270,289,317,341,375,403,407],"acute":[5,239],"oxygen":[6,131,150,153,240,287,319],"sensing,":[7],"held":[8],"at":[9],"the":[10,134,238,271],"Novartis":[11],"Foundation,":[12],"London,":[13],"25-27":[14],"January":[15],"2005.":[16],"Editors:":[17],"Derek":[18],"J.":[19,66,112,159,181,195,212,216],"Chadwick":[20],"(Organizer)":[21],"and":[22,46,64,79,95,102,120,145,165,172,193,204,228,257,268,279,308,328,337,358,390],"Jamie":[23],"Goode.":[24],"This":[25],"symposium":[26],"is":[27],"based":[28],"a":[30],"proposal":[31],"made":[32],"by":[33,54,99,314,368],"Jeremy":[34,386],"Ward.":[35],"Michael":[36],"Duchen":[37],"Chair's":[38],"introduction.":[39],"Gregg":[40],"L.":[41,244],"Semenza,":[42],"Larissa":[43],"A.":[44,115,157,188,300,346,382],"Shimoda":[45],"Nanduri":[47,138],"R.":[48,62,139,161],"Prabhakar":[49],"Regulation":[50,68,82],"of":[51,69,83,126,199,233,333,395,416],"gene":[52],"expression":[53],"Hypoxia-Inducible":[55],"Factor.":[56],"Discussion.":[57,73,87,110,137,155,176,207,242,275,293,321,345,378,411],"Ineke":[58],"P.":[59,179,182,194,387],"Stolze,":[60],"David":[61,223],"Mole":[63],"Peter":[65],"Ratcliffe":[67],"HIF:":[70,84],"prolyl":[71],"hydroxylases.":[72],"General":[74,208,322],"discussion":[75,209,323],"I.":[76,93,190,392],"Daniel":[77],"Peet":[78],"Sarah":[80],"Linke":[81],"asparaginyl":[85],"hydroxylation.":[86],"Jose":[88,92],"Lopez-Barneo,":[89],"Patricia":[90],"Ortega-Saenz,":[91],"Piruat":[94],"Maria":[96],"Garcia-Fernandez":[97],"Oxygen-sensing":[98],"ion":[100],"channels":[101,129,267,340],"mitochondrial":[103,285,366],"function":[104],"carotid":[106,135],"body":[107],"glomus":[108],"cells.":[109,175,206,377],"Keith":[111],"Buckler,":[113],"Beatrice":[114],"Williams,":[116,217],"Rodrigo":[117],"Varas":[118],"Orozco":[119],"Christopher":[121,359],"N.":[122,360],"Wyatt":[123,361],"The":[124,331],"role":[125,263,332],"TASK-like":[127],"potassium":[128,235],"sensing":[132,169],"body.":[136],"Prabhakar,":[140],"Ying-Jie":[141],"Peng,":[142],"Guoxiang":[143],"Yuan":[144],"Ganesh":[146],"K.":[147,184],"Kumar":[148,357],"Reactive":[149],"species":[151,288],"facilitate":[152],"sensing.":[154],"C.":[156,177],"Nurse,":[158],"Buttigieg,":[160],"Thompson,":[162],"M.":[163,326],"Zhang":[164],"E.":[166,185,215,224,258],"Cutz":[167],"Oxygen":[168],"neuroepithelial":[171],"adrenal":[173],"chromaffin":[174],"Peers,":[178,355],"Kang,":[180],"Boyle,":[183],"Porter,":[186],"H.":[187],"Pearson,":[189],"F.":[191],"Smith":[192],"Kemp":[196],"Hypoxic":[197,311],"regulation":[198],"Ca2+":[200,397],"signalling":[201,373],"astrocytes":[203],"endothelial":[205],"II.":[210],"Paul":[211,280],"Kemp,":[213],"Sandile":[214],"Helen":[218],"S.":[219],"Mason,":[220],"Phillippa":[221],"Wootton,":[222],"Iles,":[225],"Daniela":[226],"Riccardi":[227],"Chris":[229,354],"Peers":[230],"Functional":[231],"proteomics":[232],"BK":[234],"channels:":[236],"defining":[237],"sensor.":[241],"Stephen":[243],"Archer,":[245],"Evangelos":[246],"D.":[247,349],"Michelakis,":[248],"Bernard":[249],"Thebaud,":[250],"Sebastien":[251],"Bonnet,":[252],"Rohit":[253],"Moudgil,":[254],"Xi-Chen":[255],"Wu":[256],"Kenneth":[259],"Weir":[260],"A":[261],"central":[262],"for":[264,284],"O2-sensitive":[265],"K+":[266,339],"mitochondria":[269],"specialized":[272],"O2-sensing":[273],"system.":[274],"Gregory":[276,381],"B.":[277],"Waypa":[278],"T.":[281,297,388],"Schumacker":[282],"Role":[283,394],"reactive":[286,318],"hypoxic":[290,342,404],"pulmonary":[291,312,343,405],"vasoconstriction.":[292,344],"Norbert":[294],"Weissmann,":[295],"Ralph":[296],"Schermuly,":[298],"Hossein":[299],"Ghofrani,":[301],"Jorg":[302],"Hanze,":[303],"Parag":[304],"Goyal,":[305],"Friedrich":[306],"Grimminger":[307],"Werner":[309],"Seeger":[310],"vasoconstriction-triggered":[313],"an":[315],"increase":[316],"species?.":[320],"III.":[324],"Alison":[325],"Gurney":[327],"Shreena":[329],"Joshi":[330],"twin":[334],"pore":[335],"domain":[336],"other":[338],"Mark":[347],"Evans,":[348],"Grahame":[350],"Hardie,":[351],"Antony":[352],"Galione,":[353],"Prem":[356],"AMP-activated":[362],"protein":[363],"kinase":[364],"couples":[365],"inhibition":[367],"hypoxia":[369],"to":[370],"cell-specific":[371],"calcium":[372],"mechanisms":[374],"oxygen-sensing":[376],"Silke":[379],"Becker,":[380],"Knock,":[383],"Vladimir":[384],"Snetkov,":[385],"Ward":[389],"Philip":[391],"Aaronson":[393],"capacitative":[396],"entry":[398],"but":[399],"not":[400],"Na+/Ca2+":[401],"exchange":[402],"vasoconstriction":[406],"rat":[408],"intrapulmonary":[409],"arteries.":[410],"Final":[412],"general":[413],"discussion.":[414],"Index":[415],"contributors.":[417],"Subject":[418],"index.":[419]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}