{"id":"https://openalex.org/W567549154","doi":"https://doi.org/10.1007/978-3-642-85456-9_27","title":"Symposium Genetic Factors Influencing Drug Action","display_name":"Symposium Genetic Factors Influencing Drug Action","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W567549154","doi":"https://doi.org/10.1007/978-3-642-85456-9_27","mag":"567549154"},"language":"de","primary_location":{"id":"doi:10.1007/978-3-642-85456-9_27","doi":"https://doi.org/10.1007/978-3-642-85456-9_27","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-85456-9_27","pdf_url":null,"source":{"id":"https://openalex.org/S2752137261","display_name":"Verhandlungen der Deutschen Gesellschaft f\u00fcr Innere Medizin","issn_l":"0070-4067","issn":["0070-4067"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Verhandlungen der Deutschen Gesellschaft f\u00fcr innere Medizin","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4239781186","display_name":"Verhandlungen der Deutschen Gesellschaft f\u00fcr innere Medizin"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111567063","display_name":"Leif Bertilsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"L. Bertilsson","raw_affiliation_strings":["Dept. of Clinical Pharmacology at the Karolinska Inst., Huddinge Hospital, Huddinge, Sweden","Department of Clinical Pharmacology at the Karolinska Institute, Huddinge Hospital, Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Clinical Pharmacology at the Karolinska Inst., Huddinge Hospital, Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Clinical Pharmacology at the Karolinska Institute, Huddinge Hospital, Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085671480","display_name":"Britt Mellstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"B. Mellstr\u00f6m","raw_affiliation_strings":["Department of Clinical Pharmacology at the Karolinska Institute, Huddinge Hospital, Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology at the Karolinska Institute, Huddinge Hospital, Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111539222","display_name":"Juliette S\u00e4we","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J. S\u00e4we","raw_affiliation_strings":["Department of Clinical Pharmacology at the Karolinska Institute, Huddinge Hospital, Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology at the Karolinska Institute, Huddinge Hospital, Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112137575","display_name":"Folke Sj\u00f6qvist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"F. Sj\u00f6qvist","raw_affiliation_strings":["Department of Clinical Pharmacology at the Karolinska Institute, Huddinge Hospital, Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology at the Karolinska Institute, Huddinge Hospital, Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044453328","display_name":"Robert L. Smith","orcid":"https://orcid.org/0000-0001-6789-7076","observed_orcids":["https://orcid.org/0000-0001-6789-7076"]},"institutions":[{"id":"https://openalex.org/I4210106957","display_name":"St Mary's Hospital","ror":"https://ror.org/01aysdw42","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I4210106957"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. L. Smith","raw_affiliation_strings":["Dept. of Biochemical and Experimental Pharmacology, St. Mary\u2019s Hospital, Medical School, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biochemical and Experimental Pharmacology, St. Mary\u2019s Hospital, Medical School, London, UK","institution_ids":["https://openalex.org/I4210106957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059801319","display_name":"WERNER KALOW","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"W. Kalow","raw_affiliation_strings":["Dept. of Pharmacology, Univ. of Toronto, Canada","Department of Pharmacology, University of Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacology, Univ. of Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Pharmacology, University of Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109082148","display_name":"E. Musch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Musch","raw_affiliation_strings":["Med. Univ.-Klinik Venusberg, Bonn, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Med. Univ.-Klinik Venusberg, Bonn, Deutschland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023657124","display_name":"Michel F Eichelbaum","orcid":"https://orcid.org/0000-0001-5029-8472","observed_orcids":["https://orcid.org/0000-0001-5029-8472"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Eichelbaum","raw_affiliation_strings":["Med. Univ.-Klinik Venusberg, Bonn, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Med. Univ.