{"id":"https://openalex.org/W563081469","doi":null,"title":"Interactions et coop\u00e9rations cellulaires dans le processus m\u00e9tastatique","display_name":"Interactions et coop\u00e9rations cellulaires dans le processus m\u00e9tastatique","publication_year":2008,"publication_date":"2008-09-22","ids":{"openalex":"https://openalex.org/W563081469","mag":"563081469"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/816825","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/816825","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/816825","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005286764","display_name":"Fran\u00e7ois\u2010Cl\u00e9ment Bidard","orcid":"https://orcid.org/0000-0001-5932-8949","observed_orcids":["https://orcid.org/0000-0001-5932-8949"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fran\u00e7ois\u2010Cl\u00e9ment Bidard","raw_affiliation_strings":["Service d'Oncologie M\u00e9dicale"],"raw_orcid":"https://orcid.org/0000-0001-5932-8949","affiliations":[{"raw_affiliation_string":"Service d'Oncologie M\u00e9dicale","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5005286764"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/metastatic-phenotype","display_name":"metastatic phenotype","score":0.6110000014305115},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.4129999876022339},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6899999976158142},{"id":"https://openalex.org/keywords/disseminated-tumor-cells","display_name":"disseminated tumor cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bone-marrow-micrometastasis","display_name":"bone marrow micrometastases","score":0.9430000185966492},{"id":"https://openalex.org/keywords/clonal-selection","display_name":"clonal selection","score":0.7649999856948853},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6370000243186951},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.5519999861717224},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.6100000143051147},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.5429999828338623},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.3630000054836273},{"id":"https://openalex.org/keywords/cell-cell-interactions","display_name":"cell-cell interactions","score":0.4050000011920929},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.492000013589859},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.41100001335144043},{"id":"https://openalex.org/keywords/tumor-associated-neutrophils","display_name":"tumor-associated neutrophils","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5680376887321472},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.42645666003227234},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.35715818405151367},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35044264793395996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33174294233322144}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:hdl:10068/816825","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/816825","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:HAL:tel-00392387v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00392387","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biologie cellulaire. Universit\u00e9 Paris Sud - Paris XI, 2008. Fran\u00e7ais. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:563081469","doi":null,"is_oa":false,"landing_page_url":"https://tel.archives-ouvertes.fr/docs/00/39/23/87/PDF/These.