{"id":"https://openalex.org/W56885280","doi":null,"title":"BRCA1, Kap1 and the DNA Damage Response","display_name":"BRCA1, Kap1 and the DNA Damage Response","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W56885280","mag":"56885280"},"language":"en","primary_location":{"id":"mag:56885280","doi":null,"is_oa":false,"landing_page_url":"https://espace.library.uq.edu.au/view/UQ:194157","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054241681","display_name":"Kienan I. Savage","orcid":"https://orcid.org/0000-0002-4898-899X","observed_orcids":["https://orcid.org/0000-0002-4898-899X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kienan I. Savage","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5054241681"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00454214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/bard1","display_name":"BARD1","score":0.8090000152587891},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8870000243186951},{"id":"https://openalex.org/keywords/kap1","display_name":"KAP1","score":0.8199999928474426},{"id":"https://openalex.org/keywords/atm","display_name":"ATM","score":0.4480000138282776},{"id":"https://openalex.org/keywords/attenuated-total-reflectance","display_name":"ATR","score":0.9929999709129333},{"id":"https://openalex.org/keywords/h2ax-phosphorylation","display_name":"H2AX phosphorylation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/chk2","display_name":"Chk2","score":0.9290000200271606},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.7730000019073486},{"id":"https://openalex.org/keywords/g1-s-cell-cycle-arrest","display_name":"G1/S cell cycle arrest","score":0.9629999995231628},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9679999947547913},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.5770000219345093},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.902862548828125},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.7366423010826111},{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.7074690461158752},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.6537389755249023},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6218143105506897},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6166107654571533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5951465368270874},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5299794673919678},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.5160710215568542},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4743451178073883},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3990916907787323},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29487961530685425},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.27783793210983276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16812273859977722}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:56885280","doi":null,"is_oa":false,"landing_page_url":"https://espace.library.uq.edu.au/view/UQ:194157","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2026007913","https://openalex.org/W2022037877","https://openalex.org/W2164458581","https://openalex.org/W2005284058","https://openalex.org/W2151672430","https://openalex.org/W2023961264","https://openalex.org/W3150987078","https://openalex.org/W1661087247","https://openalex.org/W1481731879","https://openalex.org/W4306871381"],"abstract_inverted_index":{"Cancer":[0],"cells":[1],"exhibit":[2],"genomic":[3,91],"instability":[4,92],"and":[5,35,38,53,57,67,78,93,108,120,124,134,140,142,180,196,237,256,280,301],"are":[6,17,103,111,320],"commonly":[7],"defective":[8],"in":[9,85,114,170,191,204,252,386,460,477,494,521,527],"DNA":[10,14,21,59,74,100,117,157,181,193,224,259,388,425,469,479,509,530],"damage":[11,22,60,101,118,158,172,194,225,389,426,480,510,531],"signalling":[12,62],"and/or":[13,466],"repair.":[15,182],"There":[16],"many":[18,65,171],"types":[19],"of":[20,98,127,218,250,269,272,297,308,332,342,348,438,463,475,524],"inducing":[23],"agents":[24],"such":[25,146,175],"as":[26,147,176,371],"mechanical":[27],"stress":[28],"on":[29],"chromosomes":[30],"during":[31],"recombination,":[32],"chemotherapeutics,":[33],"ionising