{"id":"https://openalex.org/W56715350","doi":null,"title":"Significance of Low Plasma Homocysteine","display_name":"Significance of Low Plasma Homocysteine","publication_year":2015,"publication_date":"2015-08-22","ids":{"openalex":"https://openalex.org/W56715350","mag":"56715350"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.612.151","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.612.151","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.metametrix.com/files/learning-center/articles/hypohomocysteinemia.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Richard S. Lord","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard S. Lord","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085968488","display_name":"Kara N. Fitzgerald","orcid":"https://orcid.org/0000-0003-4062-3790","observed_orcids":["https://orcid.org/0000-0003-4062-3790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ph. D","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Kara Fitzgerald","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kara Fitzgerald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00078434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methionine-metabolism","display_name":"methionine metabolism","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cysteine-deficiency","display_name":"cysteine deficiency","score":0.7289999723434448},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8709999918937683},{"id":"https://openalex.org/keywords/taurine","display_name":"taurine","score":0.9070000052452087},{"id":"https://openalex.org/keywords/sulfate","display_name":"sulfate","score":0.4659999907016754},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9179999828338623},{"id":"https://openalex.org/keywords/sulfur-containing-amino-acids","display_name":"sulfur-containing amino acids","score":0.9020000100135803},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9670000076293945},{"id":"https://openalex.org/keywords/methionine-supplementation","display_name":"methionine supplementation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/urinary-sulfate","display_name":"urinary sulfate","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C3017560507","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Plasma homocysteine","level":3,"score":0.45558980107307434},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.3467179834842682},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21497678756713867},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19652122259140015}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.612.151","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.612.151","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.metametrix.com/files/learning-center/articles/hypohomocysteinemia.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W247823892","https://openalex.org/W1570152720","https://openalex.org/W1982322754","https://openalex.org/W1982807179","https://openalex.org/W1983881370","https://openalex.org/W1997817371","https://openalex.org/W2003475184","https://openalex.org/W2004830149","https://openalex.org/W2010546875","https://openalex.org/W2045928506","https://openalex.org/W2049210702","https://openalex.org/W2069168291","https://openalex.org/W2082937294","https://openalex.org/W2099069677","https://openalex.org/W2107193384","https://openalex.org/W2220352584","https://openalex.org/W2399825768"],"related_works":["https://openalex.org/W7099827520","https://openalex.org/W2260820957","https://openalex.org/W3140859978","https://openalex.org/W2412824661","https://openalex.org/W4211037353","https://openalex.org/W2096478507","https://openalex.org/W2003030501","https://openalex.org/W2306374937","https://openalex.org/W2382737766","https://openalex.org/W3145389628"],"abstract_inverted_index":{"While":[0],"high":[1],"plasma":[2],"homocysteine":[3,16,31,54,75],"is":[4,32,76],"widely":[5],"recognized":[6],"as":[7,83],"a":[8],"cardiovascular":[9],"disease":[10],"risk":[11,23],"factor,":[12],"individuals":[13],"with":[14,52],"low":[15,53,74],"may":[17,96,112],"also":[18,97],"be":[19,98,113],"at":[20],"risk.":[21],"The":[22,69],"of":[24,38,46,66,78,117],"hypohomocysteinemia":[25],"derives":[26],"from":[27],"the":[28,33],"fact":[29],"that":[30,111],"normal":[34],"intermediate":[35],"for":[36,44,58,73,115],"conversion":[37],"methionine":[39,101],"into":[40],"cysteine,":[41],"and":[42,49,63,86,90,102],"thus":[43],"production":[45],"glutathione,":[47],"taurine":[48],"sulfate.":[50],"Individuals":[51],"have":[55],"limited":[56],"capacity":[57],"response":[59],"to":[60],"oxidative":[61],"stress":[62],"certain":[64],"kinds":[65],"toxin":[67],"exposure.":[68],"most":[70],"common":[71],"treatment":[72],"administration":[77],"sulfur-containing":[79],"amino":[80],"acids":[81],"such":[82],"methionine,":[84],"N-acetylcysteine":[85],"taurine.":[87],"Pre-formed":[88],"glutathione":[89],"inorganic":[91],"sulfate":[92],"salts":[93],"(potassium":[94],"sulfate)":[95],"employed.":[99],"Plasma":[100],"urinary":[103],"sulfate,":[104],"pyroglutamate":[105],"or":[106],"alpha-hydroxybutyrate":[107],"are":[108],"related":[109],"tests":[110],"performed":[114],"confirmation":[116],"significant":[118],"cysteine":[119],"deficit.":[120]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-27T00:00:00"}