{"id":"https://openalex.org/W560924430","doi":null,"title":"Behavioral Aspects of Apolipoprotein E Knockout Mice","display_name":"Behavioral Aspects of Apolipoprotein E Knockout Mice","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W560924430","mag":"560924430"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.825.3925","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.825.3925","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://thekeep.eiu.edu/cgi/viewcontent.cgi?article%3D2433%26context%3Dtheses","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://thekeep.eiu.edu/theses/1424","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009738723","display_name":"Melissa T. Litherland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153871386","display_name":"Eastern Illinois University","ror":"https://ror.org/035z2ew45","country_code":"US","type":"education","lineage":["https://openalex.org/I153871386"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Melissa T. Litherland","raw_affiliation_strings":["Eastern Illinois University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Illinois University","institution_ids":["https://openalex.org/I153871386"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009738723"],"corresponding_institution_ids":["https://openalex.org/I153871386"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04087737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.890999972820282},{"id":"https://openalex.org/keywords/olfactory-dysfunction","display_name":"olfactory dysfunction","score":0.9300000071525574},{"id":"https://openalex.org/keywords/olfactory-bulb","display_name":"olfactory bulb","score":0.6899999976158142},{"id":"https://openalex.org/keywords/social-behavior","display_name":"social behavior","score":0.8489999771118164},{"id":"https://openalex.org/keywords/pup-retrieval","display_name":"pup retrieval","score":0.8939999938011169},{"id":"https://openalex.org/keywords/resident-intruder-test","display_name":"resident-intruder test","score":0.9779999852180481},{"id":"https://openalex.org/keywords/maternal-behavior","display_name":"maternal behavior","score":0.7850000262260437},{"id":"https://openalex.org/keywords/aggression","display_name":"aggression","score":0.7139999866485596},{"id":"https://openalex.org/keywords/olfactory-communication","display_name":"olfactory communication","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.6114298105239868},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.5043617486953735},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.49581393599510193},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.42607951164245605},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38693514466285706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23912200331687927},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23440304398536682},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23366078734397888},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09792149066925049},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09620919823646545},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09384506940841675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09347227215766907},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.08229935169219971},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.825.3925","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.825.3925","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://thekeep.eiu.edu/cgi/viewcontent.cgi?article%3D2433%26context%3Dtheses","raw_type":"text"},{"id":"pmh:oai:thekeep.eiu.edu:theses-2433","doi":null,"is_oa":true,"landing_page_url":"https://thekeep.eiu.edu/theses/1424","pdf_url":null,"source":{"id":"https://openalex.org/S2738785026","display_name":"Journal of Collective Bargaining in the Academy","issn_l":"1941-8043","issn":["1941-8043"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310316535","host_organization_name":"National Center for the Study of Collective Bargaining in Higher Education and the Professions","host_organization_lineage":["https://openalex.org/P4310316535"],"host_organization_lineage_names":["National Center for the