{"id":"https://openalex.org/W566545929","doi":null,"title":"Transcription Associated Recombination in Mammalian Cells","display_name":"Transcription Associated Recombination in Mammalian Cells","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W566545929","mag":"566545929"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:su-38931","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-38931","pdf_url":null,"source":{"id":"https://openalex.org/S4306400561","display_name":"DiVA (Stockholm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161593684","host_organization_name":"Stockholm University","host_organization_lineage":["https://openalex.org/I161593684"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-38931","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042436507","display_name":"Linda Savolainen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Linda Savolainen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042436507"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.8289999961853027},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.7239999771118164},{"id":"https://openalex.org/keywords/ercc2","display_name":"XPD","score":0.7820000052452087},{"id":"https://openalex.org/keywords/tfiih","display_name":"TFIIH","score":0.9959999918937683},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.7490000128746033},{"id":"https://openalex.org/keywords/uv-induced-dna-damage","display_name":"UV-induced DNA damage","score":0.7089999914169312},{"id":"https://openalex.org/keywords/dna-repair-proteins","display_name":"DNA repair proteins","score":0.7250000238418579},{"id":"https://openalex.org/keywords/transcription-elongation","display_name":"transcription elongation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.7210000157356262},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9340000152587891}],"concepts":[{"id":"https://openalex.org/C2779371275","wikidata":"https://www.wikidata.org/wiki/Q914389","display_name":"Cockayne syndrome","level":5,"score":0.9378730654716492},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.8478485345840454},{"id":"https://openalex.org/C2778378917","wikidata":"https://www.wikidata.org/wiki/Q612693","display_name":"Xeroderma pigmentosum","level":4,"score":0.8312311172485352},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.699750542640686},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6554583311080933},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6382033228874207},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.5366684198379517},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5081980228424072},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48969438672065735},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47176626324653625},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4387408196926117},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:su-38931","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-38931","pdf_url":null,"source":{"id":"https://openalex.org/S4306400561","display_name":"DiVA (Stockholm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161593684","host_organization_name":"Stockholm University","host_organization_lineage":["https://openalex.org/I161593684"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:566545929","doi":null,"is_oa":false,"landing_page_url":"http://su.diva-portal.org/smash/get/diva2:317581/FULLTEXT01","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:su-38931","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-38931","pdf_url":null,"source":{"id":"https://openalex.org/S4306400561","display_name":"DiVA (Stockholm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161593684","host_organization_name":"Stockholm University","host_organization_lineage":["https://openalex.org/I161593684"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":163,"referenced_works":["https://openalex.org/W780279","https://openalex.org/W36644418","https://openalex.org/W191858024","https://openalex.org/W1264092735","https://openalex.org/W1536685080","https://openalex.org/W1604305208","https://openalex.org/W1729746476","https://openalex.org/W1757620376","https://openalex.org/W1827569717","https://openalex.org/W1834413565","https://openalex.org/W1846876036","https://openalex.org/W1849635925","https://openalex.org/W1898145693","https://openalex.org/W1943761658","https://openalex.org/W1964370576","https://openalex.org/W1968469516","https://openalex.org/W1968789240","https