{"id":"https://openalex.org/W56473713","doi":null,"title":"Epigenetic regulation of aging.","display_name":"Epigenetic regulation of aging.","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W56473713","mag":"56473713","pmid":"https://pubmed.ncbi.nlm.nih.gov/20875344"},"language":"en","primary_location":{"id":"pmid:20875344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20875344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090232222","display_name":"Sandra Rodr\u00edguez\u2010Rodero","orcid":"https://orcid.org/0000-0001-8868-3667","observed_orcids":["https://orcid.org/0000-0001-8868-3667"]},"institutions":[{"id":"https://openalex.org/I4210133994","display_name":"Hospital Universitario Central de Asturias","ror":"https://ror.org/03v85ar63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4210133994","https://openalex.org/I4405258403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sandra Rodr\u00edguez-Rodero","raw_affiliation_strings":["Department of Endocrinology and Nutrition Service, Hospital Universitario Central de Asturias, Oviedo, 33006, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Nutrition Service, Hospital Universitario Central de Asturias, Oviedo, 33006, Spain","institution_ids":["https://openalex.org/I4210133994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006568625","display_name":"Juan Lu\u00eds Fern\u00e1ndez-Morera","orcid":"https://orcid.org/0000-0003-1244-068X","observed_orcids":["https://orcid.org/0000-0003-1244-068X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Luis Fern\u00e1ndez-Morera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037828387","display_name":"Agust\u00edn F. Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-3792-4085","observed_orcids":["https://orcid.org/0000-0002-3792-4085"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agustin F Fernandez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017004152","display_name":"Edelmiro Luis Men\u00e9ndez Torre","orcid":"https://orcid.org/0000-0002-9548-7821","observed_orcids":["https://orcid.org/0000-0002-9548-7821"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edelmiro Men\u00e9ndez-Torre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066955100","display_name":"Mario F. Fraga","orcid":"https://orcid.org/0000-0001-8450-2603","observed_orcids":["https://orcid.org/0000-0001-8450-2603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mario F Fraga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.292,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.93383156,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"52","first_page":"225","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.7820000052452087},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.996999979019165},{"id":"https://openalex.org/keywords/age-related-diseases","display_name":"age-related diseases","score":0.7319999933242798},{"id":"https://openalex.org/keywords/transgenerational-epigenetic-inheritance","display_name":"transgenerational epigenetic inheritance","score":0.824999988079071},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.9610000252723694},{"id":"https://openalex.org/keywords/phenotypic-variation","display_name":"phenotypic variability","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.9441649913787842},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6307342052459717},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.5828143358230591},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5315330624580383},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.45623230934143066},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.43273022770881653},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.41677093505859375},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4104440212249756},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.396768718957901},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.38603445887565613},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3552686274051666},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11812090873718262},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11481845378875732},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:20875344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20875344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},{"id":"mag:56473713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20875344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2050880607","https://openalex.org/W2038510075","https://openalex.org/W3209133424","https://openalex.org/W2008296007","https://openalex.org/W7074071887","https://openalex.org/W2963537251","https://openalex.org/W946452087","https://openalex.org/W4410637324","https://openalex.org/W4247307243","https://openalex.org/W2066400388"],"abstract_inverted_index":{"Aging":[0,65],"is":[1,66,121],"one":[2],"of":[3,28,69,100,133,159,170],"the":[4,86,98,107,114,126,131,146,157,167],"most":[5],"challenging":[6],"and":[7,59,71,105,117,136,162,174],"unresolved":[8],"problems":[9],"in":[10,20,84,97,123],"biology":[11],"owing":[12],"to":[13,32,34,44,51,141],"its":[14],"highly":[15],"complex":[16],"nature.":[17],"Public":[18],"interest":[19],"aging":[21,104],"has":[22,80],"increased":[23],"not":[24,154],"only":[25,155],"because":[26,41],"all":[27,75],"us":[29],"can":[30,137,151],"expect":[31],"live":[33],"a":[35,67,94,134],"ripe":[36],"old":[37],"age":[38],"but":[39,164],"also":[40,92,165],"we":[42],"wish":[43],"avoid":[45],"those":[46],"age-related":[47],"changes":[48,128],"that":[49,89,129,148],"lead":[50,130],"physical":[52],"invalidity":[53],"or":[54],"other":[55],"diseases":[56,101],"(cancer,":[57],"depression)":[58],"may":[60],"ultimately":[61],"cause":[62],"social":[63],"isolation.":[64],"process":[68],"genetic":[70,112],"epigenetic":[72,127],"interactions":[73],"at":[74],"biological":[76],"levels,":[77],"where":[78],"epigenetics":[79],"an":[81,110],"important":[82],"function":[83],"determining":[85],"phenotypic":[87],"differences":[88],"arise.":[90],"Epigenetics":[91,144],"plays":[93],"key":[95],"role":[96,132],"development":[99],"associated":[102],"with":[103],"explains":[106],"relationship":[108],"between":[109],"individual's":[111],"background,":[113],"environment,":[115],"aging,":[116],"disease.":[118],"DNA":[119],"plasticity":[120],"mediated":[122],"part":[124],"by":[125,156,166],"cell,":[135],"be":[138,152],"passed":[139],"on":[140],"future":[142],"generations.":[143],"establishes":[145],"idea":[147],"our":[149,160,171],"health":[150],"affected":[153],"interplay":[158],"genes":[161,173],"environment":[163],"inherited":[168],"effects":[169],"ancestors'":[172],"environment.":[175]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