Study of Collective Bargaining in Higher Education and the Professions"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Masters Theses","raw_type":"text"},{"id":"mag:560924430","doi":null,"is_oa":false,"landing_page_url":"https://thekeep.eiu.edu/cgi/viewcontent.cgi?article=2433&context=theses","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:thekeep.eiu.edu:theses-2433","doi":null,"is_oa":true,"landing_page_url":"https://thekeep.eiu.edu/theses/1424","pdf_url":null,"source":{"id":"https://openalex.org/S2738785026","display_name":"Journal of Collective Bargaining in the Academy","issn_l":"1941-8043","issn":["1941-8043"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310316535","host_organization_name":"National Center for the Study of Collective Bargaining in Higher Education and the Professions","host_organization_lineage":["https://openalex.org/P4310316535"],"host_organization_lineage_names":["National Center for the Study of Collective Bargaining in Higher Education and the Professions"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Masters Theses","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":127,"referenced_works":["https://openalex.org/W36773290","https://openalex.org/W98152484","https://openalex.org/W616067951","https://openalex.org/W1456846906","https://openalex.org/W1590095886","https://openalex.org/W1736154854","https://openalex.org/W1770880387","https://openalex.org/W1963568158","https://openalex.org/W1964740000","https://openalex.org/W1965835662","https://openalex.org/W1970399699","https://openalex.org/W1972768871","https://openalex.org/W1972968384","https://openalex.org/W1973220035","https://openalex.org/W1973882467","https://openalex.org/W1974462282","https://openalex.org/W1974633393","https://openalex.org/W1976162738","https://openalex.org/W1978476791","https://openalex.org/W1979395651","https://openalex.org/W1981237424","https://openalex.org/W1984001875","https://openalex.org/W1984059085","https://openalex.org/W1984327798","https://openalex.org/W1986152951","https://openalex.org/W1986440663","https://openalex.org/W1987136097","https://openalex.org/W1987526918","https://openalex.org/W1990795798","https://openalex.org/W1994816641","https://openalex.org/W1996608662","https://openalex.org/W1996649428","https://openalex.org/W1997018685","https://openalex.org/W1997913988","https://openalex.org/W1999463998","https://openalex.org/W2001688761","https://openalex.org/W2002451465","https://openalex.org/W2002558640","https://openalex.org/W2006409771","https://openalex.org/W2008693687","https://openalex.org/W2012372126","https://openalex.org/W2014289453","https://openalex.org/W2014780231","https://openalex.org/W2016836606","https://openalex.org/W2018759316","https://openalex.org/W2023639036","https://openalex.org/W2027042232","https://openalex.org/W2028658132","https://openalex.org/W2028674750","https://openalex.org/W2030432041","https://openalex.org/W2030816132","https://openalex.org/W2031164231","https://openalex.org/W2034629786","https://openalex.org/W2034968148","https://openalex.org/W2035584866","https://openalex.org/W2035883738","https://openalex.org/W2036362108","https://openalex.org/W2036425957","https://openalex.org/W2037234689","https://openalex.org/W2037778343","https://openalex.org/W2039831048","https://openalex.org/W2041477825","https://openalex.org/W2043012963","https://openalex.org/W2044400428","https://openalex.org/W2044837432","https://openalex.org/W2052422294","https://openalex.org/W2056795042","https://openalex.org/W2056863209","https://openalex.org/W2056920460","https://openalex.org/W2057597808","https://openalex.org/W2058379900","https://openalex.org/W2060352042","https://openalex.org/W2061764357","https://openalex.org/W2062386682","https://openalex.org/W2063968666","https://openalex.org/W2064798254","https://openalex.org/W2065307305","https://openalex.org/W2067064610","https://openalex.org/W2067541453","https://openalex.org/W2068014869","https://openalex.org/W2069027522","https://openalex.org/W2069130517","https://openalex.org/W2069638209","https://openalex.org/W2070617111","https://openalex.org/W2071134351","https://openalex.org/W2072422194","https://openalex.org/W2072