{"id":"https://openalex.org/W56126361","doi":null,"title":"Buprenorphine TDS: the clinical development rationale and results.","display_name":"Buprenorphine TDS: the clinical development rationale and results.","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W56126361","mag":"56126361","pmid":"https://pubmed.ncbi.nlm.nih.gov/12665119"},"language":"en","primary_location":{"id":"pmid:12665119","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12665119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical practice. Supplement","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029217489","display_name":"Lukas Radbruch","orcid":"https://orcid.org/0000-0001-9526-396X","observed_orcids":["https://orcid.org/0000-0001-9526-396X"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lukas Radbruch","raw_affiliation_strings":["University of Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037041624","display_name":"A. P. E. Vielvoye-Kerkmeer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ans Vielvoye-Kerkmeer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.4619,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.93409586,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":null,"issue":"133","first_page":"15","last_page":"8; discussion 23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/buprenorphine","display_name":"buprenorphine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/transdermal-drug-delivery","display_name":"transdermal drug delivery","score":0.890999972820282},{"id":"https://openalex.org/keywords/matrix-type-patch","display_name":"matrix-type patch","score":0.6340000033378601},{"id":"https://openalex.org/keywords/opioid-analgesics","display_name":"opioid analgesics","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cancer-pain","display_name":"cancer pain","score":0.8880000114440918},{"id":"https://openalex.org/keywords/non-cancer-pain","display_name":"non-cancer pain","score":0.9390000104904175},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.6200000047683716},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.7509999871253967},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9091366529464722},{"id":"https://openalex.org/C2778949969","wikidata":"https://www.wikidata.org/wiki/Q407721","display_name":"Buprenorphine","level":4,"score":0.9043968915939331},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7437863945960999},{"id":"https://openalex.org/C2778904085","wikidata":"https://www.wikidata.org/wiki/Q3712728","display_name":"Cancer pain","level":3,"score":0.7159688472747803},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6552795767784119},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.6474449634552002},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.6335253715515137},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.611240804195404},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6103727221488953},{"id":"https://openalex.org/C2775842315","wikidata":"https://www.wikidata.org/wiki/Q1145270","display_name":"Transdermal patch","level":3,"score":0.5478607416152954},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.5127071142196655},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43729424476623535},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.43598970770835876},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3206031620502472},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2689405083656311},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.12506699562072754},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001294","descriptor_name":"Attitude to Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002047","descriptor_name":"Buprenorphine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002047","descriptor_name":"Buprenorphine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12665119","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12665119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical practice. Supplement","raw_type":"Journal Article"},{"id":"mag:56126361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12665119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1982422239","https://openalex.org/W2017424116","https://openalex.org/W192059276","https://openalex.org/W2091448117","https://openalex.org/W1985041003","https://openalex.org/W2113199015","https://openalex.org/W2095248985","https://openalex.org/W2092241233","https://openalex.org/W4250701005","https://openalex.org/W64953331"],"abstract_inverted_index":{"Buprenorphine,":[0],"a":[1,10,85,193],"powerful":[2],"opioid,":[3],"is":[4],"newly":[5],"available":[6],"for":[7,220],"delivery":[8],"in":[9,50,131,146,170,223],"transdermal":[11,14,38,80],"formulation.":[12],"The":[13,67,209],"system's":[15],"matrix":[16],"patch":[17,205],"provides":[18],"rate-controlled":[19],"administration":[20],"of":[21,35,45,69,75,143,149,181,196,201],"the":[22,36,51,73,79,95,107,124,132,175,204],"drug.":[23],"Three":[24],"double-blind,":[25],"placebo-controlled":[26],"trials":[27],"were":[28,48,141,159],"conducted":[29],"to":[30,57,100,163,206,214],"evaluate":[31],"efficacy":[32],"and":[33,59,88,103,138,140,157,161],"tolerability":[34],"buprenorphine":[37,76,114,211],"system":[39,81],"(buprenorphine":[40],"TDS,":[41],"Transtec).":[42],"A":[43],"total":[44],"445":[46],"patients":[47,122,173,182,202,224],"enrolled":[49],"studies.":[52],"All":[53],"suffered":[54],"from":[55,84,123,174],"moderate":[56],"severe":[58,61],"very":[60],"pain,":[62,120],"both":[63],"cancer-":[64],"or":[65,189],"non-cancer-related.":[66],"percentage":[68],"responders":[70],"increased":[71],"as":[72],"rate":[74,92],"delivered":[77],"by":[78,119],"rose,":[82],"ranging":[83],"29%":[86],"(cancer)":[87,102],"36%":[89],"(non-cancer)":[90,105],"response":[91],"associated":[93],"with":[94,106,225],"lowest":[96],"dose":[97,109],"(35":[98],"microg/h),":[99],"40%":[101],"46%":[104],"highest":[108],"(70":[110],"microg/h).":[111],"Patients":[112],"receiving":[113],"TDS":[115,212],"slept":[116],"longer,":[117],"uninterrupted":[118],"than":[121],"placebo":[125],"group.":[126],"Systemic":[127],"adverse":[128,152],"effects":[129],"reported":[130,145,183],"drug":[133],"cohorts":[134],"included":[135],"nausea,":[136],"vomiting":[137],"dizziness,":[139],"typical":[142],"those":[144],"other":[147],"studies":[148,178],"opioids;":[150],"local":[151],"events,":[153],"most":[154],"commonly":[155],"erythema":[156],"pruritus,":[158],"transient":[160],"mild":[162],"moderate.":[164],"In":[165],"an":[166,216],"open-label,":[167],"follow-up":[168],"trial,":[169],"which":[171],"239":[172],"original":[176],"clinical":[177],"participated,":[179],"90%":[180],"that":[184],"their":[185],"analgesia":[186,222],"was":[187],"satisfactory":[188],"even":[190],"better":[191],"over":[192],"mean":[194],"duration":[195],"4.7":[197],"months;":[198],"nearly":[199],"95%":[200],"found":[203],"be":[207,215],"user-friendly.":[208],"new":[210,218],"appears":[213],"important":[217],"modality":[219],"administering":[221],"non-acute":[226],"pain.":[227]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
