{"id":"https://openalex.org/W5647569","doi":null,"title":"The use of animal models for stroke research: a review.","display_name":"The use of animal models for stroke research: a review.","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W5647569","mag":"5647569","pmid":"https://pubmed.ncbi.nlm.nih.gov/22330245","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3155396"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3155396","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3155396","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comp Med","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3155396","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011494897","display_name":"Juliana Barbosa Casals","orcid":"https://orcid.org/0000-0002-0037-8842","observed_orcids":["https://orcid.org/0000-0002-0037-8842"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Juliana B Casals","raw_affiliation_strings":["Veterinary Anatomy Section, College of Veterinary Medicine and Animal Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Anatomy Section, College of Veterinary Medicine and Animal Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029223745","display_name":"Naira Caroline Godoy Pieri","orcid":"https://orcid.org/0000-0002-6800-6025","observed_orcids":["https://orcid.org/0000-0002-6800-6025"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naira C G Pieri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087237861","display_name":"Matheus Levi Tajra Feitosa","orcid":"https://orcid.org/0000-0002-9247-8532","observed_orcids":["https://orcid.org/0000-0002-9247-8532"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matheus L T Feitosa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026613881","display_name":"Anna Carolina Mazeto Ercolin","orcid":"https://orcid.org/0000-0002-5832-9015","observed_orcids":["https://orcid.org/0000-0002-5832-9015"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna C M Ercolin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072881564","display_name":"Kelly Cristine Santos Roballo","orcid":"https://orcid.org/0000-0001-8420-9159","observed_orcids":["https://orcid.org/0000-0001-8420-9159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelly C S Roballo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Rodrigo S N Barreto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodrigo S N Barreto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054390163","display_name":"Fabiana Fernandes Bressan","orcid":"https://orcid.org/0000-0001-9862-5874","observed_orcids":["https://orcid.org/0000-0001-9862-5874"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabiana F Bressan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057027044","display_name":"Daniele dos Santos Martins","orcid":"https://orcid.org/0000-0002-6277-4664","observed_orcids":["https://orcid.org/0000-0002-6277-4664"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniele S Martins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111632949","display_name":"Maria A. Miglino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria A Miglino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016177211","display_name":"Carlos Eduardo Ambr\u00f3sio","orcid":"https://orcid.org/0000-0002-8224-5022","observed_orcids":["https://orcid.org/0000-0002-8224-5022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos E Ambr\u00f3sio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0755,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.9377931,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"61","issue":"4","first_page":"305","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.05609999969601631,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12249","display_name":"Veterinary Orthopedics and Neurology","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.925000011920929},{"id":"https://openalex.org/keywords/animal-models-of-stroke","display_name":"animal models of stroke","score":0.9330000281333923},{"id":"https://openalex.org/keywords/stroke-pathophysiology","display_name":"stroke pathophysiology","score":0.7929999828338623},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5899999737739563},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.8759999871253967},{"id":"https://openalex.org/keywords/nonhuman-primate-model","display_name":"nonhuman primate model","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cerebral-vasculature","display_name":"cerebral vasculature","score":0.7099999785423279},{"id":"https://openalex.org/keywords/species-differences","display_name":"species differences","score":0.6700000166893005},{"id":"https://openalex.org/keywords/stroke-treatment","display_name":"stroke treatment","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.8954355716705322},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6305325031280518},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5966695547103882},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.5913503766059875},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.5415859222412109},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.46506860852241516},{"id":"https://openalex.org/C3018263421","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Human