://openalex.org/W1968917541","https://openalex.org/W1969229317","https://openalex.org/W1970011005","https://openalex.org/W1972204126","https://openalex.org/W1972932327","https://openalex.org/W1974062259","https://openalex.org/W1977839031","https://openalex.org/W1979461110","https://openalex.org/W1980034972","https://openalex.org/W1980140992","https://openalex.org/W1980269300","https://openalex.org/W1981900473","https://openalex.org/W1982166181","https://openalex.org/W1982602899","https://openalex.org/W1982861879","https://openalex.org/W1983340499","https://openalex.org/W1984353960","https://openalex.org/W1985634689","https://openalex.org/W1986974099","https://openalex.org/W1987430471","https://openalex.org/W1988313137","https://openalex.org/W1992101827","https://openalex.org/W1993973779","https://openalex.org/W1995050542","https://openalex.org/W1995190661","https://openalex.org/W1996684631","https://openalex.org/W1997927846","https://openalex.org/W2000240413","https://openalex.org/W2000812320","https://openalex.org/W2001717159","https://openalex.org/W2003482071","https://openalex.org/W2004511402","https://openalex.org/W2006669046","https://openalex.org/W2009536322","https://openalex.org/W2010456654","https://openalex.org/W2010711320","https://openalex.org/W2010977820","https://openalex.org/W2014140511","https://openalex.org/W2014339767","https://openalex.org/W2015378640","https://openalex.org/W2015725762","https://openalex.org/W2019379779","https://openalex.org/W2019502407","https://openalex.org/W2019590540","https://openalex.org/W2023735321","https://openalex.org/W2024954071","https://openalex.org/W2025015409","https://openalex.org/W2025647725","https://openalex.org/W2028805078","https://openalex.org/W2030978639","https://openalex.org/W2034252391","https://openalex.org/W2036103078","https://openalex.org/W2036460126","https://openalex.org/W2037191150","https://openalex.org/W2038195538","https://openalex.org/W2038675517","https://openalex.org/W2039764581","https://openalex.org/W2042969047","https://openalex.org/W2043347159","https://openalex.org/W2044656608","https://openalex.org/W2044958420","https://openalex.org/W2045529026","https://openalex.org/W2046275810","https://openalex.org/W2050345170","https://openalex.org/W2052090116","https://openalex.org/W2053259460","https://openalex.org/W2054760667","https://openalex.org/W2060453248","https://openalex.org/W2060672912","https://openalex.org/W2064385019","https://openalex.org/W2065022250","https://openalex.org/W2067466498","https://openalex.org/W2068140359","https://openalex.org/W2070933029","https://openalex.org/W2071322868","https://openalex.org/W2078443851","https://openalex.org/W2080605611","https://openalex.org/W2080992989","https://openalex.org/W2082211636","https://openalex.org/W2082447947","https://openalex.org/W2082767985","https://openalex.org/W2082981258","https://openalex.org/W2083531185","https://openalex.org/W2088189164","https://openalex.org/W2091011084","https://openalex.org/W2093785124","https://openalex.org/W2094569502","https://openalex.org/W2096136751","https://openalex.org/W2096882347","https://openalex.org/W2101472561","https://openalex.org/W2102667440","https://openalex.org/W2103877069","https://openalex.org/W2104864650","https://openalex.org/W2109698643","https://openalex.org/W2110749003","https://openalex.org/W2112627245","https://openalex.org/W2113300865","https://openalex.org/W2113724086","https://openalex.org/W2115797273","https://openalex.org/W2118211036","https://openalex.org/W2118517251","https://openalex.org/W2123235480","https://openalex.org/W2123678649","https://openalex.org/W2123925380","https://openalex.org/W2127173305","https://openalex.org/W2127733528","https://openalex.org/W2128252882","https://openalex.org/W2128370098","https://openalex.org/W2130814724","https://openalex.org/W2131980596","https://openalex.org/W2134259738","https://openalex.org/W2134536765","https://openalex.org/W2136367213","https://openalex.org/W2136399386","https://openalex.org/W2137926932","https://openalex.org/W2138365701","https://openalex.org/W2139554694","https://openalex.org/W2142168955","https://openalex.org/W2144550200","https://openalex.org/W2145968044","https://openalex.org/W2147126714","https://openalex.org/W2147791743","https://openalex.org/W2149795092","https://openalex.org/W2149947954","https://openalex.org/W2149967415","https://openalex.org/W2153881449","https://openalex.org/W2153927308","https://openalex.org/W2154699761","https://