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:hdl:10068/816825","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/816825","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":320,"referenced_works":["https://openalex.org/W20888715","https://openalex.org/W27714575","https://openalex.org/W50786528","https://openalex.org/W152930514","https://openalex.org/W154028481","https://openalex.org/W400863786","https://openalex.org/W1480706413","https://openalex.org/W1489869710","https://openalex.org/W1495945591","https://openalex.org/W1501050051","https://openalex.org/W1506680628","https://openalex.org/W1514761907","https://openalex.org/W1520425169","https://openalex.org/W1521841046","https://openalex.org/W1536370890","https://openalex.org/W1538548942","https://openalex.org/W1561549145","https://openalex.org/W1565417674","https://openalex.org/W1566772021","https://openalex.org/W1568318341","https://openalex.org/W1576773659","https://openalex.org/W1588099021","https://openalex.org/W1647809223","https://openalex.org/W1651537857","https://openalex.org/W1656339735","https://openalex.org/W1743523754","https://openalex.org/W1748799809","https://openalex.org/W1797502491","https://openalex.org/W1821813067","https://openalex.org/W1854022487","https://openalex.org/W1862648001","https://openalex.org/W1880891411","https://openalex.org/W1917160644","https://openalex.org/W1949238489","https://openalex.org/W1960278053","https://openalex.org/W1963502802","https://openalex.org/W1963844966","https://openalex.org/W1964052195","https://openalex.org/W1966846872","https://openalex.org/W1969004585","https://openalex.org/W1970173966","https://openalex.org/W1971056919","https://openalex.org/W1971873096","https://openalex.org/W1973422759","https://openalex.org/W1974837959","https://openalex.org/W1975046725","https://openalex.org/W1975198479","https://openalex.org/W1977091859","https://openalex.org/W1977657840","https://openalex.org/W1978590275","https://openalex.org/W1979300931","https://openalex.org/W1979314297","https://openalex.org/W1980143004","https://openalex.org/W1980299983","https://openalex.org/W1980566259","https://openalex.org/W1984162437","https://openalex.org/W1985725701","https://openalex.org/W1985727076","https://openalex.org/W1986471913","https://openalex.org/W1987025899","https://openalex.org/W1987551912","https://openalex.org/W1987660792","https://openalex.org/W1987802161","https://openalex.org/W1989402228","https://openalex.org/W1990120645","https://openalex.org/W1990877651","https://openalex.org/W1992539008","https://openalex.org/W1992706018","https://openalex.org/W1993338076","https://openalex.org/W1993497779","https://openalex.org/W1993541144","https://openalex.org/W1993547614","https://openalex.org/W1994161105","https://openalex.org/W1994915831","https://openalex.org/W1995209724","https://openalex.org/W1996279797","https://openalex.org/W1997009310","https://openalex.org/W1998200920","https://openalex.org/W1998252347","https://openalex.org/W1998811052","https://openalex.org/W1999406693","https://openalex.org/W2000185616","https://openalex.org/W2000217512","https://openalex.org/W2003500892","https://openalex.org/W2004247096","https://openalex.org/W2005715557","https://openalex.org/W2006246922","https://openalex.org/W2006444511","https://openalex.org/W2007599495","https://openalex.org/W2007897263","https://openalex.org/W2007990744","https://openalex.org/W2009240587","https://openalex.org/W2009887475","https://openalex.org/W2009971950","https://openalex.org/W2010540709","https://openalex.org/W2010715204","https://openalex.org/W2011191202","https://openalex.org/W2013307793","https://openalex.org/W2014446933","https://openalex.org/W2014691022","https://openalex.org/W2017767253","https://openalex.org/W2019520753","https://openalex.org/W2019563632","https://openalex.org/W2019731805","https://openalex.org/W2020124057","https://openalex.org/W2020532584","https://openalex.org/W2020974847","https://openalex.org/W2021250298","https://openalex.org/W2021548785","https://openalex.org/W2021880490","https://openalex.org/W2022233074","https://openalex.org/W2024223604","https://openalex.org/W2025016998","https://openalex.org/W2025647419","https://openalex.org/W2026037933","https://openalex.org/W2026729384","https://openalex.org/W2027941483","https://openalex.org/W2028476252","https://openalex.org/W2028976862","https://openalex.org/W2028986616","https://openalex.org/W2030441031","https://openalex.org/W2031419009","https://openalex.org/W2032941886","https://openalex.org/W2033193989","https://openalex.org/W2033601733","https://openalex.org/W2034269086","https://openalex.org/W2034855589","