-Klinik Venusberg, Bonn, Deutschland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083861884","display_name":"W. Sassen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. von Sassen","raw_affiliation_strings":["Med. Univ.-Klinik Venusberg, Bonn, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Med. Univ.-Klinik Venusberg, Bonn, Deutschland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022600784","display_name":"M. Castro-Parra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Castro-Parra","raw_affiliation_strings":["Med. Univ.-Klinik Venusberg, Bonn, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Med. Univ.-Klinik Venusberg, Bonn, Deutschland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075339736","display_name":"J. K. Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. K. Wang","raw_affiliation_strings":["Med. Univ.-Klinik Venusberg, Bonn, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Med. Univ.-Klinik Venusberg, Bonn, Deutschland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037565461","display_name":"H. J. Dengler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. J. Dengler","raw_affiliation_strings":["Med. Univ.-Klinik Venusberg, Bonn, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Med. Univ.-Klinik Venusberg, Bonn, Deutschland","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"M. Doss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Doss","raw_affiliation_strings":["Abt. Klin. Biochemie, Fachbereich Humanmedizin, Univ. Marburg, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abt. Klin. Biochemie, Fachbereich Humanmedizin, Univ. Marburg, Deutschland","institution_ids":["https://openalex.org/I161103922"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2027027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1298","last_page":"1329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.8899999856948853},{"id":"https://openalex.org/keywords/nortriptyline","display_name":"nortriptyline","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-factors","display_name":"genetic factors","score":0.5360000133514404},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.6060000061988831},{"id":"https://openalex.org/keywords/therapeutic-effects","display_name":"therapeutic effects","score":0.6600000262260437},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hepatic-cytochrome-p450","display_name":"hepatic cytochrome P450","score":0.9490000009536743},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6959999799728394},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2781081902","wikidata":"https://www.wikidata.org/wiki/Q3539074","display_name":"Tricyclic","level":2,"score":0.8317685127258301},{"id":"https://openalex.org/C2780779033","wikidata":"https://www.wikidata.org/wiki/Q61387","display_name":"Nortriptyline","level":3,"score":0.8080596923828125},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6543002128601074},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5839113593101501},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.552829921245575},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.509992241859436},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.4964340329170227},{"id":"https://openalex.org/C3017575891","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma levels","level":2,"score":0.4962182641029358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4473186135292053},{"id":"https://openalex.org/C86380466","wikidata":"https://www.wikidata.org/wiki/Q5308872","display_name":"Drug action","level":3,"score":0.4189044237136841},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40155741572380066},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2387617528438568},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.203635573387146},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.19468745589256287},{"id":"https://openalex.org/C2780216858","wikidata":"https://www.wikidata.org/wiki/Q58397","display_name":"Amitriptyline","level":2,"score":0.147219717502594}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-642-85456-9_27","doi":"https://doi.org/10.1007/978-3-642-85456-9_27","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-85456-9_27","pdf_url":null,"source":{"id":"https://openalex.org/S2752137261","display_name":"Verhandlungen der Deutschen Gesellschaft f\u00fcr Innere Medizin","issn_l":"0070-4067","issn":["0070-4067"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Verhandlungen der Deutschen Gesellschaft f\u00fcr innere