{"id":"https://openalex.org/W563928100","doi":null,"title":"Comparison of the pharmacokinetic and pharmacodynamic profiles of resveratrol at dietary and pharmacological doses","display_name":"Comparison of the pharmacokinetic and pharmacodynamic profiles of resveratrol at dietary and pharmacological doses","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W563928100","mag":"563928100"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/10104920","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Comparison_of_the_pharmacokinetic_and_pharmacodynamic_profiles_of_resveratrol_at_dietary_and_pharmacological_doses/10104920","pdf_url":"https://figshare.com/articles/thesis/Comparison_of_the_pharmacokinetic_and_pharmacodynamic_profiles_of_resveratrol_at_dietary_and_pharmacological_doses/10104920","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/thesis/Comparison_of_the_pharmacokinetic_and_pharmacodynamic_profiles_of_resveratrol_at_dietary_and_pharmacological_doses/10104920","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111366981","display_name":"Edwina N. Scott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Edwina N. Scott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111366981"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8849999904632568},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.8450000286102295},{"id":"https://openalex.org/keywords/dietary-dose","display_name":"dietary dose","score":0.5109999775886536},{"id":"https://openalex.org/keywords/pharmacological-doses","display_name":"pharmacological doses","score":0.8140000104904175},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8849999904632568},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.7919999957084656},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.609000027179718},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7680000066757202},{"id":"https://openalex.org/keywords/apcmin-mice","display_name":"ApcMin/+ mice","score":0.8539999723434448},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7689999938011169},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.49799999594688416},{"id":"https://openalex.org/keywords/glucose-transport","display_name":"glucose transport","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.8989999890327454},{"id":"https://openalex.org/keywords/resveratrol-metabolites","display_name":"resveratrol metabolites","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.7910000085830688},{"id":"https://openalex.org/keywords/accelerator-mass-spectrometry","display_name":"accelerator mass spectrometry","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.8030668497085571},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.7632020711898804},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7397251129150391},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7119850516319275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.548600971698761}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/10104920","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Comparison_of_the_pharmacokinetic_and_pharmacodynamic_profiles_of_resveratrol_at_dietary_and_pharmacological_doses/10104920","pdf_url":"https://figshare.com/articles/thesis/Comparison_of_the_pharmacokinetic_and_pharmacodynamic_profiles_of_resveratrol_at_dietary_and_pharmacological_doses/10104920","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:lra.le.ac.uk:2381/10298","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/10298","pdf_url":"http://hdl.handle.net/2381/10298","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:563928100","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/530627","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/10104920","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Comparison_of_the_pharmacokinetic_and_pharmacodynamic_profiles_of_resveratrol_at_dietary_and_pharmacological_doses/10104920","pdf_url":"https://figshare.com/articles/thesis/Comparison_of_the_pharmacokinetic_and_pharmacodynamic_profiles_of_resveratrol_at_dietary_and_pharmacological_doses/10104920","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W563928100.pdf","grobid_xml":"https://content.openalex.org/works/W563928100.grobid-xml"},"referenced_works_count":228,"referenced_works":["https://openalex.org/W1166801","https://openalex.org/W90749494","https://openalex.org/W168087750","https://openalex.org/W236878035","https://openalex.org/W1558105003","https://openalex.org/W1560965218","https://openalex.org/W1568103239","https://openalex.org/W1593840699","https://openalex.org/W1789813876","https://openalex.org/W1881147845","https://openalex.org/W1926151057","https://openalex.org/W1964974475","https://openalex.org/W1966350354","https://openalex.org/W1966391164","https://openalex.org/W1967054449","https://openalex.org/W1969303075","https://openalex.org/W1969752278","https://openalex.org/W1970156673","https://openalex.org/W1970342864","https://openalex.org/W1972255467","https://openalex.org/W1975076018","https://openalex.org/W1975480225","https://openalex.org/W1975993620","https://openalex.org/W1977064151","https://openalex.org/W1979266353","https://openalex.org/W1979501382","https://openalex.org/W1979956688","https://openalex.org/W