{"id":"https://openalex.org/W56536111","doi":null,"title":"[Study on the specific immunity of dendritic cell vaccine loading human umbilical vein endothelial cell antigen against U14 cervical cancer].","display_name":"[Study on the specific immunity of dendritic cell vaccine loading human umbilical vein endothelial cell antigen against U14 cervical cancer].","publication_year":2009,"publication_date":"2009-03-01","ids":{"openalex":"https://openalex.org/W56536111","mag":"56536111","pmid":"https://pubmed.ncbi.nlm.nih.gov/19257979"},"language":"zh","primary_location":{"id":"pmid:19257979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19257979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100681886","display_name":"Jun Zhao","orcid":"https://orcid.org/0000-0001-8546-352X","observed_orcids":["https://orcid.org/0000-0001-8546-352X"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Zhao","raw_affiliation_strings":["Department of Pathophysiology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China. zhaojun_2@yahoo.com.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China. zhaojun_2@yahoo.com.cn","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063877732","display_name":"Jing-ming Zhai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing-ming Zhai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103018632","display_name":"Jing L\u00fc","orcid":"https://orcid.org/0000-0002-7831-7687","observed_orcids":["https://orcid.org/0000-0002-7831-7687"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Hong-yan Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong-yan Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090894875","display_name":"Youtian Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"You-tian Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100324701","display_name":"Shan Li","orcid":"https://orcid.org/0000-0002-1776-2592","observed_orcids":["https://orcid.org/0000-0002-1776-2592"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shan Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038431136","display_name":"Ziming Dong","orcid":"https://orcid.org/0000-0001-5741-7868","observed_orcids":["https://orcid.org/0000-0001-5741-7868"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zi-ming Dong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100430821","display_name":"Xi Zhang","orcid":"https://orcid.org/0000-0002-0422-8980","observed_orcids":["https://orcid.org/0000-0002-0422-8980","https://orcid.org/0009-0001-4861-1375"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xi Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0042771,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"3","first_page":"196","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cell-vaccine","display_name":"dendritic cell vaccine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.7459999918937683},{"id":"https://openalex.org/keywords/tumor-antigens","display_name":"tumor antigens","score":0.45399999618530273},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7580000162124634},{"id":"https://openalex.org/keywords/integrin-alphav","display_name":"ITGAV","score":0.6439999938011169},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.7450000047683716},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6391866207122803},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6338682770729065},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.5625726580619812},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5581089854240417},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5268878936767578},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5242741107940674},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46979033946990967},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46150946617126465},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4361306428909302},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.4354260265827179},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4319274425506592},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35096386075019836},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24072962999343872},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2405095398426056},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099152","descriptor_name":"Cadherin 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D040881","descriptor_name":"CD11a Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051940","descriptor_name":"B7-2 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:19257979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19257979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2777452621","https://openalex.org/W2140427609","https://openalex.org/W2990728545","https://openalex.org/W2945013498","https://openalex.org/W2771192586","https://openalex.org/W2382737309","https://openalex.org/W4307826025","https://openalex.org/W2386134152","https://openalex.org/W2530062779","https://openalex.org/W2363231118"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"explore":[2],"the":[3,61,73,83,116,122,132,240],"specific":[4,91,211,224],"immunity":[5,92,254],"of":[6,22,68,75,79,85,124,139,154,166,181,185,200,243,247],"dendritic":[7],"cell":[8,16],"(DC)":[9],"vaccine":[10,117,234,237],"loading":[11,41],"human":[12],"umbilical":[13],"vein":[14],"endothelial":[15],"(HUVEC)":[17],"antigen.against":[18],"U14":[19,53,244],"cervical":[20,54,245],"cancer":[21,55,246],"mice.":[23,62,248],"METHODS:":[24],"Primary":[25],"HUVECs":[26,101,215,264],"were":[27,37,57,88,105,223],"cultured,":[28],"identified":[29,110],"and":[30,82,97,108,113,146,151,217,229,235,252,273],"made":[31],"into":[32,60,120],"antigen.":[33],"The":[34,63,90,137,152,163,179,198,249],"BALB/c":[35],"mice":[36,125,140,155],"immunized":[38],"with":[39,102,270],"DCs":[40],"HUVEC":[42,177],"antigen":[43],"4":[44],"times":[45],"a":[46],"week.":[47],"One":[48],"week":[49],"after":[50,148,160],"last":[51],"vaccination,":[52],"cells":[56,174],"injected":[58,119],"subcutaneously":[59],"tumor":[64,241],"size,":[65],"CTL":[66,164],"response":[67,165],"spleen":[69,80,167,186],"lymphocytes":[70,168,187],"in":[71,126,134,141,156,169,188,195,263],"vitro,":[72],"percentage":[74,180],"CD3(+)CD8(+)":[76,182],"surface":[77,183],"markers":[78,184],"lymphocytes,":[81],"titer":[84,199],"serum":[86,201],"antibody":[87,202],"detected.":[89],"was":[93,118,191,203],"examined":[94],"by":[95,109,111,257],"immunocytochemistry":[96,112,205],"Western":[98,218],"blot.":[99],"RESULTS:":[100],"high":[103],"purity":[104],"successfully":[106],"cultured":[107],"RT-PCR.":[114],"After":[115],"mice,":[121],"tumors":[123,138,153],"PBS":[127],"group":[128,158,190,209],"grew":[129,144],"faster":[130],"than":[131,193],"those":[133],"other":[135,196],"groups.":[136,197],"HUVEC-DC":[142,189,208,233,258],"groups":[143],"slowly":[145],"disappeared":[147,159],"2":[149],"weeks":[150],"DC":[157,236],"3":[161],"weeks.":[162],"vitro":[170],"showed":[171],"that":[172,194],"HUVEC-DC-T":[173],"could":[175],"kill":[176],"cells.":[178],"higher":[192],"1:800.":[204],"analysis":[206,220],"indicated":[207],"had":[210],"antigen-antibody":[212],"reaction":[213,269],"to":[214],"through":[216],"blot":[219],"revealed":[221],"there":[222],"bands":[225],"at":[226],"130":[227],"KDa":[228],"220":[230],"KDa.":[231],"CONCLUSION:":[232],"can":[238],"inhibit":[239],"growth":[242],"special":[250,267],"cellular":[251],"humoral":[253],"are":[255],"induced":[256],"vaccine.":[259],"Furthermore,":[260],"some":[261],"antigens":[262],"maybe":[265],"have":[266],"immune":[268],"integrin":[271],"alphav":[272],"VEGF-R2.":[274]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}