https://openalex.org/W2035235278","https://openalex.org/W2035809865","https://openalex.org/W2036008499","https://openalex.org/W2036362283","https://openalex.org/W2038183997","https://openalex.org/W2038511343","https://openalex.org/W2039469454","https://openalex.org/W2039712657","https://openalex.org/W2041524945","https://openalex.org/W2041888522","https://openalex.org/W2045533892","https://openalex.org/W2045690475","https://openalex.org/W2047529648","https://openalex.org/W2047553717","https://openalex.org/W2047992261","https://openalex.org/W2048994014","https://openalex.org/W2055284465","https://openalex.org/W2055858765","https://openalex.org/W2056507674","https://openalex.org/W2058729408","https://openalex.org/W2059174198","https://openalex.org/W2060315334","https://openalex.org/W2060529002","https://openalex.org/W2061385217","https://openalex.org/W2062249523","https://openalex.org/W2063429605","https://openalex.org/W2064419741","https://openalex.org/W2065006933","https://openalex.org/W2067279821","https://openalex.org/W2068503417","https://openalex.org/W2068756348","https://openalex.org/W2068773189","https://openalex.org/W2070058781","https://openalex.org/W2070291618","https://openalex.org/W2072928113","https://openalex.org/W2074465378","https://openalex.org/W2074736160","https://openalex.org/W2075632157","https://openalex.org/W2076583198","https://openalex.org/W2076636899","https://openalex.org/W2078469315","https://openalex.org/W2078808106","https://openalex.org/W2080183018","https://openalex.org/W2080196370","https://openalex.org/W2081601075","https://openalex.org/W2082833890","https://openalex.org/W2083049240","https://openalex.org/W2083314390","https://openalex.org/W2086641174","https://openalex.org/W2086918041","https://openalex.org/W2088358109","https://openalex.org/W2089314353","https://openalex.org/W2089693511","https://openalex.org/W2090399120","https://openalex.org/W2092868756","https://openalex.org/W2093024420","https://openalex.org/W2094964650","https://openalex.org/W2095259408","https://openalex.org/W2095554214","https://openalex.org/W2096436239","https://openalex.org/W2097255042","https://openalex.org/W2098187416","https://openalex.org/W2098771739","https://openalex.org/W2099939399","https://openalex.org/W2100193180","https://openalex.org/W2100812787","https://openalex.org/W2101386911","https://openalex.org/W2102411854","https://openalex.org/W2102734247","https://openalex.org/W2104162140","https://openalex.org/W2106435751","https://openalex.org/W2106642283","https://openalex.org/W2108122736","https://openalex.org/W2108360007","https://openalex.org/W2108706718","https://openalex.org/W2109276980","https://openalex.org/W2109647778","https://openalex.org/W2111769468","https://openalex.org/W2111976640","https://openalex.org/W2112528220","https://openalex.org/W2112995207","https://openalex.org/W2113500634","https://openalex.org/W2113676600","https://openalex.org/W2114623825","https://openalex.org/W2115062156","https://openalex.org/W2115436106","https://openalex.org/W2115792588","https://openalex.org/W2115971576","https://openalex.org/W2116059104","https://openalex.org/W2116247281","https://openalex.org/W2116388783","https://openalex.org/W2116403488","https://openalex.org/W2117199645","https://openalex.org/W2117305280","https://openalex.org/W2117313199","https://openalex.org/W2117668915","https://openalex.org/W2118411892","https://openalex.org/W2118700885","https://openalex.org/W2119299101","https://openalex.org/W2119480061","https://openalex.org/W2119584041","https://openalex.org/W2119918421","https://openalex.org/W2121493672","https://openalex.org/W2121672045","https://openalex.org/W2121887268","https://openalex.org/W2122693202","https://openalex.org/W2124069802","https://openalex.org/W2124133814","https://openalex.org/W2125045349","https://openalex.org/W2126166557","https://openalex.org/W2128030919","https://openalex.org/W2128571346","https://openalex.org/W2130024109","https://openalex.org/W2130651544","https://openalex.org/W2131170195","https://openalex.org/W2131230383