studies","level":2,"score":0.42644521594047546},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4202066659927368},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40518784523010254},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36015474796295166},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3480522036552429},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1916031539440155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16648736596107483},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000717","descriptor_name":"Anatomy, Comparative","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3155396","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3155396","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comp Med","raw_type":"Text"},{"id":"pmid:22330245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22330245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative medicine","raw_type":"Journal Article"},{"id":"mag:5647569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22330245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3155396","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3155396","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comp Med","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W63686995","https://openalex.org/W99808092","https://openalex.org/W1537524943","https://openalex.org/W1562792231","https://openalex.org/W1595719550","https://openalex.org/W1671891003","https://openalex.org/W1960786369","https://openalex.org/W1967143034","https://openalex.org/W1972599392","https://openalex.org/W1974673706","https://openalex.org/W1978795335","https://openalex.org/W1994334993","https://openalex.org/W2006912547","https://openalex.org/W2013507150","https://openalex.org/W2023601530","https://openalex.org/W2029734851","https://openalex.org/W2032884338","https://openalex.org/W2035335195","https://openalex.org/W2038909506","https://openalex.org/W2048197336","https://openalex.org/W2053107065","https://openalex.org/W2068946010","https://openalex.org/W2070547475","https://openalex.org/W2073189217","https://openalex.org/W2083826940","https://openalex.org/W2084927173","https://openalex.org/W2087578260","https://openalex.org/W2095659535","https://openalex.org/W2104026222","https://openalex.org/W2111301792","https://openalex.org/W2123272418","https://openalex.org/W2124790480","https://openalex.org/W2126659307","https://openalex.org/W2131740398","https://openalex.org/W2135614888","https://openalex.org/W2137324084","https://openalex.org/W2137887684","https://openalex.org/W2138260298","https://openalex.org/W2139349622","https://openalex.org/W2164548131","https://openalex.org/W2166530771","https://openalex.org/W2170929546","https://openalex.org/W2197147074","https://openalex.org/W2231805418","https://openalex.org/W2253141559","https://openalex.org/W2418114904","https://openalex.org/W2944810619","https://openalex.org/W3002740628","https://openalex.org/W3092766902","https://openalex.org/W3161161312"],"related_works":["https://openalex.org/W4238552679","https://openalex.org/W2129571101","https://openalex.org/W4382786799","https://openalex.org/W2289710504","https://openalex.org/W93871000","https://openalex.org/W3126303608","https://openalex.org/W1544034244","https://openalex.org/W2095722618","https://openalex.org/W2122016325","https://openalex.org/W3003261389"],"abstract_inverted_index":{"Stroke":[0,12],"has":[1,33],"been":[2],"identified":[3],"as":[4,60,69],"the":[5,38,47,54,73,79,92,95,121,142],"second":[6],"leading":[7],"cause":[8],"of":[9,27,37,40,82,113,120,124,141,144],"death":[10],"worldwide.":[11],"is":[13,66,128],"a":[14,20],"focal":[15],"neurologic":[16],"deficit":[17],"caused":[18],"by":[19],"change":[21],"in":[22,30,146],"cerebral":[23,122],"circulation.":[24],"The":[25],"use":[26],"animal":[28,111],"models":[29,112,134],"recent":[31],"years":[32],"improved":[34],"our":[35],"understanding":[36],"physiopathology":[39],"this":[41],"disease.":[42],"Rats":[43],"and":[44,62,75,98,149],"mice":[45],"are":[46,84],"most":[48],"commonly":[49],"used":[50,108],"stroke":[51,83,145],"models,":[52,58],"but":[53],"demand":[55],"for":[56,135],"larger":[57],"such":[59],"rabbits":[61],"even":[63],"nonhuman":[64],"primates,":[65],"increasing":[67],"so":[68],"to":[70,109,130],"better":[71],"understand":[72],"disease":[74],"its":[76],"treatment.":[77],"Although":[78],"basic":[80],"mechanisms":[81],"nearly":[85],"identical":[86],"among":[87],"mammals,":[88],"we":[89,103],"here":[90],"discuss":[91],"differences":[93],"between":[94],"human":[96,148],"encephalon":[97],"various":[99,125],"animals.":[100],"In":[101],"addition,":[102],"compare":[104],"common":[105],"surgical":[106],"techniques":[107],"induce":[110],"stroke.":[114],"A":[115],"more":[116,132],"complete":[117],"anatomic":[118],"knowledge":[119,140],"vessels":[123],"model":[126],"species":[127],"needed":[129],"develop":[131],"reliable":[133],"objective":[136],"results":[137],"that":[138],"improve":[139],"pathology":[143],"both":[147],"veterinary":[150],"medicine.":[151]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