682191","https://openalex.org/W2075703394","https://openalex.org/W2078465385","https://openalex.org/W2079010413","https://openalex.org/W2082987150","https://openalex.org/W2084744450","https://openalex.org/W2085190636","https://openalex.org/W2085767237","https://openalex.org/W2086366616","https://openalex.org/W2089504946","https://openalex.org/W2090650498","https://openalex.org/W2090816512","https://openalex.org/W2091485657","https://openalex.org/W2091622065","https://openalex.org/W2092060676","https://openalex.org/W2094566837","https://openalex.org/W2094670286","https://openalex.org/W2106067304","https://openalex.org/W2109651678","https://openalex.org/W2116334261","https://openalex.org/W2120483971","https://openalex.org/W2121638990","https://openalex.org/W2121811577","https://openalex.org/W2122230892","https://openalex.org/W2130763151","https://openalex.org/W2132071754","https://openalex.org/W2139285419","https://openalex.org/W2145068263","https://openalex.org/W2147413218","https://openalex.org/W2158965128","https://openalex.org/W2161002325","https://openalex.org/W2162719960","https://openalex.org/W2165044121","https://openalex.org/W2191903912","https://openalex.org/W2314514969","https://openalex.org/W2412209012","https://openalex.org/W2413676457","https://openalex.org/W2488618527","https://openalex.org/W2493028876","https://openalex.org/W2524702995","https://openalex.org/W3003397968"],"related_works":["https://openalex.org/W2139285419","https://openalex.org/W587901982","https://openalex.org/W2762158334","https://openalex.org/W7045401491","https://openalex.org/W4382699081","https://openalex.org/W2789577735","https://openalex.org/W2799413617","https://openalex.org/W2073760075","https://openalex.org/W7067886798","https://openalex.org/W2030752283"],"abstract_inverted_index":{"Apolipoprotein":[0],"E":[1,41],"(apoE)":[2],"is":[3,28,60,204],"a":[4,14,63,215],"lipid":[5],"transporting":[6],"protein":[7],"that":[8,26,191],"has":[9],"been":[10],"shown":[11,25],"to":[12,46,132],"play":[13,214],"vital":[15],"role":[16,216],"in":[17,31,39,49,55,68,88,90,97,123,210,217,221],"nerve":[18,51],"repair":[19,52],"and":[20,33,53,100,151,174,212],"remodeling.":[21],"Previous":[22],"studies":[23,189],"have":[24],"apoE":[27],"highly":[29],"expressed":[30],"human":[32],"mouse":[34],"olfactory":[35,50,56,82,135,196,208],"bulbs.":[36],"ApoE":[37,203],"deficiency":[38],"apolipoprotein":[40],"knockout":[42],"(apoE-KO)":[43],"mice":[44,80,99,104,115,122,156,164,181,192,211],"leads":[45],"considerable":[47],"delay":[48],"deficits":[54,168],"functioning.":[57],"Olfactory":[58,93],"function":[59,94,209],"necessary":[61,205],"for":[62,198,206],"number":[64],"of":[65,71,200],"social":[66,76,91,138,144,201,219],"behaviors":[67,220],"mice.":[69,222],"Loss":[70],"olfaction":[72],"can":[73],"greatly":[74],"reduce":[75],"behaviors.":[77,202],"Since":[78],"apoE-KO":[79,98,180],"display":[81,165],"dysfunction,":[83],"this":[84],"deficit":[85],"may":[86,213],"result":[87],"alterations":[89],"behavior.":[92],"was":[95],"assessed":[96],"wild":[101],"type":[102],"(WT)":[103],"by":[105],"using":[106],"the":[107,125],"odor":[108],"cued":[109,127],"taste":[110],"avoidance":[111],"test":[112,150],"(OCTA).":[113],"ApoE-KO":[114,155,163],"were":[116,182],"significantly":[117],"less":[118,183],"effective":[119],"than":[120,185],"WT":[121,186],"avoiding":[124],"odorant":[126],"tastant":[128],"solution.":[129],"In":[130],"order":[131],"determine":[133],"if":[134],"dysfunction":[136],"disrupted":[137],"behavior,":[139],"we":[140],"used":[141],"two":[142],"standard":[143],"behavior":[145,161,167],"tests:":[146],"1)":[147],"pup":[148],"retrieval":[149],"2)":[152],"resident-intruder":[153],"test.":[154],"performed":[157],"poorly":[158],"on":[159],"both":[160],"tests.":[162],"maternal":[166],"such":[169],"as":[170],"fewer":[171],"litters":[172],"retrieved":[173],"lower":[175],"nest":[176],"quality":[177],"scores.":[178],"Furthermore,":[179],"aggressive":[184],"individuals.":[187],"These":[188],"suggest":[190],"rely":[193],"heavily":[194],"upon":[195],"communication":[197],"modification":[199],"normal":[207],"regulating":[218]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}