","https://openalex.org/W2132124066","https://openalex.org/W2132300233","https://openalex.org/W2132308320","https://openalex.org/W2135803007","https://openalex.org/W2136379419","https://openalex.org/W2136390065","https://openalex.org/W2136989218","https://openalex.org/W2138022504","https://openalex.org/W2138800766","https://openalex.org/W2139146830","https://openalex.org/W2139151018","https://openalex.org/W2140551998","https://openalex.org/W2141696951","https://openalex.org/W2141815918","https://openalex.org/W2142416414","https://openalex.org/W2143849369","https://openalex.org/W2145345239","https://openalex.org/W2145920882","https://openalex.org/W2146530991","https://openalex.org/W2146678830","https://openalex.org/W2146930593","https://openalex.org/W2147283821","https://openalex.org/W2147570487","https://openalex.org/W2147723384","https://openalex.org/W2148000660","https://openalex.org/W2148594850","https://openalex.org/W2149390058","https://openalex.org/W2149685341","https://openalex.org/W2150254130","https://openalex.org/W2150415238","https://openalex.org/W2150902592","https://openalex.org/W2152596751","https://openalex.org/W2154154147","https://openalex.org/W2154210454","https://openalex.org/W2154622748","https://openalex.org/W2155498341","https://openalex.org/W2156323704","https://openalex.org/W2156604663","https://openalex.org/W2156802024","https://openalex.org/W2157383773","https://openalex.org/W2158615473","https://openalex.org/W2159921466","https://openalex.org/W2160202154","https://openalex.org/W2160450758","https://openalex.org/W2161020561","https://openalex.org/W2162495463","https://openalex.org/W2163502506","https://openalex.org/W2163563958","https://openalex.org/W2164044508","https://openalex.org/W2164629825","https://openalex.org/W2168230468","https://openalex.org/W2168991663","https://openalex.org/W2169369613","https://openalex.org/W2169840370","https://openalex.org/W2170157144","https://openalex.org/W2170200613","https://openalex.org/W2170304997","https://openalex.org/W2170813095","https://openalex.org/W2171284757","https://openalex.org/W2171298396","https://openalex.org/W2171351216","https://openalex.org/W2172177304","https://openalex.org/W2172225180","https://openalex.org/W2183333859","https://openalex.org/W2188735123","https://openalex.org/W2248366326","https://openalex.org/W2271721498","https://openalex.org/W2288138515","https://openalex.org/W2321753125","https://openalex.org/W2363241404","https://openalex.org/W2403703460","https://openalex.org/W2416238671","https://openalex.org/W2428861015","https://openalex.org/W2467391333","https://openalex.org/W2472450258","https://openalex.org/W2995133996","https://openalex.org/W4313347834"],"related_works":["https://openalex.org/W7151512467","https://openalex.org/W2916124723","https://openalex.org/W2589787024","https://openalex.org/W626431186","https://openalex.org/W2075092168","https://openalex.org/W7148495476","https://openalex.org/W2527984487","https://openalex.org/W2085285179","https://openalex.org/W6982393431","https://openalex.org/W2867584584"],"abstract_inverted_index":{"La":[0],"formation":[1],"de":[2,8,41,61,99,117,158,167,188,190,222,270,316,351,354,366,370],"m\u00e9tastases":[3,84,105,149],"est":[4,272],"un":[5,57,155,194,238,279,326],"processus":[6,35,337,384],"comportant":[7],"multiples":[9],"\u00e9tapes,":[10],"pr\u00e9sent\u00e9es":[11],"par":[12,21,33,86,90,94,154,218,281,312],"le":[13,143],"paradigme":[14],"actuel":[15,145],"comme":[16],"devant":[17],"\u00eatre":[18],"franchies":[19],"s\u00e9quentiellement":[20],"une":[22,68,186,210,275],"(des)":[23],"cellule(s)":[24],"poss\u00e9dant":[25],"l'ensemble":[26],"des":[27,83,87,95,104,132,199,264,306,380],"capacit\u00e9s":[28],"g\u00e9n\u00e9tiques":[29,39],"et":[30,74,120,162,203,242,249,288,358,398],"ph\u00e9notypiques":[31],"requises":[32],"ce":[34,51],"s\u00e9lectif.":[36],"Les":[37,373],"d\u00e9terminants":[38],"responsables":[40],"l'acquisition":[42],"du":[43,196,383],"ph\u00e9notype":[44],"m\u00e9tastatique":[45,128,293,331,385],"restent":[46],"cependant":