":[34],"ultraviolet":[36],"radiation":[37],"endogenously":[39],"produced":[40],"free":[41],"radicals.":[42],"These":[43,453],"genetic":[44],"lesions":[45],"pose":[46],"a":[47,55,122,151,210,270,349,372,381,402,436,488,502,517],"serious":[48],"threat":[49],"to":[50,90,116,168,213,232,254,368,445,529],"the":[51,99,104,130,136,156,192,216,219,223,234,241,267,285,294,306,333,346,387,461,473,478,495,508,522,533],"cell":[52,71,177,326],"evoke":[54],"rapid":[56],"intricate":[58],"response":[61,102,115,173,195,253,390,481,511,528],"pathway":[63,87,482],"involving":[64],"transducer":[66,153],"effector":[68],"pathways":[69],"including":[70,129,277],"cycle":[72,178,327],"arrest,":[73],"repair,":[75],"chromatin":[76,143,429,464,525],"remodelling,":[77],"apoptotic":[79],"pathways.":[80],"Genetic":[81],"mutations":[82],"within":[83,155,222,409,507],"genes":[84],"this":[86,205,343,362,416],"often":[88],"lead":[89],"cancer.":[94],"The":[95,288,339,355],"main":[96],"effectors":[97],"protein":[105,353,358],"kinases":[106,132],"ATM":[107,534],"ATR":[109],"which":[110,166,443],"rapidly":[112],"activated":[113],"induction":[119,331],"phosphorylate":[121],"large":[123],"diverse":[125],"number":[126,271,437],"targets":[128,276],"checkpoint":[131,497],"Chk1,":[133],"Chk2,":[135,279],"tumour":[137],"suppressors":[138],"p53":[139,309],"BRCA1":[141,149,298,351,375,476,493],"associated":[144,357],"proteins":[145,202],"H2AX.":[148],"is":[150,161,244,303],"key":[152],"molecule":[154],"response.":[159,226],"This":[160,207,431,513],"evident":[162],"from":[163],"its":[164],"loss,":[165],"leads":[167],"defects":[169],"processes":[174],"arrest":[179,328],"BRCA1s":[183],"binding":[184],"partner":[185],"BARD1":[186],"has":[187,290,433,515],"also":[188,291,434,500],"been":[189,366],"implicated":[190],"recent":[197],"reports":[198],"indicate":[199],"that":[200,240,266,293,316,415],"these":[201,317],"co-operate":[203],"pathway.":[206,391,512,537],"study":[208,289,344,363,432,514],"utilises":[209],"multifaceted":[211],"approach":[212],"further":[214],"characterise":[215],"function":[217,491],"BRCA1/BARD1":[220,235,242,286],"complex":[221,236,243],"Firstly":[227],"we":[228,263,313,364,378,399,412,483],"have":[229,238,264,314,365,379,400,413,484,499],"used":[230],"shRNA":[231],"deplete":[233],"shown":[239,265,315,414],"required":[245,304,321],"for":[246,305,322,384,492,519],"ATM/ATR":[247,274],"dependent":[248,275,335,405],"phosphorylation":[249,268,296,307,318,406,417,450],"p53Ser-15":[251],"IR":[255,323],"UV":[257],"induced":[258,324],"damage.":[260,470],"In":[261],"contrast,":[262],"other":[273],"H2AX,":[278],"c-jun":[281],"do":[282],"not":[283,485],"require":[284],"complex.":[287],"revealed":[292],"prior":[295],"at":[299,310,451],"Ser-1423":[300],"Ser-1524":[302],"Ser-15.":[311],"Furthermore,":[312,411],"events":[319],"G1/S":[325,496],"via":[329,532],"transcriptional":[330],"cyclin":[334],"kinase":[336],"inhibitor":[337],"p21.":[338],"second":[340],"part":[341],"involved":[345],"characterisation":[347],"putative":[350],"interacting":[352,441],"\u2013":[354,535],"KRAB":[356],"1":[359],"(Kap1).":[360],"During":[361],"unable":[367],"confirm":[369],"Kap1":[370,385,440,449],"bona":[373],"fide":[374],"interactor,":[376],"however":[377],"identified":[380,401,435,501,516],"clear":[382],"role":[383,459,474,518],"Using":[392],"Mass":[393],"spectrometric":[394],"phospho":[395],"amino":[396],"acid":[397],"mapping":[398],"novel":[403,439,489,503],"Chk2":[404,536],"site,":[407],"Ser-473,":[408],"Kap1.":[410],"event":[418],"may":[419,455],"regulate":[420],"Histone":[421],"H3-Lys-9":[422],"acetylation":[423],"after":[424,468],"possibly":[427],"regulating":[428],"relaxation.":[430],"proteins,":[442],"appear":[444],"be":[446],"regulated":[447],"by":[448],"Ser-473.":[452],"interactors":[454],"play":[456],"an":[457],"important":[458],"regulation":[462,523],"modification":[465],"structure":[467,526],"By":[471],"studying":[472],"only":[486],"uncovered":[487],"scaffolding":[490],"but":[498],"protein,":[504],"Kap1,":[505],"acting":[506],"Kap-1":[520]},"counts_by_year":[],"updated_date":"2026-09-12T09:15:50.089291","created_date":"2016-06-24T00:00:00"}