1981461721","https://openalex.org/W1984367287","https://openalex.org/W1985148856","https://openalex.org/W1985235736","https://openalex.org/W1985828044","https://openalex.org/W1986254047","https://openalex.org/W1986398106","https://openalex.org/W1987013638","https://openalex.org/W1987184215","https://openalex.org/W1987562801","https://openalex.org/W1989028053","https://openalex.org/W1989206706","https://openalex.org/W1989969820","https://openalex.org/W1990296461","https://openalex.org/W1990606472","https://openalex.org/W1991949008","https://openalex.org/W1993009399","https://openalex.org/W1994114133","https://openalex.org/W1994802428","https://openalex.org/W1996013561","https://openalex.org/W1997430443","https://openalex.org/W1997951817","https://openalex.org/W1998637589","https://openalex.org/W1999481655","https://openalex.org/W2000130011","https://openalex.org/W2000238977","https://openalex.org/W2002248582","https://openalex.org/W2002375694","https://openalex.org/W2005631366","https://openalex.org/W2007869047","https://openalex.org/W2007997046","https://openalex.org/W2009056155","https://openalex.org/W2009729949","https://openalex.org/W2010174939","https://openalex.org/W2010467665","https://openalex.org/W2011355924","https://openalex.org/W2015664785","https://openalex.org/W2016322897","https://openalex.org/W2016371780","https://openalex.org/W2016979581","https://openalex.org/W2017485723","https://openalex.org/W2017879912","https://openalex.org/W2018009295","https://openalex.org/W2019616743","https://openalex.org/W2020001968","https://openalex.org/W2023460369","https://openalex.org/W2023869046","https://openalex.org/W2024105335","https://openalex.org/W2024772034","https://openalex.org/W2025322413","https://openalex.org/W2028319504","https://openalex.org/W2032931271","https://openalex.org/W2033649912","https://openalex.org/W2034269086","https://openalex.org/W2035006578","https://openalex.org/W2035683002","https://openalex.org/W2035692001","https://openalex.org/W2036492041","https://openalex.org/W2037133338","https://openalex.org/W2040692157","https://openalex.org/W2041026651","https://openalex.org/W2042810345","https://openalex.org/W2045175501","https://openalex.org/W2045486084","https://openalex.org/W2046946656","https://openalex.org/W2048000626","https://openalex.org/W2050143588","https://openalex.org/W2050776635","https://openalex.org/W2051281154","https://openalex.org/W2053232597","https://openalex.org/W2053686298","https://openalex.org/W2054284686","https://openalex.org/W2055478739","https://openalex.org/W2057688704","https://openalex.org/W2057830803","https://openalex.org/W2059724367","https://openalex.org/W2059881760","https://openalex.org/W2062188669","https://openalex.org/W2064418518","https://openalex.org/W2068262029","https://openalex.org/W2069391842","https://openalex.org/W2069430308","https://openalex.org/W2070071707","https://openalex.org/W2071359530","https://openalex.org/W2072143531","https://openalex.org/W2072878220","https://openalex.org/W2075884509","https://openalex.org/W2079030291","https://openalex.org/W2080273638","https://openalex.org/W2080666697","https://openalex.org/W2080842490","https://openalex.org/W2081909969","https://openalex.org/W2082792223","https://openalex.org/W2083210225","https://openalex.org/W2083858463","https://openalex.org/W2085615121","https://openalex.org/W2089165207","https://openalex.org/W2091564285","https://openalex.org/W2093531978","https://openalex.org/W2094127618","https://openalex.org/W2095699471","https://openalex.org/W2096089065","https://openalex.org/W2096497526","https://openalex.org/W2097903769","https://openalex.org/W2099178340","https://openalex.org/W2100672979","https://openalex.org/W2100856180","https://openalex.org/W2101515818","https://openalex.org/W2102055578","https://openalex.org/W2102673605","https://openalex.org/W2102946509","https://openalex.org/W2102950926","https://openalex.org/W2104248617","https://openalex.org/W2104525350","https://openalex.org/W2105252014","https://openalex.org/W2106032666","https://openalex.org/W2106253081","https://openalex.org/W2107259958","https://openalex.org/W2107651161","https://openalex.org/W2108218053","https://openalex.org/W2109619047","https://openalex.org/W2110385920","https://openalex.org/W2110808383","https://openalex.org/W2111274588","https://openalex.org/W2111442478","https://openalex.org/W2111480326","https://openalex.org/W2111843196","https://openalex.org/W2112392983","https://openalex.org/W2112815040","https://openalex.org/W2113302789","https://openalex.org/W2113720631","https://openalex.org/W2115514778","https://openalex.org/W2116537907","https://openalex.org/W2117222904","https://openalex.org/W2117316894","https://openalex.org/W2117859871","https://openalex.org/W2118230618","https://openalex.org/W2118913969","https://openalex.org/W2119294174","https://openalex.org/W2121334918","https://openalex.org/W2121434969","https://openalex.org/W2121836743","https://openalex.org/W2123603746","https://openalex.org/W2124142587","https://openalex.org/W2124607818","https://openalex.org/W2125323026","https://openalex.org/W2126655188","https://openalex.org/W2127218761","https://openalex.org/W2127466067","https://openalex.org/W2127929460","https://openalex.org/W2