[47],"incompl\u00e8tement":[48],"d\u00e9termin\u00e9s":[49],"\u00e0":[50,109,124,209,274,325,339],"jour.":[52],"Une":[53,170,261],"premi\u00e8re":[54],"approche,":[55],"dans":[56,179,185],"mod\u00e8le":[58,144],"in":[59],"vivo":[60],"cancer":[62,195],"colo-rectal":[63],"humain,":[64],"d\u00e9montre":[65],"qu'il":[66],"existe":[67],"coop\u00e9ration":[69,168,362],"entre":[70],"cellules":[71,88,96,118,133,175,307,318,394],"tumorales":[72,97,134,176,308,395],"m\u00e9tastatiques":[73,119],"non":[75,121,135],"m\u00e9tastatiques.":[76,136],"Nous":[77,310],"rapportons":[78,233,311],"l'existence":[79,110,269,315,335,360],"d'une":[80,361],"colonisation":[81,103],"sp\u00e9cifique":[82],"(\u00e9tablies":[85],"caract\u00e9ris\u00e9es":[89],"leur":[91],"potentiel":[92],"m\u00e9tastatique)":[93],"incapables":[98],"m\u00e9tastaser":[100],"seules.":[101],"Cette":[102,137],"n'est":[106],"pas":[107,206],"due":[108],"d'embols":[111],"tumoraux":[112],"mixtes":[113],"(qui":[114],"seraient":[115,151],"faits":[116],"m\u00e9tastatiques),":[122],"ni":[123],"l'induction":[125],"d'un":[126,336],"switch":[127],"p\u00e9renne":[129],"au":[130,304],"sein":[131],"observation":[138],"remet":[139],"fortement":[140],"en":[141,215],"cause":[142],"selon":[146],"lequel":[147],"les":[148,174,235,298,349],"ne":[150,204],"form\u00e9es":[152],"que":[153,234,268,297,314,365],"sous-clone":[156],"pr\u00e9cis":[157],"la":[159,164,180,219,223,245,250,256,329,340,352,355],"tumeur":[160,392],"primitive":[161],"introduit":[163],"notion":[165],"nouvelle":[166],"intercellulaire.":[169],"deuxi\u00e8me":[171],"approche":[172],"conerne":[173],"diss\u00e9min\u00e9es":[177,319],"(DTC)":[178],"moelle":[181],"h\u00e9matopoi\u00e9tique":[182],"(microm\u00e9tastases":[183],"m\u00e9dullaires)":[184],"cohorte":[187],"plus":[189,301,332,343],"800":[191],"patientes":[192],"pr\u00e9sentant":[193],"sein.":[197],"L'existence":[198],"DTC,":[200],"g\u00e9n\u00e9tiquement":[201],"h\u00e9t\u00e9rog\u00e8nes":[202],"donnant":[205],"obligatoirement":[207],"lieu":[208],"croissance":[211],"tumorale":[212],"secondaire,":[213],"reste":[214],"effet":[216],"inexpliqu\u00e9e":[217],"th\u00e9orie":[220,353],"pr\u00e9valente":[221],"\u00ab":[224],"s\u00e9lection":[225,356],"clonale":[226,357],"\u00bb.":[227],"En":[228,291],"situation":[229,292],"adjuvante":[230],"(n=621),":[231],"nous":[232,295],"DTC":[236,271,299,397],"ont":[237],"impact":[239],"pronostique":[240],"fort":[241],"ind\u00e9pendant":[243],"sur":[244,255],"survie":[246,251,257],"sans":[247,258],"m\u00e9tastase":[248],"globale,":[252],"mais":[253],"aussi":[254],"r\u00e9cidive":[259],"loco-r\u00e9gionale.":[260],"analyse":[262],"compl\u00e9mentaire":[263],"r\u00e9cidives":[265],"loco-r\u00e9gionales":[266],"sugg\u00e8re":[267],"associ\u00e9e":[273],"diss\u00e9mination":[276,371],"ganglionnaire":[277],"n\u00e9cessitant":[278],"traitement":[280],"radioth\u00e9rapie":[282],"\u00e9tendu":[283],"aux":[284],"aires":[285],"ganglionnaires":[286],"susclaviculaires":[287],"mammaires":[289],"internes.":[290],"(n=138),":[294],"montrons":[296],"n'ont":[300],"d'impact":[302],"pronostique,":[303],"contraire":[305],"circulantes.":[309],"ailleurs":[313],"ces":[317],"(et":[320],"potentiellement":[321,342],"dormantes)":[322],"sont":[323,387],"associ\u00e9es":[324],"temps":[327],"jusqu'\u00e0":[328],"rechute":[330],"long,":[333],"sugg\u00e9rant":[334],"alternatif":[338],"diss\u00e9mination/dormance,":[341],"rapide.":[344],"Nos":[345],"travaux":[346],"montrent":[347],"donc":[348],"limites":[350],"sugg\u00e9rent":[359],"intercellulaire":[363],"ainsi":[364],"possibles":[367],"voies":[368],"alternatives":[369],"microm\u00e9tastique.":[372],"progr\u00e8s":[374],"futurs":[375],"n\u00e9cessiteront":[376],"probablement":[377],"l'analyse":[378],"int\u00e9gr\u00e9e":[379],"diff\u00e9rentes":[381],"\u00e9tapes":[382],"qui":[386],"devenues":[388],"r\u00e9cemment":[389],"accessibles":[390],":":[391],"primitive,":[393],"circulantes,":[396],"macrom\u00e9tastases":[399],"finales.":[400]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}