{"id":"https://openalex.org/W56830911","doi":"https://doi.org/10.1007/978-1-60761-707-5_22","title":"Immunotherapy for Acute Lymphocytic Leukemia","display_name":"Immunotherapy for Acute Lymphocytic Leukemia","publication_year":2010,"publication_date":"2010-10-19","ids":{"openalex":"https://openalex.org/W56830911","doi":"https://doi.org/10.1007/978-1-60761-707-5_22","mag":"56830911"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-60761-707-5_22","doi":"https://doi.org/10.1007/978-1-60761-707-5_22","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-707-5_22","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adult Acute Lymphocytic Leukemia","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2488600581","display_name":"Adult Acute Lymphocytic Leukemia"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054346063","display_name":"Jacalyn M. Rosenblatt","orcid":"https://orcid.org/0000-0001-5582-8161","observed_orcids":["https://orcid.org/0000-0001-5582-8161"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacalyn Rosenblatt","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Harvard Medical School, Kirstein RM 135, 330 Brookline Ave, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Harvard Medical School, Kirstein RM 135, 330 Brookline Ave, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052641327","display_name":"David Avigan","orcid":"https://orcid.org/0000-0003-4624-6017","observed_orcids":["https://orcid.org/0000-0003-4624-6017"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Avigan","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Harvard Medical School, Kirstein RM 135, 330 Brookline Ave, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Harvard Medical School, Kirstein RM 135, 330 Brookline Ave, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052641327"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":1.6943,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.81334932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"351","last_page":"363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.878000020980835},{"id":"https://openalex.org/keywords/relapsed-refractory-disease","display_name":"relapsed/refractory disease","score":0.7580000162124634},{"id":"https://openalex.org/keywords/conditioning-regimen-intensity","display_name":"conditioning intensity","score":0.6880000233650208},{"id":"https://openalex.org/keywords/adverse-cytogenetics","display_name":"adverse cytogenetics","score":0.8650000095367432},{"id":"https://openalex.org/keywords/first-complete-remission","display_name":"first complete remission","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7316678762435913},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6468038558959961},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5977429747581482},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5715886354446411},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5280604958534241},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.513372540473938},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.48914816975593567},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4783363342285156},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.47340521216392517},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.46868565678596497},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4638424515724182},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4552355110645294},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43020206689834595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09479597210884094},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-60761-707-5_22","doi":"https://doi.org/10.1007/978-1-60761-707-5_22","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-707-5_22","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adult Acute Lymphocytic Leukemia","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W105534366","https://openalex.org/W185283559","https://openalex.org/W1274344746","https://openalex.org/W1536678688","https://openalex.org/W1560771952","https://openalex.org/W1574443686","https://openalex.org/W1596028061","https://openalex.org/W1624657716","https://openalex.org/W1707184873","https://openalex.org/W1959073718","https://openalex.org/W1967789754","https://openalex.org/W1971538947","https://openalex.org/W1973377350","https://openalex.org/W1975136907","https://openalex.org/W1979416799","https://openalex.org/W1983056774","https://openalex.org/W1987891242","https://openalex.org/W1993191461","https://openalex.org/W1994916640","https://openalex.org/W1996628620","https://openalex.org/W1996780160","https://openalex.org/W1999843922","https://openalex.org/W2005805770","