129738108","https://openalex.org/W2131911958","https://openalex.org/W2132299300","https://openalex.org/W2133544901","https://openalex.org/W2133774547","https://openalex.org/W2133929387","https://openalex.org/W2135685233","https://openalex.org/W2137560695","https://openalex.org/W2139290043","https://openalex.org/W2143024870","https://openalex.org/W2143104968","https://openalex.org/W2143267387","https://openalex.org/W2144170214","https://openalex.org/W2144600435","https://openalex.org/W2144810168","https://openalex.org/W2145492158","https://openalex.org/W2146291138","https://openalex.org/W2146350175","https://openalex.org/W2146698208","https://openalex.org/W2148792455","https://openalex.org/W2149726552","https://openalex.org/W2150187975","https://openalex.org/W2151089147","https://openalex.org/W2152791120","https://openalex.org/W2154404350","https://openalex.org/W2154966750","https://openalex.org/W2155530804","https://openalex.org/W2155835666","https://openalex.org/W2156227340","https://openalex.org/W2156831368","https://openalex.org/W2157108841","https://openalex.org/W2158131645","https://openalex.org/W2158719210","https://openalex.org/W2158735110","https://openalex.org/W2160222998","https://openalex.org/W2164573775","https://openalex.org/W2164867317","https://openalex.org/W2166096734","https://openalex.org/W2167226448","https://openalex.org/W2169096791","https://openalex.org/W2170539169","https://openalex.org/W2171116101","https://openalex.org/W2185652905","https://openalex.org/W2186436769","https://openalex.org/W2188406439","https://openalex.org/W2281351897","https://openalex.org/W2315403385","https://openalex.org/W2317242858","https://openalex.org/W2336169581","https://openalex.org/W2336215030","https://openalex.org/W4301066098"],"related_works":["https://openalex.org/W1697672914","https://openalex.org/W2155590575","https://openalex.org/W1951997517","https://openalex.org/W2080644780","https://openalex.org/W3133611895","https://openalex.org/W2037345578","https://openalex.org/W7099788498","https://openalex.org/W851379980","https://openalex.org/W7042560536","https://openalex.org/W1910188951"],"abstract_inverted_index":{"Epidemiological":[0],"and":[1,15,29,47,64,129,164,234,251,278,283],"preclinical":[2,59],"studies":[3],"suggest":[4,259,286],"that":[5,103,260,287],"dietary-derived":[6],"cancer":[7,100],"chemopreventive":[8],"agents":[9],"may":[10,266],"be":[11,267],"active":[12],"at":[13,109,135,184,209,238],"dietary":[14,41,186],"supra-dietary":[16,49,210],"doses.":[17,211],"This":[18],"project":[19,79],"therefore":[20],"investigated":[21],"the":[22,27,74,84,112,125,138,167,181,189,239,261],"effect":[23],"of":[24,32,77,87,191,214,216,225,264,273,276],"dose":[25,187],"on":[26],"pharmacokinetic":[28],"pharmacodynamic":[30,291],"actions":[31,215,292],"resveratrol,":[33],"a":[34,48,145,185,192,204],"polyphenol":[35],"found":[36],"in":[37,45,53,58,61,65,73,116,142,166,172,188,218,228,231,281,293],"grapes.":[38],"An":[39],"achievable":[40],"intake":[42],"(5":[43],"mg/day":[44],"humans)":[46],"dose,":[50,123,148],"previously":[51],"used":[52,72],"clinical":[54,75],"trials,":[55],"were":[56,174,220,246],"compared":[57],"systems,":[60],"healthy":[62],"volunteers":[63],"patients.":[66],"Accelerator":[67],"mass":[68],"spectrometry":[69],"(AMS)":[70],"was":[71,198],"part":[76],"this":[78,197],"as":[80,171],"its":[81,279],"sensitivity":[82],"allowed":[83],"safe":[85],"administration":[86,224],"radiolabelled":[88],"resveratrol":[89,104,217,265,277,288],"to":[90,176],"participants.":[91],"\\nIn":[92],"vitro":[93],"microarray":[94],"results":[95,258],"from":[96],"human":[97],"colon":[98,233,284],"HCA7":[99],"cells":[101],"showed":[102],"exposure":[105,134],"for":[106],"3":[107],"months":[108],"0.01":[110],"\u03bcM,":[111,137],"estimated":[113],"plasma":[114,139],"level":[115],"man":[117,143],"after":[118,144],"an":[119],"oral":[120,223],"5":[121,240],"mg":[122,241],"altered":[124],"apoptosis,":[126],"glucose":[127],"transport":[128],"cell":[130],"adhesion":[131],"pathways.":[132,154],"Resveratrol":[133,179],"1.4":[136],"Cmax":[140],"value":[141],"1":[146],"g":[147],"did":[149],"not":[150,199],"significantly":[151],"alter":[152],"any":[153],"The":[155,212,243,271],"equivalent":[156],"doses,":[157],"determined":[158],"by":[159,161],"conversion":[160],"body":[162],"weight":[163],"resulting":[165],"same":[168],"tissue":[169,236,250,285],"levels":[170,230,275],"man,":[173],"administered":[175,202],"ApcMin+/-":[177],"mice.":[178],"reduced":[180],"tumour":[182],"burden":[183],"presence":[190],"high":[193],"fat":[194,206],"diet,":[195,207],"but":[196],"seen":[200],"when":[201],"with":[203,253],"standard":[205],"nor":[208],"mechanisms":[213],"vivo":[219],"unclear.":[221],"Clinically,":[222],"[14C]-resveratrol":[226],"resulted":[227],"detectable":[229,274],"plasma,":[232,252],"prostate":[235,249,282],"even":[237],"dose.":[242],"metabolite":[244,280],"profiles":[245],"similar":[247],"between":[248],"metabolites":[254],"predominating.":[255],"Overall,":[256],"these":[257,294],"dose-response":[262],"relationship":[263],"biphasic":[268],"or":[269],"U-shaped.":[270],"confirmation":[272],"could":[289],"exert":[290],"organs.":[295]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}