Medizin","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W26625382","https://openalex.org/W47302231","https://openalex.org/W123127218","https://openalex.org/W134356693","https://openalex.org/W136722816","https://openalex.org/W137903188","https://openalex.org/W448563993","https://openalex.org/W626362826","https://openalex.org/W626485227","https://openalex.org/W973981211","https://openalex.org/W1006271402","https://openalex.org/W1484494059","https://openalex.org/W1569358837","https://openalex.org/W1574530629","https://openalex.org/W1602656876","https://openalex.org/W1604536885","https://openalex.org/W1634786944","https://openalex.org/W1783992094","https://openalex.org/W1902076426","https://openalex.org/W1963845144","https://openalex.org/W1963925706","https://openalex.org/W1964666283","https://openalex.org/W1965041568","https://openalex.org/W1968785130","https://openalex.org/W1969751183","https://openalex.org/W1969898036","https://openalex.org/W1971536751","https://openalex.org/W1975348922","https://openalex.org/W1975399959","https://openalex.org/W1986830907","https://openalex.org/W1988342374","https://openalex.org/W1994446205","https://openalex.org/W1995677296","https://openalex.org/W2000090261","https://openalex.org/W2003410018","https://openalex.org/W2003643812","https://openalex.org/W2006631688","https://openalex.org/W2021444455","https://openalex.org/W2025281971","https://openalex.org/W2026991287","https://openalex.org/W2027392324","https://openalex.org/W2027433493","https://openalex.org/W2037938474","https://openalex.org/W2038674258","https://openalex.org/W2039462507","https://openalex.org/W2039978746","https://openalex.org/W2049206316","https://openalex.org/W2056210016","https://openalex.org/W2059308749","https://openalex.org/W2059741287","https://openalex.org/W2063445451","https://openalex.org/W2066939876","https://openalex.org/W2068184288","https://openalex.org/W2072559491","https://openalex.org/W2072816311","https://openalex.org/W2074657525","https://openalex.org/W2075634729","https://openalex.org/W2078280751","https://openalex.org/W2082521916","https://openalex.org/W2084686194","https://openalex.org/W2086849290","https://openalex.org/W2090058314","https://openalex.org/W2090568923","https://openalex.org/W2093714545","https://openalex.org/W2098110794","https://openalex.org/W2104606868","https://openalex.org/W2112351457","https://openalex.org/W2117365857","https://openalex.org/W2123341617","https://openalex.org/W2133721503","https://openalex.org/W2136627781","https://openalex.org/W2146143186","https://openalex.org/W2161042319","https://openalex.org/W2165196055","https://openalex.org/W2212865070","https://openalex.org/W2228903286","https://openalex.org/W2258861734","https://openalex.org/W2316806745","https://openalex.org/W2320349909","https://openalex.org/W2401633376","https://openalex.org/W2408440791","https://openalex.org/W2409625151","https://openalex.org/W2410752083","https://openalex.org/W2411576815","https://openalex.org/W2412931189","https://openalex.org/W2415938290","https://openalex.org/W2418809779","https://openalex.org/W2418968948","https://openalex.org/W2419065070","https://openalex.org/W2427053337","https://openalex.org/W2436568872","https://openalex.org/W2516201051","https://openalex.org/W2798106919","https://openalex.org/W3021870428","https://openalex.org/W4285719527","https://openalex.org/W4317648969","https://openalex.org/W7116877509"],"related_works":["https://openalex.org/W2045049706","https://openalex.org/W2058766187","https://openalex.org/W207333685","https://openalex.org/W1986810757","https://openalex.org/W2481060404","https://openalex.org/W2992642593","https://openalex.org/W2045819006","https://openalex.org/W2007797558","https://openalex.org/W2325860564","https://openalex.org/W195923861"],"abstract_inverted_index":{"ZusammenfassungSeveral":[0],"studies":[1],"have":[2],"established":[3],"that":[4],"there":[5,32],"is":[6,29,33],"a":[7,34,77],"relationship":[8,28],"between":[9],"the":[10,58,81,84,93,97,100,104],"therapeutic":[11,59],"effect":[12],"and":[13,41],"plasma":[14,43,66],"concentrations":[15,48],"of":[16,83,99],"tricyclic":[17,71],"antidepressants":[18,72],"(cf.":[19],"Sj\u00f6qvist":[20],"et":[21],"al.":[22],"1980).":[23],"For":[24,91],"nortriptyline":[25],"(NT)":[26],"this":[27],"curvilinear,":[30],"i.e.,":[31],"less":[35],"favourable":[36],"response":[37],"both":[38],"at":[39,55],"low":[40],"high":[42],"levels":[44,56,67],"compared":[45],"to":[46,76,102],"intermediate":[47],"(200\u2013600":[49],"nM).":[50],"Side-effects":[51],"are":[52,73],"usually":[53],"seen":[54],"above":[57],"concentrations.":[60],"The":[61],"pronounced":[62],"interindividual":[63],"differences":[64],"in":[65,80],"demonstrated":[68],"for":[69],"all":[70],"mainly":[74],"due":[75],"corresponding":[78],"variability":[79],"activity":[82],"hepatic":[85],"cytochrome":[86],"P-450":[87],"system":[88],"(loc.":[89],"cit.).":[90],"NT":[92],"variation":[94],"depends":[95],"on":[96],"capacity":[98],"liver":[101],"10-hydroxylate":[103],"drug":[105],"(Alexanderson":[106],"1973).":[107]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