openalex.org/W2157422578","https://openalex.org/W2157787686","https://openalex.org/W2159647576","https://openalex.org/W2160600937","https://openalex.org/W2160793656","https://openalex.org/W2166261808","https://openalex.org/W2168143468","https://openalex.org/W2168809955","https://openalex.org/W2170711561","https://openalex.org/W2239325055","https://openalex.org/W2275654393","https://openalex.org/W2284205568","https://openalex.org/W2323963269","https://openalex.org/W2414939181","https://openalex.org/W2495272031","https://openalex.org/W2792152836","https://openalex.org/W7034777036","https://openalex.org/W7044018574"],"related_works":["https://openalex.org/W560946068","https://openalex.org/W7095705672","https://openalex.org/W2139538055","https://openalex.org/W2151488709","https://openalex.org/W2126264822","https://openalex.org/W2159647576","https://openalex.org/W2146848597","https://openalex.org/W6893228350","https://openalex.org/W2094569502","https://openalex.org/W2021199474"],"abstract_inverted_index":{"There":[0],"is":[1,23,73,79,97,188,231,265,270],"increasing":[2],"evidence":[3],"that":[4,186,193,211,253,295,313],"the":[5,8,17,52,61,64,81,105,112,130,139,178,220,244,254,258,283,305,339],"movement":[6],"of":[7,51,84,86,129,132,141,180,195,243,257,288,297,338],"transcription":[9,181,196,260,292],"machinery":[10],"through":[11],"DNA":[12,143,158,225,273,322],"has":[13],"profound":[14],"effects":[15],"on":[16,190,202,233,280],"genomic":[18],"stability.":[19],"One":[20],"such":[21],"example":[22],"a":[24,37,75,165,214,235,317,330],"phenomenon":[25],"known":[26],"as":[27,59],"Transcription":[28,32,169],"Associated":[29],"Recombination":[30,72],"(TAR).":[31],"enhances":[33],"recombination":[34,54,67,167,175,215,221,318],"levels":[35,55,204],"to":[36,46,92,110,137,150,281],"high":[38,53],"degree":[39],"in":[40,69,120,125,146,156,205,344],"all":[41],"organisms":[42],"studied,":[43],"from":[44,219,321],"bacteria":[45],"mammals.":[47,345],"The":[48,117],"underlying":[49],"causes":[50],"observed":[56],"are":[57,60,123],"unknown,":[58],"rationale":[62],"for":[63,83,238,267,272,342],"rather":[65],"riskyhazardous":[66],"event":[68],"this":[70,115,133,174],"context.":[71],"not":[74,303],"risk-free":[76],"event;":[77],"there":[78],"e.g.":[80],"chancerisk":[82],"loss":[85],"heterozygozity,":[87],"which":[88],"may":[89],"eventually":[90],"lead":[91],"tumour":[93],"formation.":[94],"So,":[95],"why":[96],"TAR":[98,122,187,203,212,314,343],"so":[99],"ubiquitous?":[100],"This":[101,229],"thesis":[102,134],"deals":[103],"with":[104,164,332],"factors":[106],"inducing":[107],"TAR,":[108,268],"trying":[109],"elucidate":[111],"mechanisms":[113],"catalyzing":[114],"event.":[116],"proteins":[118,145,160,340],"involved":[119],"executing":[121],"unknown":[124],"mammals,":[126],"and":[127,192,261,291,293,335],"one":[128],"aims":[131],"havehas":[135],"been":[136],"investigate":[138,282],"role":[140],"well-known":[142],"repair":[144,159,262,275,287,296,307],"TAR.":[147],"In":[148,248,309],"order":[149],"do":[151],"so,":[152],"cell":[153],"lines":[154],"deficient":[155],"crucial":[157],"were":[161],"stably":[162],"transfected":[163],"novel":[166],"construct.":[168],"can":[170],"be":[171],"controlled":[172],"over":[173],"construct,":[176],"enabling":[177],"detection":[179],"associated":[182],"recombination.":[183,327],"We":[184,278,328],"found":[185,210,252,294,312,329],"dependent":[189,232],"replication":[191],"inhibition":[194],"elongation":[197],"had":[198],"no":[199],"further":[200],"effect":[201],"our":[206],"system.":[207],"Further,":[208],"we":[209,251,311],"employs":[213],"pathway":[216,222,230,319],"mechanistically":[217],"separate":[218,320],"induced":[223,326],"by":[224,276,316],"double":[226,323],"strand":[227,324],"breaks.":[228],"BRCA2,":[234],"protein":[236],"required":[237,266,341],"homologous":[239],"recombination,":[240],"but":[241,269,302],"independent":[242],"RAD51":[245],"paralog":[246],"XRCC2.":[247],"subsequent":[249],"studies,":[250],"XPD":[255],"subunit":[256],"combined":[259],"factor":[263],"TFIIH":[264],"dispensable":[271],"DSB":[274],"HR.":[277],"went":[279],"connection":[284,331],"between":[285],"HR":[286],"UV":[289,298],"damages":[290,299],"requires":[300],"transcription,":[301],"via":[304],"transcription-coupled":[306],"pathway.":[308],"conclusion,":[310],"operates":[315],"break":[325],"stalled":[333],"replication,":[334],"revealed":[336],"several":[337]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