https://openalex.org/W2010607826","https://openalex.org/W2015184525","https://openalex.org/W2015929976","https://openalex.org/W2019840784","https://openalex.org/W2022360666","https://openalex.org/W2023685739","https://openalex.org/W2031196215","https://openalex.org/W2031529296","https://openalex.org/W2033611981","https://openalex.org/W2035343180","https://openalex.org/W2037845552","https://openalex.org/W2042541303","https://openalex.org/W2045267651","https://openalex.org/W2046259240","https://openalex.org/W2060450545","https://openalex.org/W2062191416","https://openalex.org/W2063898537","https://openalex.org/W2066991780","https://openalex.org/W2067536107","https://openalex.org/W2070675286","https://openalex.org/W2086891287","https://openalex.org/W2087429083","https://openalex.org/W2087548983","https://openalex.org/W2090377899","https://openalex.org/W2091537353","https://openalex.org/W2092278351","https://openalex.org/W2092332088","https://openalex.org/W2095301728","https://openalex.org/W2108008366","https://openalex.org/W2108167452","https://openalex.org/W2109440389","https://openalex.org/W2113802879","https://openalex.org/W2119036007","https://openalex.org/W2120329256","https://openalex.org/W2121056827","https://openalex.org/W2121634460","https://openalex.org/W2123033671","https://openalex.org/W2125130810","https://openalex.org/W2128633123","https://openalex.org/W2129176443","https://openalex.org/W2130040182","https://openalex.org/W2132777524","https://openalex.org/W2132925083","https://openalex.org/W2135587226","https://openalex.org/W2136800737","https://openalex.org/W2137520438","https://openalex.org/W2141410122","https://openalex.org/W2142124906","https://openalex.org/W2151210395","https://openalex.org/W2151918137","https://openalex.org/W2153270414","https://openalex.org/W2165580475","https://openalex.org/W2165984958","https://openalex.org/W2168459600","https://openalex.org/W2171831719","https://openalex.org/W2255853016","https://openalex.org/W2320955005","https://openalex.org/W2320970881","https://openalex.org/W2334677790","https://openalex.org/W2398341633","https://openalex.org/W2419036309","https://openalex.org/W2464665443","https://openalex.org/W3112116562"],"related_works":["https://openalex.org/W4387099444","https://openalex.org/W4200226100","https://openalex.org/W3030055592","https://openalex.org/W2015745605","https://openalex.org/W2736038646","https://openalex.org/W2802684531","https://openalex.org/W4249166749","https://openalex.org/W136317431","https://openalex.org/W2053845649","https://openalex.org/W2272154124"],"abstract_inverted_index":{"While":[0],"a":[1,84],"majority":[2],"of":[3,23,61,67,86,94,102],"patients":[4,40,87,130],"with":[5,14,42,145],"acute":[6],"lymphocytic":[7],"leukemia":[8],"(ALL)":[9],"demonstrate":[10],"response":[11],"following":[12],"treatment":[13,66],"standard":[15,124],"chemotherapy,":[16],"subsequent":[17],"progression":[18],"due":[19],"to":[20,31,123],"the":[21,65,72,99,103,110,159,166,172],"emergence":[22],"resistant":[24],"disease":[25,33],"is":[26,34,69,80,96,163],"often":[27],"encountered.":[28],"The":[29,59,92],"failure":[30],"eradicate":[32],"most":[35],"commonly":[36],"observed":[37,128],"in":[38,55,64,88,129,131],"adult":[39],"particularly":[41],"high-risk":[43],"features":[44],"such":[45],"as":[46,107,109,121,141,143,171],"adverse":[47],"cytogenetics.":[48],"In":[49],"contrast,":[50],"immunotherapy":[51],"may":[52,168],"be":[53,169],"successful":[54],"targeting":[56],"chemotherapy-resistant":[57],"clones.":[58],"role":[60],"immune-based":[62],"therapy":[63],"ALL":[68],"highlighted":[70],"by":[71,114,154,158],"observation":[73],"that":[74],"allogeneic":[75],"hematopoietic":[76],"stem":[77],"cell":[78],"transplantation":[79],"uniquely":[81],"curative":[82],"for":[83],"subset":[85],"this":[89],"setting":[90],"[1].":[91],"efficacy":[93],"transplant":[95,104],"derived":[97],"from":[98],"dose":[100],"intensity":[101],"conditioning":[105],"regimen":[106],"well":[108,142],"antitumor":[111],"effect":[112],"mediated":[113],"donor-derived":[115],"immune":[116],"effector":[117],"cells.":[118],"Improved":[119],"outcomes":[120],"compared":[122],"chemotherapy":[125],"have":[126],"been":[127],"first":[132],"complete":[133],"remission":[134],"(CR)":[135],"who":[136],"exhibit":[137],"negative":[138],"prognostic":[139],"factors":[140],"those":[144],"relapsed":[146],"or":[147],"refractory":[148],"disease.":[149],"These":[150],"keywords":[151,167],"were":[152],"added":[153],"machine":[155],"and":[156,165],"not":[157],"authors.":[160],"This":[161],"process":[162],"experimental":[164],"updated":[170],"learning":[173],"algorithm":[174],"improves.":[175]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
