{"id":"https://openalex.org/W561285151","doi":null,"title":"Improving downstream processing for viral vectors and viral vaccines","display_name":"Improving downstream processing for viral vectors and viral vaccines","publication_year":2015,"publication_date":"2015-03-01","ids":{"openalex":"https://openalex.org/W561285151","mag":"561285151"},"language":"en","primary_location":{"id":"pmh:oai:run.unl.pt:10362/14845","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/14845","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10362/14845","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038667460","display_name":"Piergiuseppe Nestola","orcid":"https://orcid.org/0000-0003-3186-5149","observed_orcids":["https://orcid.org/0000-0003-3186-5149"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Piergiuseppe Nestola","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3186-5149","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038667460"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/downstream-processing","display_name":"downstream processing","score":0.9190000295639038},{"id":"https://openalex.org/keywords/viral-vectors","display_name":"viral vectors","score":0.9610000252723694},{"id":"https://openalex.org/keywords/viral-vaccines","display_name":"viral vaccines","score":0.9639999866485596},{"id":"https://openalex.org/keywords/continuous-bioprocessing","display_name":"continuous bioprocessing","score":0.7400000095367432},{"id":"https://openalex.org/keywords/biopharmaceutical-purification","display_name":"biopharmaceutical purification","score":0.8309999704360962},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.5820000171661377},{"id":"https://openalex.org/keywords/production-cost-reduction","display_name":"production cost reduction","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C2776207758","wikidata":"https://www.wikidata.org/wiki/Q5303302","display_name":"Downstream (manufacturing)","level":2,"score":0.6807789206504822},{"id":"https://openalex.org/C67568554","wikidata":"https://www.wikidata.org/wiki/Q385442","display_name":"Downstream processing","level":2,"score":0.6522671580314636},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6215314865112305},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3882356286048889},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3613313138484955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3437960147857666},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.17157405614852905},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.05904993414878845},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:run.unl.pt:10362/14845","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/14845","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},{"id":"mag:561285151","doi":null,"is_oa":false,"landing_page_url":"https://run.unl.pt/bitstream/10362/14845/1/PhD%20Thesis%20Nestola%20Final%20version.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:run.unl.pt:10362/14845","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/14845","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1906127102","https://openalex.org/W4285391716","https://openalex.org/W4386575307","https://openalex.org/W2020843955","https://openalex.org/W2129178711","https://openalex.org/W2626862020","https://openalex.org/W2035476552","https://openalex.org/W4385732579","https://openalex.org/W1999919668","https://openalex.org/W2218311183"],"abstract_inverted_index":{"Viral":[0],"vectors":[1],"are":[2,45],"playing":[3],"an":[4],"increasingly":[5],"important":[6],"role":[7],"in":[8,43,73,93],"the":[9,27,32,47,57,67,74,83,87],"vaccine":[10,49],"and":[11,38,119],"gene":[12],"therapy":[13],"elds.":[14],"The":[15,90,105],"broad":[16],"spectrum":[17],"of":[18,107,126],"potential":[19],"applications,":[20],"together":[21],"with":[22,111],"expanding":[23],"medical":[24],"markets,":[25],"drives":[26],"e":[28],"orts":[29],"to":[30,55,97,116],"improve":[31],"production":[33,68],"processes":[34,100,114],"for":[35,101,123],"viral":[36,39],"vaccines":[37],"vectors.":[40],"Developing":[41],"countries,":[42],"particular,":[44],"becoming":[46],"main":[48],"market.":[50],"It":[51],"is":[52,62],"thus":[53],"critical":[54],"decrease":[56],"cost":[58],"per":[59],"dose,":[60],"which":[61],"only":[63],"achievable":[64],"by":[65],"improving":[66],"process.":[69],"In":[70],"particular":[71],"advances":[72],"upstream":[75],"processing":[76],"have":[77],"substantially":[78],"increased":[79],"bioreactor":[80],"yields,":[81],"shifting":[82],"bioprocess":[84],"bottlenecks":[85],"towards":[86],"downstream":[88],"processing.":[89],"work":[91],"presented":[92],"this":[94],"thesis":[95],"aimed":[96],"develop":[98],"new":[99],"adenoviruses":[102],"puri":[103,124],"cation.":[104],"use":[106],"state-of-the-art":[108],"technology":[109],"combined":[110],"innovative":[112],"continuous":[113],"contributed":[115],"build":[117],"robust":[118],"cost-e":[120],"ective":[121],"strategies":[122],"cation":[125],"complex":[127],"biopharmaceuticals.(...)":[128]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
